American Journal of Dermatopathology最新文献

A Case of Secondary Anetoderma Following Dermatofibroma.

IF 1.1 4区医学

American Journal of Dermatopathology Pub Date : 2025-04-02 DOI: 10.1097/DAD.0000000000002957

Tomoko Chiba-Segawa, Toshiya Takahashi, Mayuko Amagai, Yuichiro Segawa, Emi Yamazaki, Saaya Yoshida-Akai, Kenichiro Tsuchiyama, Taku Fujimura, Kenshi Yamasaki, Setsuya Aiba, Yoshihide Asano

引用次数: 0

Mucinous Syringometaplasia in the Inguinal Region: Case Report and Literature Review.

IF 1.1 4区医学

American Journal of Dermatopathology Pub Date : 2025-04-02 DOI: 10.1097/DAD.0000000000002972

Lucas Barbosa Furtado, Lorena Araújo Luz, Clarissa Viveiros Lima, Elvis Martins Cabral, Carla Riama Lopes de Pádua Moura, Rafael de Deus Moura

引用次数: 0

Histiocytoid Sweet Syndrome as a Manifestation of Myelodysplasia Cutis/Cutaneous VEXAS Syndrome.

IF 1.1 4区医学

American Journal of Dermatopathology Pub Date : 2025-04-02 DOI: 10.1097/DAD.0000000000002969

Tristen T W Ng, Chris Van Vliet, Justin Bui, Benjamin A Wood

引用次数: 0

TAX1BP1::BRAF Fusion in BRAF-Mutated Atypical Spitz Tumor/Spitz Melanocytoma: A Novel Molecular Finding With Histopathological Insights.

IF 1.1 4区医学

American Journal of Dermatopathology Pub Date : 2025-04-02 DOI: 10.1097/DAD.0000000000002973

Joana Sorino, Mario Della Mura, Giuseppe Ingravallo, Anna Colagrande, Gerardo Cazzato

引用次数: 0

The Rarity in the Rarity: A Rare Case of Bednar Tumor (Pigmented Dermatofibrosarcoma Protuberans) Localized on Acral Skin With Negative COL1A1-PDGFB Fusion on Fluorescence In Situ Hybridization.

IF 1.1 4区医学

American Journal of Dermatopathology Pub Date : 2025-04-02 DOI: 10.1097/DAD.0000000000002964

Gerardo Cazzato, Irma Trilli, Anna Colagrande, Enrica Macorano, Nadia Casatta, Carmelo Lupo, Giuseppe Ingravallo

{"title":"The Rarity in the Rarity: A Rare Case of Bednar Tumor (Pigmented Dermatofibrosarcoma Protuberans) Localized on Acral Skin With Negative COL1A1-PDGFB Fusion on Fluorescence In Situ Hybridization.","authors":"Gerardo Cazzato, Irma Trilli, Anna Colagrande, Enrica Macorano, Nadia Casatta, Carmelo Lupo, Giuseppe Ingravallo","doi":"10.1097/DAD.0000000000002964","DOIUrl":"https://doi.org/10.1097/DAD.0000000000002964","url":null,"abstract":"Abstract: Dermatofibrosarcoma protuberans (DFSP) is a rare, low-grade fibroblastic tumor that typically exhibits CD34 positivity and a storiform growth pattern. Although commonly found on the trunk and proximal extremities, DFSP can also present in less frequent locations, such as the head, neck, and acral sites. This report discusses a rare case of pigmented DFSP, also known as Bednar tumor, located on the back of the left hand in a 48-year-old woman. Histological examination revealed a mesenchymal proliferation with a storiform pattern and occasional dendritic melanocytes. Immunohistochemical analysis confirmed strong CD34 positivity while excluding other markers. Despite the absence of the typical COL1A1-PDGFB gene fusion, a diagnosis of pigmented DFSP was rendered. This case underscores the importance of considering DFSP in differential diagnoses of acral tumors and suggests the possibility of noncanonical genetic rearrangements in DFSP occurring in atypical locations. The patient remains under close clinical and ultrasound follow-up because of the potential for local recurrence.","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143765732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Plaque-like Myofibroblastic Tumor: First Report of a Locally Advanced Tumor.

IF 1.1 4区医学

American Journal of Dermatopathology Pub Date : 2025-04-01 Epub Date: 2024-06-14 DOI: 10.1097/DAD.0000000000002749

Francisco Vílchez-Márquez, María Narváez-Simón, Pablo Díaz-Calvillo, Clara Ureña-Paniego, Salvador Arias-Santiago

引用次数: 0

Acral Cutaneous Intraneural Pseudoperineurioma.

IF 1.1 4区医学

American Journal of Dermatopathology Pub Date : 2025-04-01 Epub Date: 2025-02-06 DOI: 10.1097/DAD.0000000000002938

Badr AbdullGaffar, Rabiah Farhan

{"title":"Acral Cutaneous Intraneural Pseudoperineurioma.","authors":"Badr AbdullGaffar, Rabiah Farhan","doi":"10.1097/DAD.0000000000002938","DOIUrl":"10.1097/DAD.0000000000002938","url":null,"abstract":"Abstract: Several cutaneous neurovascular stromal lesions are clinically and pathologically ill-defined entities. They are known by different nomenclatures, often unrecognized, misinterpreted, and confused with other skin lesions. Reports have documented cases of palmar and oral lesions in both children and adults. There is uncertainty regarding their true prevalence, clinicopathologic characteristics, and classification. Our aim is to highlight the salient histopathologic, histochemical, and immunohistochemical features of acral nodular tumors showing perineuriomatous differentiation. We found 3 teenagers (0.2%) [2 females, 1 male, average age: 13 years] with hand nodules out of 1331 patients with cutaneous and oral polypoid lesions. They were isolated, asymptomatic, nontraumatic, subcentimetric, palmar, digital nodules with an average duration of 5 years. They demonstrated dermal-based anomalous growths composed of thick tortuous neurovascular bundles and collagenous fibrovascular stroma. Masson trichome demarcated micronodular and plexiform neurovascular bundles showing concentric onion-bulb whorls ensheathed in collagenous fibrovascular stroma. Elastic fibers were absent. Alcian blue demonstrated intraneural mucinous alteration and loose interstitial myxoid mesenchyme. CD31, ERG, and smooth muscle actin highlighted small intraneural capillary-sized, and larger venous and arteriolar interstitial vasculatures. CD34 decorated the interstitial mesenchyme. S100, SOX10, and neurofilament revealed sparse neural components, whereas EMA and GLUT1 highlighted prominent perineurial components within the neurovascular bundles and onion-bulb micronodules. The findings suggest that cutaneous intraneural pseudoperineurioma nodules may represent a distinct clinicopathologic entity among traumatic neuromas, resembling cutaneous intraneural perineurioma. Further validation studies are necessary because of the small size of the case series and the lack of molecular genetic studies.","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":"274-282"},"PeriodicalIF":1.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PIK3CA Mutation in FAVA of Adults With Unusual Anatomical Localization.

IF 1.1 4区医学

American Journal of Dermatopathology Pub Date : 2025-04-01 Epub Date: 2025-02-06 DOI: 10.1097/DAD.0000000000002935

Angel Fernandez-Flores

引用次数: 0

Evaluating Advanced Machine Learning Models for Histopathological Diagnosis of Hansen Disease. 评估用于汉森氏病组织病理学诊断的高级机器学习模型。

IF 1.1 4区医学

American Journal of Dermatopathology Pub Date : 2025-04-01 Epub Date: 2024-11-05 DOI: 10.1097/DAD.0000000000002875

Mariana Vargas-Clavijo, Nora Cardona-Castro, Juan Pablo Ospina-Gómez, Héctor Serrano-Coll

{"title":"Evaluating Advanced Machine Learning Models for Histopathological Diagnosis of Hansen Disease.","authors":"Mariana Vargas-Clavijo, Nora Cardona-Castro, Juan Pablo Ospina-Gómez, Héctor Serrano-Coll","doi":"10.1097/DAD.0000000000002875","DOIUrl":"10.1097/DAD.0000000000002875","url":null,"abstract":"Introduction: Leprosy is a neglected infectious disease caused by Mycobacterium leprae and Mycobacterium lepromatosis and remains a public health challenge in tropical regions. Therefore, the development of technological tools such as machine learning (ML) offers an opportunity to innovate strategies for improving the diagnosis of this complex disease.Objective: To validate the utility of different ML models for the histopathological diagnosis of Hansen disease.Methodology: An observational study was conducted where 55 H&E-stained tissue slides from leprosy patients and 51 healthy skin controls were analyzed using microphotographs captured at various magnifications. These images were categorized based on histopathological findings and processed using the Cross-Industry Standard Process for Data Mining methodology for designing and training ML models. Five types of ML models were evaluated using standard metrics such as accuracy, sensitivity, and specificity, emphasizing data normalization as a fundamental step in optimizing model performance.Results: The artificial neural network (ANN) model demonstrated an accuracy of 70%, sensitivity of 74%, and specificity of 65%, demonstrating its ability to identify leprosy cases with moderate precision. The receiver operating characteristic curve of the ANN model showed an area under the curve of 0.71. Conversely, models such as decision trees, logistic regression, and random forests showed similar accuracy results but with slightly lower sensitivity, potentially indicating a higher risk of false negatives in detecting leprosy-positive cases.Conclusion: The ANN model emerges as a promising alternative for leprosy detection. However, further refinement of these models is necessary to enhance their adaptability across different clinical settings and participation in patient care.","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":"301-307"},"PeriodicalIF":1.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142584965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hidradenocarcinoma of the Chest With Axillary Lymph Node Metastasis: Report of 2 Cases and Systematic Literature Review of a Breast Cancer Mimicker. 胸部汗腺癌伴腋窝淋巴结转移：2例报告及1例乳腺癌模拟者的系统文献复习。

IF 1.1 4区医学

American Journal of Dermatopathology Pub Date : 2025-04-01 Epub Date: 2024-12-10 DOI: 10.1097/DAD.0000000000002874

Francesco Fortarezza, Giuseppe Maggioni, Anna Colagrande, Gerardo Cazzato, Angelo Paolo Dei Tos

{"title":"Hidradenocarcinoma of the Chest With Axillary Lymph Node Metastasis: Report of 2 Cases and Systematic Literature Review of a Breast Cancer Mimicker.","authors":"Francesco Fortarezza, Giuseppe Maggioni, Anna Colagrande, Gerardo Cazzato, Angelo Paolo Dei Tos","doi":"10.1097/DAD.0000000000002874","DOIUrl":"10.1097/DAD.0000000000002874","url":null,"abstract":"Abstract: Hidradenocarcinoma (HAC) is a rare malignant neoplasm originating from eccrine sweat glands, often presenting diagnostic challenges because of its resemblance to other malignancies, particularly breast cancer when occurring in the chest region. This report describes 2 cases of HAC with axillary lymph node metastasis, both initially misinterpreted clinically. The first case involved a 63-year-old woman with a sternal mass, near the right breast, initially suspected to be a sebaceous cyst. Histologic examination revealed a solid-cystic epithelial tumor with features suggestive of HAC, confirmed by immunohistochemical analysis. The second case concerned an 81-year-old woman with a subcutaneous growth in the sternal area, also diagnosed as HAC after histopathologic and immunohistochemical assessment. Both cases demonstrated strong estrogen receptor positivity, leading to the recommendation of hormonal therapy. A systematic review of the literature identified 21 similar cases of HAC in the chest wall, highlighting the diagnostic complexities and the potential for these tumors to mimic breast carcinoma. This review underscores the need for careful histologic and immunohistochemical evaluation to differentiate HAC from other malignancies, particularly in the breast region. Given the rare and the potential aggressive nature of HAC, early and accurate diagnosis is crucial for guiding appropriate therapeutic strategies and improving patient outcomes.","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":"321-326"},"PeriodicalIF":1.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142808320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0