{"title":"A Solitary Fibrofolliculoma on the Back With a Nevus.","authors":"Sanah Basrai, David S Cassarino","doi":"10.1097/DAD.0000000000002980","DOIUrl":null,"url":null,"abstract":"<p><strong>Abstract: </strong>Multiple fibrofolliculomas (FFs) are a major feature for the rare autosomal dominant disorder Birt-Hogg-Dubé syndrome. Individuals with this condition carry a mutation in the FLCN (folliculin) gene that increases their risk for pneumothorax and renal cell carcinoma. Solitary FFs do not have a genetic component to suggest BHD syndrome. However, they are rare, benign tumors with epithelial and connective tissue features, primarily reported on the face, head, and neck. Here, we present the case of 46-year-old woman with a solitary FF on the back coexisting with a nevus. Histological analysis confirmed the diagnosis of FF, characterized by an irregular follicular structure with epithelial cords and an associated fibromyxoid stroma. This case contributes to the limited reports of solitary FFs, highlighting the rare occurrence and unique association with a nevus.</p>","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":"e68-e70"},"PeriodicalIF":1.1000,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"American Journal of Dermatopathology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/DAD.0000000000002980","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/4/22 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"DERMATOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Abstract: Multiple fibrofolliculomas (FFs) are a major feature for the rare autosomal dominant disorder Birt-Hogg-Dubé syndrome. Individuals with this condition carry a mutation in the FLCN (folliculin) gene that increases their risk for pneumothorax and renal cell carcinoma. Solitary FFs do not have a genetic component to suggest BHD syndrome. However, they are rare, benign tumors with epithelial and connective tissue features, primarily reported on the face, head, and neck. Here, we present the case of 46-year-old woman with a solitary FF on the back coexisting with a nevus. Histological analysis confirmed the diagnosis of FF, characterized by an irregular follicular structure with epithelial cords and an associated fibromyxoid stroma. This case contributes to the limited reports of solitary FFs, highlighting the rare occurrence and unique association with a nevus.
期刊介绍：
The American Journal of Dermatopathology offers outstanding coverage of the latest diagnostic approaches and laboratory techniques, as well as insights into contemporary social, legal, and ethical concerns. Each issue features review articles on clinical, technical, and basic science advances and illuminating, detailed case reports.
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