American Journal of Dermatopathology最新文献_第3页

A Stranger in the Slide: A Rare Collision of a Spitz Melanocytoma With a Novel MYH9::LTK Fusion and a Common BRAF Mutated Nevus Mimicking a Melanoma With a Preexistent Nevus. 幻灯片中的陌生人：罕见的斯皮兹黑色素细胞瘤与新型MYH9::LTK融合和常见的BRAF突变痣的碰撞，模拟黑色素瘤与先前存在的痣。

IF 1.1 4区医学

American Journal of Dermatopathology Pub Date : 2025-06-25 DOI: 10.1097/DAD.0000000000003039

Puk R Meijs-Hermanns, Juliette M J Spitzer-Naaijkens, Lennart A Kester, Anne M L Jansen, Willeke A M Blokx

{"title":"A Stranger in the Slide: A Rare Collision of a Spitz Melanocytoma With a Novel MYH9::LTK Fusion and a Common BRAF Mutated Nevus Mimicking a Melanoma With a Preexistent Nevus.","authors":"Puk R Meijs-Hermanns, Juliette M J Spitzer-Naaijkens, Lennart A Kester, Anne M L Jansen, Willeke A M Blokx","doi":"10.1097/DAD.0000000000003039","DOIUrl":"https://doi.org/10.1097/DAD.0000000000003039","url":null,"abstract":"Abstract: In this case report, we present a rare collision tumor consisting of a Spitz melanocytoma with a novel MYH9::LTK fusion, and a BRAFV600E mutated common dermal nevus in a 25-year-old man. Based on morphology alone, the lesion could easily have been misdiagnosed as a melanoma with a preexisting nevus. However, only the common dermal nevus showed BRAFV600E expression on immunohistochemical analysis, pointing toward the possibility of a collision tumor and guiding further molecular analyses. Although MYH9::LTK fusions have not been previously described in Spitz tumors, we classified this lesion as Spitz based on the epithelioid morphology and kinase fusion driver. Because there was dermal mitotic activity and heterozygous CDKN2A loss, we signed this lesion out as Spitz melanocytoma, in association with an unrelated BRAFV600E mutated dermal nevus. This case underscores the relevance of performing immunohistochemistry and if needed additional molecular analyses to confirm the lineage and dignity of an atypical melanocytic lesion, in which a Spitz tumor is a diagnostic consideration, to prevent misdiagnosis.","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144486864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Two Cases of Cutaneous Adverse Events Induced by Enfortumab Vedotin With Ring Mitosis: A Characteristic but Rare Histologic Finding. 两例维多酮引起的皮肤不良事件伴环状有丝分裂：一个特征性但罕见的组织学发现。

IF 1.1 4区医学

American Journal of Dermatopathology Pub Date : 2025-06-25 DOI: 10.1097/DAD.0000000000003004

Urara Aitake, Teruaki Izumi, Xiaofeng Lei, Shigeru Koizumi, Tatsuhiko Mori, Naoko Shojiguchi, Toshifumi Nomura, Yasuhiro Nakamura

{"title":"Two Cases of Cutaneous Adverse Events Induced by Enfortumab Vedotin With Ring Mitosis: A Characteristic but Rare Histologic Finding.","authors":"Urara Aitake, Teruaki Izumi, Xiaofeng Lei, Shigeru Koizumi, Tatsuhiko Mori, Naoko Shojiguchi, Toshifumi Nomura, Yasuhiro Nakamura","doi":"10.1097/DAD.0000000000003004","DOIUrl":"https://doi.org/10.1097/DAD.0000000000003004","url":null,"abstract":"Abstract: An 80-year-old man with a history of metastatic urothelial cancer involving multiple lymph nodes and the lungs received an infusion of enfortumab vedotin (EV) as third-line treatment 1 month before presentation. Thereafter, he presented with fever and diffuse erythema on the trunk and extremities. A 77-year-old man with a history of metastatic urothelial cancer involving multiple lymph nodes and bones received an infusion of EV as fourth-line treatment 10 days before presentation. He developed fever and dusky erythema on the trunk and extremities. Cutaneous biopsy specimens of the erythema of both patients showed starburst-like ring mitosis in the basal layer of the epidermis. Based on this histologic finding, erythema was diagnosed as an EV-induced cutaneous adverse event in both patients. Oral prednisolone resolved both cases of erythema. EV is an antibody-drug conjugate that inhibits microtubule polymerization. Ring mitosis has been observed in several organs, mainly the gastrointestinal tract, of patients treated with agents such as taxanes and colchicine that inhibit microtubule polymerization, similar to EV. These findings may be useful for discriminating between cutaneous adverse events caused by EV and those caused by other agents.","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144486874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New Onset Violaceous Draining Plaques on the Toes: Challenge. 新发作的静脉引流斑块在脚趾：挑战。

IF 1.1 4区医学

American Journal of Dermatopathology Pub Date : 2025-06-24 DOI: 10.1097/DAD.0000000000003029

Nathalia Simonetti, Julia McGee, Erin Boh, Carole Bitar

引用次数: 0

Immunohistochemical Expression of Plasmacytoid Dendritic Cell Markers in Cutaneous Lupus Erythematosus Subtypes in Skin of Color. 浆浆细胞样树突状细胞标记物在有色皮肤红斑狼疮亚型中的免疫组织化学表达。

IF 1.1 4区医学

American Journal of Dermatopathology Pub Date : 2025-06-24 DOI: 10.1097/DAD.0000000000003033

Pavithra Ayyanar, Madhusmita Sethy, Biswanath Behera, Ajit Sahu, Bhini Ameta

{"title":"Immunohistochemical Expression of Plasmacytoid Dendritic Cell Markers in Cutaneous Lupus Erythematosus Subtypes in Skin of Color.","authors":"Pavithra Ayyanar, Madhusmita Sethy, Biswanath Behera, Ajit Sahu, Bhini Ameta","doi":"10.1097/DAD.0000000000003033","DOIUrl":"https://doi.org/10.1097/DAD.0000000000003033","url":null,"abstract":"Abstract: The role of plasmacytoid dendritic cells (PDCs) has been studied in the cutaneous lupus erythematosus (CLE) to differentiate from their mimickers. We aimed to study the expression pattern of PDC markers in CLE subtypes, analyze their association with histopathological findings, and correlate them with disease activity in skin of color. This cross-sectional study included 115 newly diagnosed CLE cases [acute CLE = 41; discoid lupus erythematosus (DLE) = 72, subacute CLE = 2] from January 2022 to July 2024. Immunohistochemistry (IHC) for CD123, blood-derived dendritic cell antigen-2 (BDCA2), and human myxovirus resistance protein A (MXA) were performed in all cases. In DLE, the mean percentage of CD123 + cells in the superficial dermis (28.36 ± 2.584 vs. 23.05 ± 3.123) and deep dermis (14.83 ± 2.567 vs. 12.24 ± 3.377) were higher than in ACLE. No significant difference was noted in BDCA2 and MXA scores between DLE and ACLE. ACLE was marked by the absence of clustering (P = 0.01, 73.2% vs. 44.4%), whereas DLE showed a significant presence of small clusters (P = 0.01, 33.3% vs. 17.1%) and CD123 + cells at the dermoepidermal junction (P = 0.05, 61.1% vs. 41.5%). A significant association was noted between CD123 + cells at specific locations and histopathological parameters. A linear trend was observed between positivity for CD123, BDCA2, and MXA with ordinal histopathological parameters. These markers did not show any significant correlations with disease activity scores. This is the largest comparative study to highlight the variability in the number, location, and clustering of PDCs among CLE subtypes, possibly relating to their clinical morphology and pathological features.","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144486872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Giant Molluscum Contagiosum Presenting as Foot Tumors in an Immunocompetent Female. 巨大的传染性软疣在免疫功能正常的女性中表现为足部肿瘤。

IF 1.1 4区医学

American Journal of Dermatopathology Pub Date : 2025-06-24 DOI: 10.1097/DAD.0000000000003035

Yinhua Wu, Jianjun Qiao, Hong Fang

引用次数: 0

Granulomatous Alopecia Areata: A Rare Report With a Review. 肉芽肿性斑秃：一个罕见的报告与回顾。

IF 1.1 4区医学

American Journal of Dermatopathology Pub Date : 2025-06-24 DOI: 10.1097/DAD.0000000000003036

Biswanath Behera, Madhusmita Sethy, Akshatha Nayak, Bevan Priyadharsan, Bhini Ameta, Pavithra Ayyanar

引用次数: 0

Atypical Spitz Tumor (Spitz Melanocytoma) With Lymph Node Metastasis and Long-Term Clinical Follow-Up. 伴有淋巴结转移的非典型Spitz肿瘤（Spitz黑色素细胞瘤）及长期临床随访。

IF 1.1 4区医学

American Journal of Dermatopathology Pub Date : 2025-06-23 DOI: 10.1097/DAD.0000000000002982

Schaida Schirwani, Jeff Theaker, Lucy Side, Karwan Moutasim

{"title":"Atypical Spitz Tumor (Spitz Melanocytoma) With Lymph Node Metastasis and Long-Term Clinical Follow-Up.","authors":"Schaida Schirwani, Jeff Theaker, Lucy Side, Karwan Moutasim","doi":"10.1097/DAD.0000000000002982","DOIUrl":"https://doi.org/10.1097/DAD.0000000000002982","url":null,"abstract":"Abstract: Spitz tumors are clinically and histologically challenging because of their close histologic resemblance to melanomas. Differentiating metastatic atypical Spitz tumors from melanoma has been a controversial issue for many decades. Diagnosis relies on expert pathologist review and a host of immunohistochemical and genomic testing including gene fusions in ALK, ROS, and NTRK, which has been informative in diagnosing and classifying these challenging lesions. Evidence suggest that atypical Spitz tumors associated with regional lymph node metastasis have good prognosis and do not spread to internal organs, however, cases of childhood melanomas (often with TERT mutations) can occur, often with a fatal outcome. Therefore, making a conclusive diagnosis is crucial when treating patients. In this study, we report a girl diagnosed with atypical Spitz tumor with lymph node metastasis at the age of 10 years. She has shown no recurrence after 20 years of follow-up. The formalin-fixed, paraffin-embedded tissue was retrospectively analyzed by next-generation sequencing and additional immunohistochemistry. PRAME immunohistochemistry was negative, as were ALK and ROS. No BRAF or TERT mutations were identified. No pathogenic or likely pathogenic variant was identified on testing lymphocyte DNA for familial malignant melanoma, including CDKN2A, CDK4, and BAP1 and a panel of 79 genes associated with childhood solid tumors.","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144486867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Annular Lesions Mimicking Mpox in a Patient With HIV. HIV患者的环状病变模拟m痘。

IF 1.1 4区医学

American Journal of Dermatopathology Pub Date : 2025-06-20 DOI: 10.1097/DAD.0000000000003044

Ruixin Deng, Tianyi Xu, Yalong Li, Shaoqin Zhou, Yinggai Song, Aiping Wang

引用次数: 0

Subcutaneous Panniculitis-Like T-Cell Lymphoma With Increased γδ T Cells: A Potential Diagnostic Pitfall. 皮下泛膜炎样T细胞淋巴瘤伴γδ T细胞增多：一个潜在的诊断缺陷。

IF 1.1 4区医学

American Journal of Dermatopathology Pub Date : 2025-06-18 DOI: 10.1097/DAD.0000000000002999

Elsayed Ibrahim, Julia Dai, Volha Lenskaya, Carlos A Torres-Cabala, Woo Cheal Cho

{"title":"Subcutaneous Panniculitis-Like T-Cell Lymphoma With Increased γδ T Cells: A Potential Diagnostic Pitfall.","authors":"Elsayed Ibrahim, Julia Dai, Volha Lenskaya, Carlos A Torres-Cabala, Woo Cheal Cho","doi":"10.1097/DAD.0000000000002999","DOIUrl":"https://doi.org/10.1097/DAD.0000000000002999","url":null,"abstract":"Abstract: Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a rare primary cutaneous T-cell lymphoma with adipotropism characterized by infiltration of CD8+ T cells exhibiting a cytotoxic and αβ phenotype. Although SPTCL is typically indolent, distinguishing it from more aggressive cutaneous lymphomas such as primary cutaneous γδ T-cell lymphoma is critical for accurate prognosis. We present a case of SPTCL in a 26-year-old Asian woman with a history of hemophagocytic lymphohistiocytosis, who presented with nonulcerated, erythematous patches and hyperpigmented nodules on her extremities and trunk persisting for 5 months. Biopsy specimens revealed an atypical lymphoid infiltrate with prominent adipotropism, predominantly comprising atypical medium-sized lymphocytes rimming the adipocytes. Immunophenotypically, the lesional lymphocytes were CD3+/CD4-/CD8+/CD7+ T cells expressing TIA1, granzyme B, and TCR βF1, while lacking CD30 and Epstein-Barr virus-encoded small RNA expression. Intriguingly, there was a markedly increased density of T cells expressing TCR δ, some surrounding adipocytes and appearing neoplastic. CD123 failed to reveal aggregates of plasmacytoid dendritic cells. Molecular analysis revealed monoclonal TCR β and γ gene rearrangements. Despite the elevated γδ T-cell population (20%-50% of the T cells), the overall clinical, histopathologic, and molecular findings, along with the absence of rapid disease progression, supported a diagnosis of SPTCL. Although increased densities of reactive γδ T-cells or γδ T-cell phenotypes in neoplastic cells are observed in various benign and malignant dermatologic conditions, the literature on this phenomenon-particularly in SPTCL-remains scarce. Our case highlights the importance of recognizing an increased γδ T-cell population in SPTCL to prevent misdiagnosis as a more aggressive lymphoma such as primary cutaneous γδ T-cell lymphoma, underscoring the need for thorough clinicopathologic correlation.","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144327660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Case of Secondary Anetoderma Following Dermatofibroma. 皮肤纤维瘤继发无皮病1例。

IF 1.1 4区医学

American Journal of Dermatopathology Pub Date : 2025-06-01 Epub Date: 2025-04-02 DOI: 10.1097/DAD.0000000000002957

Tomoko Chiba-Segawa, Toshiya Takahashi, Mayuko Amagai, Yuichiro Segawa, Emi Yamazaki, Saaya Yoshida-Akai, Kenichiro Tsuchiyama, Taku Fujimura, Kenshi Yamasaki, Setsuya Aiba, Yoshihide Asano

引用次数: 0