Merkel Cell Carcinoma Arising in Combination With Basal Cell Carcinoma: A Rare Diagnosis and Potential Pitfall.

IF 1 4区医学 Q4 DERMATOLOGY

American Journal of Dermatopathology Pub Date : 2025-10-01 Epub Date: 2025-07-03 DOI:10.1097/DAD.0000000000003052

Katharina Janda, Sena Zengin, Nicholas Zoumberos, Sara Shalin

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引用次数: 0

Abstract

Abstract: Merkel cell carcinoma (MCC) is a rare and aggressive neuroendocrine skin cancer, often associated with a poor prognosis due to its propensity for rapid growth, local recurrence, and metastasis. Combined squamous and Merkel cell carcinoma are welldescribed in the literature; however, concomitant basal cell and Merkel cell carcinoma are exceedingly uncommon. We report a 69-year-old male patient presenting with red, crusted, exophytic plaque on the right postauricular area. Further evaluation revealed nodular basal cell carcinoma (BCC) with an additional, morphologically, and immunophenotypically distinct neuroendocrine component, and areas indicating possible lymphovascular invasion. Overall, the histopathology was most compatible with a combined tumor involving Merkel cell carcinoma and basal cell carcinoma. Our case suggests that this unusual morphologic appearance of Merkel cell carcinoma can be overlooked and should be recognized when evaluating biopsies demonstrating basal cell carcinoma.

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默克尔细胞癌合并基底细胞癌：一个罕见的诊断和潜在的陷阱。

摘要：默克尔细胞癌（Merkel cell carcinoma， MCC）是一种罕见的侵袭性神经内分泌皮肤癌，由于其快速生长、局部复发和转移的倾向，预后往往较差。合并鳞状细胞癌和默克尔细胞癌在文献中有很好的描述；然而，合并基底细胞癌和默克尔细胞癌是非常罕见的。我们报告一位69岁的男性患者，在右侧耳后区域出现红色，结痂，外生性斑块。进一步的评估显示结节性基底细胞癌（BCC）具有额外的、形态学上和免疫表型上独特的神经内分泌成分，以及可能的淋巴血管侵犯区域。总的来说，组织病理学最符合合并肿瘤，包括默克尔细胞癌和基底细胞癌。我们的病例表明，默克尔细胞癌的这种不寻常的形态表现可以被忽视，在评估基底细胞癌的活检时应该被认识到。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American Journal of Dermatopathology 医学-皮肤病学

CiteScore

1.80

自引率

9.10%

发文量

453

审稿时长

3 months

期刊介绍： The American Journal of Dermatopathology offers outstanding coverage of the latest diagnostic approaches and laboratory techniques, as well as insights into contemporary social, legal, and ethical concerns. Each issue features review articles on clinical, technical, and basic science advances and illuminating, detailed case reports. With the The American Journal of Dermatopathology you''ll be able to: -Incorporate step-by-step coverage of new or difficult-to-diagnose conditions from their earliest histopathologic signs to confirmatory immunohistochemical and molecular studies. -Apply the latest basic science findings and clinical approaches to your work right away. -Tap into the skills and expertise of your peers and colleagues the world over peer-reviewed original articles, "Extraordinary cases reports", coverage of practical guidelines, and graphic presentations. -Expand your horizons through the Journal''s idea-generating forum for debating controversial issues and learning from preeminent researchers and clinicians