Progressive Immunotherapy-Related Mucocutaneous Eruption: A Mimicker of SJS-TEN.

IF 1 4区医学 Q4 DERMATOLOGY

American Journal of Dermatopathology Pub Date : 2025-07-30 DOI:10.1097/DAD.0000000000003083

Kishan A Sangani, Victoria Lee, Liesl Schroedl, Christopher R Shea, Oluwakemi Onajin, Angad A Chadha

引用次数: 0

Abstract

Abstract: Immune checkpoint inhibitors are an integral component of oncology treatment. Adverse systemic effects of this immune modulation are often manifested in the skin and, therefore, must be carefully described and characterized to inform clinical decision making in medically complex patients. Here we report 2 cases of progressive immunotherapy-related mucocutaneous eruption that resemble Stevens-Johnson Syndrome but is unique in its clinical and histopathologic presentation, supporting a distinction from classic medication-induced Stevens-Johnson syndrome and toxic epidermal necrolysis.

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进行性免疫治疗相关粘膜皮肤爆发：模拟SJS-TEN。

免疫检查点抑制剂是肿瘤治疗中不可或缺的组成部分。这种免疫调节的不良全身效应通常表现在皮肤上，因此，必须仔细描述和表征，以便为医学复杂患者的临床决策提供信息。在此，我们报告2例与免疫治疗相关的进行性皮肤粘膜爆发，类似于Stevens-Johnson综合征，但其临床和组织病理学表现独特，支持与经典药物诱导的Stevens-Johnson综合征和中毒性表皮坏死松解症的区别。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American Journal of Dermatopathology 医学-皮肤病学

CiteScore

1.80

自引率

9.10%

发文量

453

审稿时长

3 months

期刊介绍： The American Journal of Dermatopathology offers outstanding coverage of the latest diagnostic approaches and laboratory techniques, as well as insights into contemporary social, legal, and ethical concerns. Each issue features review articles on clinical, technical, and basic science advances and illuminating, detailed case reports. With the The American Journal of Dermatopathology you''ll be able to: -Incorporate step-by-step coverage of new or difficult-to-diagnose conditions from their earliest histopathologic signs to confirmatory immunohistochemical and molecular studies. -Apply the latest basic science findings and clinical approaches to your work right away. -Tap into the skills and expertise of your peers and colleagues the world over peer-reviewed original articles, "Extraordinary cases reports", coverage of practical guidelines, and graphic presentations. -Expand your horizons through the Journal''s idea-generating forum for debating controversial issues and learning from preeminent researchers and clinicians