American Journal of Dermatopathology最新文献_第3页

Familial Darier Disease Across 3 Generations: Highlighting the Spectrum of Neuropsychiatric Comorbidities. 跨越三代的家族性痢疾：强调神经精神合并症的频谱。

IF 0.8 4区医学

American Journal of Dermatopathology Pub Date : 2026-10-15 DOI: 10.1097/DAD.0000000000003453

Hasan E İlgenli, Selami A Temiz, İlkay Özer, Pembe Oltulu

{"title":"Familial Darier Disease Across 3 Generations: Highlighting the Spectrum of Neuropsychiatric Comorbidities.","authors":"Hasan E İlgenli, Selami A Temiz, İlkay Özer, Pembe Oltulu","doi":"10.1097/DAD.0000000000003453","DOIUrl":"https://doi.org/10.1097/DAD.0000000000003453","url":null,"abstract":"Abstract: Darier disease (DD) is a rare genodermatosis caused by mutations in the ATP2A2 gene, leading to impaired intracellular calcium signaling, acantholysis, and dyskeratosis. Although traditionally viewed primarily as a cutaneous disorder, DD shows significant intragenerational and intergenerational phenotypic variability and systemic associations. We present an extraordinary case series of 3 patients from a single Turkish family representing 3 successive generations of DD, each demonstrating distinct clinical manifestations alongside varying neuropsychiatric comorbidities. Specifically, the first-generation patient presented with Alzheimer disease, the second with obsessive-compulsive disorder, and the third with cognitive impairment. The diagnosis was supported by classical clinical and histopathological findings. To our knowledge, this is the first report specifically characterizing the spectrum of neuropsychiatric manifestations across 3 consecutive generations within a single family affected by DD. This familial presentation highlights the disease's complex pleiotropic effects and underscores the need for a multidisciplinary approach to evaluating these patients.","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149197656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dysplastic Nevus Terminology in Contemporary Literature: A Descriptive Content Analysis. 当代文学中的发育不良痣术语：描述性内容分析。

IF 0.8 4区医学

American Journal of Dermatopathology Pub Date : 2026-10-15 DOI: 10.1097/DAD.0000000000003466

Ismail H Unal, Dilara Aydemir, Aslan Yürekli

{"title":"Dysplastic Nevus Terminology in Contemporary Literature: A Descriptive Content Analysis.","authors":"Ismail H Unal, Dilara Aydemir, Aslan Yürekli","doi":"10.1097/DAD.0000000000003466","DOIUrl":"https://doi.org/10.1097/DAD.0000000000003466","url":null,"abstract":"Background: The term dysplastic nevus (DN) remains included in current World Health Organization classification and embedded in routine diagnostic practice, despite longstanding debate regarding its diagnostic reproducibility, biological specificity, and clinical relevance. However, the extent to which these theoretical controversies are reflected in contemporary academic literature remains insufficiently quantified.Objective: This study aims to descriptively examine how dysplastic nevus terminology is operationalized in contemporary dermatology and pathology literature, determining whether the term functions as a routine diagnostic entity or as an actively contested concept.Methods: Peer-reviewed English-language publications indexed in PubMed and published between December 1, 2024, and December 20, 2025, were screened. The included publications were categorized by 2 researchers into the predefined patterns of terminology usage. Disagreements, borderline cases, and uncertain classifications were resolved through discussion, with input from the study's senior author when needed.Results: Of the 56 publications included, 46 (82.1%) used dysplastic nevus terminology. In most of these papers, the term appeared as a routine diagnostic label without any critical evaluation or conceptual questioning. Explicit critical discussion of the terminology was identified in 8 publications (14.3%), whereas conventional use was observed across all journal quartiles.Conclusions: Despite half a century of debate and recent calls for revised classification, dysplastic nevus terminology maintains its dominance in recent literature. A transition to a unified, behavior-oriented diagnostic language has not yet been fully realized, and routine use of the term may contribute to ongoing diagnostic and communicative ambiguity when its intended meaning is not explicitly clarified.","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149197679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trichoblastic Carcinoma Arising Within a Trichoepithelioma: A Biphasic Follicular Neoplasm With Compartment-Specific CK15, CK20, and Ki-67 Findings. 毛上皮瘤内产生的毛母细胞癌：一种具有室特异性CK15、CK20和Ki-67结果的双相滤泡性肿瘤。

IF 0.8 4区医学

American Journal of Dermatopathology Pub Date : 2026-10-15 DOI: 10.1097/DAD.0000000000003463

Arthur William Passos Raetsch, Jeffrey P North

{"title":"Trichoblastic Carcinoma Arising Within a Trichoepithelioma: A Biphasic Follicular Neoplasm With Compartment-Specific CK15, CK20, and Ki-67 Findings.","authors":"Arthur William Passos Raetsch, Jeffrey P North","doi":"10.1097/DAD.0000000000003463","DOIUrl":"https://doi.org/10.1097/DAD.0000000000003463","url":null,"abstract":"Abstract: Trichoblastic carcinoma (TBC) is a rare malignant follicular neoplasm whose distinction from trichoblastoma/trichoepithelioma (TE) and basal cell carcinoma may be challenging. We report an 83-year-old woman with a nodule on the left superior parietal scalp suspected clinically to be a pilar cyst. Histopathologic analysis showed a large basaloid epithelial neoplasm in the dermis and subcutis composed of variably sized nests and clusters of basaloid cells with peripheral palisading and a hypercellular fibrocytic stroma. A biphasic pattern was evident, with one component composed of small, cytologically bland cells typical of TE and a second component composed of larger cells with atypical nuclei and nuclear crowding. CK15 staining diffusely labeled the benign component and showed minimal positivity in the atypical component. CK20-positive Merkel cells colonized tumor aggregations in the benign component but not in the atypical component. The Ki-67 proliferation index was low in the bland component and elevated in the atypical component. Taken together, the findings support TBC arising within a TE. This report highlights evolution from a TE to TBC and illustrates the value of immunohistochemistry in confirming a diagnosis of TBC.","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149197226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neutrophilic Fixed Drug Eruption Mimicking Neutrophilic Dermatosis: Two Cases, Including Sequential Biopsies Demonstrating Time-Dependent Histopathology. 中性粒细胞固定药疹模拟中性粒细胞性皮肤病：2例，包括顺序活检显示时间依赖性组织病理学。

IF 0.8 4区医学

American Journal of Dermatopathology Pub Date : 2026-10-15 DOI: 10.1097/DAD.0000000000003454

Padol Chamninawakul, Ziying Vanessa Lim, Lawrence Shih Wee Khoo, Joyce Siong See Lee

{"title":"Neutrophilic Fixed Drug Eruption Mimicking Neutrophilic Dermatosis: Two Cases, Including Sequential Biopsies Demonstrating Time-Dependent Histopathology.","authors":"Padol Chamninawakul, Ziying Vanessa Lim, Lawrence Shih Wee Khoo, Joyce Siong See Lee","doi":"10.1097/DAD.0000000000003454","DOIUrl":"https://doi.org/10.1097/DAD.0000000000003454","url":null,"abstract":"Abstract: Fixed drug eruption (FDE) is classically a lymphocyte-predominant interface dermatitis, but an early lesion may show a prominent neutrophilic infiltrate that closely simulates a primary neutrophilic dermatosis. We report 2 cases. The first, a 42-year-old woman, developed a multifocal eruption approximately 45 minutes after re-exposure to etoricoxib, recurring at previously affected and new sites. A punch biopsy performed 21 hours after ingestion of the drug showed a basketweave stratum corneum, intense papillary dermal edema with pseudovesiculation, and a superficial and deep infiltrate rich in neutrophils with karyorrhexis, closely resembling Sweet syndrome. Only occasional apoptotic keratinocytes were present within the epidermis, and the marked edema obscured any interface dermatitis, although admixed eosinophils were noted. Clinicopathologic correlation ultimately established the diagnosis of neutrophilic FDE. The second, a 55-year-old man, had an eruption recurring at the same sites after pseudoephedrine. A biopsy of an established lesion 2-3 weeks after ingestion showed classic interface dermatitis with numerous eosinophils and pigment incontinence, whereas one taken from the same region within 24 hours of re-exposure showed a neutrophil-predominant infiltrate with prominent karyorrhexis and only focal interface change. These cases, biopsied at documented time points, support the concept that the neutrophil-rich appearance of FDE represents an early phase in its histopathologic evolution, demonstrate how it can be mistaken for a neutrophilic dermatosis in the absence of adequate clinical history, and show that clinicopathologic correlation and a high index of suspicion are necessary to reliably arrive at the correct diagnosis.","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149197281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Classic Cutaneous Presentation of Thymoma-Associated Multiorgan Autoimmunity and Review of the Literature. 胸腺瘤相关多器官自身免疫的典型皮肤表现及文献综述。

IF 0.8 4区医学

American Journal of Dermatopathology Pub Date : 2026-10-14 DOI: 10.1097/DAD.0000000000003458

Rebecca Fliorent, Alexandra Gershman, Cynthia Magro

{"title":"A Classic Cutaneous Presentation of Thymoma-Associated Multiorgan Autoimmunity and Review of the Literature.","authors":"Rebecca Fliorent, Alexandra Gershman, Cynthia Magro","doi":"10.1097/DAD.0000000000003458","DOIUrl":"10.1097/DAD.0000000000003458","url":null,"abstract":"Abstract: Thymoma-associated multiorgan autoimmunity (TAMA) is a rare paraneoplastic syndrome characterized by graft-versus-host disease (GVHD)-like manifestations. The disorder is thought to arise from a disruption to central immune tolerance of T cells secondary to neoplastic growth of thymic epithelial cells. Thymic epithelial cells are crucial in T-cell education: distinguishing between self-antigens and foreign antigens. This process relies on a protein, the autoimmune regulator (AIRE), which negatively selects and eliminates T cells that are self-reactive. With neoplastic transformation of thymic cells, these cells may exhibit reduced AIRE, leading to an overabundance of autoreactive T cells. These autoreactive T cells mediate the sequelae of the GVHD-like presentation, with skin, liver, and gastrointestinal tract manifestations. We describe a case of a 74-year-old patient with a medical history of thymoma and multiple autoimmune conditions, who presented for diffuse psoriasiform eruption of the trunk and back. Skin biopsy further revealed epidermal hyperplasia with interface change, extensive dyskeratosis, and numerous apoptotic keratinocytes within parakeratotic scale, including striking involvement of the follicular epithelium. Our patient developed hepatobiliary and cholestasis injury, with rising bilirubin, AST, and ALT levels. Despite therapeutic modifications, his cutaneous and systemic disease progressed, and he died approximately 1 month after the diagnosis of TAMA due to complications of small bowel obstruction. This case highlights the pressing need for heightened clinical suspicion and a multidisciplinary team approach when presented with a thymoma patient.","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149185888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Histopathological Patterns in Bullous Dermatitis Artefacta: A Retrospective Case Series. 大疱性人工皮炎的组织病理学模式：回顾性病例系列。

IF 0.8 4区医学

American Journal of Dermatopathology Pub Date : 2026-10-09 DOI: 10.1097/DAD.0000000000003430

Paula Gerlero, Nycolle Louise Klein Ottoni Guedes, Marcella Soares Pincelli, Alexandre Jack Dwan, Marcello Menta Simonsen Nico

{"title":"Histopathological Patterns in Bullous Dermatitis Artefacta: A Retrospective Case Series.","authors":"Paula Gerlero, Nycolle Louise Klein Ottoni Guedes, Marcella Soares Pincelli, Alexandre Jack Dwan, Marcello Menta Simonsen Nico","doi":"10.1097/DAD.0000000000003430","DOIUrl":"https://doi.org/10.1097/DAD.0000000000003430","url":null,"abstract":"Background: Dermatitis artefacta (DA) is associated with self-harming behaviors, which can be conscious or unconscious. It is characterized by lesions with atypical distributions and geometric patterns, produced by manipulation of the skin through friction, suction, heat, cold, electric current, or chemicals. Diagnosis is challenging, and there are no confirmatory tests, but histology can provide important clues for identifying artificial causes.Objective: Our aim was to retrospectively review histological characteristics and anatomopathological patterns in patients with bullous DA.Methods: We performed a retrospective chart review of patients with a diagnosis of bullous DA. Patients with self-induced skin diseases related to other psychic causes (such as anxiety, depression, or obsessive-compulsive disorder) were excluded. Fifteen cases were analyzed between 2009 and 2024. Biopsies were submitted to histological analyses using different techniques including hematoxylin-eosin, periodic acid-Schiff, and direct immunofluorescence, with investigation of IgA, IgM, IgG, and C3.Results: Histopathology showed 4 main patterns: subepidermal blisters with neutrophils, spongiotic blisters with sparse necrotic keratinocytes, dermoepidermal or mixed cleavage blisters with follicular compromise, and \"erythema-multiforme-like\" blisters with extensive necrosis.Conclusions: Dermatologists are uniquely positioned to diagnose and manage DA. Nevertheless, when clinical diagnosis is inconclusive, recognition of these histopathological patterns may provide valuable diagnostic clues for dermatopathologists evaluating biopsies from patients with suspected DA.","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149148913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Pigmented Nodule on the Forehead of a Young Man: Challenge. 一个年轻人额头上的色素结节：挑战。

IF 0.8 4区医学

American Journal of Dermatopathology Pub Date : 2026-10-05 DOI: 10.1097/DAD.0000000000003426

Rishi Agrawal, Vidette Wong, Sreedhar Krishna, Alwalid Freih, Richard Carr

引用次数: 0

Quantitative Digital Image Analysis Detects Differences in Nuclear Features Between CK20-Negative and CK20-Positive Merkel Cell Carcinomas. 定量数字图像分析检测ck20阴性和ck20阳性默克尔细胞癌之间核特征的差异。

IF 0.8 4区医学

American Journal of Dermatopathology Pub Date : 2026-10-05 DOI: 10.1097/DAD.0000000000003450

Jiho Park, Subramaniam Ramkumar, Gerardo Cazzato, Elisa Belloni, Carlos Torres-Cabala, Alessio Giubellino

{"title":"Quantitative Digital Image Analysis Detects Differences in Nuclear Features Between CK20-Negative and CK20-Positive Merkel Cell Carcinomas.","authors":"Jiho Park, Subramaniam Ramkumar, Gerardo Cazzato, Elisa Belloni, Carlos Torres-Cabala, Alessio Giubellino","doi":"10.1097/DAD.0000000000003450","DOIUrl":"10.1097/DAD.0000000000003450","url":null,"abstract":"Abstract: Merkel cell carcinoma (MCC) is a rare, aggressive neuroendocrine cutaneous malignancy that can arise through 2 oncogenic pathways: a Merkel cell polyomavirus-positive pathway and a virus-negative pathway driven by ultraviolet exposure. Cytokeratin 20 (CK20), expressed in a paranuclear dot-like pattern, is a cornerstone diagnostic marker for MCC, yet roughly 5% of cases are CK20 negative, an uncommon immunophenotype that can cause diagnostic difficulty. In this exploratory study, we asked whether CK20-negative tumors show a distinct nuclear phenotype on digital image analysis. Using the HALO artificial intelligence platform (Indica Labs), we performed artificial intelligence-assisted whole-slide image analysis of 5 CK20-negative and 36 CK20-positive MCC sections (from 30 patients), extracting nuclear and cytoplasmic metrics from manually annotated tumor regions. Because sections from the same patient are not independent, we repeated the primary comparison at the patient level across all 24 possible one-section-per-patient combinations. CK20-negative MCC showed lower average nucleus roundness than CK20-positive tumors; the difference was significant by the Welch t test in the section-level analysis (0.731 vs. 0.754; P = 0.012) and remained significant by the Welch t test across all 24 patient-level combinations ( P = 0.032 to 0.048), although the Mann-Whitney U test was no longer significant at the patient level. We also observed trends toward smaller nuclear area and perimeter, while cell, cytoplasmic, and tissue areas did not differ. Because Merkel cell polyomavirus status was unavailable, these differences cannot be attributed specifically to CK20 or viral status. These preliminary findings suggest that computational pathology can detect nuclear differences in this rare subset; larger, molecularly characterized cohorts from multiple institutions are needed for validation.","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149118367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Basal Cell Carcinosarcoma with an Osteosarcomatous Component: A Case Report Supporting the Diagnostic Utility of SATB2 and TRAP Immunostaining with a Literature Review of 22 Cases. 伴有骨肉瘤成分的基底细胞癌肉瘤：一份支持SATB2和TRAP免疫染色诊断功能的病例报告，并对22例病例进行文献回顾。

IF 0.8 4区医学

American Journal of Dermatopathology Pub Date : 2026-10-01 Epub Date: 2026-06-30 DOI: 10.1097/DAD.0000000000003366

Erina Kodaka, Shiro Iino, Chinami Kishimoto, Takako Matsuda-Okazaki, Noritaka Oyama, Akifumi Muramoto, Shohei Higuchi, Yoshiaki Imamura, Kosuke Katsuo, Minoru Hasegawa

{"title":"Basal Cell Carcinosarcoma with an Osteosarcomatous Component: A Case Report Supporting the Diagnostic Utility of SATB2 and TRAP Immunostaining with a Literature Review of 22 Cases.","authors":"Erina Kodaka, Shiro Iino, Chinami Kishimoto, Takako Matsuda-Okazaki, Noritaka Oyama, Akifumi Muramoto, Shohei Higuchi, Yoshiaki Imamura, Kosuke Katsuo, Minoru Hasegawa","doi":"10.1097/DAD.0000000000003366","DOIUrl":"10.1097/DAD.0000000000003366","url":null,"abstract":"Abstract: Basal cell carcinoma rarely coexists with malignant mesenchymal component(s), termed as basal cell carcinosarcoma (BCCS). BCCS often comprises an osteosarcomatous change, which considerably varies in the histological extent among reported cases. Owing to its rarity and morphological heterogeneity, the disease may be underrecognized and pose accurate diagnosis and treatment approaches. In this study, we present a case of BCCS with a focal osteosarcomatous component in a 91-year-old woman with a rapidly enlarging solitary tumor on the left cheek. Histopathological examination revealed a biphasic tumor composed of conventional basal cell carcinoma and a high-grade sarcomatous component, both of which were intermingled gradually in the transitional zone. Limited portions of the sarcomatous component contained atypical spindle-to oval-shaped cells and osteoclast-like multinucleated giant cells surrounded by an osteoid matrix. Immunohistochemically, these cells were positive for an osteoblastic marker SATB2 and an osteoclast-associated marker tartrate-resistant acid phosphatase, respectively, but negative for epithelial markers AE1/AE3 and BerEP4. These findings supported a diagnosis of BCCS with an osteosarcomatous component. To the best of our knowledge, literature review identified only 21 similar cases thus far reported, but no previous reports have used a combined use of SATB2 and tartrate-resistant acid phosphatase immunostaining to substantiate the osteosarcomatous focus in cutaneous carcinosarcoma. Our case may highlight the potential diagnostic value of these 2 markers in distinguishing the true osteosarcomatous components from mimicking elements such as dystrophic calcification or hyalinized collagen deposition, but also in detecting a subtle osteosarcomatous component in carcinosarcoma.","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":"e103-e108"},"PeriodicalIF":0.8,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148363650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Persistent Agmination of Lymphomatoid Papulosis with Features of Lymphomatoid Papulosis in Both the Regressing Papular Component and the Persistent Patch: A Case Report and Review of the Literature. 顽固性丘疹和顽固性斑块兼有类淋巴瘤丘疹特征的类淋巴瘤丘疹持续发炎1例报告及文献复习

IF 0.8 4区医学

American Journal of Dermatopathology Pub Date : 2026-10-01 Epub Date: 2026-07-13 DOI: 10.1097/DAD.0000000000003387

Ana Spajic, Larisa J Geskin, Cynthia M Magro

{"title":"Persistent Agmination of Lymphomatoid Papulosis with Features of Lymphomatoid Papulosis in Both the Regressing Papular Component and the Persistent Patch: A Case Report and Review of the Literature.","authors":"Ana Spajic, Larisa J Geskin, Cynthia M Magro","doi":"10.1097/DAD.0000000000003387","DOIUrl":"https://doi.org/10.1097/DAD.0000000000003387","url":null,"abstract":"Abstract: Persistent agmination of lymphomatoid papulosis (PALP) is a rare, anatomically localized variant of lymphomatoid papulosis (LYP) characterized by clustered papules superimposed on a chronic persistent patch or plaque which resembles cutaneous T-cell lymphoma. The histologic patterns may be variable, and differentiation from early-stage cutaneous T-cell lymphoma (CTCL), particularly unilesional mycosis fungoides (MF), can be challenging. We report an 18-year-old woman with a longstanding CD8-positive T-cell dyscrasia, initially diagnosed at age 10 as Type B LYP showing folliculocentricity. She experienced a recurrence at age 14, and 3 years later she developed a persistent, localized patch on the thigh with superimposed papules which exhibited a waxing and waning course. Histologic examination of both the persistent patch and episodic papular component revealed a very similar morphology which was the one manifesting an overlapping morphology of Type B LYP and pityriasis lichenoides chronica (PLC); there was follicular involvement similar to the earlier 2016 biopsy. PALP is a very rare variant of LYP with most of the reported cases describing the persistent patch as having features of cutaneous T-cell lymphoma, typically mycosis fungoides. We describe a patient with PALP where both the episodic papules and the persistent patch showed a similar histomorphology which in turn mirrored the previous pathology from 2016 that was characteristic for LYP clinically and was biopsy proven folliculotropic Type B LYP. Two other cases of PALP showing a persistent patch with classic features of LYP have been previously published. Hence, there is a subset of PALP where the persistent lesion is compatible with LYP as opposed to being one of lymphoma. The persistence of LYP challenges this conceptualization of LYP as a lymphoproliferative disorder where complete regression is a requisite.","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":"48 10","pages":"798-803"},"PeriodicalIF":0.8,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149002805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0