Structure, performance and tissue repair evaluation of biodegradable core-sheath fiber patch loaded with curcumin nano-micelles

IF 6 2区医学 Q2 MATERIALS SCIENCE, BIOMATERIALS

Materials Science & Engineering C-Materials for Biological Applications Pub Date : 2025-07-30 DOI:10.1016/j.bioadv.2025.214432

Fuxun Qi , Shasha Zhang , Mingyu Zhang , Yiru Xu , Deng-Guang Yu , Lei Chu , Chenghao Wu , Xiaoyan Li , Xinliang Chen

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引用次数: 0

Abstract

In this paper, curcumin nanomicelles (Cur@M) were uniformly encapsulated in the core-sheath polylactic acid (PLA) fibers using coaxial electrospinning technology, and the structure and properties were adjusted by post-processing to develop a multifunctional tissue repair patch. The optimized patch demonstrated sustained curcumin release, hydrophilic surface, enhanced mechanical strength and predicable degradation. The patch had excellent biocompatibility and exhibited significant anti-inflammatory efficacy by polarizing pro-inflammatory M1 macrophages to anti-inflammatory M2 phenotypes while inhibiting the production of reactive oxygen species (ROS) and nitric oxide (NO). In vivo evaluation showed that the patch was able to promote the regeneration of defective tissue while providing biomechanical strength comparable to that of natural autologous tissue. The therapeutic mechanism involves M2 macrophage-mediated anti-inflammatory response and enhanced synthesis of type I collagen (COL1), which is critical for tissue repair. This multifunctional patch shows significant potential in biomedical applications, especially in pelvic floor reconstruction and soft tissue engineering.

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姜黄素纳米胶束可生物降解芯鞘纤维贴片的结构、性能及组织修复评价

本文采用同轴静电纺丝技术将姜黄素纳米胶束（Cur@M）均匀包裹在聚乳酸（PLA）纤维中，并通过后处理调整其结构和性能，制成多功能组织修复贴片。优化后的贴片具有姜黄素持续释放、表面亲水、机械强度增强和可降解等特点。该贴片具有良好的生物相容性，通过将促炎M1巨噬细胞极化为抗炎M2表型，同时抑制活性氧（ROS）和一氧化氮（NO）的产生，显示出显著的抗炎功效。体内评估表明，该贴片能够促进缺陷组织的再生，同时提供与天然自体组织相当的生物力学强度。治疗机制涉及M2巨噬细胞介导的抗炎反应和I型胶原（COL1）合成的增强，COL1对组织修复至关重要。这种多功能贴片在生物医学领域具有重要的应用潜力，特别是在盆底重建和软组织工程方面。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Materials Science & Engineering C-Materials for Biological Applications 工程技术-材料科学：生物材料

CiteScore

17.80

自引率

0.00%

发文量

501

审稿时长

27 days

期刊介绍： Biomaterials Advances, previously known as Materials Science and Engineering: C-Materials for Biological Applications (P-ISSN: 0928-4931, E-ISSN: 1873-0191). Includes topics at the interface of the biomedical sciences and materials engineering. These topics include: • Bioinspired and biomimetic materials for medical applications • Materials of biological origin for medical applications • Materials for "active" medical applications • Self-assembling and self-healing materials for medical applications • "Smart" (i.e., stimulus-response) materials for medical applications • Ceramic, metallic, polymeric, and composite materials for medical applications • Materials for in vivo sensing • Materials for in vivo imaging • Materials for delivery of pharmacologic agents and vaccines • Novel approaches for characterizing and modeling materials for medical applications Manuscripts on biological topics without a materials science component, or manuscripts on materials science without biological applications, will not be considered for publication in Materials Science and Engineering C. New submissions are first assessed for language, scope and originality (plagiarism check) and can be desk rejected before review if they need English language improvements, are out of scope or present excessive duplication with published sources. Biomaterials Advances sits within Elsevier''s biomaterials science portfolio alongside Biomaterials, Materials Today Bio and Biomaterials and Biosystems. As part of the broader Materials Today family, Biomaterials Advances offers authors rigorous peer review, rapid decisions, and high visibility. We look forward to receiving your submissions!