Lucas Barbosa Furtado, Lorena Araújo Luz, Clarissa Viveiros Lima, Elvis Martins Cabral, Carla Riama Lopes de Pádua Moura, Rafael de Deus Moura
{"title":"Mucinous Syringometaplasia in the Inguinal Region: Case Report and Literature Review.","authors":"Lucas Barbosa Furtado, Lorena Araújo Luz, Clarissa Viveiros Lima, Elvis Martins Cabral, Carla Riama Lopes de Pádua Moura, Rafael de Deus Moura","doi":"10.1097/DAD.0000000000002972","DOIUrl":"10.1097/DAD.0000000000002972","url":null,"abstract":"<p><strong>Abstract: </strong>A 66-year-old man presented with a pedunculated papule measuring 9.0 mm in the left inguinal region. Excision was performed based on the clinical hypotheses of soft fibroma and pyogenic granuloma. Histopathologic evaluation demonstrated invagination of the epidermis, with a tubular tortuous path showing the presence of squamous cells and goblet cells rich in mucin, and adjacent epithelium showing acanthosis, papillomatosis, and hyperkeratosis, with a diagnosis of mucinous syringometaplasia. This is a rare entity, with 19 cases reported to date, including the present case, usually clinically diagnosed as a viral wart or basal cell carcinoma, with no cases of recurrence reported after complete excision.</p>","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":"435-438"},"PeriodicalIF":1.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143765714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Case of Recurrent Eyelid Cutaneous Myxoma With Basaloid Proliferation in a Child.","authors":"Margaryta Stoieva, Emily O'Donnell","doi":"10.1097/DAD.0000000000002926","DOIUrl":"10.1097/DAD.0000000000002926","url":null,"abstract":"<p><strong>Abstract: </strong>Cutaneous myxomas are extremely rare in the pediatric population. We describe a case of an eyelid cutaneous myxoma with multiple recurrences in an 8-year-old child. The lesion once previously diagnosed as eccrine hidrocystoma had been excised three times with subsequent recurrence. Frozen section diagnosis performed during the fourth excision showed striking basaloid features, prompting deferral of definitive diagnosis to permanent sections. Following routine processing, basaloid proliferations were again seen without significant atypia or mitotic activity in addition to background features of myxoma. CD10 immunostain highlighted both basaloid nests and surrounding stroma. Cutaneous myxoma was diagnosed. The diagnosis was corroborated by an external consultation. The patient underwent genetic testing for the Carney complex with negative results. This case report raises some practical points. First, due to their rarity in the pediatric population and potential to mimic other entities, cutaneous myxomas can be misdiagnosed as other benign neoplasms. Second, although induction of basaloid proliferation has been well-documented in myxoma, it can be easily misinterpreted as a malignant process, particularly in the setting of a frozen section diagnosis and lack of available clinical information. Third, even though solitary cutaneous myxomas are less likely to be associated with the Carney complex, a possibility of such an association should always be born in mind, as consequences of missing syndromic neoplasms, such as cardiac myxoma, can be lethal.</p>","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":"477-480"},"PeriodicalIF":1.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jesse Veenstra, Wyatt Boothby-Shoemaker, Ben J Friedman
{"title":"Response to \"Appropriate Statistical Methods to Assess Cross-Study Diagnostic 23-Gene Expression Profile Test Performance for Cutaneous Melanocytic Neoplasms\".","authors":"Jesse Veenstra, Wyatt Boothby-Shoemaker, Ben J Friedman","doi":"10.1097/DAD.0000000000002983","DOIUrl":"10.1097/DAD.0000000000002983","url":null,"abstract":"","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":"497-498"},"PeriodicalIF":1.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144057784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gerardo Cazzato, Giuseppe Ingravallo, Paola Vitiello, Francesca Pagliuca, Renato Franco, Andrea Ronchi
{"title":"Unusual Nodule on the Left Leg of an Elderly Woman-A Case Report: Answer.","authors":"Gerardo Cazzato, Giuseppe Ingravallo, Paola Vitiello, Francesca Pagliuca, Renato Franco, Andrea Ronchi","doi":"10.1097/DAD.0000000000002962","DOIUrl":"https://doi.org/10.1097/DAD.0000000000002962","url":null,"abstract":"","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":"47 6","pages":"493-494"},"PeriodicalIF":1.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144095411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Elastosis Amyloidosis as a Histologic Pattern in Cutaneous Amyloidosis.","authors":"Eva Sánchez-Martínez, Jörg Schaller","doi":"10.1097/DAD.0000000000002952","DOIUrl":"10.1097/DAD.0000000000002952","url":null,"abstract":"<p><strong>Abstract: </strong>Elastosis amyloidosis is an exceptionally rare form of cutaneous amyloidosis characterized by amyloid deposition around dermal elastic fibers. To date, only 11 cases have been documented in the literature, some of them with associated systemic involvement. We report a case of a 60-year-old man presenting with an asymptomatic umbilical nodule. Histopathological analysis revealed amyloid deposits in the upper reticular dermis with characteristic distribution around the elastic fibers, confirmed by positive staining with PAS and Congo red. Immunohistochemical staining was positive for cytokeratins but negative for light chains and other systemic amyloid markers, leading to a diagnosis of elastosis amyloidosis with deposit of amyloid-AK, a finding previously unreported. We consider this an incidental discovery that may provide new insights into the etiopathogenesis of amyloidosis in both localized and systemic processes.</p>","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":"433-434"},"PeriodicalIF":1.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143659705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Elaine Kunzler, Clinton Enos, Mary Bohannon, Addie Walker, Leah Hooey, Tricia Missall, Kiran Motaparthi, Vladimir Vincek
{"title":"The University of Florida Dermatopathology Experience With the Pigmented Lesion Assay.","authors":"Elaine Kunzler, Clinton Enos, Mary Bohannon, Addie Walker, Leah Hooey, Tricia Missall, Kiran Motaparthi, Vladimir Vincek","doi":"10.1097/DAD.0000000000002974","DOIUrl":"10.1097/DAD.0000000000002974","url":null,"abstract":"<p><strong>Abstract: </strong>The pigmented lesion assay (PLA) is a noninvasive test used to risk stratify pigmented lesions and rule out melanoma. There is a scarcity of data from nonbiased studies on PLA performance in the real world. PLA results from 107 skin specimens were compared with final pathologic diagnoses. To determine clinical relevance of PLA results, diagnoses were categorized into actionable melanocytic, nonactionable melanocytic, and nonmelanocytic. Of specimens with positive PLA results, 24.0% (25/104) were actionable melanocytic diagnoses, 42.3% (44/104) nonactionable melanocytic, and 33.7% (35/104) nonmelanocytic. Because most specimens submitted for pathologic evaluation had positive PLA results, positive predictive values were calculated for overall PLA results and the individual genes tested. The overall positive predictive value for surgically actionable melanocytic lesions was 24.0%. The positive predictive values of the individual genes were determined to be 28.2% for LINC00518, 34.7% for PReferentially expressed Antigen in Melanoma, and 31.8% for telomerase reverse transcriptase.</p>","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":"468-471"},"PeriodicalIF":1.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144056545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Apoorva Mehta, Anna Bowling, Emily R Gordon, Oluwaseyi Adeuyan, Brigit A Lapolla, Alejandro Gru, Larisa J Geskin
{"title":"Concomitant Squamous Cell Carcinoma and Mycosis Fungoides Within the Same Lesion: A Case Report and Literature Review.","authors":"Apoorva Mehta, Anna Bowling, Emily R Gordon, Oluwaseyi Adeuyan, Brigit A Lapolla, Alejandro Gru, Larisa J Geskin","doi":"10.1097/DAD.0000000000002975","DOIUrl":"10.1097/DAD.0000000000002975","url":null,"abstract":"<p><strong>Abstract: </strong>Concomitant squamous cell carcinoma (SCC) and mycosis fungoides (MF) within the same lesion are exceedingly rare, with only 3 cases previously reported. Cutaneous T-cell lymphoma (CTCL) predisposes patients to malignancies because of immune dysregulation, and treatments such as narrow-band ultraviolet-B phototherapy increase carcinogenic risk. We describe a 78-year-old man with stage IVA1 CTCL who presented with a scaly, painful tumor on his left temple. Biopsy revealed well-differentiated SCC with atypical lymphoid infiltrate consistent with MF, marked by immunohistochemical positivity for CD3, CD5, CD30, and a CD4:CD8 ratio of 50:1. Mohs surgery was performed, and histopathology analysis confirmed the coexistence of SCC and MF, with greater loss of CD7 expression in atypical lymphocytes. Concurrent SCC and MF demonstrate the need for vigilant surveillance for secondary cutaneous malignancies in patients with advanced CTCL. The case presented herein contributes to expand the reported literature and highlights the necessity of individualized management strategies optimized on an individual's Fitzpatrick skin type and unique risk factors.</p>","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":"472-476"},"PeriodicalIF":1.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144065225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jesús Machuca-Aguado, Ana López-Prieto, Rodrigo Mora-Díaz, Álvaro Gutiérrez-Domingo, María Garrido-Ruiz, José Luis Rodríguez-Peralto, Juan José Ríos-Martín
{"title":"PRAME Immunostaining in BAP-1-Inactivated Melanocytic Tumors: Unraveling Diagnostic Complexity and Exploring Germline Mutation Associations.","authors":"Jesús Machuca-Aguado, Ana López-Prieto, Rodrigo Mora-Díaz, Álvaro Gutiérrez-Domingo, María Garrido-Ruiz, José Luis Rodríguez-Peralto, Juan José Ríos-Martín","doi":"10.1097/DAD.0000000000002717","DOIUrl":"https://doi.org/10.1097/DAD.0000000000002717","url":null,"abstract":"<p><strong>Background: </strong>Cutaneous melanocytic tumors with BAP-1 inactivation (BIMTs), linked to mutations in the BAP-1 gene, present diagnostic challenges due to their morphological similarities with other melanocytic lesions. The search for reliable diagnostic markers, including PRAME, holds potential to significantly improve the accuracy of differential diagnoses.</p><p><strong>Methods: </strong>A retrospective analysis of 32 BIMTs from 25 patients, collected between 2018 and 2022, involved histologic examination and immunostaining for BAP-1 and PRAME.</p><p><strong>Results: </strong>Positive PRAME expression, defined as diffuse staining in at least 75% of nevic cells, was observed in 19% of cases. Variations in PRAME expression patterns were noted, particularly in biphasic lesions and those associated with germline BAP-1 mutations.</p><p><strong>Conclusions: </strong>The diagnostic complexities of BIMTs necessitate a comprehensive diagnostic strategy. While BAP-1 immunostaining remains pivotal, this study explored PRAME as a potential adjunctive diagnostic tool. PRAME antibody shows highly variable expression in BIMTs, limiting its utility as a supportive tool for the differential diagnosis with melanomas, especially in patients with biphasic lesions and germline mutations in BAP-1.</p>","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":"47 6","pages":"421-427"},"PeriodicalIF":1.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144095318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gerardo Cazzato, Maged Daruish, Francesco Fortarezza, Anna Colagrande, Andrea Marzullo, Giuseppe Ingravallo, Angelo Paolo Dei Tos, Richard K Yang, Woo Cheal Cho
{"title":"Gene Fusion-Driven Cutaneous Adnexal Neoplasms: An Updated Review Emphasizing Molecular Characteristics.","authors":"Gerardo Cazzato, Maged Daruish, Francesco Fortarezza, Anna Colagrande, Andrea Marzullo, Giuseppe Ingravallo, Angelo Paolo Dei Tos, Richard K Yang, Woo Cheal Cho","doi":"10.1097/DAD.0000000000002933","DOIUrl":"10.1097/DAD.0000000000002933","url":null,"abstract":"<p><strong>Abstract: </strong>Gene rearrangements or fusions have emerged as critical oncogenic drivers in various cutaneous adnexal neoplasms. This review offers a comprehensive overview of both established and recently identified molecular alterations, with a specific focus on gene fusions. Key alterations discussed include YAP1 rearrangements, CRTC1::MAML2 fusions, BRD3 rearrangements, MYB::NFIB fusions, ETV6::NTRK3 fusions, and PLAG1 rearrangements, alongside rarer fusion transcripts, such as MEF2C::SS18 , FOXK1::GRHL1/2 , GPS2::GRHL , and RARA::NPEPPS . The article highlights the significance of these genetic changes in tumor biology and their potential therapeutic implications for locally advanced and metastatic skin adnexal tumors. It also addresses diagnostic challenges and molecular distinctions, providing updated insights into adnexal tumors driven by these gene fusions.</p>","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":"453-461"},"PeriodicalIF":1.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}