American Journal of Dermatopathology最新文献_第9页

Spiradenocarcinoma With Associated Mucinous Glandular Differentiation: A Unique Histopathologic Presentation of a Rare Diagnosis. 螺旋腺癌伴黏液腺分化：罕见诊断的独特组织病理学表现。

IF 1 4区医学

American Journal of Dermatopathology Pub Date : 2025-06-26 DOI: 10.1097/DAD.0000000000003024

Patricia K Mansfield, Samantha Ong, Sean Massa, Collin Chen, Emily Reisenbichler, M Yadira Hurley, Emily Smith, Kristin Smith

{"title":"Spiradenocarcinoma With Associated Mucinous Glandular Differentiation: A Unique Histopathologic Presentation of a Rare Diagnosis.","authors":"Patricia K Mansfield, Samantha Ong, Sean Massa, Collin Chen, Emily Reisenbichler, M Yadira Hurley, Emily Smith, Kristin Smith","doi":"10.1097/DAD.0000000000003024","DOIUrl":"10.1097/DAD.0000000000003024","url":null,"abstract":"Abstract: Spiradenocarcinoma, also known as malignant eccrine spiradenoma or malignant spiradenoma, is a rare malignant adnexal tumor. We present a case of a 60-year-old woman with an enlarging, symptomatic, 5-cm exophytic mass on her left scalp, which was treated with wide local excision after a biopsy demonstrated suspicion for a ductal neoplasm. Histopathologic examination revealed a dermal tumor composed of nodules of monotonous basaloid cells with small intratumoral duct-like structures. In addition, squamous morules and scattered small glands with mucinous cytoplasm were seen. Immunohistochemical staining showed positivity for cytokeratin 7, p63, epithelial membrane antigen, SOX-10, and carcinoembryonic antigen (in duct lumens), with increased Ki67 proliferation index. A small focus reminiscent of benign spiradenoma was also noted. The final diagnosis was consistent with spiradenocarcinoma, uniquely presenting with mucinous glandular differentiation and squamous morules. This case highlights the importance of using precise histopathologic descriptors in diagnosing rare adnexal tumors and contributes to the growing body of literature on the heterogeneous morphology of these malignant lesions.","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":"699-702"},"PeriodicalIF":1.0,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144499085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lucio's Leprosy and Lucio's Phenomenon: The Man Behind the Eponymous. 卢西奥的麻风病和卢西奥现象：同名背后的人。

IF 1 4区医学

American Journal of Dermatopathology Pub Date : 2025-06-26 DOI: 10.1097/DAD.0000000000003041

Mario Magaña

引用次数: 0

Atypical Presentation of Calcinosis Cutis in a Patient With Renal Lupus. 肾性狼疮患者皮肤钙质沉着症的不典型表现。

IF 1.1 4区医学

American Journal of Dermatopathology Pub Date : 2025-06-25 DOI: 10.1097/DAD.0000000000003016

Sree Yazhini Ramar, Arun Somasundaram, Kashish Arora, Sivaranjini Ramassamy, Sanjay Sriram

引用次数: 0

Fatal Langerhans Cell Histiocytosis in an 84-Year-Old Man: A Case Report. 84岁男性致死性朗格汉斯细胞组织细胞增多症1例报告。

IF 1.1 4区医学

American Journal of Dermatopathology Pub Date : 2025-06-25 DOI: 10.1097/DAD.0000000000003001

Miguel Mansilla-Polo, Helena Hernández-Évole, Daniel Martín-Torregrosa, Margarita Llavador-Ros, Eduardo Giner-Moreno, Judith Pérez-Rojas, Montserrat Évole-Buselli

引用次数: 0

Febrile Ulceronecrotic Mucha-Habermann Disease in a 22-Month-Old Boy: A Case Presentation and Literature Review. 22月龄男童发热性溃疡性Mucha-Habermann病1例报告及文献复习。

IF 1.1 4区医学

American Journal of Dermatopathology Pub Date : 2025-06-25 DOI: 10.1097/DAD.0000000000003019

Daniela Milanova-Ilieva, Georgi Bukov, Ksenia Baadji, Tsvetana Abadjieva, Kostadin Ketev, Ivanka Karavelikova, Ivan Ivanov

引用次数: 0

Papulosquamous Rash Progressing to Erythroderma With Worsening Eosinophilia: Challenge. 丘疹鳞状皮疹进展为红皮病伴嗜酸性粒细胞恶化：挑战。

IF 1.1 4区医学

American Journal of Dermatopathology Pub Date : 2025-06-25 DOI: 10.1097/DAD.0000000000003009

Yuta Kioi, Kohei Ogawa, Satoru Shinkuma, Yasuhiro Mitsui, Chinatsu Shobatake, Fumi Miyagawa, Hideo Asada

引用次数: 0

Adenocarcinoma Arising in Sporadic Apocrine Papillary Cystadenoma of the Scalp. 发源于头皮散发大汗腺乳头状囊腺瘤的腺癌。

IF 1.1 4区医学

American Journal of Dermatopathology Pub Date : 2025-06-25 DOI: 10.1097/DAD.0000000000003017

Patricia-Irina Stinga, Thibault Kervarrec, Dmitry V Kazakov

{"title":"Adenocarcinoma Arising in Sporadic Apocrine Papillary Cystadenoma of the Scalp.","authors":"Patricia-Irina Stinga, Thibault Kervarrec, Dmitry V Kazakov","doi":"10.1097/DAD.0000000000003017","DOIUrl":"https://doi.org/10.1097/DAD.0000000000003017","url":null,"abstract":"Abstract: Hidrocystomas and cystadenomas are benign tumors, with malignant transformation being exceptionally rare, most commonly reported in the periocular region. We present a rare case of adenocarcinoma in situ arising within an apocrine papillary cystadenoma of the scalp in a 53-year-old man, without an associated nevus sebaceus. Microscopically, the tumor appeared as a predominantly cystic lesion and was located in the deep dermis. The neoplasm was composed of cuboidal to cylindrical cells, displaying decapitation secretion and forming glands, micropapillae, and occasional papillae with fibrovascular cores projecting into the cystic lumen. In addition, a considerable extraluminal proliferation of small, closely packed glands with a visible peripheral layer of myoepithelial cells was evident. Whereas most tumor cells were monomorphic, a focal area exhibited significant cellular atypia and pleomorphism. There were numerous necrotic cells, both isolated and clustered, and frequent mitotic figures, including atypical ones. RNA sequencing was performed using the Archer FusionPlex panel and revealed an HMGA2 fusion transcript of unknown significance. The lesion was surgically removed, and the patient had no evidence of disease 4 months after the diagnosis.","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144486865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ectopic Lactating Adenoma of Breast Presenting as a Vulvar Tumor. 乳腺异位泌乳腺瘤表现为外阴肿瘤。

IF 1.1 4区医学

American Journal of Dermatopathology Pub Date : 2025-06-25 DOI: 10.1097/DAD.0000000000003008

Myat Ei Mon, Valeria Reina, David Suster

{"title":"Ectopic Lactating Adenoma of Breast Presenting as a Vulvar Tumor.","authors":"Myat Ei Mon, Valeria Reina, David Suster","doi":"10.1097/DAD.0000000000003008","DOIUrl":"https://doi.org/10.1097/DAD.0000000000003008","url":null,"abstract":"Abstract: Ectopic breast tissue is a rare occurrence that has been well-documented along the length of the milk lines. For the most part, ectopic breast is easily recognizable on routine histology; however, difficulties may arise when dealing with tumors arising from such tissues, such as adenomas or carcinomas. We report the case of a 29-year-old pregnant woman who presented with a 1.6-cm cystic lesion in her vulva. Surgical excision was performed which showed a well-circumscribed tumor composed of compact tubular structures lined by columnar cells with round nuclei and small nucleoli devoid of mitotic activity. The tubular structures were remarkable for the presence of numerous clear vacuoles in the cytoplasm resulting in a histologic picture that is indistinguishable from so-called \"lactating\" adenomas of the breast. Immunohistochemical stains demonstrated nuclear positivity of the cells lining the ductules for estrogen and progesterone receptors, GATA3, and cytoplasmic staining for mammaglobin, supporting the breast origin of the tissue. Recognition of this lesion is of importance to avoid misdiagnosis of malignancy.","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144486869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bilateral Symmetric Tender Nodules on Elbows and Feet: Challenge. 双侧肘部和足部对称嫩嫩的结节：挑战。

IF 1.1 4区医学

American Journal of Dermatopathology Pub Date : 2025-06-25 DOI: 10.1097/DAD.0000000000003013

Joana Amat Calbet, María Concepción Campos Mármol

引用次数: 0

A Stranger in the Slide: A Rare Collision of a Spitz Melanocytoma With a Novel MYH9::LTK Fusion and a Common BRAF Mutated Nevus Mimicking a Melanoma With a Preexistent Nevus. 幻灯片中的陌生人：罕见的斯皮兹黑色素细胞瘤与新型MYH9::LTK融合和常见的BRAF突变痣的碰撞，模拟黑色素瘤与先前存在的痣。

IF 1.1 4区医学

American Journal of Dermatopathology Pub Date : 2025-06-25 DOI: 10.1097/DAD.0000000000003039

Puk R Meijs-Hermanns, Juliette M J Spitzer-Naaijkens, Lennart A Kester, Anne M L Jansen, Willeke A M Blokx

{"title":"A Stranger in the Slide: A Rare Collision of a Spitz Melanocytoma With a Novel MYH9::LTK Fusion and a Common BRAF Mutated Nevus Mimicking a Melanoma With a Preexistent Nevus.","authors":"Puk R Meijs-Hermanns, Juliette M J Spitzer-Naaijkens, Lennart A Kester, Anne M L Jansen, Willeke A M Blokx","doi":"10.1097/DAD.0000000000003039","DOIUrl":"https://doi.org/10.1097/DAD.0000000000003039","url":null,"abstract":"Abstract: In this case report, we present a rare collision tumor consisting of a Spitz melanocytoma with a novel MYH9::LTK fusion, and a BRAFV600E mutated common dermal nevus in a 25-year-old man. Based on morphology alone, the lesion could easily have been misdiagnosed as a melanoma with a preexisting nevus. However, only the common dermal nevus showed BRAFV600E expression on immunohistochemical analysis, pointing toward the possibility of a collision tumor and guiding further molecular analyses. Although MYH9::LTK fusions have not been previously described in Spitz tumors, we classified this lesion as Spitz based on the epithelioid morphology and kinase fusion driver. Because there was dermal mitotic activity and heterozygous CDKN2A loss, we signed this lesion out as Spitz melanocytoma, in association with an unrelated BRAFV600E mutated dermal nevus. This case underscores the relevance of performing immunohistochemistry and if needed additional molecular analyses to confirm the lineage and dignity of an atypical melanocytic lesion, in which a Spitz tumor is a diagnostic consideration, to prevent misdiagnosis.","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144486864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0