American Journal of Dermatopathology最新文献

{"title":"A Look Back at Mercury Soap as a Treatment for Yaws.","authors":"John A Papalas","doi":"10.1097/DAD.0000000000003364","DOIUrl":"https://doi.org/10.1097/DAD.0000000000003364","url":null,"abstract":"<p><strong>Abstract: </strong>The centuries-old practice of using mercury as a treatment for syphilis is well-known. The historical use of mercury for other treponematoses is less well-recognized. Afridol was a mercury containing soap produced by Bayer which they promoted as a cure for various cutaneous aliments, including yaws (frambosia). In this article, I briefly outline the development of Afridol and its subsequent marketing with the use of early 20th century medical advertising art.</p>","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":"48 10","pages":"770-774"},"PeriodicalIF":0.8,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149002854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Histopathologic Comparison Between Morphea, Lichen Sclerosus, and Systemic Sclerosis: A Prospective Cross-Sectional Observational Study From a Tertiary Care Hospital.","authors":"Bevan Priyadharsan, Revathi Selvaraj, Pavithra Ayyanar, Madhusmita Sethy, Shreya K Gowda, M Richardson, Ashok K Sahoo, Biswanath Behera","doi":"10.1097/DAD.0000000000003241","DOIUrl":"10.1097/DAD.0000000000003241","url":null,"abstract":"<p><strong>Abstract: </strong>Morphea, lichen sclerosus (LS), and systemic sclerosis (SSc) are chronic sclerosing dermatoses with overlapping clinical features that can complicate diagnosis. Although histopathology is essential for differentiation, comparative studies on their histopathologic characteristics remain limited. This study aimed to compare the histopathologic features of morphea, LS, and SSc, and assess their association with disease duration and clinical induration. Ninety cases (30 each of morphea, LS, and SSc) meeting the inclusion criteria were enrolled. Participants underwent comprehensive clinical evaluation, laboratory investigations, and masked histopathologic analysis. Clinical induration was graded on a 1-3 scale. Significant differences were observed across epidermal, dermal, and subcutaneous features. Epidermal alterations included hyperkeratosis, hypergranulosis, irregular acanthosis, pigmentation, lymphocytic exocytosis, vacuolar interface dermatitis, and subepidermal split (all false discovery rate [FDR] P = 0.001). Dermal and subcutaneous distinctions included sclerosis depth, dermal edema, lymphocytic infiltration, subcutaneous inflammation, increased collagen deposition, and lipomembranous panniculitis (all FDR P = 0.001). Distinctive histologic signs further aided differentiation. Diagnostic performance analysis of histopathologic features revealed several key parameters that reliably differentiate the 3 entities. No histopathologic features were significantly associated with disease duration after FDR correction. Lymphocytic exocytosis was strongly negatively correlated with induration grade (Somer D = -0.632), while hypocellular dermis (Somer D = 0.598) and sclerosis depth (ρ = 0.591) showed positive correlations. This study elucidates distinct histopathologic features that discriminate morphea, LS, and SSc, underscoring the critical importance of a methodical histopathologic evaluation. The correlation between histologic findings and clinical induration emphasizes its pivotal role in both diagnosis and guiding treatment decisions.</p>","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":"48 10","pages":"751-767"},"PeriodicalIF":0.8,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149002877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Desmoplastic Trichilemmoma Mimicking Basal Cell Carcinoma: Two New Cases, Systematic Review of 92 Cases and Dual Staining Diagnostic Approach.","authors":"Mokhtar H Abdelhammed, Hong Yu, Nisha S Ramani","doi":"10.1097/DAD.0000000000003322","DOIUrl":"10.1097/DAD.0000000000003322","url":null,"abstract":"<p><strong>Abstract: </strong>Desmoplastic trichilemmoma (DTM) is a rare and benign variant of conventional trichilemmoma which presents a diagnostic challenge. It closely mimics malignant neoplasms, particularly basal cell carcinoma (BCC), because of overlapping clinical and histopathological features. Accurate differentiation is crucial to prevent misdiagnosis and management. The aim of this study was to synthesize the available clinical and histopathological data on DTM by presenting 2 new cases and conducting a systematic review of the literature. A retrospective query was conducted of database from 2012 to 2026 identifying 2 DTM cases. In addition, a systematic review of the PubMed database was performed for English language publications from 1990 to present day, yielding 29 publications for inclusion. The addition of 2 new cases brings the total number of DTMs in the compiled dataset to 94 cases. DTM typically presents as a solitary lesion on the head and neck of older adults, ranging in size from 0.3 to 7 cm, with rare cases reported on the chest, vulva, and lower extremities. Histopathologically, its lobular and cord-like growth pattern, peripheral palisading, and desmoplastic stroma closely mimic BCC. Immunohistochemically, the current cases showed immunoreactivity for CD34 and a concurrent negativity for BerEP4. Based on the current findings and review data, 8 CD34-positive/BerEP4-negative and 10 CD34-positive DTMs were identified. Accurate distinction between DTM and BCC requires careful histological examination, which is enhanced by the application of the proposed CD34-BerEP4 dual-marker approach. This diagnostic utility guides appropriate clinical management and prevents unnecessary or inadequate treatment.</p>","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":"804-809"},"PeriodicalIF":0.8,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148334160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hidden Malignancy: Predominantly InSitu Porocarcinoma Arising in a Poroma.","authors":"Fabio Del Carro, Giovanni Evalli, Giovanni Fellegara","doi":"10.1097/DAD.0000000000003400","DOIUrl":"10.1097/DAD.0000000000003400","url":null,"abstract":"<p><strong>Abstract: </strong>Porocarcinoma is a rare malignant adnexal tumor which can originate either de novo or-much more rarely-from a preexisting eccrine poroma. Given its aggressive clinical behavior, a timely diagnosis is essential for optimal patient's management. We report the case of a 79-year-old woman presenting with a well-circumscribed exophytic mass located on her right calcaneal region, which had been present for 2 years but had recently shown progressive enlargement. An excisional diagnostic biopsy was performed, and histopathological examination showed a poroid lesion with no malignant features. A diagnosis of eccrine poroma was then considered. However, deeper sections revealed a focal intraepidermal proliferation of markedly atypical cells and a small intradermal nest suggestive of early dermal invasion. The atypical population was characterized by overexpression of both p53 and p16, an increased ki-67 proliferation index, and preserved mismatch repair proteins. The diagnosis was then changed into a predominantly in situ , focally invasive porocarcinoma arising in an eccrine poroma. The patient underwent electrocautery of the wound margins and an echographic examination of pelvic nodes-which were negative for metastases-and was free of recurrence at a 6-month follow-up. This case provides evidence that benign-looking eccrine poromas may harbor microscopic foci of malignant transformation, thus emphasizing the need for a careful and thorough histopathological evaluation of these lesions.</p>","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":"768-769"},"PeriodicalIF":0.8,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13585160/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148834056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endogenous Ochronosis: Clinicopathological Features in a Late-Onset Case.","authors":"Eva Sticova, Jan Hugo, Monika Arenbergerova","doi":"10.1097/DAD.0000000000003338","DOIUrl":"10.1097/DAD.0000000000003338","url":null,"abstract":"","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":"831-833"},"PeriodicalIF":0.8,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148334234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Histologic Features of Secondary Syphilis: A Systematic Review and Meta-Analysis: Erratum.","authors":"Izadora Lapenda, Amanda Tauana, Alana Pereira, Ana Carolina Putini Vieira, Maria Antônia Akabane, Babar Rao","doi":"10.1097/DAD.0000000000003309","DOIUrl":"https://doi.org/10.1097/DAD.0000000000003309","url":null,"abstract":"","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149082741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unilateral Myxedema on the Forearm Without Thyroid Diseases.","authors":"Yao Zhang, Tong Zhang, Yinxia Yu, Haibin Cai","doi":"10.1097/DAD.0000000000003432","DOIUrl":"https://doi.org/10.1097/DAD.0000000000003432","url":null,"abstract":"","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148984174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aggressive Cytotoxic Lymphomas of the Auricle: An Under-recognized Presentation.","authors":"Madeline J Hooper, Tessa M LeWitt, Yue Zhang, Paola Aguilar Neuville, Kimberly Bohjanen, Alessio Giubellino, Adriana Garcia-Herrera, Maria Teresa Estrach, Christiane Querfeld, Xiaolong A Zhou, Elias Campo, Joan Guitart","doi":"10.1097/DAD.0000000000003433","DOIUrl":"https://doi.org/10.1097/DAD.0000000000003433","url":null,"abstract":"<p><strong>Abstract: </strong>Primary cutaneous acral CD8+ T-cell lymphoproliferative disorder has been recognized by the World Health Organization as a distinct entity characterized by dermal-based, nonulcerated nodules typically involving the auricle and following an indolent course. By contrast, cytotoxic cutaneous lymphomas presenting with tumoral lesions of the auricle can follow a locally aggressive or metastatic course. In this study, we discuss the presentation, diagnosis, molecular characteristics, and treatment options for these under-recognized, aggressive cytotoxic lymphomas of the auricle. Six cases of cytotoxic lymphoma NOS and 4 cases of CD4+ primary cutaneous γδ T-cell lymphoma that presented as auricular tumors were included in this series. Patches at other sites resembling mycosis fungoides with variable immunophenotypes were observed in 7 cases. Despite multimodal therapy, 7 of 10 patients died within median 14 months of presentation. Necrotizing and locally progressive tumors of the auricle may represent an ominous sign of aggressive treatment-refractory cytotoxic lymphomas characterized by swift mortality.</p>","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148978635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Superficial Thrombophlebitis With Abundant Mucin Deposition.","authors":"Misaki Kusano, Ko-Ron Chen, Toshiyuki Yamamoto","doi":"10.1097/DAD.0000000000003438","DOIUrl":"https://doi.org/10.1097/DAD.0000000000003438","url":null,"abstract":"","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148978596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blaschko-Linear Lesions With Epidermolytic Hyperkeratosis.","authors":"Kaihong Fang, Jiechen Zhang","doi":"10.1097/DAD.0000000000003429","DOIUrl":"https://doi.org/10.1097/DAD.0000000000003429","url":null,"abstract":"","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148931715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}