老年妇女左腿上的异常结节--病例报告：挑战。

IF 1.1 4区医学 Q4 DERMATOLOGY

American Journal of Dermatopathology Pub Date : 2025-03-26 DOI:10.1097/DAD.0000000000002961

Gerardo Cazzato, Giuseppe Ingravallo, Paola Vitiello, Francesca Pagliuca, Renato Franco, Andrea Ronchi

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Unusual Nodule on the Left Leg of an Elderly Woman-A Case Report: Challenge.

Abstract: We present the case of a 71-year-old woman with no significant medical history who developed a nodular, ulcerated lesion on her left leg, alongside bruise-like lesions on her extremities. Histologic examination revealed basal cell carcinoma with adenoid-cystic features colliding with blastic plasmacytoid dendritic cell neoplasm (BPDCN), a rare and aggressive hematologic malignancy. Immunohistochemical analysis confirmed BPDCN, with markers such as CD123, CD4, CD56, and TCL1, and a high proliferation index (Ki67 >90%). This represents the first reported case of a collision lesion comprising adenoid-cystic basal cell carcinoma and BPDCN. The findings highlight the need for comprehensive histopathologic evaluation in atypical cases to achieve an accurate diagnosis.

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来源期刊

American Journal of Dermatopathology 医学-皮肤病学

CiteScore

1.80

自引率

9.10%

发文量

453

审稿时长

3 months

期刊介绍： The American Journal of Dermatopathology offers outstanding coverage of the latest diagnostic approaches and laboratory techniques, as well as insights into contemporary social, legal, and ethical concerns. Each issue features review articles on clinical, technical, and basic science advances and illuminating, detailed case reports. With the The American Journal of Dermatopathology you''ll be able to: -Incorporate step-by-step coverage of new or difficult-to-diagnose conditions from their earliest histopathologic signs to confirmatory immunohistochemical and molecular studies. -Apply the latest basic science findings and clinical approaches to your work right away. -Tap into the skills and expertise of your peers and colleagues the world over peer-reviewed original articles, "Extraordinary cases reports", coverage of practical guidelines, and graphic presentations. -Expand your horizons through the Journal''s idea-generating forum for debating controversial issues and learning from preeminent researchers and clinicians