American Journal of Dermatopathology最新文献

In Situ Protein Expression Analysis of Melanocyte Differentiation Antigen TRP1 (Tyrosinase-Related Protein-1). 黑色素细胞分化抗原 TRP1（酪氨酸酶相关蛋白-1）的原位蛋白表达分析。

IF 1.1 4区医学

American Journal of Dermatopathology Pub Date : 2024-09-01 Epub Date: 2024-06-28 DOI: 10.1097/DAD.0000000000002772

Joyce M Chen, Enmily Hernandez, Denise Frosina, Peter A Ruh, Charlotte Ariyan, Klaus J Busam, Achim A Jungbluth

{"title":"In Situ Protein Expression Analysis of Melanocyte Differentiation Antigen TRP1 (Tyrosinase-Related Protein-1).","authors":"Joyce M Chen, Enmily Hernandez, Denise Frosina, Peter A Ruh, Charlotte Ariyan, Klaus J Busam, Achim A Jungbluth","doi":"10.1097/DAD.0000000000002772","DOIUrl":"10.1097/DAD.0000000000002772","url":null,"abstract":"Abstract: Melanocyte differentiation antigens refer to molecules expressed in cells of melanocytic lineage such as gp100/PMEL, tyrosinase, and Melan-A. Corresponding antibodies such as HMB45, T311, and A103 have become key immunohistochemical tools in surgical pathology for the diagnosis of pigmented and related lesions. Little is known about tyrosinase-related protein 1 (TRP1), another melanocyte differentiation antigen, which is an enzymatic component of melanogenesis and known as the brown locus in mice. In this study, we tested several commercial reagents to TRP1 and identified one clone, EPR13063, which we further characterized by testing its specificity and usefulness for surgical pathology. Subsequently, we analyzed the expression of TRP1 in panels of normal tissues and tumors. TRP1 is regularly expressed in normal skin and in cutaneous nevi predominantly present in junctional and to a lesser extent in dermal nevocytes. In melanoma, TRP1 is present in 100% and 44% of primary and metastatic melanomas, respectively. TRP1 was absent in 5 desmoplastic melanomas but heterogeneously present in 9 of 11 PEComas/angiomyolipomas. No TRP1 was found in neoplasms of nonmelanocytic lineage. We demonstrate that EPR13063 is a valuable reagent for the analysis of TRP1 expression in archival surgical pathology material. The TRP1 expression pattern in melanocytic and related lesions appears to parallel other melanocyte differentiation antigens with a higher incidence in primary and a lower incidence in metastatic melanomas.","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141621749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pigmented Villonodular Synovitis: A Metastatic Melanoma Imitator. 色素性绒毛结节性滑膜炎：转移性黑色素瘤的模仿者

IF 1.1 4区医学

American Journal of Dermatopathology Pub Date : 2024-09-01 Epub Date: 2024-07-12 DOI: 10.1097/DAD.0000000000002771

Brittany C Fields, Anish J Jain, Victor G Prieto, Spencer J Frink, Ashley M Holder

引用次数: 0

A Complex Vasculitis: Thrombophlebitis, Subcutaneous Granulomatous Arteritis, and Eosinophilic Granulomatosis With Polyangiitis Presenting Clinically as Livedo Racemosa With Nodular Erythema. 复杂的脉管炎：血栓性静脉炎、皮下肉芽肿性动脉炎和多发性血管炎嗜酸性肉芽肿临床表现为带结节性红斑的红斑狼疮

IF 1.1 4区医学

American Journal of Dermatopathology Pub Date : 2024-09-01 Epub Date: 2024-07-12 DOI: 10.1097/DAD.0000000000002763

Toshiyuki Yamamoto, Ko-Ron Chen

引用次数: 0

Cellular Schwannoma Mimicking a Nodular Melanoma on the Sole of the Foot, an Avoidable Diagnostic Pitfall. 模仿足底结节性黑色素瘤的细胞性许旺瘤，一个可避免的诊断陷阱。

IF 1.1 4区医学

American Journal of Dermatopathology Pub Date : 2024-09-01 Epub Date: 2024-06-20 DOI: 10.1097/DAD.0000000000002770

Begoña Ruz Portero, Carmen García de Sola Llamas, Manuel Pérez Pérez, María Luisa Sánchez Bernal, David Moreno Ramírez, Juan José Ríos Martín

{"title":"Cellular Schwannoma Mimicking a Nodular Melanoma on the Sole of the Foot, an Avoidable Diagnostic Pitfall.","authors":"Begoña Ruz Portero, Carmen García de Sola Llamas, Manuel Pérez Pérez, María Luisa Sánchez Bernal, David Moreno Ramírez, Juan José Ríos Martín","doi":"10.1097/DAD.0000000000002770","DOIUrl":"https://doi.org/10.1097/DAD.0000000000002770","url":null,"abstract":"Abstract: We report a rare case of cellular schwannoma (CS) manifesting as an ulcerated nodular lesion, mimicking spindle cell melanoma on the sole of the foot. CS, a benign variant of schwannoma, typically occurs in deep soft tissues but can rarely present cutaneously. The diagnosis of CS heavily relies on histopathological examination and immunohistochemical staining for specific markers such as SOX10 and S100. In this case, initial clinical suspicion of nodular melanoma was confirmed on biopsy, which revealed a spindle cell neoplasm positive for SOX10 and negative for melanocytic markers. Misdiagnosis of nodular melanoma was averted through complete excision. CS diagnosis demands careful consideration due to its resemblance to other spindle cell neoplasms, especially melanoma. Meticulous histopathological evaluation and immunostaining are important to differentiate CS from similar lesions, ensuring accurate diagnosis and appropriate management. This report contributes valuable insights into the diagnostic challenges and management of CS, particularly in unusual cutaneous presentations.","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141989476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tumor necrosis factor ALPHA Inhibitor Associated Köhlmeier-Degos Disease as a Novel Iatrogenic Paradigm That Underscores Excessive Type I Interferon in Its Pathogenesis. 肿瘤坏死因子 ALPHA 抑制剂相关的科尔迈耶-德戈斯病是一种新的先天性范例，它强调了过量的 I 型干扰素在其发病机制中的作用。

IF 1.1 4区医学

American Journal of Dermatopathology Pub Date : 2024-09-01 Epub Date: 2024-06-14 DOI: 10.1097/DAD.0000000000002765

Cynthia M Magro, Scott Sanders

{"title":"Tumor necrosis factor ALPHA Inhibitor Associated Köhlmeier-Degos Disease as a Novel Iatrogenic Paradigm That Underscores Excessive Type I Interferon in Its Pathogenesis.","authors":"Cynthia M Magro, Scott Sanders","doi":"10.1097/DAD.0000000000002765","DOIUrl":"10.1097/DAD.0000000000002765","url":null,"abstract":"Abstract: Malignant atrophic papulosis/Köhlmeier-Degos disease was first described in 1941 by Köhlmeier in an anecdotal case report that described a young man who presented with extensive multiple intestinal perforations and a papular skin rash. Köhlmeier-Degos disease represents a unique vasculopathy targeting both the microvasculature and the arterial system. One of its most characteristic features is reflected by the discrete multifocal depressed porcelain lesions involving the skin and gastrointestinal tract. The pathological findings are striking and can be broadly categorized into those that are vascular in nature versus extravascular matrix production in the context of extensive extravascular hyaluronic acid and collagen deposition. A dynamic evolutionary morphology is observed not only clinically but also histologically. The microvascular alterations are particularly evident in the skin and are characterized by endothelial cell necrosis with subsequent endothelial cell detachment accompanied by intraluminal fibrin deposition, defining a thrombogenic microangiopathy that in later stage lesions is typically pauci-inflammatory. The arterial lesions are very distinctive and include significant neointimal proliferation with vascular luminal occlusion by amorphous plugs of collagen intimately admixed with platelets. Pathogenetically enhanced type I interferon signaling and endothelial cell injury mediated by the membranolytic attack complex (ie, C5b-9) are key in the evolution of the thrombotic microvascular and obliterative fibrosing arteriopathic changes. We describe a case of Köhlmeier-Degos disease that developed in the setting of tumor necrosis factor (TNF)-alpha inhibitor therapy with the drug golimumab. The clinical features, light microscopic findings, and a pathophysiologic paradigm based on the critical role of TNF-alpha in controlling the type I interferon response are discussed.","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11328922/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141989481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of 2 T-Cell Receptor-γ Clonality Assays on Skin Biopsies Suspicious for Mycosis Fungoides. 对疑似真菌病皮肤活检组织进行两种 T 细胞受体-γ 克隆测定的比较

IF 1.1 4区医学

American Journal of Dermatopathology Pub Date : 2024-09-01 Epub Date: 2024-03-08 DOI: 10.1097/DAD.0000000000002654

Stan Miller, Travis Vandergriff, Heather Woodworth Goff, Jing Xu, Dwight Oliver

{"title":"Comparison of 2 T-Cell Receptor-γ Clonality Assays on Skin Biopsies Suspicious for Mycosis Fungoides.","authors":"Stan Miller, Travis Vandergriff, Heather Woodworth Goff, Jing Xu, Dwight Oliver","doi":"10.1097/DAD.0000000000002654","DOIUrl":"10.1097/DAD.0000000000002654","url":null,"abstract":"Abstract: PCR-based fragment analysis of the T-cell receptor (TCR) gene is used extensively in diagnostic labs to assess clonality in T-cell populations in multiple tissue sites. Of the numerous TCR assays that have been reported, studies assessing use on biopsies suspicious for mycosis fungoides specifically are lacking. We compared clonality findings from a previously run 2-tube/2-fluorochrome dye assay to a redesigned 1-tube/1-fluorochrome dye assay on formalin-fixed skin biopsies. Overall, the accuracy of the 2-tube assay was marginally better (75.7% vs. 71.4%), when using clinical history combined with histologic diagnosis as the gold standard. The 2-tube assay had better sensitivity (73.7% vs. 65.8%), while the 1-tube assay had superior specificity (93.8% vs. 87.5%). Clonality results were easier to interpret with the 1-tube assay. In nearly 19% of cases, a change of assays on the same biopsy resulted in a change of clonality interpretation. For laboratories that change TCR-γ clonality assays, follow-up biopsies for mycosis fungoides assessment may result in a change of diagnosis.","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140066109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic Accuracy of ChatGPT for Textbook Descriptions of Epidermal Tumors: An Exploratory Study. 表皮肿瘤教科书描述的 ChatGPT 诊断准确性：一项探索性研究

IF 1.1 4区医学

American Journal of Dermatopathology Pub Date : 2024-09-01 Epub Date: 2024-06-06 DOI: 10.1097/DAD.0000000000002767

Kevin Yang, Lawangeen Zeb, Sejong Bae, Peter G Pavlidakey

引用次数: 0

Two Squamomelanocytic Tumors With Dendritic Melanocytes: Thoughts About Origin. 两种带有树突状黑色素细胞的鳞状黑素细胞瘤：关于起源的思考

IF 1.1 4区医学

American Journal of Dermatopathology Pub Date : 2024-09-01 Epub Date: 2024-06-06 DOI: 10.1097/DAD.0000000000002746

Juliet Suen, Kiley K Fagan, Douglas J Grider

引用次数: 0

Pseudolymphomatous Cutaneous Angiosarcoma Presenting With Persistent Firm Facial Edema in a Patient With Systemic Sclerosis. 假性淋巴瘤性皮肤血管肉瘤伴有系统性硬化症患者面部持续性坚实水肿

IF 1.1 4区医学

American Journal of Dermatopathology Pub Date : 2024-09-01 Epub Date: 2024-06-06 DOI: 10.1097/DAD.0000000000002740

Silvia Méndez-Flores, Marcela Saeb-Lima, Hilda Esther Fragoso-Loyo

{"title":"Pseudolymphomatous Cutaneous Angiosarcoma Presenting With Persistent Firm Facial Edema in a Patient With Systemic Sclerosis.","authors":"Silvia Méndez-Flores, Marcela Saeb-Lima, Hilda Esther Fragoso-Loyo","doi":"10.1097/DAD.0000000000002740","DOIUrl":"10.1097/DAD.0000000000002740","url":null,"abstract":"Abstract: Pseudolymphomatous cutaneous angiosarcoma (cAS) is a rare subtype characterized by a prominent lymphocytic infiltrate, posing diagnostic challenges due to its resemblance to lymphoid neoplastic processes. We present a novel case highlighting the clinical and histopathological features, notably its association with persistent firm facial edema in a patient with systemic sclerosis (SSc). A 47-year-old woman with a 21-year history of SSc presented with firm palpebral edema evolving to involve the entire face and cervical region over six months. Diagnostic imaging revealed inflammatory changes in orbital regions, supradiaphragmatic lymphadenopathies, and lytic lesions. Skin biopsy demonstrated a diffuse neoplasm with vascular channels and solid areas, accompanied by dense lymphocytic proliferation. Pseudolymphomatous cutaneous angiosarcoma, a rare malignant neoplasm, exhibits variable clinical presentations and rapid progression. Histologically, it manifests as irregularly shaped vascular channels lined by prominent endothelial cells. Immunohistochemistry, particularly markers such as v-ets erythroblastosis virus E26 oncogene homolog (avian) (ERG), aids in diagnosis. Notably, this case marks the first presentation of cAS with persistent facial edema in SSc, highlighting the association between SSc and cancer risk. This case underscores the diagnostic challenges posed by cAS and emphasizes the importance of early detection for optimal patient outcomes. Further understanding of its association with autoimmune disorders such as SSc is crucial for comprehensive management strategies.","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141263195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Two Cases of Cutaneous Sarcomatoid Squamous Cell Carcinoma Resembling Cutaneous Giant Cell Tumor of Soft Tissue. 两例类似皮肤软组织巨细胞瘤的皮肤肉瘤样鳞状细胞癌。

IF 1.1 4区医学

American Journal of Dermatopathology Pub Date : 2024-09-01 Epub Date: 2024-06-06 DOI: 10.1097/DAD.0000000000002739

Sarah G McAlpine, Osward Y Carrasquillo, Jayson Miedema, Paul B Googe

{"title":"Two Cases of Cutaneous Sarcomatoid Squamous Cell Carcinoma Resembling Cutaneous Giant Cell Tumor of Soft Tissue.","authors":"Sarah G McAlpine, Osward Y Carrasquillo, Jayson Miedema, Paul B Googe","doi":"10.1097/DAD.0000000000002739","DOIUrl":"10.1097/DAD.0000000000002739","url":null,"abstract":"Abstract: Cutaneous sarcomatoid squamous cell carcinoma is well-described with histology resembling pleomorphic undifferentiated sarcoma featuring collagenous or myxoid stroma with or without elements of keratinizing squamous carcinoma. This report presents 2 cases of dedifferentiated squamous cell carcinoma (SCC) composed of sheets of malignant mononuclear cells with malignant osteoclast-like multinucleated giant cells, extravasated blood, and hemosiderin resembling cutaneous giant cell tumor (cGCT). In the first case, an exophytic facial mass of a 96-year-old woman removed by shave showing extensive cGCT-like tumor but with microscopic elements of SCC in situ and positivity for cytokeratin 5/6 in the malignant spindle cells and SCC. The second case involved a 32-year-old man with a pedunculated penile mass removed by shave biopsy, displaying malignant cytology resembling cGCT, focal staining for cytokeratin AE1/AE3 and p63, and CD68 highlighting the osteoclast-like giant cells. Molecular analysis revealed CDKN2A, TP53, and TERT. Upon reexcision, case 2 showed focally invasive keratinizing SCC associated with differentiated penile intraepithelial neoplasia and lichen sclerosus. Skin specimens with an exophytic mass histologically resembling cGCT but with malignant cytology should be meticulously evaluated for elements of SCC. Molecular analysis, detecting mutations like H3F3 or HMGA2-NCOR2 fusion, can aid in distinguishing cutaneous sarcomatoid squamous cell carcinoma from GCT bone or GCT soft tissue.","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141263208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0