面部hpv6阳性的原位鳞状细胞癌具有模仿默克尔细胞癌的小细胞特征。

IF 1 4区医学 Q4 DERMATOLOGY

American Journal of Dermatopathology Pub Date : 2025-07-03 DOI:10.1097/DAD.0000000000003064

Sonsoles Berenguer-Ruiz, Carmen-Amalia Vásquez-Dongo, Noelia Perez-Muñoz, Maria-Teresa Fernández-Figueras

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引用次数: 0

摘要

摘要：我们描述了一种以前未报道的皮肤鳞状细胞原位癌（SCCis）变异，其小细胞形态模仿表皮内默克尔细胞癌。该病变发生在86岁男性的上唇，表现为双相组织学：主要是小基底样细胞和表面的类bowenoid成分。免疫组织化学显示不同的表达模式，PCR证实HPV6。活检后发生完全自发消退。本病例扩展了SCCis的组织病理学谱，提示表皮内基底样变异可能与低风险的α型HPV有关。

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Facial HPV6-Positive in Situ Squamous Cell Carcinoma With Small Cell Features Mimicking Merkel Cell Carcinoma.

Abstract: We describe a previously unreported variant of cutaneous squamous cell carcinoma in situ (SCCis) with small cell morphology mimicking intraepidermal Merkel cell carcinoma. The lesion, arising on the upper lip of an 86-year-old man, displayed biphasic histology: a predominant population of small basaloid cells and a superficial bowenoid component. Immunohistochemistry showed divergent expression patterns, and PCR confirmed HPV6. Complete spontaneous regression occurred post-biopsy. This case expands the histopathologic spectrum of SCCis and suggests an intraepidermal basaloid variant potentially linked to low-risk alpha HPV.

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来源期刊

American Journal of Dermatopathology 医学-皮肤病学

CiteScore

1.80

自引率

9.10%

发文量

453

审稿时长

3 months

期刊介绍： The American Journal of Dermatopathology offers outstanding coverage of the latest diagnostic approaches and laboratory techniques, as well as insights into contemporary social, legal, and ethical concerns. Each issue features review articles on clinical, technical, and basic science advances and illuminating, detailed case reports. With the The American Journal of Dermatopathology you''ll be able to: -Incorporate step-by-step coverage of new or difficult-to-diagnose conditions from their earliest histopathologic signs to confirmatory immunohistochemical and molecular studies. -Apply the latest basic science findings and clinical approaches to your work right away. -Tap into the skills and expertise of your peers and colleagues the world over peer-reviewed original articles, "Extraordinary cases reports", coverage of practical guidelines, and graphic presentations. -Expand your horizons through the Journal''s idea-generating forum for debating controversial issues and learning from preeminent researchers and clinicians