American Journal of Dermatopathology最新文献_第7页

Giant Vulvar Pseudoangiomatous Stromal Hyperplasia After Bilateral Breast and Axillary Lesions: A Delayed Multifocal Presentation. 双侧乳腺和腋窝病变后巨大外阴假性血管瘤间质增生：延迟多灶表现。

IF 1.1 4区医学

American Journal of Dermatopathology Pub Date : 2025-07-16 DOI: 10.1097/DAD.0000000000003066

Ceren Unal, Sebile Guler Cekic, Zuhal Gucin, Serdar Aydin

{"title":"Giant Vulvar Pseudoangiomatous Stromal Hyperplasia After Bilateral Breast and Axillary Lesions: A Delayed Multifocal Presentation.","authors":"Ceren Unal, Sebile Guler Cekic, Zuhal Gucin, Serdar Aydin","doi":"10.1097/DAD.0000000000003066","DOIUrl":"https://doi.org/10.1097/DAD.0000000000003066","url":null,"abstract":"Abstract: Pseudoangiomatous stromal hyperplasia (PASH) is a benign myofibroblastic proliferation frequently encountered in the breast but rarely affects anogenital mammary-like glands, where it typically presents as small nodules. We report a rare case of a 38-year-old woman who developed a 95 × 60 × 60-mm vulvar mass 4 months after undergoing bilateral mastectomy and axillary excisions for histologically confirmed PASH. Pelvic MRI revealed a well-circumscribed, hypointense lesion in the posterolateral vaginal wall. Wide local excision was performed. Histopathology demonstrated a dense collagenous stroma with bland spindle cells forming interanastomosing slit-like, endothelial-free pseudovascular spaces, confirming the diagnosis of PASH. No fibroadenomatous component was observed. Immunohistochemical staining was positive for SMA and negative for CD31 and Factor VIII in the pseudovascular spaces, aiding in the exclusion of vascular neoplasms such as angiosarcoma. The patient remains recurrence-free at 1 year. This case highlights the potential for delayed multifocal PASH involving hormonally responsive anogenital sites, emphasizes its inclusion in the differential diagnosis of large vulvar masses, and underscores the need for surveillance of ectopic mammary-like tissues in patients with a history of PASH.","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144644098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Histiocytoid Variant of Cutaneous Apocrine Carcinoma: A Rare Case With Literature Review. 皮肤大汗腺癌的组织细胞样变异：一例罕见病例并文献复习。

IF 1 4区医学

American Journal of Dermatopathology Pub Date : 2025-07-10 DOI: 10.1097/DAD.0000000000003061

J N Aparnna, Biswanath Behera, Naveen Purushothaman, Madhusmita Sethy, Deepak Kumar Sahu, Pavithra Ayyanar

引用次数: 0

Architecturally Low-Grade Pure Cylindrocarcinoma With CYLD1 Mutation. 低级别纯柱状癌伴CYLD1突变。

IF 1 4区医学

American Journal of Dermatopathology Pub Date : 2025-07-08 DOI: 10.1097/DAD.0000000000002984

Ronan Knittel, Shona Hendry, Benjamin A Wood

引用次数: 0

Facial HPV6-Positive in Situ Squamous Cell Carcinoma With Small Cell Features Mimicking Merkel Cell Carcinoma. 面部hpv6阳性的原位鳞状细胞癌具有模仿默克尔细胞癌的小细胞特征。

IF 1 4区医学

American Journal of Dermatopathology Pub Date : 2025-07-03 DOI: 10.1097/DAD.0000000000003064

Sonsoles Berenguer-Ruiz, Carmen-Amalia Vásquez-Dongo, Noelia Perez-Muñoz, Maria-Teresa Fernández-Figueras

引用次数: 0

Zosteriform Mycosis Fungoides: A Case Report and Literature Review. 带状虫状真菌病1例报告并文献复习。

IF 1 4区医学

American Journal of Dermatopathology Pub Date : 2025-07-03 DOI: 10.1097/DAD.0000000000003057

Lina Al-Soufi, Aya Marashli, Mohammad Adi, Yaman Saiouf, Zuheir Al-Shehabi

{"title":"Zosteriform Mycosis Fungoides: A Case Report and Literature Review.","authors":"Lina Al-Soufi, Aya Marashli, Mohammad Adi, Yaman Saiouf, Zuheir Al-Shehabi","doi":"10.1097/DAD.0000000000003057","DOIUrl":"10.1097/DAD.0000000000003057","url":null,"abstract":"Abstract: Primary cutaneous lymphomas are the third most common lymphomas, with mycosis fungoides (MF) being the predominant subtype of cutaneous T-cell lymphoma. Zosteriform distribution of MF is a rare presentation, complicating diagnosis and management because of its resemblance to other skin disorders. This subtype usually presents with typical lesions of classic MF, including patches and patches that progress to plaques and sometimes tumors, but in a distribution limited to a dermatomal distribution. This case involves a 29-year-old woman with a recurrent, unilateral itchy, and painful rash on her lower back, misdiagnosed for a decade as fungal infection and eczema. The rash evolved into a resistant scaly plaque, unresponsive to steroids and phototherapy. Histopathologic examination of skin biopsies suggested large plaque parapsoriasis. Based on clinical, histologic, and therapeutic response features, a final diagnosis of early-stage MF was established. The patient showed partial improvement after treatment with methotrexate and corticosteroids. Zosteriform MF is a rare and challenging variant, showing relatively good prognosis in most cases. Literature review highlights its occurrence across a wide age range, with prior herpes zoster viral infection proposed as a potential trigger influencing disease onset and distribution. Treatment outcomes vary, with some patients benefiting from immunosuppressive therapies, while others experience recurrence or poor prognosis. Zosteriform MF is a rare, diagnostically challenging variant of MF. This case underscores the importance of thorough diagnostic evaluation and the potential for variable treatment responses. Further research is needed to understand its pathogenesis and optimize therapeutic strategies.","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":"719-724"},"PeriodicalIF":1.0,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144561900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Demodex Infestation in Discoid Lupus Erythematosus: A Histopathologic Study. 盘状红斑狼疮蠕形螨感染的组织病理学研究。

IF 1 4区医学

American Journal of Dermatopathology Pub Date : 2025-07-03 DOI: 10.1097/DAD.0000000000003058

Gülhan Aksoy Saraç, Selma Emre, Merve Kaya, Rümeysa Kankoç, Gülnaz Kurt Çevik, Nuran Süngü

{"title":"Demodex Infestation in Discoid Lupus Erythematosus: A Histopathologic Study.","authors":"Gülhan Aksoy Saraç, Selma Emre, Merve Kaya, Rümeysa Kankoç, Gülnaz Kurt Çevik, Nuran Süngü","doi":"10.1097/DAD.0000000000003058","DOIUrl":"10.1097/DAD.0000000000003058","url":null,"abstract":"Abstract: Discoid lupus erythematosus (DLE) is a chronic form of cutaneous lupus that mainly affects the face, scalp, and neck. It presents as erythematous and infiltrated plaques that may lead to atrophy, scarring, and alopecia. Recent studies suggest a possible link between Demodex mite infestation and DLE pathogenesis. This study aims to evaluate the prevalence of Demodex mites in patients with DLE and their potential role in disease pathogenesis. A total of 85 histopathologically and clinically confirmed patients with DLE were assessed. Clinical and histopathologic data were collected, and hematoxylin-eosin-stained biopsy specimens were evaluated for Demodex infestation. Demodex mites were detected in 31 patients (36.5%). Infestation was more common in face localization (47.1%) than in scalp (16.7%) ( P = 0.006). No significant association was found between Demodex positivity and age, sex, or histopathologic findings of DLE. Although Demodex mites may not play a direct role in DLE pathogenesis, their increased prevalence in facial lesions suggests a secondary association because of immune dysregulation and autoimmune background. Further studies are needed to assess the impact of Demodex positivity on DLE progression, pathogenesis, and treatment response.","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":"688-691"},"PeriodicalIF":1.0,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144561898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Atypical Spitz Tumor/Spitz Melanocytoma Revealing a VIM::NTRK3 Gene Fusion: Clinicopathological Correlation of a Unique Molecular Finding. 揭示VIM::NTRK3基因融合的非典型Spitz肿瘤/Spitz黑素细胞瘤：一个独特分子发现的临床病理相关性

IF 1.1 4区医学

American Journal of Dermatopathology Pub Date : 2025-07-01 DOI: 10.1097/DAD.0000000000003051

Mario Della Mura, Joana Sorino, Anna Colagrande, Giuseppe Ingravallo, Alessio Giubellino, Francesco Fortarezza, Richard K Yang, Woo Cheal Cho, Gerardo Cazzato

{"title":"Atypical Spitz Tumor/Spitz Melanocytoma Revealing a VIM::NTRK3 Gene Fusion: Clinicopathological Correlation of a Unique Molecular Finding.","authors":"Mario Della Mura, Joana Sorino, Anna Colagrande, Giuseppe Ingravallo, Alessio Giubellino, Francesco Fortarezza, Richard K Yang, Woo Cheal Cho, Gerardo Cazzato","doi":"10.1097/DAD.0000000000003051","DOIUrl":"https://doi.org/10.1097/DAD.0000000000003051","url":null,"abstract":"Abstract: Spitz tumors are a heterogeneous group of melanocytic neoplasms ranging from benign Spitz nevi to malignant Spitz melanomas, with atypical Spitz tumors/Spitz melanocytoma occupying an intermediate position within this biological spectrum. A hallmark of all these lesions is the presence of specific genetic alterations, distinct from those seen in common nevi, that include, among others, receptor tyrosine kinase fusions. NTRK3 gene rearrangements are rare, with only a few fusion partners described in the existing literature (ETV6, MYO5A, MYH9, and SQSTM1). We report the first case of an atypical Spitz tumor/Spitz melanocytoma harboring a novel VIM::NTRK3 gene fusion, occurring in a 10-year-old girl. Histopathology revealed a compound melanocytic proliferation composed of both epithelioid and spindle-shaped melanocytes, that displays atypical features, including increased number of single junctional elements, evident pagetoid spread, and lack of maturation. Immunohistochemistry showed diffuse pan-TRK positivity, with a peculiar granular cytoplasmic and perinuclear dot-like pattern, the latter possibly reflecting the microtubule organizing center/centrosome. This case expands the spectrum of known NTRK3 fusion partners and underscores the importance of molecular characterization through next-generation sequencing for accurate diagnosis and potential therapeutic implications in challenging lesions.","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144545936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hypertrichotic Verrucous Pigmented Plaque Over Extremities-A Clue Toward Early Verrucous Venous Malformation. 四肢多毛疣状色素斑块-早期疣状静脉畸形的线索。

IF 1 4区医学

American Journal of Dermatopathology Pub Date : 2025-06-26 DOI: 10.1097/DAD.0000000000002998

Shreya K Gowda, Nikhil Mehta, Sudheer Arava

{"title":"Hypertrichotic Verrucous Pigmented Plaque Over Extremities-A Clue Toward Early Verrucous Venous Malformation.","authors":"Shreya K Gowda, Nikhil Mehta, Sudheer Arava","doi":"10.1097/DAD.0000000000002998","DOIUrl":"10.1097/DAD.0000000000002998","url":null,"abstract":"Abstract: Verrucous venous malformation (VVM), also known as verrucous hemangioma, is a congenital vascular anomaly characterized by malformed dermal venule-like channels and hyperkeratotic skin. This study presents 5 cases of VVM that manifested as hyperpigmented, slightly verrucous plaques with hypertrichosis, where the diagnosis was not initially suspected. The average age of the patients was 9 years, with lesions predominantly located on the lower extremities. Histopathological examination confirmed VVM through findings of hyperkeratosis, acanthosis, and dilated vascular channels in the dermis. The differential diagnoses included dermatofibroma, mastocytoma, and eccrine angiomatous hamartoma. Dermoscopic features revealed bluish red lagoons and blue-white veil patterns, assisting in distinguishing VVM from other vascular lesions. Notably, the presence of hypertrichosis and hyperpigmentation in these patients has not been previously documented and may serve as early indicators of VVM. The study highlights the need for awareness of these clinical features to avoid misdiagnosis because VVM can often be confused with other dermatological conditions.","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":"679-683"},"PeriodicalIF":1.0,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144499077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cutaneous Rhabdomyosarcoma With FUS::TFCP2 Fusion: An Emerging Entity That Expands the Differential Diagnosis of ALK-Positive Spindle Cell Neoplasm of the Skin. 皮肤横纹肌肉瘤与FUS::TFCP2融合：一个新兴的实体，扩大了皮肤alk阳性梭形细胞肿瘤的鉴别诊断。

IF 1 4区医学

American Journal of Dermatopathology Pub Date : 2025-06-26 DOI: 10.1097/DAD.0000000000003031

Kentaro Tsuji, Masakazu Fujimoto, Yuki Togashi, Satoko Baba, Akito Dobashi, Kengo Takeuchi, Tomoki Sakiyama, Yui Hirano-Lotman, Hiroyuki Irie, Yuichiro Endo, Yasuhide Takeuchi, Hironori Haga

{"title":"Cutaneous Rhabdomyosarcoma With FUS::TFCP2 Fusion: An Emerging Entity That Expands the Differential Diagnosis of ALK-Positive Spindle Cell Neoplasm of the Skin.","authors":"Kentaro Tsuji, Masakazu Fujimoto, Yuki Togashi, Satoko Baba, Akito Dobashi, Kengo Takeuchi, Tomoki Sakiyama, Yui Hirano-Lotman, Hiroyuki Irie, Yuichiro Endo, Yasuhide Takeuchi, Hironori Haga","doi":"10.1097/DAD.0000000000003031","DOIUrl":"10.1097/DAD.0000000000003031","url":null,"abstract":"Abstract: Rhabdomyosarcoma with EWSR1/FUS::TFCP2 fusion is an emerging subtype of rhabdomyosarcoma that rarely arises in skin. It is characterized by spindle and epithelioid morphology, and frequent expression of cytokeratin and anaplastic lymphoma kinase (ALK). We report a case of primary cutaneous rhabdomyosarcoma with FUS::TFCP2 fusion in a 59-year-old man who initially presented with an erythematous lesion on the chest that progressed to a mass-forming lesion 6 months before his hospital visit. On examination, an irregularly shaped 12-cm indurated erythematous plaque with a 2-cm multinodular solid mass was observed. Histologic examination revealed sparse infiltration of round cells with minimal atypia within the thickened dermis of the erythematous area, while the mass exhibited fascicular or sheet-like proliferation of atypical spindle and epithelioid cells. Diffuse expression of ALK and cytokeratin, along with partial expression of alpha smooth muscle actin and desmin, raised suspicion of ALK -rearranged mesenchymal neoplasms, including inflammatory myofibroblastic tumor. However, fluorescence in situ hybridization (FISH) failed to detect ALK rearrangements. FUS::TFCP2 fusion was identified by RNA sequencing and confirmed by FISH. Additional immunohistochemistry for myogenin and MyoD1 demonstrated myogenic differentiation, leading to the final diagnosis. The patient underwent chemotherapy and surgical resection, followed by radiotherapy, and remains disease free for 8 months postoperatively. This case highlights the diagnostic challenges posed by aberrant ALK expression and the indolent appearance of early stage lesions. Awareness of this rare entity combined with molecular testing is crucial for accurate diagnosis and appropriate management.","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":"703-708"},"PeriodicalIF":1.0,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144499018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Atypical Rash Following Radiotherapy in a Patient With Breast Cancer: Challenge. 乳腺癌患者放疗后的非典型皮疹：挑战。

IF 1 4区医学

American Journal of Dermatopathology Pub Date : 2025-06-26 DOI: 10.1097/DAD.0000000000003042

Mathilde Kvamme, Mia Lie Petersen, Erlend Aass Engstrøm, Urša Maierhofer, Asok Biswas, Jan Øyvind Holm, Thomas Papathomas

引用次数: 0