American Journal of Dermatopathology最新文献_第6页

Dermatofibrosarcoma Protuberans Arising in a Digit: A Case Report.

IF 1.1 4区医学

American Journal of Dermatopathology Pub Date : 2025-02-19 DOI: 10.1097/DAD.0000000000002948

Samantha Sun, Jordan Odom, Nathalie Ruiz, Patricia Moody

引用次数: 0

A Rare Cutaneous Presentation of Malignant Tenosynovial Giant Cell Tumor.

IF 1.1 4区医学

American Journal of Dermatopathology Pub Date : 2025-02-19 DOI: 10.1097/DAD.0000000000002943

Sophia Luyten, Apoorva Mehta, Alejandro A Gru

{"title":"A Rare Cutaneous Presentation of Malignant Tenosynovial Giant Cell Tumor.","authors":"Sophia Luyten, Apoorva Mehta, Alejandro A Gru","doi":"10.1097/DAD.0000000000002943","DOIUrl":"https://doi.org/10.1097/DAD.0000000000002943","url":null,"abstract":"Abstract: Malignant tenosynovial giant cell tumor (MTGCT) is a rare and aggressive variant of tenosynovial giant cell tumors, with fewer than 60 reported cases. Although typically localized to joints and soft tissues, cutaneous presentations of MTGCT are exceedingly rare, with only a handful of documented cases involving direct dermal invasion. Here we report the case of an 88-year-old man with a history of nonmelanoma skin cancers who presented with a friable, ulcerated 2.5 cm nodule on the midchest. The lesion, present for approximately 1 month, was excised and found to be a malignant TGCT. Histopathology revealed a neoplasm with multinucleated giant cells and malignant features such as numerous and atypical mitotic figures, necrosis, and severe cellular pleomorphism. Immunohistochemistry showed positivity for CD45 and CD68, with weak partial expression of smooth muscle actin, and negative for CD34, P40, SOX10, pancytokeratin, CD163, CD1a, S100, and Melan-A, confirming the diagnosis. The patient underwent complete surgical excision. This case highlights a rare presentation of MTGCT with direct cutaneous involvement, adding to the sparse literature on this malignancy. Early recognition and accurate diagnosis of such unusual presentations are crucial because of the tumor's aggressive potential.","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143473238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Periungual Cyst or Pseudocyst Featuring Low-Grade Dysplasia Associated With High-Risk Human Papillomavirus Infection: A Cystic Presentation of Human Papillomavirus-Related Intraepithelial Neoplasia of the Nail Bed?

IF 1.1 4区医学

American Journal of Dermatopathology Pub Date : 2025-02-19 DOI: 10.1097/DAD.0000000000002950

Jean-Louis Dargent, Michel Hérin, Isabelle Fayt, Jean-Christophe Noël

引用次数: 0

A Case of Pancreatitis-Panniculitis-Polyarthritis Syndrome due to Primary Hepatic Neuroendocrine Tumor.

IF 1.1 4区医学

American Journal of Dermatopathology Pub Date : 2025-02-19 DOI: 10.1097/DAD.0000000000002947

Wenjin Fan, Huan Wang, Lin Hou, Shanshan Li

引用次数: 0

34βE12 is the Most Reliable Marker for Keratin-Derived Cutaneous Amyloid: A Comparative Study.

IF 1.1 4区医学

American Journal of Dermatopathology Pub Date : 2025-02-19 DOI: 10.1097/DAD.0000000000002942

Maged Daruish, Ghada Al-Sharbatee, Corrado D'Arrigo, Saleem Taibjee

引用次数: 0

Focal Oral Elastosis: Case Series, Proposed Nomenclature, and Literature Review.

IF 1.1 4区医学

American Journal of Dermatopathology Pub Date : 2025-02-19 DOI: 10.1097/DAD.0000000000002920

Lama Alabdulaaly, Dahee Chung, Sook-Bin Woo

引用次数: 0

Late Recurrent Spitz Melanoma With a TMEM106B::BRAF Fusion.

IF 1.1 4区医学

American Journal of Dermatopathology Pub Date : 2025-02-19 DOI: 10.1097/DAD.0000000000002946

Shunsuke Koga, Giorgos C Karakousis, Guang Yang, David E Elder

{"title":"Late Recurrent Spitz Melanoma With a TMEM106B::BRAF Fusion.","authors":"Shunsuke Koga, Giorgos C Karakousis, Guang Yang, David E Elder","doi":"10.1097/DAD.0000000000002946","DOIUrl":"https://doi.org/10.1097/DAD.0000000000002946","url":null,"abstract":"Abstract: Melanoma is a clinically and genetically heterogeneous malignancy that can recur long after initial treatment. We report the case of a 70-year-old man who presented with metastatic cutaneous melanoma 36 years after the initial diagnosis. Initially diagnosed with nodular melanoma on the left heel at age 34 years, the patient experienced metastatic spread to the left groin lymph nodes by age 36 years, followed by various systemic therapies, including interferon and cytokine therapy, and subsequent observation, over 15 years. Two years before his current presentation, the patient noted a growing mass in his right thigh and an enlarged left inguinal lymph node. Fine-needle aspiration biopsy of the lymph node confirmed the recurrence of melanoma. He subsequently underwent inguinofemoral lymph node dissection and resection of the right thigh mass. Histopathological evaluation revealed melanoma characterized by tumorigenic proliferation of pleomorphic epithelioid and spindle cells with abundant eosinophilic cytoplasm, large nuclei with prominent nucleoli, sparse lymphocyte infiltration, and minimal necrosis, consistent with an initial diagnosis of Spitzoid melanoma. Genetic profiling using targeted next-generation sequencing identified a novel TMEM106B::BRAF fusion, along with CHEK2 and MUTYH mutations. The BRAF fusion supports the diagnosis of Spitz melanoma, a genetically defined subset of Spitzoid melanoma. This case represents the first report of a TMEM106B::BRAF fusion in melanoma, emphasizing the critical role of molecular profiling in diagnosing and managing this malignancy, and suggesting a potential avenue for future therapeutic exploration.","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143473294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Case of Recurrent Eyelid Cutaneous Myxoma With Basaloid Proliferation in a Child.

IF 1.1 4区医学

American Journal of Dermatopathology Pub Date : 2025-02-06 DOI: 10.1097/DAD.0000000000002926

Margaryta Stoieva, Emily O'Donnell

{"title":"A Case of Recurrent Eyelid Cutaneous Myxoma With Basaloid Proliferation in a Child.","authors":"Margaryta Stoieva, Emily O'Donnell","doi":"10.1097/DAD.0000000000002926","DOIUrl":"https://doi.org/10.1097/DAD.0000000000002926","url":null,"abstract":"Abstract: Cutaneous myxomas are extremely rare in the pediatric population. We describe a case of an eyelid cutaneous myxoma with multiple recurrences in an 8-year-old child. The lesion once previously diagnosed as eccrine hidrocystoma had been excised three times with subsequent recurrence. Frozen section diagnosis performed during the fourth excision showed striking basaloid features, prompting deferral of definitive diagnosis to permanent sections. Following routine processing, basaloid proliferations were again seen without significant atypia or mitotic activity in addition to background features of myxoma. CD10 immunostain highlighted both basaloid nests and surrounding stroma. Cutaneous myxoma was diagnosed. The diagnosis was corroborated by an external consultation. The patient underwent genetic testing for the Carney complex with negative results. This case report raises some practical points. First, due to their rarity in the pediatric population and potential to mimic other entities, cutaneous myxomas can be misdiagnosed as other benign neoplasms. Second, although induction of basaloid proliferation has been well-documented in myxoma, it can be easily misinterpreted as a malignant process, particularly in the setting of a frozen section diagnosis and lack of available clinical information. Third, even though solitary cutaneous myxomas are less likely to be associated with the Carney complex, a possibility of such an association should always be born in mind, as consequences of missing syndromic neoplasms, such as cardiac myxoma, can be lethal.","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gene Fusion-Driven Cutaneous Adnexal Neoplasms: An Updated Review Emphasizing Molecular Characteristics.

IF 1.1 4区医学

American Journal of Dermatopathology Pub Date : 2025-02-06 DOI: 10.1097/DAD.0000000000002933

Gerardo Cazzato, Maged Daruish, Francesco Fortarezza, Anna Colagrande, Andrea Marzullo, Giuseppe Ingravallo, Angelo Paolo Dei Tos, Richard K Yang, Woo Cheal Cho

引用次数: 0

Expression of p16 in Hypertrophic Lichen Planus.

IF 1.1 4区医学

American Journal of Dermatopathology Pub Date : 2025-02-06 DOI: 10.1097/DAD.0000000000002940

Katie R Xu, Kord Honda, Bethany R Rohr

{"title":"Expression of p16 in Hypertrophic Lichen Planus.","authors":"Katie R Xu, Kord Honda, Bethany R Rohr","doi":"10.1097/DAD.0000000000002940","DOIUrl":"10.1097/DAD.0000000000002940","url":null,"abstract":"Background: Although cutaneous squamous cell carcinoma (SCC) arising from lichen planus is rare, hypertrophic lichen planus (HLP) accounts for most of these malignant transformations. Although the mechanism of malignant pathogenesis remains unknown, reports of similar premalignant conditions suggest a potential role of tumor suppressor p16. This is the first study to our knowledge to examine p16 expression in HLP in comparison to cutaneous invasive SCC and normal skin and its implications for malignant transformation.Methods: p16 immunohistochemistry of HLP (n = 34) was performed alongside location-matched well-differentiated SCC (WDSCC) and normal skin. Percentage of positive cells, nuclear and cytoplasmic staining intensity, and staining distribution patterns were reviewed by 2 Board-certified dermatopathologists.Results: HLP and WDSCC both showed an increased percentage of positive cells compared with normal skin ( P < 0.001). Cytoplasmic p16 was overexpressed in HLP compared with WDSCC ( P < 0.05). Most cases of HLP and WDSCC demonstrated stronger basal and suprabasal keratinocyte staining with weaker superficial staining. In WDSCC, a predominant pattern of focal cytoplasmic margination of staining along the cellular periphery was observed.Conclusions: Our finding of cytoplasmic p16 overexpression in HLP suggests a potential mechanism of p16-mediated cell cycle dysregulation seen in other premalignant conditions. p16 overexpression seems to be a possible contributor in the malignant transformation of HLP to SCC.","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0