American Journal of Dermatopathology最新文献

Primary Cutaneous Anaplastic Large Cell Lymphoma in a Patient With Li Fraumeni Syndrome. 李氏综合征患者的原发性皮肤间变性大细胞淋巴瘤。

IF 0.8 4区医学

American Journal of Dermatopathology Pub Date : 2026-11-01 Epub Date: 2026-08-03 DOI: 10.1097/DAD.0000000000003398

Aliya Shabbir, Katherine Awh, Neha Gupta, Mia S DeSimone, Eric Jacobsen, Cecilia Larocca

{"title":"Primary Cutaneous Anaplastic Large Cell Lymphoma in a Patient With Li Fraumeni Syndrome.","authors":"Aliya Shabbir, Katherine Awh, Neha Gupta, Mia S DeSimone, Eric Jacobsen, Cecilia Larocca","doi":"10.1097/DAD.0000000000003398","DOIUrl":"10.1097/DAD.0000000000003398","url":null,"abstract":"Abstract: Li-Fraumeni syndrome (LFS) is an inherited cancer predisposition syndrome caused by germline TP53 mutations and is associated with an increased risk of several malignancies. Although breast implant-associated anaplastic large cell lymphoma has been reported in patients with LFS, primary cutaneous anaplastic large cell lymphoma has not previously been described. We report a case of primary cutaneous anaplastic large cell lymphoma in a 64-year-old man with LFS harboring a germline TP53 p.R196* mutation who presented with a solitary ulcerated nodule on the left anterior thigh. Histopathologic examination demonstrated an ulcerated dermal infiltrate of large atypical CD30-positive T lymphocytes admixed with small lymphocytes and eosinophils. Immunophenotyping showed expression of CD3, CD2, CD4, CD30, CD43, and CD45, with weak CD5 expression and loss of CD7 and EMA. Targeted exome sequencing identified the patient's known germline TP53 mutation together with additional somatic mutations and copy number alterations, whereas whole-body positron emission tomography/computed tomography demonstrated no evidence of systemic disease. The lesion was completely excised, and radiotherapy was deferred because of the patient's underlying LFS and associated risk of radiation-induced malignancy. The patient remains disease-free 36 months after diagnosis. This case expands the spectrum of lymphoid malignancies reported in patients with LFS and highlights the importance of recognizing hereditary cancer predisposition syndromes when selecting treatment strategies for primary cutaneous lymphomas.","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":"e119-e122"},"PeriodicalIF":0.8,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148671251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

On the Progression From Early-to Late-Stage Melanoma: A Potential Sequence of Molecular Events Using Data From Droplet Digital PCR and Array Comparative Genomic Hybridization, A Pilot Study. 从早期到晚期黑色素瘤的进展：利用液滴数字PCR和阵列比较基因组杂交数据的潜在分子事件序列，一项初步研究。

IF 0.8 4区医学

American Journal of Dermatopathology Pub Date : 2026-11-01 Epub Date: 2026-06-16 DOI: 10.1097/DAD.0000000000003350

Jason R McFadden, Arkar Htoo, Advaita S Chaudhari, Mirjana Stevanovic, Gregory J Tsongalis, Edward G Hughes, Aravindhan Sriharan

{"title":"On the Progression From Early-to Late-Stage Melanoma: A Potential Sequence of Molecular Events Using Data From Droplet Digital PCR and Array Comparative Genomic Hybridization, A Pilot Study.","authors":"Jason R McFadden, Arkar Htoo, Advaita S Chaudhari, Mirjana Stevanovic, Gregory J Tsongalis, Edward G Hughes, Aravindhan Sriharan","doi":"10.1097/DAD.0000000000003350","DOIUrl":"10.1097/DAD.0000000000003350","url":null,"abstract":"Abstract: Melanoma progression is generally associated with a stepwise increase in genomic complexity. Although the copy number variations (CNVs) known to occur in melanoma are well characterized, the order in which they accumulate during melanomagenesis remains incompletely understood. To explore this, we used droplet digital polymerase chain reaction to calculate absolute copy numbers of RREB1 and CDKN2A , the most commonly amplified and deleted genes in melanoma, in 51 formalin-fixed, paraffin-embedded melanomas. Each sample also underwent chromosomal microarray analysis to determine its CNV burden, which we graded according to the number of the following melanoma-associated CNVs present: RREB1 gain, CDKN2A loss, MYC gain, and MYB loss. In this pilot study, increasing CNV burden was associated with a gradual increase in average RREB1 copy number: from 2.00 in CNV-negative melanomas to 2.68 in melanomas with isolated RREB1 gain; 2.75 in melanomas with RREB1 gain and CDKN2A loss; 2.93 in melanomas with RREB1 gain and MYC gain; and 3.23 in melanomas with RREB1 gain, CDKN2A loss, and MYC gain ( F = 10.43, P < 0.001). A parallel trend was observed for average CDKN2A copy number, which decreased progressively with increasing CNV burden: from 2.02 in CNV-negative melanomas to 1.33 in melanomas with isolated CDKN2A loss; 1.15 in melanomas with CDKN2A loss and MYC gain; and 0.53 in melanomas with CDKN2A loss and MYB loss ( F = 12.01, P < 0.001). These findings support a potential model of stepwise CNV accumulation in melanoma: early RREB1 gain and/or CDKN2A loss, followed by MYC gain, and ultimately MYB loss.","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":"853-859"},"PeriodicalIF":0.8,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148334273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dupilumab-Associated Mycosis Fungoides: Unmasked, Direct Effect, or a Lymphoid Reaction? 杜匹单抗相关蕈样真菌病：暴露，直接作用，还是淋巴反应？

IF 0.8 4区医学

American Journal of Dermatopathology Pub Date : 2026-11-01 Epub Date: 2026-09-02 DOI: 10.1097/DAD.0000000000003423

Pauline C Xu, Corey J Georgesen, Matthew A Lunning, Dinesh Pradhan

{"title":"Dupilumab-Associated Mycosis Fungoides: Unmasked, Direct Effect, or a Lymphoid Reaction?","authors":"Pauline C Xu, Corey J Georgesen, Matthew A Lunning, Dinesh Pradhan","doi":"10.1097/DAD.0000000000003423","DOIUrl":"10.1097/DAD.0000000000003423","url":null,"abstract":"Abstract: Dupilumab, an interleukin (IL)-4 and IL-13 antagonist, is a biological agent approved in 2017 for the treatment of moderate-to-severe atopic dermatitis (AD). While dupilumab has proven revolutionary in managing AD, recent reports have emerged linking its use with the subsequent development of cutaneous T-cell lymphomas (CTCLs), including mycosis fungoides (MF) and Sézary syndrome. Between 2017 and 2023, a total of 178 cases of CTCLs were reportedly associated with dupilumab therapy for AD. The most common theory for this association is \"unmasking,\" where patients were initially misdiagnosed with AD, failed first-line treatments and dupilumab, and later were correctly diagnosed with CTCLs. Another possibility is dupilumab might exacerbate or cause progression of preexisting CTCLs in a patient with concomitant AD. However, conversely, there is also the confounder of a false-positive diagnosis of MF after dupilumab that may overinflate the association data. It has also been reported that dupilumab can cause a reversible benign cutaneous lymphoid reaction that mimics early-stage MF both clinically and histologically, though data are sparse. As CTCL has been exclusively diagnosed in patients who received dupilumab for AD and not in patients who received dupilumab for other conditions such as asthma and since no increased incidence of noncutaneous lymphoma has been reported with dupilumab therapy, it appears unlikely that dupilumab causes or has an actual oncopathogenic effect in developing CTCL or transforming AD into lymphoma. However, this alarming observation emphasizes the need for further biological investigation in determining the mechanism by which dupilumab is associated with CTCL.","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":"845-852"},"PeriodicalIF":0.8,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148882517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-Term Outcomes Support Utilization of 23-GEP in Clinically Ambiguous Melanocytic Neoplasms. 长期结果支持23-GEP在临床上模棱两可的黑色素细胞肿瘤中的应用。

IF 0.8 4区医学

American Journal of Dermatopathology Pub Date : 2026-11-01 Epub Date: 2026-09-09 DOI: 10.1097/DAD.0000000000003419

Kavenpreet S Bal, Nikita J Patel, Leandra Doan, Sophia Liang, David S Cassarino

{"title":"Long-Term Outcomes Support Utilization of 23-GEP in Clinically Ambiguous Melanocytic Neoplasms.","authors":"Kavenpreet S Bal, Nikita J Patel, Leandra Doan, Sophia Liang, David S Cassarino","doi":"10.1097/DAD.0000000000003419","DOIUrl":"10.1097/DAD.0000000000003419","url":null,"abstract":"Abstract: Difficult-to-diagnose melanocytic neoplasms often require additional diagnostic tools beyond histopathological assessment to reach a definitive diagnosis. The 23-gene expression profile (GEP) test provides additional diagnostic information, returning a result of suggestive of benign , intermediate , or suggestive of malignant . Here, we present a real-world cohort of ambiguous melanocytic lesions where the 23-GEP test was used to arrive at a definitive diagnosis with long-term follow-up. Melanocytic lesions were included in this study if 23-GEP testing was performed as part of their original diagnostic workup (n = 267). Long-term follow-up to determine disease recurrence and/or metastasis (ie, an event) was obtained (median, 6 years). Following 23-GEP testing, 89.5% of difficult-to-diagnose lesions were provided definitive diagnoses. Event rates were 11.5% for lesions with malignant 23-GEP results, 2.9% for lesions with intermediate results, and 1.3% for lesions with benign results (Fisher exact, P = 0.002). Lesions with at least 5 years of clinical follow-up and/or an event (n = 163) had similar results to the overall cohort ( P = 0.007). A benign 23-GEP result is associated with a low risk of recurrence/metastasis, whereas a malignant 23-GEP result is associated with a significantly higher risk of recurrence/metastasis, supporting the value of 23-GEP in guiding clinical management decisions for ambiguous melanocytic lesions.","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":"878-882"},"PeriodicalIF":0.8,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13680773/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148914218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unveiling Deep Mycoses: Histopathological Challenges in Diagnosing Deep Mycoses as a Neglected Tropical Disease. 揭示深部真菌病：诊断深部真菌病作为一种被忽视的热带疾病的组织病理学挑战。

IF 0.8 4区医学

American Journal of Dermatopathology Pub Date : 2026-11-01 Epub Date: 2026-04-10 DOI: 10.1097/DAD.0000000000003282

Stella Adevita, Flandiana Yogianti, Sitanaja Raymond, Agnes Sri Siswati, Paranita Ferronika

{"title":"Unveiling Deep Mycoses: Histopathological Challenges in Diagnosing Deep Mycoses as a Neglected Tropical Disease.","authors":"Stella Adevita, Flandiana Yogianti, Sitanaja Raymond, Agnes Sri Siswati, Paranita Ferronika","doi":"10.1097/DAD.0000000000003282","DOIUrl":"https://doi.org/10.1097/DAD.0000000000003282","url":null,"abstract":"Abstract: Deep mycoses are rare invasive fungal infections involving subcutaneous or systemic tissues and remain underrecognized neglected tropical diseases in Indonesia. This study aims to describe clinicopathological features and highlight histopathological challenges in diagnosing cutaneous deep mycoses at a tertiary hospital in Yogyakarta. A retrospective review of skin biopsies submitted with a differential diagnosis of deep mycosis to the Anatomical Pathology Department, Dr Sardjito Hospital, between 2020 and 2024 was conducted, including cases with demonstrable fungal elements on histopathology and/or histochemistry and complete clinical data. Of 39 suspected cases, 12 were confirmed as deep mycoses, predominantly subcutaneous infections in male patients over 50 years working in agriculture. Chromoblastomycosis was most frequent (8/12), followed by eumycetoma, actinomycetoma, phaeohyphomycosis, and 1 systemic histoplasmosis in an HIV-positive adolescent. Verrucous plaques on the lower extremities predominated clinically, whereas histology showed pseudoepitheliomatous hyperplasia with muriform cells in chromoblastomycosis, pigmented hyphae with necroinflammatory changes in phaeohyphomycosis, characteristic grains with Splendore-Hoeppli phenomenon in eumycetoma, filamentous grains in actinomycetoma, and intracellular yeasts within histiocytes in histoplasmosis. In conclusion, deep mycoses are uncommon but clinically nonspecific, leading to diagnostic delay, and histopathology remains a pivotal, accessible tool for their recognition and differentiation in resource-limited tropical settings.","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":"48 11","pages":"835-844"},"PeriodicalIF":0.8,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149229434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multifocal Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type, Presenting on Face and Chest: Complete Remission With R-CHOP. 多灶性原发性皮肤弥漫性大b细胞淋巴瘤，腿部型，表现为面部和胸部：R-CHOP完全缓解。

IF 0.8 4区医学

American Journal of Dermatopathology Pub Date : 2026-11-01 Epub Date: 2026-08-21 DOI: 10.1097/DAD.0000000000003410

Michael Panagiotidis, Iclal Gerdemeli, Nikolaos Chaitidis, Kalliopi Gianna, Nikolaos Tsiaras, Zoi Papadopoulou, Panagiotis Kalmoukos, Maria Daviti, Stavritsa-Taxiarchoula Varvara, Michael Arabatzis, Efstratios Vakirlis, Elena Sotiriou

{"title":"Multifocal Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type, Presenting on Face and Chest: Complete Remission With R-CHOP.","authors":"Michael Panagiotidis, Iclal Gerdemeli, Nikolaos Chaitidis, Kalliopi Gianna, Nikolaos Tsiaras, Zoi Papadopoulou, Panagiotis Kalmoukos, Maria Daviti, Stavritsa-Taxiarchoula Varvara, Michael Arabatzis, Efstratios Vakirlis, Elena Sotiriou","doi":"10.1097/DAD.0000000000003410","DOIUrl":"10.1097/DAD.0000000000003410","url":null,"abstract":"Abstract: Primary cutaneous diffuse large B-cell lymphoma, leg type (PCDLBCL-LT), is an aggressive subtype of primary cutaneous B-cell lymphoma that predominantly affects the lower extremities of elderly individuals. We report a rare case of a 79-year-old woman presenting with rapidly enlarging, erythematous-to-violaceous tumors and plaques on the face, chest, left upper arm, and upper back, an uncommon non-leg manifestation of PCDLBCL-LT, confirmed by histopathology and immunohistochemistry. The patient was successfully treated with six cycles of the rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) therapy, achieving complete remission with no relapse during 1.5 years of follow-up. This case emphasizes that PCDLBCL-LT can present in locations outside the legs, highlighting the need for early recognition and systemic therapy in atypical locations.","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":"902-906"},"PeriodicalIF":0.8,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148801152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Myxoid Variant of Primary Cutaneous Anaplastic Large Cell Lymphoma Mimicking Soft Tissue Sarcoma: Diagnostic Pitfalls and Literature Review. 模拟软组织肉瘤的原发性皮肤间变性大细胞淋巴瘤的黏液样变异：诊断缺陷和文献回顾。

IF 0.8 4区医学

American Journal of Dermatopathology Pub Date : 2026-11-01 Epub Date: 2026-07-06 DOI: 10.1097/DAD.0000000000003380

Ihar I Haiduk, Oxana A Podyacheva, Maria S Vladimirkina, Diana A Davydova, Anna S Artemyeva, Andrey Y Valkov

{"title":"Myxoid Variant of Primary Cutaneous Anaplastic Large Cell Lymphoma Mimicking Soft Tissue Sarcoma: Diagnostic Pitfalls and Literature Review.","authors":"Ihar I Haiduk, Oxana A Podyacheva, Maria S Vladimirkina, Diana A Davydova, Anna S Artemyeva, Andrey Y Valkov","doi":"10.1097/DAD.0000000000003380","DOIUrl":"10.1097/DAD.0000000000003380","url":null,"abstract":"Abstract: Primary Cutaneous Anaplastic Large Cell Lymphoma (PCALCL) is a CD30-positive T-cell lymphoma that typically manifests as a dermal nodule or tumor with favorable prognosis. Rare morphologic variants with prominent myxoid stroma can closely mimic myxoid soft tissue sarcomas and lead to misdiagnosis. A 40-year-old man presented with a slowly enlarging ulcerated mass on the left thigh that was radiologically regarded as a superficial soft tissue sarcoma, prompting wide excision with sentinel lymph node biopsy. Histological examination showed a multinodular, dermal, and subcutaneous tumor composed of highly pleomorphic hallmark-type, rhabdoid, epithelioid, and spindle cells, along with multinucleated forms embedded in abundant myxoid stroma, and associated with delicate curvilinear vessels. Immunohistochemically, all tumor cells demonstrated strong and diffuse CD30, CD2, and CD4 expression; and weak positivity for EMA. They were negative for CD3, CD5, CD7, CD8, TIA-1, and perforin, and also showed no expression of ALK or of epithelial, melanocytic, myogenic, vascular, or B-cell markers. These findings support the diagnosis of ALK-negative myxoid PCALCL. Comprehensive staging with positron emission tomography-computed tomography and bone marrow biopsy revealed no extracutaneous disease, and the patient achieved a complete metabolic remission after 6 cycles of CHOP-E chemotherapy, remaining disease-free for 40 months after diagnosis. This case broadens the clinicopathologic spectrum of PCALCL and highlights that infiltrative and myxoid CD30-positive tumors of the extremities may masquerade as sarcoma, underscoring the importance of including CD30 and T-cell markers in the evaluation of pleomorphic myxoid soft tissue tumors.","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":"891-897"},"PeriodicalIF":0.8,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148400004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Morphologic and Molecular Differences of BAP1 Melanocytomas and BAP1 Inactivated Melanomas. BAP1黑素细胞瘤和BAP1失活黑素瘤的形态学和分子差异。

IF 0.8 4区医学

American Journal of Dermatopathology Pub Date : 2026-11-01 Epub Date: 2026-07-23 DOI: 10.1097/DAD.0000000000003390

Pedram Gerami, Jonathan Braat, Lindsay Jeanne Holic, Nithya Sai Trichy, Shantel Olivares, Klaus J Busam

{"title":"Morphologic and Molecular Differences of BAP1 Melanocytomas and BAP1 Inactivated Melanomas.","authors":"Pedram Gerami, Jonathan Braat, Lindsay Jeanne Holic, Nithya Sai Trichy, Shantel Olivares, Klaus J Busam","doi":"10.1097/DAD.0000000000003390","DOIUrl":"10.1097/DAD.0000000000003390","url":null,"abstract":"Abstract: BAP1 inactivated melanocytomas are considered intermediate grade melanocytic tumors. They may have overlapping morphologic features with melanoma. Nuclear atypia, expansile growth, and mitotic activity often raise concern for the possibility of melanoma. However, there is limited information in the literature on outcomes-based diagnostic criteria that may be useful for the distinction of BAP1 inactivated melanocytomas from BAP1 inactivated melanomas. Herein, we present a series of 20 BAP1 inactivated melanomas with clinical follow-up (n = 17) and compare the genomic and morphologic features with 23 BAP1 inactivated melanocytomas. In this series, only BAP1 inactivated melanomas had ulceration, tumor necrosis, invasion of the subcutis, and mitotic activity ≥4/mm 2 . BAP1 inactivated melanomas had more pathogenic variants on average than BAP1 inactivated melanocytomas (6.6 vs. 2.4, P = 0.0001) and a higher TMB (31.2 m/Mb vs. 7.8 m/Mb, P = 0.0071). Pathogenic variants in TERT -promoter, CDKN2A , CDK4 , MYC , the SWI/SNF complex, and the PI3K-AKT pathway were only seen in BAP1 inactivated melanomas. Because BAP1 inactivated melanomas are uncommon compared with BAP1 inactivated melanocytomas, useful diagnostic criteria must have very high specificity and be rare to absent in BAP1 inactivated melanocytomas. In this study, we identified morphologic and molecular features that were strongly associated with BAP1 inactivated melanomas but not seen in BAP1 inactivated melanocytomas. Our findings may be helpful for the diagnostic assessment of challenging melanocytic tumors with BAP1 inactivation.","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":"871-877"},"PeriodicalIF":0.8,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148581112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stealth Pigmented Squamous Cell Carcinoma in Situ: An Undescribed Variant With Deceptive Clinical and Histological Features. 隐匿性原位色素鳞状细胞癌：一种具有欺骗性临床和组织学特征的未描述变异。

IF 0.8 4区医学

American Journal of Dermatopathology Pub Date : 2026-11-01 Epub Date: 2026-06-25 DOI: 10.1097/DAD.0000000000003354

Raul Pisano, Cynthia X Chan, Mark Jacobson

{"title":"Stealth Pigmented Squamous Cell Carcinoma in Situ: An Undescribed Variant With Deceptive Clinical and Histological Features.","authors":"Raul Pisano, Cynthia X Chan, Mark Jacobson","doi":"10.1097/DAD.0000000000003354","DOIUrl":"10.1097/DAD.0000000000003354","url":null,"abstract":"Abstract: Cutaneous squamous cell carcinoma in situ is characterized by well-established architectural and cytological abnormalities that are readily appreciated at both low and high magnification. We have encountered a subset of lesions with a deceptively bland appearance at scanning magnification that demonstrated unequivocal malignant features on closer examination, which we term \"stealth pigmented squamous cell carcinoma in situ.\" In this study, we describe 51 cases of this entity and compare its clinical, histological, and immunohistochemical features with those of its closest morphologic mimickers. These stealth lesions are most often found on the lower extremities and pigmented, thus clinically suspected to be melanocytic lesions or pigmented keratoses, not atypical squamous proliferations. At low magnification, they typically seem flat and orthokeratotic with basal hyperpigmentation above minimal solar elastosis. At higher magnification, keratinocyte atypia, dysmaturation, and numerous mitotic figures are evident throughout the epidermis. This stealth variant is as proliferative as conventional squamous cell carcinoma in situ by Ki67 but significantly less likely to overexpress p16. We believe stealth pigmented squamous cell carcinoma in situ represents a distinct variant of squamous cell carcinoma in situ. Although prognostic significance remains to be studied, recognition of this pigmented entity is important to avoid misdiagnosis and undertreatment as a benign epidermal lesion.","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":"860-863"},"PeriodicalIF":0.8,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148310341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Montgomery Tubercles in the Male Areola: Histological Observations and a Brief About Past Investigators. 蒙哥马利结节在男性乳晕：组织学观察和简要介绍过去的研究者。

IF 0.8 4区医学

American Journal of Dermatopathology Pub Date : 2026-11-01 Epub Date: 2026-06-26 DOI: 10.1097/DAD.0000000000003367

Sanjay A Pai, Sulakshana M Srihari, Sachi S Kantha

{"title":"Montgomery Tubercles in the Male Areola: Histological Observations and a Brief About Past Investigators.","authors":"Sanjay A Pai, Sulakshana M Srihari, Sachi S Kantha","doi":"10.1097/DAD.0000000000003367","DOIUrl":"10.1097/DAD.0000000000003367","url":null,"abstract":"Abstract: There are conflicting statements in the literature about the existence of Montgomery tubercles in the male areola. We wished to determine whether the male breast contains Montgomery tubercles and to determine additional pathology, if any, in the male areola. Serial sections from areola of paraffin blocks from six retrospective and five prospective cases of male breast carcinoma were evaluated. Only hematoxylin-stained and eosin-stained sections were studied. There were definite Montgomery tubercles in two cases and putative Montgomery tubercles in two other cases, among the 11 cases (age range, 42-85 years) studied. Demodex mites (n = 8) and dermatophytes (n = 3) were noted in the areola. Toker cells were absent, Paget disease was present (n = 1), and Pagetoid dyskeratosis was present in 5 cases. We conclude that Montgomery tubercles are present in the male areola. Demodex and dermatophytes are common commensals in the male areola. Giovanni Morgagni, Johann Roederer, Johann Meckel the Younger, William Montagna, and A. Bernard Ackerman have made scientific contributions to Montgomery tubercles of females and in other areas of pathology.","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":"864-870"},"PeriodicalIF":0.8,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148334329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0