American Journal of Dermatopathology最新文献_第8页

Primary Cutaneous Melanoma With Sebocyte-like Melanocytes: Case Report and Review of the Literature. 原发性皮肤黑色素瘤伴皮脂腺样黑色素细胞：病例报告及文献回顾。

IF 1 4区医学

American Journal of Dermatopathology Pub Date : 2025-06-26 DOI: 10.1097/DAD.0000000000003007

Carmelo Urso

{"title":"Primary Cutaneous Melanoma With Sebocyte-like Melanocytes: Case Report and Review of the Literature.","authors":"Carmelo Urso","doi":"10.1097/DAD.0000000000003007","DOIUrl":"10.1097/DAD.0000000000003007","url":null,"abstract":"Abstract: Melanocytes with clear vacuolated cytoplasm and scalloped nuclei, resembling mature sebocytes, can occur in congenital, acquired, and blue melanocytic nevi but are rare in malignant melanomas. A case of primary cutaneous melanoma with sebocyte-like cells is reported. The patient was a 75-year-old male patient with a large pigmented lesion located on his right forearm. Histopathologically, the tumor showed two distinctive types of neoplastic cells: atypical melanocytes with eosinophilic cytoplasm and scattered cells with scalloped nuclei, sometimes containing pseudoinclusions, and clear multivacuolated cytoplasm, closely mimicking sebaceous differentiation. Immunohistochemically, sebocyte-like cells were positive for SOX10, PRAME, EMA, and factor XIIIa. A literature review identified six additional cases, three metastatic and three primary melanomas with sebocytes-like cells. Histopathologically, two variants were recognized. In addition to conventional melanoma cells, most of lesions (three metastatic and two primary tumors) contained sebocyte-like melanocytes only; two primary tumors showed sebocyte-like cells mixed to other clear cells, such as intermediate and/or balloon melanocytes.","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":"684-687"},"PeriodicalIF":1.0,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144499080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Significance of Sectioning (Breadloafing) the Entire Skin Tissue When Pathology Does Not Match Clinical Appearance. 当病理与临床表现不符时，对整个皮肤组织进行切片（面包切片）的意义。

IF 1 4区医学

American Journal of Dermatopathology Pub Date : 2025-06-26 DOI: 10.1097/DAD.0000000000003046

Ayesha Mujeb, Maria Salomé Páez-García, Noah Musolff, Madeline Tchack, Bassem Rafiq, Babar Rao

{"title":"Significance of Sectioning (Breadloafing) the Entire Skin Tissue When Pathology Does Not Match Clinical Appearance.","authors":"Ayesha Mujeb, Maria Salomé Páez-García, Noah Musolff, Madeline Tchack, Bassem Rafiq, Babar Rao","doi":"10.1097/DAD.0000000000003046","DOIUrl":"10.1097/DAD.0000000000003046","url":null,"abstract":"Abstract: Melanocytic nevi, or moles, are benign melanocyte proliferations, often presenting diagnostic challenges when clinical and histopathologic findings are inconsistent. Melanoma in situ (MIS), the earliest melanoma stage, remains confined to the epidermis, making early diagnosis critical for optimal outcomes. This case report highlights the diagnostic utility of the breadloafing, a serial sectioning technique, in cases where conventional histopathology might miss malignancy. This case presents a 35-year-old woman with a recurrent pigmented lesion initially diagnosed as a compound melanocytic nevus. Ten months postbiopsy, the lesion recurred, and subsequent histopathology revealed MIS. The lesion's complete excision showed an intradermal nevus without atypia, raising concerns of misdiagnosis. However, breadloafing confirmed MIS adjacent to the intradermal nevus. This case highlights the importance of integrating serial sectioning techniques, such as breadloafing, to reconcile clinicopathologic discrepancies and enhance diagnostic accuracy for atypical pigmented lesions.","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":"709-712"},"PeriodicalIF":1.0,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144509292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-Standing Vascular Lesions of the Ear and Periauricular Area: Challenge. 耳朵和耳周区域的长期血管病变：挑战。

IF 1 4区医学

American Journal of Dermatopathology Pub Date : 2025-06-26 DOI: 10.1097/DAD.0000000000003011

Gilberto Pires da Rosa, Catarina Pedrosa Costa, Alberto Mota, Maria J Cruz

引用次数: 0

Primary Cutaneous NUT Adnexal Carcinoma With BRD4::NUTM1 Fusion: A 19-Year Follow-Up. 原发性皮肤NUT附件癌合并BRD4::NUTM1融合：19年随访。

IF 1 4区医学

American Journal of Dermatopathology Pub Date : 2025-06-26 DOI: 10.1097/DAD.0000000000003034

Elsayed Ibrahim, Richard K Yang, Maria A Gubbiotti, Victor G Prieto, Woo Cheal Cho

引用次数: 0

Molluscum-Like Lesions in an Immunocompromised Patient: Challenge. 免疫功能低下患者的软体样病变：挑战。

IF 1 4区医学

American Journal of Dermatopathology Pub Date : 2025-06-26 DOI: 10.1097/DAD.0000000000003037

Songhee Han, Sabrina Newman, Shyam S Raghavan

引用次数: 0

Molluscum-Like Lesions in an Immunocompromised Patient: Answer. 免疫功能低下患者的软体样病变：答案。

IF 1 4区医学

American Journal of Dermatopathology Pub Date : 2025-06-26 DOI: 10.1097/DAD.0000000000003038

Songhee Han, Sabrina Newman, Shyam S Raghavan

引用次数: 0

Long-Standing Vascular Lesions of the Ear and Periauricular Area: Answer. 耳部和耳周区域的长期血管病变：答案。

IF 1 4区医学

American Journal of Dermatopathology Pub Date : 2025-06-26 DOI: 10.1097/DAD.0000000000003012

Gilberto Pires da Rosa, Catarina Pedrosa Costa, Alberto Mota, Maria J Cruz

引用次数: 0

Role of Histopathology of Skin Lesions in Diagnosing MAP2K1-Positive Cardiofaciocutaneous Syndrome. 皮肤病变组织病理学在诊断map2k1阳性心皮肤综合征中的作用。

IF 1 4区医学

American Journal of Dermatopathology Pub Date : 2025-06-26 DOI: 10.1097/DAD.0000000000003015

Rallapalli Rajyalakshmi, Chavali Venkata Lakshmi, Valasapalli Rajani

{"title":"Role of Histopathology of Skin Lesions in Diagnosing MAP2K1-Positive Cardiofaciocutaneous Syndrome.","authors":"Rallapalli Rajyalakshmi, Chavali Venkata Lakshmi, Valasapalli Rajani","doi":"10.1097/DAD.0000000000003015","DOIUrl":"10.1097/DAD.0000000000003015","url":null,"abstract":"Abstract: Cardiofaciocutaneous syndrome (CFC) is a rare autosomal dominant RASopathy with multisystem involvement and a wide spectrum of clinical findings. Cardiac, facial, and cutaneous features are characteristic of this developmental disorder. The diagnosis of this rare syndrome is challenging because it is based on a set of clinical features alone that are similar to those of other RASopathies, such as Noonan syndrome and Costello syndrome. Cutaneous manifestations are one of the diagnostic features of CFC syndrome, and most documented cases of CFC syndrome provide clinical descriptions of skin lesions with minimal information about the histology. In this study, we present the unique histopathology features of cutaneous lesions in a 7-month-old male child with typical facial features and cardiac abnormalities of CFC syndrome. These were acanthosis, hyperkeratosis, and squamous metaplasia of the eccrine glands with granuloma formation. Molecular analysis by next-generation sequencing showed MAP2K1 gene mutation within exon 3. In addition, we conducted a comprehensive study of the histopathology of skin lesions of CFC syndrome by various authors. On 7 years follow-up, the patient was found to have global developmental delay and muscle contractures, which are common with MAP2K1 gene mutations. Skin lesions in CFC syndrome are usually associated with BRAF mutations, and the present case is one of the few to describe the detailed histopathology of skin lesions in CFC syndrome with MAP2K1 gene mutation.","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":"e104-e110"},"PeriodicalIF":1.0,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144499083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SBF1::BRAF -Fused Melanoma With Prominent Rhabdoid Morphology and Reed-Sternberg-Like Cells: Potential Morphologic Clues to BRAF -Fused Melanomas of Non-Spitz Lineage? 具有突出横纹肌样形态和里德-斯特恩伯格样细胞的braf融合黑色素瘤：非spitz谱系braf融合黑色素瘤的潜在形态学线索？

IF 1 4区医学

American Journal of Dermatopathology Pub Date : 2025-06-26 DOI: 10.1097/DAD.0000000000003048

Woo Cheal Cho, Richard K Yang, Volha Lenskaya, Victor G Prieto

引用次数: 0

An Atypical Rash After Radiotherapy in a Patient With Breast Cancer: Answer. 乳腺癌患者放疗后的非典型皮疹：答案。

IF 1 4区医学

American Journal of Dermatopathology Pub Date : 2025-06-26 DOI: 10.1097/DAD.0000000000003043

Mathilde Kvamme, Mia Lie Petersen, Erlend Aass Engstrøm, Urša Maierhofer, Asok Biswas, Jan Øyvind Holm, Thomas Papathomas

引用次数: 0