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Selective Clonal Regression After Interferon Therapy in Metastatic Melanoma. 转移性黑色素瘤接受干扰素治疗后的选择性克隆消退
IF 1.1 4区 医学
American Journal of Dermatopathology Pub Date : 2025-01-01 Epub Date: 2024-10-31 DOI: 10.1097/DAD.0000000000002873
Angel Fernandez-Flores
{"title":"Selective Clonal Regression After Interferon Therapy in Metastatic Melanoma.","authors":"Angel Fernandez-Flores","doi":"10.1097/DAD.0000000000002873","DOIUrl":"10.1097/DAD.0000000000002873","url":null,"abstract":"<p><strong>Abstract: </strong>Regression (total or partial) is a common phenomenon in melanoma. From a pathogenic perspective, it is highly complex and only partially understood, involving aspects of both the tumor and the individual. One of the determining factors is the clonal selection of the tumor, wherein some clones within the tumor survive while others perish. This clonal selection can sometimes occur as a selective mechanism after the initiation of a therapeutic intervention. In many of these cases, the effect is detrimental, because the surviving clone is resistant to the applied therapy. However, occasionally, the therapy can successfully select the less harmful clone. We present an example of the latter, where therapy with interferon induced regression of the metastatic-capable melanocytic population, with only the primary tumor melanocytic population persisting. To confirm this, we demonstrated BRAF mutational similarity between the 2 populations, and an additional NRAS mutation in the metastatic population, which was absent in the primary tumor.</p>","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":"46-49"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142559341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Beyond the Surface: Dermoscopic, Clinical, and Histopathological Insights Into Secondary Extramammary Paget Disease of the Glans Linked to Urothelial Carcinoma. 超越表面：皮肤镜、临床和组织病理学透视与泌尿道癌相关的继发性龟头乳头外皮样病变。
IF 1.1 4区 医学
American Journal of Dermatopathology Pub Date : 2025-01-01 Epub Date: 2024-10-31 DOI: 10.1097/DAD.0000000000002876
Alexandre Raphael Meduri, Benedetta Tirone, Lucia Lospalluti, Francesca Ambrogio, Gerardo Cazzato, Marco Bellino
{"title":"Beyond the Surface: Dermoscopic, Clinical, and Histopathological Insights Into Secondary Extramammary Paget Disease of the Glans Linked to Urothelial Carcinoma.","authors":"Alexandre Raphael Meduri, Benedetta Tirone, Lucia Lospalluti, Francesca Ambrogio, Gerardo Cazzato, Marco Bellino","doi":"10.1097/DAD.0000000000002876","DOIUrl":"10.1097/DAD.0000000000002876","url":null,"abstract":"","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":"77-79"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142559328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Two Cases of FAVA With an Uncommon Localization in Adults. 两例定位不常见的成人 FAVA。
IF 1.1 4区 医学
American Journal of Dermatopathology Pub Date : 2025-01-01 Epub Date: 2024-11-05 DOI: 10.1097/DAD.0000000000002711
Angel Fernandez-Flores, José Luis Martínez-Amo
{"title":"Two Cases of FAVA With an Uncommon Localization in Adults.","authors":"Angel Fernandez-Flores, José Luis Martínez-Amo","doi":"10.1097/DAD.0000000000002711","DOIUrl":"10.1097/DAD.0000000000002711","url":null,"abstract":"<p><strong>Abstract: </strong>The fibroadipose vascular anomaly (FAVA) is a relatively unknown vascular anomaly in the realm of adult dermatopathology. Despite its intramuscular location, dermatologists often encounter cases, approaching them surgically under the presumption of a potential lipoma. This entity was first described in 2014, and consequently, many FAVA cases may be concealed in our archives under diagnoses of other entities that require differential diagnoses, such as intramuscular fast-flow vascular anomaly. Clinically, these anomalies typically manifest preferably in young women or girls and predominantly in the extremities. In this article, we present 2 cases of FAVA with atypical clinical features in terms of their topography and age at onset. However, histopathologically, they exhibit typical characteristics with fibroadipose tissue and dysmorphic venous vessels dissecting the affected striated muscle.</p>","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":"50-54"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142584980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
SOX-10 and Melan-A Immunostaining in Areas of Focal Acantholytic Dyskeratosis and Epidermolytic Hyperkeratosis Within Dysplastic Nevi Biopsies: An Observational Study. 发育不良痣活检组织中局灶性角化不良和表皮溶解性角化过度区域的 SOX-10 和 Melan-A 免疫染色：一项观察性研究。
IF 1.1 4区 医学
American Journal of Dermatopathology Pub Date : 2025-01-01 Epub Date: 2024-10-31 DOI: 10.1097/DAD.0000000000002866
Kayley L Erickson, Raghav Tripathi, Bethany R Rohr
{"title":"SOX-10 and Melan-A Immunostaining in Areas of Focal Acantholytic Dyskeratosis and Epidermolytic Hyperkeratosis Within Dysplastic Nevi Biopsies: An Observational Study.","authors":"Kayley L Erickson, Raghav Tripathi, Bethany R Rohr","doi":"10.1097/DAD.0000000000002866","DOIUrl":"10.1097/DAD.0000000000002866","url":null,"abstract":"<p><strong>Background: </strong>Focal acantholytic dyskeratosis (FAD) and epidermolytic hyperkeratosis (EHK) are common incidental epidermal histologic findings within dysplastic nevi biopsies. We evaluate whether areas of FAD and EHK within dysplastic nevi biopsies stain with immunostains used to characterize melanocytic neoplasms.</p><p><strong>Methods: </strong>In this case series, a natural language search of histopathology reports from our institution in the past year (2020-2021) identified dysplastic nevus biopsies with concurrent FAD and/or EHK. Tissue samples were examined for positive melanocytic immunostaining with SOX-10 and Melan-A in areas of FAD and EHK.</p><p><strong>Results: </strong>Out of 32 biopsies, 20 of 26 FAD specimens (76.9%) and 2 of 6 EHK specimens (33.3%) showed unexpected suprabasal layer staining with a melanocytic marker that did not correspond to definitively identified melanocytes on the H&E-stained sections. The immunohistochemical staining of FAD and EHK was observed in 2 forms: nonspecific background staining or \"true\" staining (ie, seemed nuclear on SOX-10 or cytoplasmic on Melan-A).</p><p><strong>Conclusions: </strong>This pilot examination provides evidence that areas of incidental FAD within dysplastic nevi biopsies demonstrate unexpected suprabasal layer staining with melanocytic markers. When dermatopathologists evaluate melanocytic neoplasms with melanocytic markers, it is possible the presence of incidental FAD could lead to over diagnosing pagetoid scatter within these lesions. This study is a proof of concept with mild to moderately dysplastic nevi that do not typically incur the use of melanocytic stains; however, the implication of this unexpected staining pattern would be important when using melanocytic markers on borderline melanocytic neoplasms that have incidental FAD. Close correlation with H&E is imperative to prevent misinterpretation in these cases.</p>","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":"36-41"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142559342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Case of Recurrent Atypical Lipomatous Tumor. 一个复发性非典型脂肪瘤病例
IF 1.1 4区 医学
American Journal of Dermatopathology Pub Date : 2025-01-01 Epub Date: 2024-10-15 DOI: 10.1097/DAD.0000000000002844
Keisuke Anju, Kazumasa Oya, Yoshiyuki Ishii, Yasuhiro Fujisawa
{"title":"A Case of Recurrent Atypical Lipomatous Tumor.","authors":"Keisuke Anju, Kazumasa Oya, Yoshiyuki Ishii, Yasuhiro Fujisawa","doi":"10.1097/DAD.0000000000002844","DOIUrl":"10.1097/DAD.0000000000002844","url":null,"abstract":"","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":"81-82"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142480039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cutaneous "Microcystic" Microsecretory Adenocarcinoma With Marked Adnexal Hyperplasia: A Simulant of Microcystic Adnexal Carcinoma. 皮肤 "微囊 "微分泌性腺癌伴明显附件增生：微囊附件癌的模拟物
IF 1.1 4区 医学
American Journal of Dermatopathology Pub Date : 2025-01-01 Epub Date: 2024-06-28 DOI: 10.1097/DAD.0000000000002788
Taylor Novice, Gautham Vellaichamy, Timothy H McCalmont, John Moesch
{"title":"Cutaneous \"Microcystic\" Microsecretory Adenocarcinoma With Marked Adnexal Hyperplasia: A Simulant of Microcystic Adnexal Carcinoma.","authors":"Taylor Novice, Gautham Vellaichamy, Timothy H McCalmont, John Moesch","doi":"10.1097/DAD.0000000000002788","DOIUrl":"10.1097/DAD.0000000000002788","url":null,"abstract":"<p><strong>Abstract: </strong>Microsecretory adenocarcinoma (MSA) was first described in 2019 as a low-grade salivary gland neoplasm of intraoral origin with distinct histopathologic features and a characteristic  MEF2C::SS18  fusion. Recently, skin was also identified as a primary site for MSA in a report by Bishop et al. Due to its rarity and resemblance to other adnexal tumors, MSA is a challenging diagnosis. Herein, we present a case of cutaneous MSA that was unique for the presence of a significant microcystic component and marked adnexal hyperplasia, which mimicked myxoid microcystic adnexal carcinoma (MAC). A 58-year-old presented with a 1 year history of an enlarging eyelid nodule. Histopathologic analysis revealed dermal tumor composed of small tubules containing inspissated bluish mucinous material. Accompanying marked adnexal hyperplasia and many microcysts were also present. Tumor cells expressed S100 protein, which is distinct from MAC, while p63 immunohistochemistry showed marked loss of myoepithelial labeling, as is common in primary adenocarcinomas. Next generation gene sequencing detected the characteristic MSA fusion protein  MEF2c::SS18 . We report a novel presentation of MSA that simulated MAC because of the presence of associated microcystic change. The presence of S100 immunopositivity and the identification of  MEF2C::SS18  fusion confirmed the diagnosis of cutaneous MSA.</p>","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":"62-64"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141472263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Perianal Pulse Granuloma Induced by Plant-Derived Baby Wipes. 植物制成的婴儿湿巾诱发肛周脉冲肉芽肿
IF 1.1 4区 医学
American Journal of Dermatopathology Pub Date : 2025-01-01 Epub Date: 2024-10-31 DOI: 10.1097/DAD.0000000000002877
Robin H Wang, Jenna J Lullo, Madhu Dahiya, David B Eilers
{"title":"Perianal Pulse Granuloma Induced by Plant-Derived Baby Wipes.","authors":"Robin H Wang, Jenna J Lullo, Madhu Dahiya, David B Eilers","doi":"10.1097/DAD.0000000000002877","DOIUrl":"10.1097/DAD.0000000000002877","url":null,"abstract":"<p><strong>Abstract: </strong>Pulse granulomas are unusual foreign body reactions to exogenous plant material, featuring the presence of hyaline ring structures and granulomatous inflammation. Pulse granulomas have been reported to occur in the oral cavity, gastrointestinal tract, and respiratory tract. Cutaneous pulse granulomas are exceedingly rare. All reported cases have been closely associated with underlying pathology such as chronic inflammatory conditions, trauma, or surgical procedures which likely facilitated implantation of exogenous plant material. We report a novel case of a cutaneous pulse granuloma presenting in the perianal region of an otherwise healthy man. The authors propose that the source of the exogenous plant material is plant-derived baby wipes, which the patient had been using daily to the perianal region.</p>","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":"55-58"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142559340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Malignant Proliferating Pilar Tumor With Sarcomatous Transformation ("Carcinosarcoma"): Case Report With Molecular Profile. 恶性增生性唇缘肿瘤伴肉瘤样变（"癌肉瘤"）：病例报告及分子图谱
IF 1.1 4区 医学
American Journal of Dermatopathology Pub Date : 2025-01-01 Epub Date: 2024-08-14 DOI: 10.1097/DAD.0000000000002831
Jakob M T Moran, Mai P Hoang, Adrian Mariño-Enríquez, Mia S DeSimone
{"title":"Malignant Proliferating Pilar Tumor With Sarcomatous Transformation (\"Carcinosarcoma\"): Case Report With Molecular Profile.","authors":"Jakob M T Moran, Mai P Hoang, Adrian Mariño-Enríquez, Mia S DeSimone","doi":"10.1097/DAD.0000000000002831","DOIUrl":"10.1097/DAD.0000000000002831","url":null,"abstract":"<p><strong>Abstract: </strong>Malignant proliferating pilar tumors (MPPTs) are rare, unique cutaneous adnexal tumors. Sarcomatous transformation in MPPTs is even rarer (4 previous cases reported). Here, we report an extraordinary case of a MPPT with sarcomatous transformation occurring on the scalp of a 63-year-old man with an in-depth molecular profile along with histologic, immunohistochemical, and follow-up data. Shared mutations in the epithelial and sarcomatous components included a loss-of-function TP53 mutation. An inactivating TP53 mutation was only identified in the epithelial component, and an inactivating CDKN2A mutation was only identified in the sarcomatous component. Copy number variations previously reported in MPPT were also identified, including 6p21.1 loss, 6q arm loss, and 15q21.1-q26.3 gain [epithelial], and 6p22.2-p22.3 loss [sarcoma]. Histologically, the tumor demonstrated juxtaposed areas of proliferating pilar tumor, carcinoma with clear cell change, and sarcomatous areas that did not stain for AE1/AE3, p40, CD34, S100 protein, and smooth muscle actin  by immunohistochemistry. The patient is alive at 2 years without evidence of recurrence or metastasis.</p>","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":"65-69"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141983846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ki-67 Differentiates Pagetoid Dyskeratosis From Koilocytosis in Low-Grade Squamous Intraepithelial Lesions. Ki-67在低级别鳞状上皮内病变中区分页样角化不良症和白细胞增多症。
IF 1.1 4区 医学
American Journal of Dermatopathology Pub Date : 2024-12-31 DOI: 10.1097/DAD.0000000000002894
Katharina S Kommoss, Richard I Crawford
{"title":"Ki-67 Differentiates Pagetoid Dyskeratosis From Koilocytosis in Low-Grade Squamous Intraepithelial Lesions.","authors":"Katharina S Kommoss, Richard I Crawford","doi":"10.1097/DAD.0000000000002894","DOIUrl":"https://doi.org/10.1097/DAD.0000000000002894","url":null,"abstract":"","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142958137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lineal Sebaceous Hyperplasia: An Acquired Hamartoma Distinct from Nevus Sebaceous. 直系皮脂腺增生：一种不同于皮脂腺痣的后天性错构瘤。
IF 1.1 4区 医学
American Journal of Dermatopathology Pub Date : 2024-12-31 DOI: 10.1097/DAD.0000000000002910
Cecilia Buján Bonino, Brais Chao Maseda, Carmen Cánovas Seva, José Sáez Padilla, José Manuel Suárez Peñaranda
{"title":"Lineal Sebaceous Hyperplasia: An Acquired Hamartoma Distinct from Nevus Sebaceous.","authors":"Cecilia Buján Bonino, Brais Chao Maseda, Carmen Cánovas Seva, José Sáez Padilla, José Manuel Suárez Peñaranda","doi":"10.1097/DAD.0000000000002910","DOIUrl":"https://doi.org/10.1097/DAD.0000000000002910","url":null,"abstract":"","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142958138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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