Architecturally Low-Grade Pure Cylindrocarcinoma With CYLD1 Mutation.

IF 1 4区医学 Q4 DERMATOLOGY

American Journal of Dermatopathology Pub Date : 2025-07-08 DOI:10.1097/DAD.0000000000002984

Ronan Knittel, Shona Hendry, Benjamin A Wood

引用次数: 0

Abstract

Abstract: Cylindrocarcinoma is a very rare malignant adnexal neoplasm. The diagnosis of cylindrocarcinoma typically requires identifying a precursor benign component; indeed the current World Health Organization classification classifies these lesions within the group of malignant neoplasms arising from cylindroma. We present a unique case of architecturally low-grade pure cylindrocarcinoma, supported by striking morphologic and immunohistochemical features and showing an inactivating CYLD1 mutation.

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低级别纯柱状癌伴CYLD1突变。

摘要：柱状癌是一种非常罕见的附件恶性肿瘤。柱状癌的诊断通常需要确定一个前兆良性成分；事实上，目前世界卫生组织的分类将这些病变归类为由圆筒状瘤引起的恶性肿瘤。我们报告了一例独特的低级别纯柱状癌，具有显著的形态学和免疫组织化学特征，并表现出灭活CYLD1突变。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American Journal of Dermatopathology 医学-皮肤病学

CiteScore

1.80

自引率

9.10%

发文量

453

审稿时长

3 months

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