American Journal of Dermatopathology最新文献_第9页

Majocchi Granuloma-like Deep Follicular Granulomatous Eruption Secondary to Aspergillus niger in an Immunocompetent Male. 免疫功能正常男性继发于黑曲霉的马氏肉芽肿样深滤泡性肉芽肿。

IF 0.8 4区医学

American Journal of Dermatopathology Pub Date : 2026-08-25 DOI: 10.1097/DAD.0000000000003408

Ashish Jagati, Hetal Vaghela, Jeta Buch, Chirag Desai, Pooja Shah, Dhruv Gupta, Santoshdev P Rathod

{"title":"Majocchi Granuloma-like Deep Follicular Granulomatous Eruption Secondary to Aspergillus niger in an Immunocompetent Male.","authors":"Ashish Jagati, Hetal Vaghela, Jeta Buch, Chirag Desai, Pooja Shah, Dhruv Gupta, Santoshdev P Rathod","doi":"10.1097/DAD.0000000000003408","DOIUrl":"https://doi.org/10.1097/DAD.0000000000003408","url":null,"abstract":"Abstract: Majocchi's granuloma is a deep folliculocentric fungal infection characterized by suppurative and granulomatous inflammation, most commonly caused by dermatophytes. Non-dermatophytic molds, including Aspergillus species, are uncommon etiological agents. We report a 20-year-old immunocompetent male presenting with multiple dark red to brownish papules and nodules involving the groin, genitalia, buttocks, and lower abdomen for 6 months. Histopathological examination demonstrated a suppurative granulomatous infiltrate containing numerous fungal elements, with positive periodic acid-Schiff staining and direct microscopy using potassium hydroxide preparation. Fungal culture yielded Aspergillus niger, with species identification supported by characteristic morphology on lactophenol cotton blue preparation. The patient was treated with oral itraconazole 100 mg twice daily for 2 months, resulting in marked clinical improvement with flattening of the lesions and absence of new lesions. This case represents an uncommon A. niger-associated deep follicular granulomatous infection in an immunocompetent host and underscores the importance of histopathological and mycological evaluation in persistent or atypical papulonodular eruptions, particularly at unusual anatomical sites.","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148820209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Coexistence of Acantholytic Dyskeratosis and Epidermolytic Hyperkeratosis in a Single Cutaneous Lesion: A Case Report and Brief Review. 棘溶性角化不良和表皮松解性角化过度在单一皮肤病变中的共存：1例报告和简要回顾。

IF 0.8 4区医学

American Journal of Dermatopathology Pub Date : 2026-08-21 DOI: 10.1097/DAD.0000000000003407

Manuel Sánchez-Arjona, Manuel Lecona, Luis Requena

{"title":"Coexistence of Acantholytic Dyskeratosis and Epidermolytic Hyperkeratosis in a Single Cutaneous Lesion: A Case Report and Brief Review.","authors":"Manuel Sánchez-Arjona, Manuel Lecona, Luis Requena","doi":"10.1097/DAD.0000000000003407","DOIUrl":"https://doi.org/10.1097/DAD.0000000000003407","url":null,"abstract":"Abstract: Acantholytic dyskeratosis and epidermolytic hyperkeratosis are distinct histopathologic patterns reflecting abnormalities in keratinocyte differentiation. Although typically considered separate histopathologic reaction patterns, their coexistence within a single lesion is uncommon and remains poorly characterized. We report the case of a 51-year-old woman with a lumbar skin lesion excised for suspected intradermal nevus or basal cell carcinoma. Histopathologic examination revealed a combination of Acantholytic dyskeratosis and epidermolytic hyperkeratosis features without evidence of malignancy. This association, previously described in the literature, suggests that both patterns may represent overlapping responses within a shared spectrum of epidermal alterations, potentially triggered by external factors or occurring as incidental findings. Recognition of this coexistence is important for accurate histopathologic classification of keratotic lesions and to avoid overinterpretation of incidental epidermolytic change. In most cases, it likely represents a secondary phenomenon without direct clinical significance, although further studies are needed to clarify its pathogenic basis.","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148801148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Granular Cell (Granular-type) Fibrous Papule of the Face: Case Report and Literature Review Emphasizing Morphologic and Immunohistochemical Pitfalls. 面部颗粒细胞（颗粒型）纤维丘疹：病例报告和文献回顾，强调形态学和免疫组织化学缺陷。

IF 0.8 4区医学

American Journal of Dermatopathology Pub Date : 2026-08-21 DOI: 10.1097/DAD.0000000000003409

Paul K Vance, Howard L Martin

引用次数: 0

PD-1, PD-L1, and PD-L2 Immunoexpression in Mycosis Fungoides Biopsies. PD-1、PD-L1和PD-L2在蕈样真菌病活检中的免疫表达。

IF 0.8 4区医学

American Journal of Dermatopathology Pub Date : 2026-08-03 DOI: 10.1097/DAD.0000000000003404

Fahriye Kılınç, Naile Kökbudak, Zeliha Çelik

{"title":"PD-1, PD-L1, and PD-L2 Immunoexpression in Mycosis Fungoides Biopsies.","authors":"Fahriye Kılınç, Naile Kökbudak, Zeliha Çelik","doi":"10.1097/DAD.0000000000003404","DOIUrl":"https://doi.org/10.1097/DAD.0000000000003404","url":null,"abstract":"Abstract: Mycosis fungoides (MF) is a cutaneous T-cell lymphoma that typically progresses slowly and has a favorable initial prognosis; however, the clinical course worsens in advanced stages. The aim of this study was to investigate the levels of programmed death-1 (PD-1), PD-L1, and PD-L2 immunoexpression in the biopsies of patients with MF. Paraffin blocks from biopsies of 82 patients diagnosed with MF between 2019 and 2025 were selected for this study. Early-phase (initial) and later-phase lesion groups, as well as CD4-positive and CD8-positive disease groups were formed based on histological findings. Immunohistochemical staining was performed for PD-1, PD-L1, and PD-L2. Positivity scores were generated for tumor cells, cells in the tumor microenvironment, and combined positivity scores. Immune scores were statistically compared across the lesion phase, CD4‑CD8 positivity status, age, and sex. Of the patients, 56 (68%) had later-phase lesions, 26 (32%) had early-phase lesions, 64 (78%) were CD4-positive, and 18 (22%) were CD8-positive. PD-1, PD-L1, and PD-L2 expression levels are higher in later-phase lesions than in early-phase lesions. The effect size was found to be small to moderate. CD4 or CD8 positivity, age, and sex did not affect PD-1, PD-L1, or PD-L2 levels. Immune checkpoint inhibitors could be beneficial in the management of MF, a disease that is difficult to treat in the advanced stages. Studies with larger patient series, in which evaluation can be performed alongside clinical staging, are needed.","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148671230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Follicular Mucinosis Associated with Adult T-Cell Leukemia-Lymphoma. 滤泡性黏液病与成人t细胞白血病淋巴瘤相关。

IF 0.8 4区医学

American Journal of Dermatopathology Pub Date : 2026-08-01 Epub Date: 2026-06-08 DOI: 10.1097/DAD.0000000000003337

Haley D Heibel, Yasmine Oprea, Hatice B Zengin, Cynthia X Chan, Dennis L Cooper, Bijal Amin, Beth N McLellan

引用次数: 0

Utility of p16, p21, and PRAME Immunohistochemistry in Melanocytic Lesions. p16、p21和PRAME免疫组化在黑色素细胞病变中的应用

IF 0.8 4区医学

American Journal of Dermatopathology Pub Date : 2026-08-01 Epub Date: 2026-05-20 DOI: 10.1097/DAD.0000000000003326

Ainsley J Ruley, Shannon K Moran, Heath T Blankenship, Sofia Martinez, Brian N White, Christine Ahn

引用次数: 0

Sclerotic Epithelioid Dermatofibroma With Cytokeratin Expression. 伴有细胞角蛋白表达的硬化上皮样皮肤纤维瘤。

IF 0.8 4区医学

American Journal of Dermatopathology Pub Date : 2026-08-01 Epub Date: 2026-04-06 DOI: 10.1097/DAD.0000000000003288

Zita Álvarez Bobillo, Agustín Viera Ramírez, Ángel Fernández Flores

{"title":"Sclerotic Epithelioid Dermatofibroma With Cytokeratin Expression.","authors":"Zita Álvarez Bobillo, Agustín Viera Ramírez, Ángel Fernández Flores","doi":"10.1097/DAD.0000000000003288","DOIUrl":"10.1097/DAD.0000000000003288","url":null,"abstract":"Background: Dermatofibromas are common benign dermal lesions with numerous histological variants. The combination of sclerotic and epithelioid features is extremely rare, with very few cases documented in the literature.Case report: We describe a 64-year-old male with a history of rheumatoid arthritis treated with methotrexate who presented with an asymptomatic 1-cm erythematous plaque on the chest. Histopathological examination revealed a symmetrical intradermal lesion composed of epithelioid cells with prominent nucleoli, dispersed between thick, hyalinized collagen bundles. No epidermal connection or cytological atypia was identified. Immunohistochemical analysis showed a unique profile: the neoplastic cells were positive for factor XIIIa, CD68, and vimentin, but also demonstrated strong, aberrant expression of cytokeratins (AE1/AE3, CK8/18) and the epithelial markers p40 and p63. Markers for muscle, vascular, melanocytic, and neural differentiation were negative.Conclusion: This is the first reported case of sclerosing epithelioid dermatofibroma exhibiting diffuse cytokeratin and p40/p63 expression. Recognizing this atypical immunophenotype is crucial to avoid diagnostic pitfalls, as it may mimic malignant epithelial or mesenchymal neoplasms such as sarcomatoid squamous cell carcinoma or epithelioid sarcoma. The expression likely reflects phenotypic plasticity rather than true epithelial malignancy.","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":"637-641"},"PeriodicalIF":0.8,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147629186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vascular Proliferation in Biopsies from Active Lichen Planopilaris as a Novel Pathologic Finding. 活动性扁平苔藓活检中血管增生的新病理发现。

IF 0.8 4区医学

American Journal of Dermatopathology Pub Date : 2026-08-01 Epub Date: 2026-04-17 DOI: 10.1097/DAD.0000000000003304

Anna Beyryumova, Julio A Diaz-Perez, Paolo Romanelli, Mariya Miteva

引用次数: 0

Squamous Cell Carcinoma Arising in a Lobomycosis Ulcer: A Rare Presentation. 由肺叶菌病性溃疡引起的鳞状细胞癌：一种罕见的表现。

IF 0.8 4区医学

American Journal of Dermatopathology Pub Date : 2026-08-01 Epub Date: 2026-04-16 DOI: 10.1097/DAD.0000000000003302

Kinan M Hayani, Omar P Sangüeza, Rute F Lellis

引用次数: 0

Dermal Interstitial Glycogenosis and Stromal Senescence-Associated Marker Expression in Fibrofolliculomas: Implications for Pathogenesis and mTOR-Targeted Therapy. 纤维滤泡瘤中真皮间质糖原性和间质衰老相关标志物的表达：发病机制和mtor靶向治疗的意义。

IF 0.8 4区医学

American Journal of Dermatopathology Pub Date : 2026-08-01 Epub Date: 2026-06-02 DOI: 10.1097/DAD.0000000000003336

Rosalynn M Nazarian, Yohei Miyagi, Yukio Nakatani

{"title":"Dermal Interstitial Glycogenosis and Stromal Senescence-Associated Marker Expression in Fibrofolliculomas: Implications for Pathogenesis and mTOR-Targeted Therapy.","authors":"Rosalynn M Nazarian, Yohei Miyagi, Yukio Nakatani","doi":"10.1097/DAD.0000000000003336","DOIUrl":"10.1097/DAD.0000000000003336","url":null,"abstract":"Abstract: Fibrofolliculomas, benign adnexal tumors often associated with Birt-Hogg-Dubé syndrome, exhibit characteristic perifollicular epithelial and stromal proliferation. Although their clinicopathologic features are well established, the molecular and metabolic drivers of stromal remodeling remain poorly understood, particularly in sporadic cases. We investigate the presence of dermal interstitial glycogenosis (DIG) and stromal senescence in fibrofolliculomas, exploring potential mechanistic parallels with pulmonary interstitial glycogenosis and mammalian target of rapamycin (mTOR)-driven cutaneous lesions. Archival skin biopsy specimens diagnosed as fibrofolliculoma between 2015 and 2025 (n = 13) were analyzed using Periodic acid-Schiff ± diastase staining and immunohistochemistry for p53, GLB1 (β-galactosidase), CD68, and phospho-S6 and compared with age-matched, sex-matched, and site-matched controls (n = 3). Clinical data, including imaging and genetic testing, were reviewed in cases of fibrofolliculoma. All fibrofolliculomas exhibited diastase-sensitive Periodic acid-Schiff-positive stromal granules consistent with glycogen accumulation. Stromal cells demonstrated immunoreactivity for GLB1, p53, and phospho-S6 in the absence of CD68 expression, indicating nonhistiocytic stromal senescence and mTOR activation. Birt-Hogg-Dubé syndrome was suspected in 4 of 10 patients but unconfirmed; DIG and senescence markers were present regardless of clinical context. Glycogenosis and cellular senescence markers were absent in controls. These findings identify DIG and stromal senescence as conserved features of fibrofolliculomas, suggesting a metabolic-senescence axis driven by mTOR signaling, and provide a rationale for mTOR-targeted therapies, including topical rapamycin, in the treatment of fibrofolliculomas.","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":"617-621"},"PeriodicalIF":0.8,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148334207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0