American Journal of Dermatopathology最新文献_第2页

Progressive Painful Growth on the Right Middle Finger: A Diagnostic Challenge: Answer. 右中指进行性疼痛生长：诊断挑战：答案。

IF 1 4区医学

American Journal of Dermatopathology Pub Date : 2025-10-01 Epub Date: 2025-06-26 DOI: 10.1097/DAD.0000000000003028

Kiera Murphy, Matthew F Helm, Thomas N Helm

引用次数: 0

Bumps on My Head-A Case of Acute T-Cell Lymphoblastic Lymphoma. 我头上的肿块——一例急性t细胞淋巴母细胞淋巴瘤。

IF 1 4区医学

American Journal of Dermatopathology Pub Date : 2025-10-01 Epub Date: 2025-07-28 DOI: 10.1097/DAD.0000000000003081

Lisa Brambert, Aashni Bhukhan, Victoria Dukharan, Panagiotis Mitropoulos, Etan Marks

引用次数: 0

Vancomycin-Induced Linear IgA Bullous Dermatosis Mimicking Stevens-Johnson Syndrome Associated With Anticancer Therapy. 万古霉素诱导的线性IgA大疱性皮肤病模拟史蒂文斯-约翰逊综合征与抗癌治疗相关

IF 1 4区医学

American Journal of Dermatopathology Pub Date : 2025-10-01 Epub Date: 2025-06-26 DOI: 10.1097/DAD.0000000000003023

Maedot A Haymete, Grace L Casado, Marissa T Rizzo, Karla C Guerra, Zachary E Holcomb, Douglas J Grider

{"title":"Vancomycin-Induced Linear IgA Bullous Dermatosis Mimicking Stevens-Johnson Syndrome Associated With Anticancer Therapy.","authors":"Maedot A Haymete, Grace L Casado, Marissa T Rizzo, Karla C Guerra, Zachary E Holcomb, Douglas J Grider","doi":"10.1097/DAD.0000000000003023","DOIUrl":"10.1097/DAD.0000000000003023","url":null,"abstract":"Abstract: Linear IgA bullous dermatosis (LABD), also known as linear IgA disease, is a subepidermal blistering disorder presenting with linear deposits of IgA along the basement membrane zone. Although LABD is commonly idiopathic, it can also rarely be triggered by certain drugs, including vancomycin. Herein, we document the rare case of a 41-year-old woman with a history of invasive ductal breast carcinoma, receiving an anticancer regimen of pembrolizumab, cyclophosphamide, and doxorubicin, who developed erythema, tense bullae, and extensive sloughing of skin after vancomycin therapy. Initially, the patient was suspected to have drug-induced Stevens-Johnson syndrome/toxic epidermal necrosis; however, biopsies of the right thigh revealed subepidermal bullous dermatosis with neutrophils and necrotic keratinocytes. Direct immunofluorescence revealed 3+/3+ anti-IgA and 1+/3+ anti-C3 deposits that were linear at the dermal-epidermal junction. The clinical and histopathologic findings confirmed the diagnosis of vancomycin-induced LABD. This report examines the complicated relationship between immunobullous disease, neoplasms, and oncologic treatment. Presented is a rare case of vancomycin-induced LABD in a patient receiving concurrent chemotherapy and immunotherapy. Clinician awareness of the increased susceptibility of vancomycin-induced LABD in this population subset can improve clinical outcomes and decrease morbidity/mortality.","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":"798-802"},"PeriodicalIF":1.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144499086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nonspecific Granular Reactivity of EBER In-Situ Hybridization in a Patient of Black Hairy Tongue. 黑毛舌患者原位杂交的非特异性颗粒反应性。

IF 1 4区医学

American Journal of Dermatopathology Pub Date : 2025-10-01 Epub Date: 2025-07-31 DOI: 10.1097/DAD.0000000000003088

Niloofar Sina, Carlos A Torres-Cabala, Victor G Prieto

引用次数: 0

Persistent Rash Along the Bra Line: Answer. 持续皮疹沿胸罩线：答案。

IF 1 4区医学

American Journal of Dermatopathology Pub Date : 2025-10-01 Epub Date: 2025-06-26 DOI: 10.1097/DAD.0000000000003026

Allie Preston, Katelen Korty, Morgan M Wharton, Catherine Pham

引用次数: 0

Secreted Frizzled Related Protein 5 in Nonsegmental Vitiligo: A Clinical and Immunohistochemical Study. 非节段性白癜风中分泌卷曲相关蛋白5：临床和免疫组织化学研究

IF 1 4区医学

American Journal of Dermatopathology Pub Date : 2025-10-01 DOI: 10.1097/DAD.0000000000003148

Wafaa Ahmed Shehata, Mohamed A Shoeib, Eman Samy Mahmoud Abdou Flefal, Asmaa S Mohamed

{"title":"Secreted Frizzled Related Protein 5 in Nonsegmental Vitiligo: A Clinical and Immunohistochemical Study.","authors":"Wafaa Ahmed Shehata, Mohamed A Shoeib, Eman Samy Mahmoud Abdou Flefal, Asmaa S Mohamed","doi":"10.1097/DAD.0000000000003148","DOIUrl":"10.1097/DAD.0000000000003148","url":null,"abstract":"Abstract: Vitiligo is a depigmentation skin disorder affecting 0.5%-1% of the inhabitants worldwide. Wtn signaling cascade is crucial in differentiation and development of melanocytes. Secreted frizzled-related protein 5 (SFRP5), member of the secreted frizzled-related proteins group, is well known as a suppressor of the Wnt signaling and represents a potential target of vitiligo. This study aimed to investigate immunohistochemical expression of SFRP5 in patients with nonsegmental vitiligo in comparison with healthy controls and to associate the results with the clinicopathologic information and included 48 participants: 24 patients with vitiligo and 24 healthy controls. All included participants were exposed to full history taking, full general and skin examination, scoring of vitiligo was done using vitiligo disease activity and vitiligo area scoring index scores. Immunohistochemical staining of SFRP5 was performed on punch biopsies from lesional, perilesional skin, and control skin. Comparison between lesional, perilesional, and control biopsies concerning epidermal SFRP5 expression revealed that SFRP5 staining, H score, and immunoreactivity scoring (IRS) were significantly elevated in all lesional and perilesional samples on comparison with controls ( P < 0.001). There were significant correlations regarding epidermal and dermal SFRP5 expression regarding percentage of positive cells, H-Score, and IRS ( P < 0.001). Also, dermal SFRP5 was significantly associated with vitiligo disease activity score ( P = 0.051). SFRP5 being expressed in lesional and perilesional areas could have a potential role in pathogenesis of nonsegmental vitiligo and it can be a promising therapeutic target in the future. Also, SFRP5 has a prognostic role in these patients.","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145208143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neurotrophic Tyrosine Receptor Kinase-Rearranged Spindle Cell Neoplasm Presenting on the Breast of a 44-Year-Old Woman. 神经营养性酪氨酸受体激酶重排梭形细胞肿瘤出现在一个44岁妇女的乳房。

IF 1 4区医学

American Journal of Dermatopathology Pub Date : 2025-10-01 DOI: 10.1097/DAD.0000000000003147

Fatimatou Saka, Shanice McKenzie, Nima Milani-Nejad, Chandra Smart

{"title":"Neurotrophic Tyrosine Receptor Kinase-Rearranged Spindle Cell Neoplasm Presenting on the Breast of a 44-Year-Old Woman.","authors":"Fatimatou Saka, Shanice McKenzie, Nima Milani-Nejad, Chandra Smart","doi":"10.1097/DAD.0000000000003147","DOIUrl":"10.1097/DAD.0000000000003147","url":null,"abstract":"Abstract: Neurotrophic tyrosine receptor kinase-rearranged spindle cell neoplasms (NTRK-RSCN) are rare soft tissue sarcomas distinguished by various NTRK gene fusions. These tumors display a range of histologic features and tumor characteristics, with NTRK fusion genes serving as critical oncogenic drivers. We present the case of a 44-year-old woman who presented with a several-year history of a slowly enlarging, 1.3 cm, erythematous nodule on the right medial breast. A punch biopsy revealed a dermal proliferation of bland, monomorphic, spindled cells infiltrating the subcutaneous fat with admixed lymphoplasmacytic inflammation. Lesional cells were positive for S100, CD34, and Pan-TRK. Next-generation sequencing identified an EML4-NTRK3 rearrangement. Given that NTRK-RSCN tends to be locally aggressive and there are rare reports of metastasis, complete surgical excision was recommended. The patient underwent wide local excision with positive margins that were subsequently cleared after re-excision. Next-generation sequencing played a crucial role in reaching the correct diagnosis in this case. This is the first reported case of a cutaneous EML4-NTRK3 fusion spindle cell neoplasm located on the cutaneous breast.","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145208200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lyme Borreliosis Incognito-Expanding the Spectrum of Invisible Dermatoses. 隐身莱姆病-扩大不可见皮肤病的频谱。

IF 1 4区医学

American Journal of Dermatopathology Pub Date : 2025-10-01 Epub Date: 2025-07-03 DOI: 10.1097/DAD.0000000000003055

Wiebke Pruessmann, Gisela Huebner, Christian Rose

引用次数: 0

Mesenchymal-Follicular Hamartoma: A Case Report of a Cutaneous Hamartoma With Dominant Mesenchymal Overgrowth. 间充质-滤泡性错构瘤：一例以间充质增生为主的皮肤错构瘤。

IF 1 4区医学

American Journal of Dermatopathology Pub Date : 2025-10-01 Epub Date: 2025-07-31 DOI: 10.1097/DAD.0000000000003096

Sepehr Hamidi, Masoud Asgari

{"title":"Mesenchymal-Follicular Hamartoma: A Case Report of a Cutaneous Hamartoma With Dominant Mesenchymal Overgrowth.","authors":"Sepehr Hamidi, Masoud Asgari","doi":"10.1097/DAD.0000000000003096","DOIUrl":"10.1097/DAD.0000000000003096","url":null,"abstract":"Background: Cutaneous hamartomas are benign lesions composed of disorganized but mature tissue elements normally found at the site. Although many types are well defined, some rare variants do not conform to established categories.Case presentation: We present a unique case of a cutaneous hamartoma with prominent mesenchymal overgrowth and minimal epithelial and adnexal components.Assessment: The mesenchymal component consisted of mature fibrocytes, adipocytes, and blood vessels. The epithelial/adnexal component was limited to a few terminal hairs with aberrant trichogenesis, reminiscent of trichofolliculoma, and small cystic apocrine ducts/glands resembling hidrocystoma.Diagnosis: We found it challenging to classify this lesion, because it did not conform to any well-known hamartomas. Given the prominent mesenchymal component and limited adnexal involvement, \"mesenchymal-follicular hamartoma\" may be the most concise and descriptive term, emphasizing the dominant mesenchymal component in our case.Conclusions: This case report highlights a rare presentation of a cutaneous hamartoma with dominant mesenchymal features. This predominance suggests that mesenchymal proliferation may play a primary role in the histogenesis of the lesion.","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":"794-797"},"PeriodicalIF":1.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144762234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Progressive Painful Growth on the Right Middle Finger: A Diagnostic Challenge. 进行性疼痛生长在右手中指：诊断的挑战。

IF 1 4区医学

American Journal of Dermatopathology Pub Date : 2025-10-01 Epub Date: 2025-06-26 DOI: 10.1097/DAD.0000000000003027

Kiera Murphy, Matthew F Helm, Thomas N Helm

引用次数: 0