American Journal of Dermatopathology最新文献

{"title":"Erratum: Cutaneous Involvement by Diffuse Large B-Cell Lymphoma With Dual B-Cell and T-Cell Clonality and Heavy Admixed T-Cell Infiltrate: Answer.","authors":"Nada Shaker, Robert Phelps, Carlos Torres-Cabala, George Niedt, Omar P Sangueza, Dinesh Pradhan","doi":"10.1097/DAD.0000000000003250","DOIUrl":"10.1097/DAD.0000000000003250","url":null,"abstract":"","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":"750"},"PeriodicalIF":0.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148334200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intraepidermal Merkel Cell Carcinoma in Association With Squamous Cell Carcinoma In Situ and Adjacent Invasive Merkel Cell Carcinoma.","authors":"Federico Repetto, Eleanor E Russell-Goldman, Christine G Lian, Mia S DeSimone","doi":"10.1097/DAD.0000000000003346","DOIUrl":"10.1097/DAD.0000000000003346","url":null,"abstract":"","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":"e88-e90"},"PeriodicalIF":0.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148334164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Readability to Reliability: Audit-Ready, Equity-Aware Simplification of Dermatopathology Reports.","authors":"Anjali Sharma, M Vijayasimha, Rajesh P Jayaswal, Vasudha Kapani","doi":"10.1097/DAD.0000000000003271","DOIUrl":"10.1097/DAD.0000000000003271","url":null,"abstract":"","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":"744-745"},"PeriodicalIF":0.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148334217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum: Navigating the Complexity of Dual Clonality in Cutaneous Lymphoma: Challenge.","authors":"Nada Shaker, Robert Phelps, Carlos Torres-Cabala, George Niedt, Omar P Sangueza, Dinesh Pradhan","doi":"10.1097/DAD.0000000000003249","DOIUrl":"10.1097/DAD.0000000000003249","url":null,"abstract":"","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":"750"},"PeriodicalIF":0.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148334188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Melanoma Colonizing Basal Cell Carcinoma: A Rarely Described Entity.","authors":"Ferhat Özden, İbrahim Serdar Coşkun, İhsan Kasapgil","doi":"10.1097/DAD.0000000000003348","DOIUrl":"10.1097/DAD.0000000000003348","url":null,"abstract":"<p><strong>Background: </strong>Collision tumors combining basal cell carcinoma (BCC) and melanoma are exceptionally rare, and their distinction from melanoma colonization remains controversial.</p><p><strong>Case presentation: </strong>A 68-year-old man presented with a persistent ulcer on the lower lip, initially believed to represent BCC. Wedge resection revealed a 2.2 cm ulcerated lesion composed of BCC with malignant melanocyte colonization. Immunohistochemical analysis confirmed the biphasic nature: the melanocytic component was positive for S100, Melan-A, SOX10, and PRAME (with p16 loss), and the epithelial component was positive for p40 and Bcl-2. The melanoma measured 7.5 mm in Breslow thickness (pT4b) with ulceration and perineural invasion, but no lymphovascular involvement. Margins were negative. A sentinel lymph node biopsy was recommended but was declined by the patient.</p><p><strong>Conclusion: </strong>This case illustrates the diagnostic complexity and clinical effect of BCC-melanoma collision/colonization tumors. Prognosis is dictated by the melanoma component, underscoring the need for meticulous histopathologic evaluation and immunohistochemistry in guiding patient management.</p>","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":"734-736"},"PeriodicalIF":0.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148334198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utility of Combined Immunohistochemical Staining for AMBRA1 and Loricrin for Improving the Pathologic Diagnosis of High-Grade Dysplastic Nevi.","authors":"Philip Sloan, Akhtar Husain, Jonathan Lye, Katie Best, Laura Walker, Grant Richardson, Jane Armstrong, Penny Lovat","doi":"10.1097/DAD.0000000000003330","DOIUrl":"10.1097/DAD.0000000000003330","url":null,"abstract":"<p><strong>Background: </strong>The diagnosis of high-grade dysplastic nevus (HGDNs) can present a challenge for a pathologist. The utility of combined AMBRA1 and loricrin staining for the diagnosis of HGDN was evaluated using preferentially expressed antigen in melanoma (PRAME) as a comparator.</p><p><strong>Materials and methods: </strong>A cohort of 145 cases of HGDN was selected from a consecutive series of 409 dysplastic nevi ascertained in a single pathology service between 2015 and 2019. Combined immunohistochemistry for AMBRA1 and loricrin expression in the epidermis overlying the HGDN was consensus scored by 2 experienced pathologists. PRAME immunohistochemistry was also consensus scored in the melanocyte population using a five-point scale (0-4+).</p><p><strong>Results: </strong>All HGDNs showed maintenance of either 1 or both AMBRA1 and loricrin epidermal expression with 3 exceptions. In 1 instance, a focus of melanocytes within the HGDN was associated with loss of both markers in the overlying epidermis and the melanocytes in the focus were strongly positive (4+) for PRAME. On expert review, the diagnosis was changed to thin melanoma. In the other 2 cases showing loss of both markers, the absence of staining was focal and restricted to mounds of parakeratosis. Most HGDN were negative for PRAME although 48% were positive to some degree and 4% showed a 4+ expression.</p><p><strong>Observations: </strong>Clinical follow-up showed no evidence of progression or metastasis. We found that 23 patients (16%) had previous, concurrent, or subsequent early stage melanomas and 2 patients (1%) had previous melanoma in situ. One HGDN recurred after 3 years, and the further excision sample showed recurrent HGDN only. We observed that mild epidermal hyperplasia and parakeratosis were often found in HGDNs, suggesting an active melanocyte-epidermal interaction in the lesions. We speculate that epidermal hyperplasia resulted in some of the HGDN showing single-cell loricrin gaps or thinning of the loricrin band. AMBRA1, loricrin, and PRAME staining was additionally performed on 39 benign melanocytic nevi covering a range of types for comparison. Epidermal hyperplasia was generally not seen and almost all cases showed maintenance of both epidermal AMBRA1 and loricrin, with loricrin gaps and thinning seen only in 3 Meyerson nevi where there was parakeratosis (3/5 Meyerson nevi).</p><p><strong>Conclusion: </strong>This study suggests that AMBRA1 and loricrin staining is a useful biomarker to confirm the diagnosis and/or to signal low-risk behavior in HGDN, particularly in cases where 4+ PRAME staining could potentially point to a melanoma diagnosis.</p>","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":"691-697"},"PeriodicalIF":0.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148334326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PRAME Expression and Melanoma In Situ Margin Assessment.","authors":"Thomas N Helm, Charlene Lam, Bohdan Zoshchuk, Matthew F Helm","doi":"10.1097/DAD.0000000000003349","DOIUrl":"10.1097/DAD.0000000000003349","url":null,"abstract":"<p><strong>Abstract: </strong>Melanoma in situ on chronically sun-damaged skin may extend significantly beyond clinically visible borders. Immunohistochemistry, particularly PRAME (PReferentially expressed Antigen in MElanoma), has emerged as a useful adjunct in delineating subclinical spread of lentigo maligna-type melanoma in situ. We report a case illustrating the diagnostic challenge of determining margins for melanoma in situ of lentigo maligna type even with the benefit of PRAME immunohistochemistry.</p>","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":"682-683"},"PeriodicalIF":0.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13489762/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148303421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nonfamilial Unilateral Linear Eccrine Syringofibroadenoma of the Plantar Surface: A Diagnostic Consideration in Acral Eccrine Proliferations.","authors":"Jing Xu, Lianjun Chen, Huyan Chen, Shangshang Wang","doi":"10.1097/DAD.0000000000003329","DOIUrl":"10.1097/DAD.0000000000003329","url":null,"abstract":"<p><strong>Abstract: </strong>Eccrine syringofibroadenoma (ESFA) is an uncommon benign adnexal neoplasm characterized by eccrine ductal differentiation and a distinctive reticulated architectural pattern. The nonfamilial unilateral linear subtype is exceedingly rare and may pose diagnostic difficulty, particularly in acral locations. We describe a long-standing unilateral linear plantar lesion in a middle-aged woman. Histopathological examination revealed anastomosing epithelial cords extending from the epidermis into a fibrovascular stroma, with associated eccrine duct-like structures, consistent with ESFA. Recognition of these characteristic features is essential to distinguish ESFA from other reactive, infectious, and neoplastic eccrine proliferations encountered in dermatopathology practice.</p>","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":"717-719"},"PeriodicalIF":0.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148334302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunoglobulin G4 Immunohistochemistry for Pemphigus: Practical Considerations for Diagnostic Implementation.","authors":"Rajesh P Jayaswal, Reena Tomar, Rama K Badyal","doi":"10.1097/DAD.0000000000003310","DOIUrl":"10.1097/DAD.0000000000003310","url":null,"abstract":"","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":"748-749"},"PeriodicalIF":0.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148334222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Underreporting of Interrater Agreement in Diagnostic Accuracy Studies of Immunohistochemistry in Dermatopathology: A Systematic Review.","authors":"Margaryta Stoieva, Garth Fraga","doi":"10.1097/DAD.0000000000003334","DOIUrl":"10.1097/DAD.0000000000003334","url":null,"abstract":"<p><strong>Abstract: </strong>Immunohistochemistry (IHC) is widely used in dermatopathology to support diagnostic classification, yet the reproducibility of IHC interpretation is rarely evaluated in studies of diagnostic performance. Because most IHC tests require visual interpretation by pathologists, variability in reader interpretation may influence reported test accuracy. We conducted a systematic review of diagnostic accuracy studies of dermatopathology IHC diagnostic biomarkers published between 2015 and 2025 to determine how frequently interobserver agreement is reported. Searches of PubMed, Embase, and Web of Science identified 1461 abstracts, of which 84 studies met inclusion criteria. Although most studies reported sensitivity and specificity, 73 of 84 (87%) did not report any measure of interobserver agreement. When reported, agreement was most commonly assessed using Cohen kappa statistic, although qualitative descriptions of concordance were also used. To integrate diagnostic accuracy with reproducibility, we explored a composite metric, the kappa-balanced score, defined as the geometric mean of balanced accuracy and Cohen kappa. Kappa-balanced score was calculable in three studies and ranged from 0.62 to 0.93. These findings indicate that interobserver agreement is substantially underreported in dermatopathology IHC studies, highlighting the need for routine reporting of reproducibility metrics in diagnostic accuracy research.</p>","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":"710-716"},"PeriodicalIF":0.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148334294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}