American Journal of Dermatopathology最新文献

{"title":"Cutaneous Panniculitis in Q Fever: A Case of Diagnostic Granulomas.","authors":"Eva Sticova, Jan Hugo","doi":"10.1097/DAD.0000000000003079","DOIUrl":"https://doi.org/10.1097/DAD.0000000000003079","url":null,"abstract":"","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":"47 10","pages":"816-817"},"PeriodicalIF":1.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145088002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Unusual Cause of Folliculitis.","authors":"Anubhab Bhattacharyya, Sivaranjini Ramassamy, Sree Rekha Jinkala","doi":"10.1097/DAD.0000000000003047","DOIUrl":"10.1097/DAD.0000000000003047","url":null,"abstract":"","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":"e119-e120"},"PeriodicalIF":1.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144499017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retrospective Analysis of the Utility of Polymerase Chain Reaction-Reverse Sequence-Specific Oligonucleotide (GENOSEARCH HPV31) and Human Papillomavirus Immunohistochemistry (BSB-66) in the Diagnosis of Digital Papillary Adenocarcinoma.","authors":"Tsubasa Hiraki, Toshihiro Takai, Yoshifumi Iwahashi, Shin-Ichi Murata, Yuna Noda, Masatoshi Jinnin, Shusuke Yoshikawa, Keisuke Goto","doi":"10.1097/DAD.0000000000003065","DOIUrl":"10.1097/DAD.0000000000003065","url":null,"abstract":"<p><strong>Abstract: </strong>Digital papillary adenocarcinoma (DPA) is a rare malignant sweat gland tumor associated with human papillomavirus genotype 42 (HPV42). Currently, the only established test for detecting HPV42 in DPA is RNAscope in situ hybridization. However, this test incurs extremely high acquisition and running costs. To find an alternative method for the detection of human papillomavirus (HPV) in DPA, we evaluated the utility of polymerase chain reaction-reverse sequence-specific oligonucleotide (PCR-rSSO) (GENOSEARCH HPV31) and immunohistochemistry (IHC) using an anti-HPV antibody (BSB-66) for the detection of HPV in DPA. A total of 6 cases of DPA and 16 cases of other cutaneous tumors were reviewed, all of which had been practically performed by GENOSEARCH HPV31 using formalin-fixed paraffin-embedded (FFPE) tissues. The results revealed the presence of HPV42 in all 5 available cases of DPA (5/5, 100%) in GENOSEARCH HPV31. However, 1 case of DPA could not be processed because of poor DNA quality. HPV42 was not detected in the remaining 16 controls. IHC for HPV (BSB-66) showed no reactivity in any of the 6 DPA tumors. For the detection of HPV42 in the FFPE tissue of DPA, GENOSEARCH HPV31 can be used as an alternative to RNAscope in situ hybridization, unless the DNA quality in the FFPE tissue is poor. A notable advantage of GENOSEARCH HPV31 is its lower financial burden, both regarding purchase and operational costs, compared with RNAscope. Furthermore, GENOSEARCH HPV31 can identify additional 30 major genotypes of HPV, other than HPV42. By contrast, HPV (BSB-66) IHC cannot be used to detect HPV in DPA.</p>","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":"775-781"},"PeriodicalIF":1.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144627686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lower Lip Lesions in Fair-Skinned Patients: Time to Make Specific Diagnoses Other Than Actinic Cheilitis.","authors":"Ana Laura Bordini, Nycolle Louise Klein Ottoni Guedes, Silvia Vanessa Lourenço, Marcello Menta Simonsen Nico","doi":"10.1097/DAD.0000000000003082","DOIUrl":"10.1097/DAD.0000000000003082","url":null,"abstract":"<p><strong>Abstract: </strong>Patients with light skin and chronic sun damage commonly develop lower lip lesions that are diagnosed as having actinic cheilitis. Unfortunately, there is no uniform definition for \"actinic cheilitis\" in the dermatologic or dental literature, impeding optimal patient treatment. Furthermore, unrelated, disparate cutaneous conditions have been labeled as \"actinic cheilitis,\" preventing comparisons between studies. We sought to reassess the diagnosis of patients who have been considered to have actinic cheilitis using only histopathologic diagnoses that are reproducible on other areas of the skin. To this end, we reanalyzed biopsies and vermilionectomy specimens that were obtained from 117 patients who were formerly diagnosed with actinic cheilitis in our hospital. A total of 117 biopsy specimens from 117 patients were reanalyzed. An additional 797 slides from vermilionectomy specimens that were acquired from several of these patients were examined. The following diagnoses were made: solar elastosis with normal or atrophic epithelium (603 slides from 83 patients); lichen simplex chronicus (105 slides from 30 patients); actinic keratosis/squamous cell carcinoma (85 slides from 50 patients); and lichen planus (4 slides from 4 patients). Actinic cheilitis is not a specific diagnosis; furthermore, such a diagnosis can be misleading in the treatment of patients. Specific dermatologic diagnoses should always be considered to improve patient treatment.</p>","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":"763-768"},"PeriodicalIF":1.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144765776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subcutaneous Panniculitis-Like T-Cell Lymphoma in a 2-Year-Old: Case Report and Literature Review.","authors":"Clara Ureña-Paniego, Francisco Vílchez-Márquez, María Narváez-Simón, Elena Masana-Flores, Salvador Arias-Santiago","doi":"10.1097/DAD.0000000000003070","DOIUrl":"10.1097/DAD.0000000000003070","url":null,"abstract":"<p><strong>Abstract: </strong>Subcutaneous panniculitis-like T-cell lymphoma is a rare cutaneous T-cell lymphoma characterized by cytotoxic T-cell infiltration of subcutaneous fat that clinically mimics panniculitis. It predominantly affects adults and is rarely present in young children. We report a case of subcutaneous panniculitis-like T-cell lymphoma in a 2-year-old child and review the pediatric literature to highlight the unique clinical features and outcomes in this age group.</p>","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":"754-759"},"PeriodicalIF":1.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144683557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unicentric Subcutaneous Hyaline Vascular Castleman Disease With Concurrent Features of Calcifying Fibrous Tumor.","authors":"Petro Vavrukh, Rohan Katti, Nitya Gulati, Vikash K Modi, Cynthia M Magro","doi":"10.1097/DAD.0000000000003138","DOIUrl":"https://doi.org/10.1097/DAD.0000000000003138","url":null,"abstract":"<p><strong>Abstract: </strong>A calcifying fibrous tumor (CFT) is a rare benign soft tissue lesion characterized by dense hyalinizing fibrosis and psammomatous calcifications. Chronic inflammatory infiltrates are described but never emphasized as being a conspicuous aspect of the pathology. Initially described as a reactive fibrosing inflammatory lesion, CFTs are typically asymptomatic and have been reported in various anatomical locations but rarely manifest in subcutaneous tissue. Unicentric Castleman disease (CD) is a rare lymphoproliferative disorder whereby the initial description of the disease emphasized atrophic germinal centers and hypervascularity within the germinal centers, first described in the context of mediastinal nodular unicentric CD (UCD). Since that original description, a multicentric variant has been observed. Furthermore, the histopathology of both the unicentric and multicentric variants has been expanded to include many plasma cells, with the potential for lambda light chain restriction, and hyperplastic germinal centers, which fall under the histologic designation of the plasma cell variant of CD. Extranodal UCD is uncommon, with its presentation in the skin being especially rare. There are cases of CFT with concomitant features of CD either in the same lesion or at contiguous sites. In this study, we report the first pediatric case of subcutaneous CFT that exhibited concurrent features of UCD showing a mixed hyaline vascular and plasma cell pathology. In particular the sample demonstrated nodular hyalinizing fibrosis, small psammomatous calcifications, and atrophic hypervascular lymphoid follicles with characteristic \"castlemanoid\" architecture characterized by atrophic germinal centers with increased vascularity. There were also plasma cells that exhibited a polytypic profile. The germinal center foci exhibited a prominent CD21 follicular dendritic cell network. IL-6 immunohistochemical staining revealed expression localized predominantly to benign macrophages and reactive CD8+ cytotoxic T cells at the periphery of germinal centers. Hyaline vascular CD and mixed plasma cell and hyaline vascular CD encompass a morphologic spectrum that includes a predominantly fibrotic phase that could potentially obscure the primary diagnosis.</p>","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145186494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical, Morphologic, and Molecular Findings in MET Fusion Spitz Neoplasms.","authors":"Julia Edwin Jeyakumar, Afua Konadu Addo, Haya Mary Beydoun, Shantel Olivares, David Dittmann, Lucas Santana Dos Santos, Michael Volek, Lawrence Jennings, Alina Bridges, Nika Finelt, Lori Lowe, Klaus J Busam, Pedram Gerami","doi":"10.1097/DAD.0000000000003141","DOIUrl":"https://doi.org/10.1097/DAD.0000000000003141","url":null,"abstract":"<p><strong>Abstract: </strong>Characterizing the typical clinical, morphologic, and molecular findings of distinct subtypes of Spitz neoplasms may help facilitate diagnosis and management of these cases. Approximately 1%-2% of Spitz neoplasms have a MET fusion driver. However, there is minimal data in the current literature regarding this specific subtype of Spitz neoplasm. Most cases in our series (9/10) were diagnosed as atypical Spitz tumors, whereas 1 case was diagnosed as a Spitz nevus. We found 3 characteristic morphologic patterns, the first consisted of either expansile nests of spindle shaped spitzoid melanocytes with plexiform arrangement in the dermis forming a large nodular lesion or thin chords and fascicles of spindle shaped spitzoid melanocytes with a tightly interwoven plexiform pattern in the dermis forming a plaque-like architecture. The second pattern consisted of sheets of epithelioid melanocytes with spitzoid cytology, and the third pattern consisted of a both epithelioid and spindle shaped cytology with plexiform arrangement in the dermis as seen in various subtypes of Spitz neoplasms. Compared to a cohort of 81 control Spitz neoplasms, MET fusions were more likely to have spindle cytology and a plexiform growth pattern in the dermis. The most common fusion pattern was ZKSCAN1 (4/10). Copy number gains of the fusion gene were frequent, seen in 61% of cases. None of our cases had a TERT promoter mutation or homozygous deletions of CDKN2A. All of our patients had an uneventful clinical course with no evidence of recurrence after reexcision with average follow-up time of 35 months.</p>","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145180219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methylthioadenosine Phosphorylase (MTAP) and p16 Expression in Melanocytic Nevi and Melanoma with Molecular Correlation.","authors":"Lin J He, Jason L Hornick, Eleanor Russell-Goldman","doi":"10.1097/DAD.0000000000003139","DOIUrl":"https://doi.org/10.1097/DAD.0000000000003139","url":null,"abstract":"<p><strong>Abstract: </strong>Homozygous deletion of CDKN2A in melanoma is common, but loss of p16 expression by immunohistochemistry is an imperfect surrogate marker for CDKN2A deletion. Methylthioadenosine phosphorylase (MTAP), located at the same chromosomal locus as CDKN2A (9p21.3), is frequently codeleted. Recently, protein arginine methyltransferase 5 (PRMT5), a downstream effector of MTAP, has emerged as a therapeutic target, and loss of MTAP expression may both inform and enhance the use of PRMT5 inhibitors. We evaluate the expression of MTAP in nevi and melanomas, comparing it with p16 as a diagnostic surrogate for CDKN2A deletion, and evaluating its utility as a marker for MTAP locus deletion. We included 45 nevi and 70 melanomas, with correlation of p16 and MTAP expression to CDKN2A and MTAP locus status in 63 melanoma cases. Most nevi (71%) showed a mosaic pattern of p16 expression, whereas 100% of nevi showed retained expression of MTAP. In melanoma, 59% of cases showed loss of p16, and 10% showed loss of MTAP. p16 had a moderate sensitivity (82%) and negative predictive value (NPV; 87%) and low specificity (43%) and positive predictive value (PPV; 35%) for detection of CDKN2A homozygous deletion. In contrast, MTAP loss was 100% specific for homozygous deletion of CDKN2A, with a PPV of 100%, sensitivity of 41%, and NPV of 82%. Complete loss of p16 expression was seen in 90% of melanomas with single copy CDKN2A deletion, whereas MTAP showed retained or mosaic expression in 100% of these cases. These findings support the use of MTAP as a surrogate marker for the homozygous deletion of CDKN2A in melanoma. Furthermore, loss of MTAP expression also strongly correlates with homozygous deletion of the MTAP locus with 100% specificity, 70% sensitivity, and a PPV of 100% and NPV of 93%. This finding may have implications for the susceptibility of melanoma to PRMT5 and related inhibitors. Methylthioadenosine Phosphorylase (MTAP) and p16 Expression in Melanocytic Nevi and Melanoma with Molecular Correlation.</p>","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145180200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monoclonal Cryoglobulinemia Clinically Mimicking Leukocytoclastic Vasculitis: A Case Report and Literature Review.","authors":"Taylor E Arnoff, Nicholas Gessner, Fatima N Mirza, Dean David George, Leslie Robinson-Bostom","doi":"10.1097/DAD.0000000000003129","DOIUrl":"https://doi.org/10.1097/DAD.0000000000003129","url":null,"abstract":"<p><strong>Abstract: </strong>Monoclonal cryoglobulinemia commonly presents with cutaneous manifestations and develops almost exclusively in the setting of an underlying lymphoproliferative or hematologic disorder of B-cell lineage. Herein, we describe a case of a 48-year-old woman who presented with a recurrent and symmetric hemorrhagic papular eruption. Punch biopsy and direct immunofluorescence were consistent with monoclonal cryoglobulinemia. Systemic workup was notable for elevated kappa free light chains with a monoclonal immunoglobulin M kappa component on serum protein electrophoresis, and bone marrow biopsy was consistent with lymphoplasmacytic lymphoma.</p>","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145132546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PRAME Expression in Mammary and Extramammary Paget Disease.","authors":"Jean Kanitakis, Christos Topalidis, Kassiani Boulogeorgou, Georgia Karayannopoulou, Triantafyllia Koletsa","doi":"10.1097/DAD.0000000000003133","DOIUrl":"https://doi.org/10.1097/DAD.0000000000003133","url":null,"abstract":"","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145132510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}