American Journal of Dermatopathology最新文献_第2页

A Subcutaneous Spindle Cell Neoplasm Originating From the Undifferentiated Mesoderm: An Uncommon Tumor in an Unusual Site: Challenge. 起源于未分化中胚层的皮下纺锤形细胞肿瘤：不寻常部位的不寻常肿瘤：挑战。

IF 1.1 4区医学

American Journal of Dermatopathology Pub Date : 2024-11-01 DOI: 10.1097/DAD.0000000000002781

Nada Shaker, George Niedt, Nuha Shaker, Nasir Saleem, Rafat Abu Shakra, Omar P Sangueza, Robert Phelps

引用次数: 0

Unveiling the Rare: Retroauricular Subcutaneous Embryonal Rhabdomyosarcoma: Answer. 揭开罕见的面纱耳后皮下胚胎性横纹肌肉瘤：答案。

IF 1.1 4区医学

American Journal of Dermatopathology Pub Date : 2024-11-01 DOI: 10.1097/DAD.0000000000002782

Nada Shaker, George Niedt, Nuha Shaker, Nasir Saleem, Rafat Abu Shakra, Omar P Sangueza, Robert Phelps

引用次数: 0

Immunohistochemical Expression of CXCL 10 in Vitiligo. 白癜风中 CXCL 10 的免疫组化表达。

IF 1.1 4区医学

American Journal of Dermatopathology Pub Date : 2024-11-01 Epub Date: 2024-09-17 DOI: 10.1097/DAD.0000000000002774

Asmaa Omar Abdelmonem, Amany Mohammad Abdel-Latif, Dareen Abdulaziz Mohamed, Ghada Fawzy Rezk Hassan

{"title":"Immunohistochemical Expression of CXCL 10 in Vitiligo.","authors":"Asmaa Omar Abdelmonem, Amany Mohammad Abdel-Latif, Dareen Abdulaziz Mohamed, Ghada Fawzy Rezk Hassan","doi":"10.1097/DAD.0000000000002774","DOIUrl":"10.1097/DAD.0000000000002774","url":null,"abstract":"Background: Vitiligo is a skin disorder characterized by the loss of melanocytes from the epidermis. Cysteine x cysteine motif chemokine ligand 10 (CXCL10) is linked to the Th1 pattern and has been suggested as one of the most relevant chemokine axes that promote T-cell migration in different autoimmune and inflammatory processes. The aim of this study was to assess the immunohistochemical (IHC) expression of CXCL 10 in skin lesions of patients with vitiligo to explore its possible role in the pathogenesis of the disease.Methods: In this prospective, case-control study, we examined biopsies from the lesional skin of 20 patients with vitiligo for IHC expression of CXCL 10: 10 patients presented with stable nonsegmental vitiligo (group A), 10 patients presented with active nonsegmental vitiligo (group B), and 10 apparently healthy volunteers were examined as controls (group C).Results: Nine patients in group A had mild IHC expression of CXCL 10 (+1) and 1 patient had moderate expression (+2). In group B, 8 patients had strong expression of CXCL 10 (+3), and the remaining patients had moderate expression (+2). However, there was no expression of CXCL 10 in all skin specimens in the control group.Conclusions: CXCL10 IHC expression was increased in vitiligo lesions indicating a possible role in the pathogenesis of disease. The expression was significantly increased in active vitiligo compared with stable vitiligo.","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142300131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Penile and Scrotal Porokeratosis: A Single-Institution Experience. 阴茎和阴囊角化病：单机构经验

IF 1.1 4区医学

American Journal of Dermatopathology Pub Date : 2024-11-01 Epub Date: 2024-09-17 DOI: 10.1097/DAD.0000000000002801

Burak Tekin, Sounak Gupta, Ruifeng Guo, Julia S Lehman, Carilyn N Wieland, Emma F Johnson

{"title":"Penile and Scrotal Porokeratosis: A Single-Institution Experience.","authors":"Burak Tekin, Sounak Gupta, Ruifeng Guo, Julia S Lehman, Carilyn N Wieland, Emma F Johnson","doi":"10.1097/DAD.0000000000002801","DOIUrl":"https://doi.org/10.1097/DAD.0000000000002801","url":null,"abstract":"Abstract: There is a paucity of data regarding porokeratosis confined to the penis and scrotum. We evaluated our single-institutional experience regarding this entity. We interrogated our pathology archive for all specimens from the penis or scrotum, signed out as porokeratosis between 2000 and 2022. Clinical and histopathological features were reviewed, including the number of cornoid lamella(e) per tissue profile and squamous dysplasia. Nine patients were included in the study. The median age at the time of diagnosis was 51 years. Multiple lesions were present in 3 patients. Six patients had exclusively penile involvement, whereas 2 patients had exclusively scrotal involvement. One patient had multiple lesions consistent with porokeratosis ptychotropica, extending from the scrotum to the buttocks and perineum. Clinically, a collarette of scale was noted in 3 patients and diagnosis of porokeratosis was considered in 1 patient before biopsy. Histopathologically, 2 patients exhibited multiple cornoid lamellae in the same profile and 1 patient had follicular cornoid lamellae. Focal squamous dysplasia was only present in 1 patient. Follow-up was available for 5 patients (median duration: 35 months). In 4 patients, the lesions were removed completely during the shave biopsy procedure. At the past follow-up, there were no signs of recurrence or malignant transformation to squamous cell carcinoma in any patient. Porokeratosis involving the penis and/or scrotum may be elusive to diagnosis based on clinical features alone, emphasizing the role of histopathological examination. Increased awareness of this entity may help better delineate its clinicopathological presentation and appropriate classification.","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142480056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hookworm Folliculitis: Report of Two Cases of Cutaneous Larva Migrans With Histologically Identified Follicular Involvement. 钩虫毛囊炎：报告两例经组织学鉴定为毛囊受累的皮肤幼虫移行症。

IF 1.1 4区医学

American Journal of Dermatopathology Pub Date : 2024-11-01 Epub Date: 2024-08-14 DOI: 10.1097/DAD.0000000000002803

Alberto Soto-Moreno, Daniel Muñoz-Barba, Daniel Martín-Torregrosa, Francisco Manuel Ramos-Pleguezuelos, Ángel Santos-Briz

{"title":"Hookworm Folliculitis: Report of Two Cases of Cutaneous Larva Migrans With Histologically Identified Follicular Involvement.","authors":"Alberto Soto-Moreno, Daniel Muñoz-Barba, Daniel Martín-Torregrosa, Francisco Manuel Ramos-Pleguezuelos, Ángel Santos-Briz","doi":"10.1097/DAD.0000000000002803","DOIUrl":"10.1097/DAD.0000000000002803","url":null,"abstract":"Abstract: Cutaneous larva migrans (CLM) is an ectoparasitic infestation predominantly caused by nematodes, specifically Ancylostoma braziliense and Ancylostoma caninum , found in tropical and subtropical regions. Although follicular involvement by the parasite is a rare manifestation, with approximately 20 cases reported in the English literature, its pathogenesis remains underexplored. The present study reports 2 cases of CLM presenting with follicular involvement in patients with pruritic lesions following travel to subtropical areas. The first of them is a 32-year-old woman who developed an abdominal skin lesion subsequent to a trip to Thailand and the second is a 28-year-old woman who exhibited a knee lesion after a volunteer mission in Senegal. Histologic examination revealed characteristic features of CLM, such as nematode larvae traversing the hair follicle. The hookworm larvae were observed creating tunnels within the external root sheath. In addition, they were interfacing with the vitreous layer, sparing the perifollicular connective tissue sheath and the Henle layer, and approaching the vicinity of the hair bulb. The application of skin ultrasound to guide the biopsy facilitated the visualization and identification of the parasite within the follicle in the latter case. This study not only underscores follicular involvement in CLM but also provides insights into its anatomopathological presentation and spread through the hair follicle.","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141983845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anetoderma in the Setting of a Hematologic Abnormality and COVID-19 Infection. 伴有血液异常和 COVID-19 感染的网状皮疹

IF 1.1 4区医学

American Journal of Dermatopathology Pub Date : 2024-11-01 Epub Date: 2024-08-14 DOI: 10.1097/DAD.0000000000002823

Kathryn K Xu, Sydney L Proffer, Rochelle R Torgerson, Margot S Peters

引用次数: 0

Lower Lip Swelling in a Young Woman: Challenge. 年轻女性下唇肿胀：挑战。

IF 1.1 4区医学

American Journal of Dermatopathology Pub Date : 2024-11-01 DOI: 10.1097/DAD.0000000000002779

Eduardo Rozas-Muñoz, Jaime Piquero-Casals, Juan-Francisco Mir-Bonafé, Juan-Andres Madariaga

引用次数: 0

Malignant Dendritic Cell Sarcomas in the Skin: 2 Cases of Rare Sarcoma Subtypes With Literature Review. 皮肤中的恶性树突状细胞肉瘤：2例罕见肉瘤亚型及文献综述。

IF 1.1 4区医学

American Journal of Dermatopathology Pub Date : 2024-11-01 Epub Date: 2024-07-12 DOI: 10.1097/DAD.0000000000002797

Apoorva Mehta, Sophia Luyten, Abraham Abdulhak, Haseeb Mahmud, William Gillen, Alejandro A Gru

{"title":"Malignant Dendritic Cell Sarcomas in the Skin: 2 Cases of Rare Sarcoma Subtypes With Literature Review.","authors":"Apoorva Mehta, Sophia Luyten, Abraham Abdulhak, Haseeb Mahmud, William Gillen, Alejandro A Gru","doi":"10.1097/DAD.0000000000002797","DOIUrl":"10.1097/DAD.0000000000002797","url":null,"abstract":"Abstract: Interdigitating dendritic cell sarcoma is a rare, aggressive hematological malignancy primarily originating in lymph nodes, with only 10 reported cases presenting in the skin (primary cutaneous interdigitating dendritic cell sarcoma). Past presentations showed erythematous nodules on the proximal extremities, back, or face. Morphologically, these neoplasms are similar to melanomas and other dendritic cell (DC) tumors, making their diagnosis difficult. Here, we present 1 case of primary cutaneous interdigitating dendritic cell sarcomas and another 1 of malignant indeterminate dendritic cell tumor (indeterminate DC sarcoma). The first case is an 83-year-old man who presented with recent ulceration and bleeding of an asymptomatic, slow growing lesion on his right thigh with biopsy revealing a large, well-circumscribed polypoid spindle cell tumor in the dermis with atypical cells with vesicular nuclei in a lymphoplasmacytic background and immunohistochemistry positivity for CD45, CD68, S100, and Cyclin D1. The second case is a 74-year-old man who presented with a progressively darkening and enlarging abdominal skin lesion with biopsy revealing a diffuse infiltrate of atypical poorly differentiated pleomorphic nuclear cells and immunohistochemistry positivity for S100, CD1a, CD56, CD43, cyclin D1, CD31, CD4, and BRAF V600E. Our findings contribute to expand the reported literature on primary cutaneous DC sarcomas.","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141621752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nail as a Window to Diagnosing Multisystem Langerhans Cell Histiocytosis: A Case Report and Review of Literature. 指甲是诊断多系统朗格汉斯细胞组织细胞增生症的窗口：病例报告与文献综述。

IF 1.1 4区医学

American Journal of Dermatopathology Pub Date : 2024-11-01 Epub Date: 2024-08-14 DOI: 10.1097/DAD.0000000000002818

Arun Somasundaram, Senthil Kumar Periyasamy, Narayanan Arunachalam, Tirekha Suyamprakasam Vimala, Sree Rekha Jinkala, Gunasekaran Dhandapany, Ramassamy Sivaranjini

引用次数: 0

Multiple Follicular Hybrid Tumors Presenting in Association With Myotonic Dystrophy Type 1. 伴有肌营养不良症 1 型的多发性滤泡混合瘤

IF 1.1 4区医学

American Journal of Dermatopathology Pub Date : 2024-11-01 Epub Date: 2024-06-20 DOI: 10.1097/DAD.0000000000002784

Robin H Wang, Adam Krouse, David B Eilers, Madhu Dahiya

引用次数: 0