临床模拟白细胞分裂性血管炎的单克隆冷球蛋白血症1例报告及文献复习。

IF 1 4区医学 Q4 DERMATOLOGY

American Journal of Dermatopathology Pub Date : 2025-09-23 DOI:10.1097/DAD.0000000000003129

Taylor E Arnoff, Nicholas Gessner, Fatima N Mirza, Dean David George, Leslie Robinson-Bostom

{"title":"临床模拟白细胞分裂性血管炎的单克隆冷球蛋白血症1例报告及文献复习。","authors":"Taylor E Arnoff, Nicholas Gessner, Fatima N Mirza, Dean David George, Leslie Robinson-Bostom","doi":"10.1097/DAD.0000000000003129","DOIUrl":null,"url":null,"abstract":"Abstract: Monoclonal cryoglobulinemia commonly presents with cutaneous manifestations and develops almost exclusively in the setting of an underlying lymphoproliferative or hematologic disorder of B-cell lineage. Herein, we describe a case of a 48-year-old woman who presented with a recurrent and symmetric hemorrhagic papular eruption. Punch biopsy and direct immunofluorescence were consistent with monoclonal cryoglobulinemia. Systemic workup was notable for elevated kappa free light chains with a monoclonal immunoglobulin M kappa component on serum protein electrophoresis, and bone marrow biopsy was consistent with lymphoplasmacytic lymphoma.","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":""},"PeriodicalIF":1.0000,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Monoclonal Cryoglobulinemia Clinically Mimicking Leukocytoclastic Vasculitis: A Case Report and Literature Review.\",\"authors\":\"Taylor E Arnoff, Nicholas Gessner, Fatima N Mirza, Dean David George, Leslie Robinson-Bostom\",\"doi\":\"10.1097/DAD.0000000000003129\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Abstract: Monoclonal cryoglobulinemia commonly presents with cutaneous manifestations and develops almost exclusively in the setting of an underlying lymphoproliferative or hematologic disorder of B-cell lineage. Herein, we describe a case of a 48-year-old woman who presented with a recurrent and symmetric hemorrhagic papular eruption. Punch biopsy and direct immunofluorescence were consistent with monoclonal cryoglobulinemia. Systemic workup was notable for elevated kappa free light chains with a monoclonal immunoglobulin M kappa component on serum protein electrophoresis, and bone marrow biopsy was consistent with lymphoplasmacytic lymphoma.\",\"PeriodicalId\":50967,\"journal\":{\"name\":\"American Journal of Dermatopathology\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":1.0000,\"publicationDate\":\"2025-09-23\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"American Journal of Dermatopathology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1097/DAD.0000000000003129\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"DERMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"American Journal of Dermatopathology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/DAD.0000000000003129","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"DERMATOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

摘要：单克隆性冷球蛋白血症通常表现为皮肤症状，并且几乎完全发生在b细胞谱系的潜在淋巴增生性或血液学疾病的背景下。在这里，我们描述了一个48岁的妇女谁提出了复发和对称出血性丘疹爆发的情况。穿刺活检和直接免疫荧光与单克隆性冷球蛋白血症一致。全身检查显示，kappa游离轻链升高，血清蛋白电泳显示单克隆免疫球蛋白M kappa成分，骨髓活检与淋巴浆细胞性淋巴瘤一致。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Monoclonal Cryoglobulinemia Clinically Mimicking Leukocytoclastic Vasculitis: A Case Report and Literature Review.

Abstract: Monoclonal cryoglobulinemia commonly presents with cutaneous manifestations and develops almost exclusively in the setting of an underlying lymphoproliferative or hematologic disorder of B-cell lineage. Herein, we describe a case of a 48-year-old woman who presented with a recurrent and symmetric hemorrhagic papular eruption. Punch biopsy and direct immunofluorescence were consistent with monoclonal cryoglobulinemia. Systemic workup was notable for elevated kappa free light chains with a monoclonal immunoglobulin M kappa component on serum protein electrophoresis, and bone marrow biopsy was consistent with lymphoplasmacytic lymphoma.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

American Journal of Dermatopathology 医学-皮肤病学

CiteScore

1.80

自引率

9.10%

发文量

453

审稿时长

3 months

期刊介绍： The American Journal of Dermatopathology offers outstanding coverage of the latest diagnostic approaches and laboratory techniques, as well as insights into contemporary social, legal, and ethical concerns. Each issue features review articles on clinical, technical, and basic science advances and illuminating, detailed case reports. With the The American Journal of Dermatopathology you''ll be able to: -Incorporate step-by-step coverage of new or difficult-to-diagnose conditions from their earliest histopathologic signs to confirmatory immunohistochemical and molecular studies. -Apply the latest basic science findings and clinical approaches to your work right away. -Tap into the skills and expertise of your peers and colleagues the world over peer-reviewed original articles, "Extraordinary cases reports", coverage of practical guidelines, and graphic presentations. -Expand your horizons through the Journal''s idea-generating forum for debating controversial issues and learning from preeminent researchers and clinicians