American Journal of Dermatopathology最新文献_第2页

Primary Cutaneous Anaplastic Large Cell Lymphoma With Rare Extracutaneous Disseminated Disease: A Case Report. 原发性皮肤变性大细胞淋巴瘤伴罕见的皮外播散性疾病：病例报告。

IF 1.1 4区医学

American Journal of Dermatopathology Pub Date : 2025-04-01 Epub Date: 2024-12-10 DOI: 10.1097/DAD.0000000000002896

Meaghan C Dougher, Alexander Cartron, Jennifer Scott, Michael G Bayerl, Matthew Helm

{"title":"Primary Cutaneous Anaplastic Large Cell Lymphoma With Rare Extracutaneous Disseminated Disease: A Case Report.","authors":"Meaghan C Dougher, Alexander Cartron, Jennifer Scott, Michael G Bayerl, Matthew Helm","doi":"10.1097/DAD.0000000000002896","DOIUrl":"10.1097/DAD.0000000000002896","url":null,"abstract":"Abstract: Primary cutaneous anaplastic large cell lymphoma (pcALCL) is a CD30 + lymphoproliferative disorder with generally favorable outcomes and infrequent extracutaneous spread, usually limited to local lymph nodes. However, there may be extensive histologic overlap with more aggressive CD30 + lymphomas, such as large cell transformation of mycosis fungoides or secondary skin involvement by anaplastic lymphoma kinase (ALK)-negative anaplastic large cell lymphoma. Definitive diagnosis relies on clinicopathologic correlation. We report on a 26-year-old woman who presented to our institution with progressive lower extremity wounds for several months, previously treated with antibiotics and vacuum-assisted closure dressings. Consultation with dermatology and 2 separate biopsies eventually led to the diagnosis of pcALCL. Subsequent imaging revealed stage IV disease with innumerable intensely fluorodeoxyglucose (FDG)-avid subcutaneous, intramuscular, and visceral foci, but paucity of lymph node involvement. The patient's condition deteriorated, and she died during her hospitalization. This case reviews the clinicopathologic findings of pcALCL, emphasizes the importance of clinicopathologic correlation in differentiating between CD30 + lymphoproliferative disorders, highlights the extremely rare phenomenon of systemic intramuscular and visceral disseminated disease occurring in pcALCL, and discusses implications for prognosis.","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":"311-315"},"PeriodicalIF":1.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142848392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hybrid Epithelioid Schwannoma/Neurofibroma: A Report of 3 Cases.

IF 1.1 4区医学

American Journal of Dermatopathology Pub Date : 2025-04-01 Epub Date: 2025-02-06 DOI: 10.1097/DAD.0000000000002931

Yasuhiro Mitsui, Eiwa Ishida, Kohei Ogawa, Takaya Fukumoto, Hideo Asada

{"title":"Hybrid Epithelioid Schwannoma/Neurofibroma: A Report of 3 Cases.","authors":"Yasuhiro Mitsui, Eiwa Ishida, Kohei Ogawa, Takaya Fukumoto, Hideo Asada","doi":"10.1097/DAD.0000000000002931","DOIUrl":"10.1097/DAD.0000000000002931","url":null,"abstract":"Abstract: Peripheral nerve sheath tumors can include neurofibroma, schwannoma, and perineurioma, with hybrid nerve sheath tumor (HNST) being rare. We describe 3 HNST cases with epithelioid schwannoma and neurofibroma features, an uncommon manifestation of hybrid schwannoma/neurofibroma. The 3 cases involved the upper back, forearm, and thigh. Histopathologically, the tumors were located in the subcutis or dermis and subcutis. The epithelioid schwannoma component showed nests/cords of epithelioid cells with round nuclei and abundant cytoplasm. In contrast, the neurofibroma component showed spindle cell proliferation within myxoid stroma. The 3 cases showed variable proportions of both components. Immunohistochemically, the epithelioid schwannoma components were positive for S100 protein and negative for CD34, whereas the neurofibroma component showed partial S100 immunoreactivity and contained abundant CD34-positive cells with a fingerprint pattern. Epithelial membrane antigen and GLUT1 revealed the perineurial capsules. In conclusion, our cases expand the morphologic spectrum of HNST and underscore the importance of recognizing this variant.","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":"260-263"},"PeriodicalIF":1.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Skin Biopsy of the Abdominal Wall Without a Rash Is Safe and Effective in the Diagnosis of Systemic Amyloidosis.

IF 1.1 4区医学

American Journal of Dermatopathology Pub Date : 2025-04-01 Epub Date: 2024-11-07 DOI: 10.1097/DAD.0000000000002862

Koya Obara, Kyoko Baba

{"title":"A Skin Biopsy of the Abdominal Wall Without a Rash Is Safe and Effective in the Diagnosis of Systemic Amyloidosis.","authors":"Koya Obara, Kyoko Baba","doi":"10.1097/DAD.0000000000002862","DOIUrl":"https://doi.org/10.1097/DAD.0000000000002862","url":null,"abstract":"Abstract: The diagnosis of systemic amyloidosis is decided through histologic materials from biopsy from different organs. This is a retrospective study from the institutional database of our hospital and consisted of patients to being judged to need skin biopsy for the purpose of diagnosing systemic amyloidosis visiting dermatology between April 2005 and August 2022. A total of 30 patients underwent the skin biopsy of dermis and fatty tissue on abdominal wall without rash and a total of 36 specimens were obtained. A total of 14 of these specimens showed amyloid deposition histologically. Among the 14 specimens, amyloid immunoglobin light chain amyloidosis in 8 samples (57.1%) was the most diagnosed, the others being wild-type amyloid transthyretin amyloidosis in 5 samples (35.8%) and amyloid A amyloidosis in 1 sample (7.1%). The skin biopsy has an 87.5% (14 of 16) sensitivity and 100% (20 of 20) specificity, with 12.5% (2 of 16) false negatives and 0% (0 of 20) false positives in diagnosis of systemic amyloidosis. Skin biopsy from normal abdominal wall skin to evaluate dermis and fatty tissue is a safe, sensitive, and specific procedure to the diagnosis of systemic amyloidosis.","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":"47 4","pages":"251-259"},"PeriodicalIF":1.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143630971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Circumferential Eschar-Covered Necrotic Leg Ulcers in a Case of Granulomatous Vasculitis: Looking Beyond ANCA Serology.

IF 1.1 4区医学

American Journal of Dermatopathology Pub Date : 2025-04-01 Epub Date: 2025-02-06 DOI: 10.1097/DAD.0000000000002929

Shilpi Tyagi, Shubham Kumar, Afroz Alam, Deepak Vedant, Saurabh Singh

引用次数: 0

Letter to the Editor: Enteropathy Associated T-Cell Lymphoma Versus Refractory Celiac Disease.

IF 1.1 4区医学

American Journal of Dermatopathology Pub Date : 2025-04-01 Epub Date: 2025-02-06 DOI: 10.1097/DAD.0000000000002930

Joan Guitart

引用次数: 0

Carcinoma Cuniculatum of the Scrotum.

IF 1.1 4区医学

American Journal of Dermatopathology Pub Date : 2025-04-01 Epub Date: 2025-02-06 DOI: 10.1097/DAD.0000000000002918

Badr AbdullGaffar, Lakshmiah R Ganapathy

引用次数: 0

Intravascular Large B-Cell Lymphoma With Exclusively Cutaneous Involvement, Colonizing Pre-Existing Hemangiomas: A Rare Case With Aberrant HMB45 Expression.

IF 1.1 4区医学

American Journal of Dermatopathology Pub Date : 2025-04-01 Epub Date: 2025-02-06 DOI: 10.1097/DAD.0000000000002922

Carmen García de Sola-Llamas, Manuel Pérez-Pérez, Mercedes Morillo-Andújar, Juan J Ríos-Martín

引用次数: 0

Clinicopathologic Characteristics of 40 Cases of Juvenile Conjunctival Nevus.

IF 1.1 4区医学

American Journal of Dermatopathology Pub Date : 2025-04-01 Epub Date: 2025-01-23 DOI: 10.1097/DAD.0000000000002921

Ying Zhao, Wangpan Shi, Yateng Tie, Xiaorong Li, Huifang Wang, Dong Ren, Fengmei Cai

{"title":"Clinicopathologic Characteristics of 40 Cases of Juvenile Conjunctival Nevus.","authors":"Ying Zhao, Wangpan Shi, Yateng Tie, Xiaorong Li, Huifang Wang, Dong Ren, Fengmei Cai","doi":"10.1097/DAD.0000000000002921","DOIUrl":"10.1097/DAD.0000000000002921","url":null,"abstract":"Aims: Limited studies have been conducted on juvenile conjunctival nevus (JCN) in Asian populations. This study aims to investigate the clinical and pathologic characteristics of JCN cases among the Han ethnicity in northwest China, providing insights for pathologists and ophthalmologists in diagnosing this condition.Methods: A subset of conjunctival nevi in children and adolescents, characterized by a confluent growth pattern and lack of maturation, was identified and defined as JCN. A retrospective analysis of the clinicopathologic features of these cases was performed.Results: The study included 40 patients aged 3-20 years, with a median age of 15.5 years. Six cases involved congenital conjunctival pigmentation. Twenty-four were male patients and 16 were female patients, with a male-to-female ratio of 1.5:1. Microscopically, nevus cells grew confluently within or beneath the epidermis and exhibited moderate cellular atypia. In some cases, the junction of the epithelium and the lamina propria layer was obscured by the integration of nevus cell clusters, mimicking epithelial invasion and potentially leading to a misdiagnosis. Over an average follow-up of 78.5 months, no recurrence or postoperative complications were observed.Conclusions: Diagnosing JCN is challenging because of its histologic resemblance to conjunctival melanoma. A systematic analysis of JCN can improve the recognition of its benign nature by pathologists and ophthalmologists, helping to prevent overdiagnosis of conjunctival malignant melanoma in this young population.","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":"287-291"},"PeriodicalIF":1.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11913227/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143025698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vegetative Pyoderma Gangrenosum Mimicking Squamous Cell Carcinoma: A Poorly Recognized Diagnostic Challenge. 模拟鳞状细胞癌的营养性坏疽性脓皮病：一个难以识别的诊断挑战。

IF 1.1 4区医学

American Journal of Dermatopathology Pub Date : 2025-04-01 Epub Date: 2024-12-31 DOI: 10.1097/DAD.0000000000002919

Megan Hoang, Mayra B C Maymone, Gladys H Telang, Su-Jean Seo, Leslie Robinson-Bostom

{"title":"Vegetative Pyoderma Gangrenosum Mimicking Squamous Cell Carcinoma: A Poorly Recognized Diagnostic Challenge.","authors":"Megan Hoang, Mayra B C Maymone, Gladys H Telang, Su-Jean Seo, Leslie Robinson-Bostom","doi":"10.1097/DAD.0000000000002919","DOIUrl":"10.1097/DAD.0000000000002919","url":null,"abstract":"Abstract: Pyoderma gangrenosum (PG) is a rare inflammatory neutrophilic dermatosis that is difficult to diagnose due to non-specific clinical, laboratory, and histopathologic features. Distinguishing pseudoepitheliomatous hyperplasia (PEH) from squamous cell carcinoma (SCC) is also histopathologically challenging. The connection between PEH and PG is not well recognized, and instances of PG mimicking SCC are rare. We report a case of vegetative PG accompanied by PEH, originally mistaken for SCC. A 78-year-old woman presented with a 3-month history of an ulcerated, exophytic, and painful mass on her right lower leg. An incisional biopsy revealed PEH and neutrophilic microabscesses, initially raising concerns for SCC keratoacanthoma type with PEH or well-differentiated, infiltrative SCC. However, following additional review of clinical and histopathologic findings at the cutaneous oncology tumor board, the diagnosis of vegetative PG with associated PEH was favored. This case highlights the significance of recognizing PEH as a histopathology feature that can be seen in PG and lead to difficulty distinguishing PG with PEH from SCC. We stress the importance of promptly diagnosing PG through clinical and histopathologic correlation to prevent diagnostic delays and unnecessary surgeries or treatments.","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":"e47-e49"},"PeriodicalIF":1.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142958144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PRAME as a Diagnostic Marker in Desmoplastic Melanocytic Lesions: Insights and Challenges. PRAME作为促结缔组织增生黑色素细胞病变的诊断标志物：见解和挑战。

IF 1.1 4区医学

American Journal of Dermatopathology Pub Date : 2025-04-01 Epub Date: 2024-12-10 DOI: 10.1097/DAD.0000000000002904

Şule Öztürk Sarı, Ali Kubilay Kolik, Begüm Yeni Erdem, Nesimi Büyükbabani

引用次数: 0