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American Journal of Dermatopathology最新文献

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Superficial Papular Neuroma: Two Cases of a Distinctive Dermal Neoplasm. 表皮乳头状神经瘤：两例独特的皮肤肿瘤。
IF 1.1 4区 医学
American Journal of Dermatopathology Pub Date : 2025-01-01 Epub Date: 2024-10-31 DOI: 10.1097/DAD.0000000000002872
Ronan Knittel, David Paton, Trevor W Beer
{"title":"Superficial Papular Neuroma: Two Cases of a Distinctive Dermal Neoplasm.","authors":"Ronan Knittel, David Paton, Trevor W Beer","doi":"10.1097/DAD.0000000000002872","DOIUrl":"10.1097/DAD.0000000000002872","url":null,"abstract":"<p><strong>Abstract: </strong>Superficial papular neuroma is a rare cutaneous spindle cell lesion, with only 5 cases reported in 2 studies. We document 2 additional cases in a 45-year-old man and a 43-year-old woman (the first case identified in a woman). Clinically, superficial papular neuromas appear as a single, non-specific papule on the head, neck, or back. Histologically, these lesions are within the papillary and superficial reticular dermis, with nerve-like structures composed of bland spindle-shaped cells intersecting normal tissue with mild reactive acanthosis. The cells are SOX10 positive with neurofilament protein staining multiple axons within. The nerve-like structures in this study were occasionally surrounded by a thin rim of CD34 positivity, with no epithelial membrane antigen staining, similar to normal sensory neurons. Superficial papular neuroma are rare benign neoplasms with no reports of recurrence, even when incompletely excised.</p>","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":"59-61"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142559343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Invasive Cuniculatum Carcinoma of the Groin Mimicking Hidradenitis Suppurativa. 模仿化脓性湿疹的腹股沟浸润性阴茎癌
IF 1.1 4区 医学
American Journal of Dermatopathology Pub Date : 2025-01-01 Epub Date: 2024-09-17 DOI: 10.1097/DAD.0000000000002809
Natacha Stchepinsky, Marie-Ange Alkassir, Aurélie Charissoux, Justine Lavaud, Philippe Bernard
{"title":"Invasive Cuniculatum Carcinoma of the Groin Mimicking Hidradenitis Suppurativa.","authors":"Natacha Stchepinsky, Marie-Ange Alkassir, Aurélie Charissoux, Justine Lavaud, Philippe Bernard","doi":"10.1097/DAD.0000000000002809","DOIUrl":"10.1097/DAD.0000000000002809","url":null,"abstract":"","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":"80-81"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142300132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multiple Facial Deep Dermatophytosis Caused by Trichophyton rubrum in an Immunocompromised Patient. 免疫功能低下患者由红毛癣菌引起的多发性面部深部皮肤癣。
IF 1.1 4区 医学
American Journal of Dermatopathology Pub Date : 2025-01-01 Epub Date: 2024-10-15 DOI: 10.1097/DAD.0000000000002861
Wilson Loginus, Chi-Kai Wong, Yang-Chi Lin, Yu-Hung Wu
{"title":"Multiple Facial Deep Dermatophytosis Caused by Trichophyton rubrum in an Immunocompromised Patient.","authors":"Wilson Loginus, Chi-Kai Wong, Yang-Chi Lin, Yu-Hung Wu","doi":"10.1097/DAD.0000000000002861","DOIUrl":"10.1097/DAD.0000000000002861","url":null,"abstract":"","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":"47 1","pages":"75-76"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142814636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Histopathologic Perspective of Nail Lichen Planus: A 10-year Case Series From a Tertiary Care Center in South India. 从组织病理学角度看甲扁平苔藓：印度南部一家三级医疗中心的 10 年病例系列。
IF 1.1 4区 医学
American Journal of Dermatopathology Pub Date : 2025-01-01 Epub Date: 2024-11-05 DOI: 10.1097/DAD.0000000000002870
Ashrita Laura Fernandez, Maria Frances Bukelo, Pernaje Ishwara Bhat, Inchara Yeliur Kalegowda
{"title":"Histopathologic Perspective of Nail Lichen Planus: A 10-year Case Series From a Tertiary Care Center in South India.","authors":"Ashrita Laura Fernandez, Maria Frances Bukelo, Pernaje Ishwara Bhat, Inchara Yeliur Kalegowda","doi":"10.1097/DAD.0000000000002870","DOIUrl":"10.1097/DAD.0000000000002870","url":null,"abstract":"<p><strong>Abstract: </strong>Nail involvement is seen in 10% of lichen planus patients, with a subset developing severe destruction of the nail matrix. Nail biopsy is a complex procedure usually done when nails are the only site of involvement. The pathology of nail lichen planus (NLP) has been the subject of very few studies. Most studies refer to the major and minor histopathologic criteria proposed by Hanno et al. This study aims to characterize the histopathologic features of NLP. Twenty five patients of NLP with nail biopsies, diagnosed in the last 10 years were included in the study. Lichen planus was suspected in all patients, and the alternative diagnosis was psoriasis/onychomycosis and melanoma. On histopathology, the common features included acanthosis (88%), lichenoid lymphocytic inflammation (96%), and hypergranulosis (72%). Detachment of epithelium from the subepithelium, a hitherto unreported feature, was noted in 60% of cases. Less common features were lymphocytic exocytosis (48%), melanophages (40%), basal vacuolar alteration (24%), apoptotic keratinocytes (28%), fraying of the nail plate (24%), and spongiosis (20%). Understanding the common and less common histopathologic features and their correlation with clinical findings is essential to diagnose NLP accurately rather than stressing histologic criteria as major/minor, which may lead to the underdiagnosis of cases.</p>","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":"17-21"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142584969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Selective Clonal Regression After Interferon Therapy in Metastatic Melanoma. 转移性黑色素瘤接受干扰素治疗后的选择性克隆消退
IF 1.1 4区 医学
American Journal of Dermatopathology Pub Date : 2025-01-01 Epub Date: 2024-10-31 DOI: 10.1097/DAD.0000000000002873
Angel Fernandez-Flores
{"title":"Selective Clonal Regression After Interferon Therapy in Metastatic Melanoma.","authors":"Angel Fernandez-Flores","doi":"10.1097/DAD.0000000000002873","DOIUrl":"10.1097/DAD.0000000000002873","url":null,"abstract":"<p><strong>Abstract: </strong>Regression (total or partial) is a common phenomenon in melanoma. From a pathogenic perspective, it is highly complex and only partially understood, involving aspects of both the tumor and the individual. One of the determining factors is the clonal selection of the tumor, wherein some clones within the tumor survive while others perish. This clonal selection can sometimes occur as a selective mechanism after the initiation of a therapeutic intervention. In many of these cases, the effect is detrimental, because the surviving clone is resistant to the applied therapy. However, occasionally, the therapy can successfully select the less harmful clone. We present an example of the latter, where therapy with interferon induced regression of the metastatic-capable melanocytic population, with only the primary tumor melanocytic population persisting. To confirm this, we demonstrated BRAF mutational similarity between the 2 populations, and an additional NRAS mutation in the metastatic population, which was absent in the primary tumor.</p>","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":"46-49"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142559341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Beyond the Surface: Dermoscopic, Clinical, and Histopathological Insights Into Secondary Extramammary Paget Disease of the Glans Linked to Urothelial Carcinoma. 超越表面：皮肤镜、临床和组织病理学透视与泌尿道癌相关的继发性龟头乳头外皮样病变。
IF 1.1 4区 医学
American Journal of Dermatopathology Pub Date : 2025-01-01 Epub Date: 2024-10-31 DOI: 10.1097/DAD.0000000000002876
Alexandre Raphael Meduri, Benedetta Tirone, Lucia Lospalluti, Francesca Ambrogio, Gerardo Cazzato, Marco Bellino
{"title":"Beyond the Surface: Dermoscopic, Clinical, and Histopathological Insights Into Secondary Extramammary Paget Disease of the Glans Linked to Urothelial Carcinoma.","authors":"Alexandre Raphael Meduri, Benedetta Tirone, Lucia Lospalluti, Francesca Ambrogio, Gerardo Cazzato, Marco Bellino","doi":"10.1097/DAD.0000000000002876","DOIUrl":"10.1097/DAD.0000000000002876","url":null,"abstract":"","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":"77-79"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142559328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Two Cases of FAVA With an Uncommon Localization in Adults. 两例定位不常见的成人 FAVA。
IF 1.1 4区 医学
American Journal of Dermatopathology Pub Date : 2025-01-01 Epub Date: 2024-11-05 DOI: 10.1097/DAD.0000000000002711
Angel Fernandez-Flores, José Luis Martínez-Amo
{"title":"Two Cases of FAVA With an Uncommon Localization in Adults.","authors":"Angel Fernandez-Flores, José Luis Martínez-Amo","doi":"10.1097/DAD.0000000000002711","DOIUrl":"10.1097/DAD.0000000000002711","url":null,"abstract":"<p><strong>Abstract: </strong>The fibroadipose vascular anomaly (FAVA) is a relatively unknown vascular anomaly in the realm of adult dermatopathology. Despite its intramuscular location, dermatologists often encounter cases, approaching them surgically under the presumption of a potential lipoma. This entity was first described in 2014, and consequently, many FAVA cases may be concealed in our archives under diagnoses of other entities that require differential diagnoses, such as intramuscular fast-flow vascular anomaly. Clinically, these anomalies typically manifest preferably in young women or girls and predominantly in the extremities. In this article, we present 2 cases of FAVA with atypical clinical features in terms of their topography and age at onset. However, histopathologically, they exhibit typical characteristics with fibroadipose tissue and dysmorphic venous vessels dissecting the affected striated muscle.</p>","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":"50-54"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142584980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
SOX-10 and Melan-A Immunostaining in Areas of Focal Acantholytic Dyskeratosis and Epidermolytic Hyperkeratosis Within Dysplastic Nevi Biopsies: An Observational Study. 发育不良痣活检组织中局灶性角化不良和表皮溶解性角化过度区域的 SOX-10 和 Melan-A 免疫染色：一项观察性研究。
IF 1.1 4区 医学
American Journal of Dermatopathology Pub Date : 2025-01-01 Epub Date: 2024-10-31 DOI: 10.1097/DAD.0000000000002866
Kayley L Erickson, Raghav Tripathi, Bethany R Rohr
{"title":"SOX-10 and Melan-A Immunostaining in Areas of Focal Acantholytic Dyskeratosis and Epidermolytic Hyperkeratosis Within Dysplastic Nevi Biopsies: An Observational Study.","authors":"Kayley L Erickson, Raghav Tripathi, Bethany R Rohr","doi":"10.1097/DAD.0000000000002866","DOIUrl":"10.1097/DAD.0000000000002866","url":null,"abstract":"<p><strong>Background: </strong>Focal acantholytic dyskeratosis (FAD) and epidermolytic hyperkeratosis (EHK) are common incidental epidermal histologic findings within dysplastic nevi biopsies. We evaluate whether areas of FAD and EHK within dysplastic nevi biopsies stain with immunostains used to characterize melanocytic neoplasms.</p><p><strong>Methods: </strong>In this case series, a natural language search of histopathology reports from our institution in the past year (2020-2021) identified dysplastic nevus biopsies with concurrent FAD and/or EHK. Tissue samples were examined for positive melanocytic immunostaining with SOX-10 and Melan-A in areas of FAD and EHK.</p><p><strong>Results: </strong>Out of 32 biopsies, 20 of 26 FAD specimens (76.9%) and 2 of 6 EHK specimens (33.3%) showed unexpected suprabasal layer staining with a melanocytic marker that did not correspond to definitively identified melanocytes on the H&E-stained sections. The immunohistochemical staining of FAD and EHK was observed in 2 forms: nonspecific background staining or \"true\" staining (ie, seemed nuclear on SOX-10 or cytoplasmic on Melan-A).</p><p><strong>Conclusions: </strong>This pilot examination provides evidence that areas of incidental FAD within dysplastic nevi biopsies demonstrate unexpected suprabasal layer staining with melanocytic markers. When dermatopathologists evaluate melanocytic neoplasms with melanocytic markers, it is possible the presence of incidental FAD could lead to over diagnosing pagetoid scatter within these lesions. This study is a proof of concept with mild to moderately dysplastic nevi that do not typically incur the use of melanocytic stains; however, the implication of this unexpected staining pattern would be important when using melanocytic markers on borderline melanocytic neoplasms that have incidental FAD. Close correlation with H&E is imperative to prevent misinterpretation in these cases.</p>","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":"36-41"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142559342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Case of Recurrent Atypical Lipomatous Tumor. 一个复发性非典型脂肪瘤病例
IF 1.1 4区 医学
American Journal of Dermatopathology Pub Date : 2025-01-01 Epub Date: 2024-10-15 DOI: 10.1097/DAD.0000000000002844
Keisuke Anju, Kazumasa Oya, Yoshiyuki Ishii, Yasuhiro Fujisawa
{"title":"A Case of Recurrent Atypical Lipomatous Tumor.","authors":"Keisuke Anju, Kazumasa Oya, Yoshiyuki Ishii, Yasuhiro Fujisawa","doi":"10.1097/DAD.0000000000002844","DOIUrl":"10.1097/DAD.0000000000002844","url":null,"abstract":"","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":"81-82"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142480039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cutaneous "Microcystic" Microsecretory Adenocarcinoma With Marked Adnexal Hyperplasia: A Simulant of Microcystic Adnexal Carcinoma. 皮肤 "微囊 "微分泌性腺癌伴明显附件增生：微囊附件癌的模拟物
IF 1.1 4区 医学
American Journal of Dermatopathology Pub Date : 2025-01-01 Epub Date: 2024-06-28 DOI: 10.1097/DAD.0000000000002788
Taylor Novice, Gautham Vellaichamy, Timothy H McCalmont, John Moesch
{"title":"Cutaneous \"Microcystic\" Microsecretory Adenocarcinoma With Marked Adnexal Hyperplasia: A Simulant of Microcystic Adnexal Carcinoma.","authors":"Taylor Novice, Gautham Vellaichamy, Timothy H McCalmont, John Moesch","doi":"10.1097/DAD.0000000000002788","DOIUrl":"10.1097/DAD.0000000000002788","url":null,"abstract":"<p><strong>Abstract: </strong>Microsecretory adenocarcinoma (MSA) was first described in 2019 as a low-grade salivary gland neoplasm of intraoral origin with distinct histopathologic features and a characteristic  MEF2C::SS18  fusion. Recently, skin was also identified as a primary site for MSA in a report by Bishop et al. Due to its rarity and resemblance to other adnexal tumors, MSA is a challenging diagnosis. Herein, we present a case of cutaneous MSA that was unique for the presence of a significant microcystic component and marked adnexal hyperplasia, which mimicked myxoid microcystic adnexal carcinoma (MAC). A 58-year-old presented with a 1 year history of an enlarging eyelid nodule. Histopathologic analysis revealed dermal tumor composed of small tubules containing inspissated bluish mucinous material. Accompanying marked adnexal hyperplasia and many microcysts were also present. Tumor cells expressed S100 protein, which is distinct from MAC, while p63 immunohistochemistry showed marked loss of myoepithelial labeling, as is common in primary adenocarcinomas. Next generation gene sequencing detected the characteristic MSA fusion protein  MEF2c::SS18 . We report a novel presentation of MSA that simulated MAC because of the presence of associated microcystic change. The presence of S100 immunopositivity and the identification of  MEF2C::SS18  fusion confirmed the diagnosis of cutaneous MSA.</p>","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":"62-64"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141472263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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