American Journal of Dermatopathology最新文献_第4页

Congenital Adnexal Carcinoma with Cribriform Pattern in a Pediatric Patient. 小儿先天性附件癌伴筛状型。

IF 0.8 4区医学

American Journal of Dermatopathology Pub Date : 2026-10-01 DOI: 10.1097/DAD.0000000000003446

Erika Koh, Oluwadamilare Ajayi, Danielle McClanahan, Louise van der Weyden, Jamie Billington, Josephine IIott, David J Adams, Timothy McCalmont, Kevin White

引用次数: 0

Dissecting a Diagnostic Enigma, Multiple Bilateral Facial Nodules in a Middle Aged Woman. 一位中年妇女双侧面部多发结节的诊断之谜。

IF 0.8 4区医学

American Journal of Dermatopathology Pub Date : 2026-10-01 Epub Date: 2026-08-07 DOI: 10.1097/DAD.0000000000003399

Nasser Almadan, Reem Althubaiti, Ahmed Almotairi, Chibuzo Uguru, Abdullah AlBuqaey, Mahmoud AlAwa

{"title":"Dissecting a Diagnostic Enigma, Multiple Bilateral Facial Nodules in a Middle Aged Woman.","authors":"Nasser Almadan, Reem Althubaiti, Ahmed Almotairi, Chibuzo Uguru, Abdullah AlBuqaey, Mahmoud AlAwa","doi":"10.1097/DAD.0000000000003399","DOIUrl":"10.1097/DAD.0000000000003399","url":null,"abstract":"Abstract: Hereditary leiomyomatosis and renal cell carcinoma is a rare autosomal-dominant tumor predisposition syndrome that is caused by a germline defect in fumarate hydratase. We report a case of a 40-year-old woman who presented with multiple bilateral facial nodules arranged in a zosteriform pattern that increased in distribution over 15 years. The patient reported slight pain with eating spicy food and similar lesions in her younger sister. Biopsy was performed, and histopathological examination confirmed the diagnosis of pilar leiomyoma. An immunohistochemical study showed loss of fumarate hydratase in tumoral cells with a positive internal control, confirming the diagnosis of hereditary leiomyomatosis and renal cell carcinoma. An abdominal ultrasound was performed, revealing masses in the right and left ovaries and uterus, whereas the kidneys were free from masses. This case highlights the importance of clinical suspicion and histological evaluation for any bilateral facial nodules arranged in a zosteriform pattern, which can be part of a syndrome.","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":"810-814"},"PeriodicalIF":0.8,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148690211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lipomatosis of the Median Nerve: A Case Report. 正中神经脂肪变性1例报告。

IF 0.8 4区医学

American Journal of Dermatopathology Pub Date : 2026-10-01 Epub Date: 2026-06-09 DOI: 10.1097/DAD.0000000000003345

Ayat N Ghazy, Eric C Honaker, Terrence M Katona

引用次数: 0

Clear Cell Hyperplasia of the Eccrine Duct With Eccrine Squamous Syringometaplasia: Overlapping Reactive Ductal Changes. 胰腺导管透明细胞增生伴胰腺鳞状淋巴管化生：重叠反应性导管改变。

IF 0.8 4区医学

American Journal of Dermatopathology Pub Date : 2026-10-01 Epub Date: 2026-06-24 DOI: 10.1097/DAD.0000000000003361

Carlos Abimael Salazar Martínez, Isabela Agudelo, Carolina Arboleda Gómez, Isabel Espinosa, Cristina Vélez Arroyave

引用次数: 0

Case Series of Cutaneous Rothia Mucilaginosa Infection and an Important Potential Pitfall Case. 皮肤粘胶蔷薇感染病例系列及一个重要的潜在隐患病例。

IF 0.8 4区医学

American Journal of Dermatopathology Pub Date : 2026-10-01 Epub Date: 2026-06-09 DOI: 10.1097/DAD.0000000000003340

Volha Lenskaya, Audrey Liu, Priyadharsini Nagarajan, Phyu P Aung, Jonathan L Curry, Carlos A Torres-Cabala

{"title":"Case Series of Cutaneous Rothia Mucilaginosa Infection and an Important Potential Pitfall Case.","authors":"Volha Lenskaya, Audrey Liu, Priyadharsini Nagarajan, Phyu P Aung, Jonathan L Curry, Carlos A Torres-Cabala","doi":"10.1097/DAD.0000000000003340","DOIUrl":"10.1097/DAD.0000000000003340","url":null,"abstract":"Abstract: Rothia mucilaginosa has emerged as an important opportunistic pathogen, challenging the traditional view of this organism as a harmless oral commensal. Invasive infections are increasingly recognized in immunocompromised patients, particularly those with hematolymphoid malignancies, solid organ, and stem cell transplants, and neutropenia. Cutaneous involvement, however, remains underrepresented and remains a diagnostic challenge in view of its ambiguous morphology in tissue sections and nonspecific special stains results. We report 3 cases of suspected or confirmed cutaneous involvement by R. mucilaginosa in immunocompromised patients with hematolymphoid malignancies and profound neutropenia. In all cases, the organisms appeared as small, round eosinophilic coccoid structures predominantly within the vascular spaces and forming aggregates within the papillary dermis. The organisms were positive on periodic acid-Schiff, Grocott methenamine silver, and gram stains, with some variable stain reactivity. One case demonstrated culture-proven R. mucilaginosa bacteremia with a fatal clinical course in the setting of systemic sepsis. In addition, we present a pitfall case in which platelet aggregates closely mimicked morphology of R. mucilaginosa aggregates, creating a potential diagnostic trap. In this context, CD61 immunohistochemistry was helpful in distinguishing platelet aggregates, which showed strong positivity, from R. mucilaginosa organisms, which were negative. Our findings highlight the importance of considering R. mucilaginosa in the differential diagnosis of cutaneous infections in immunocompromised patients and emphasize potential histopathologic pitfall. Awareness of the R. mucilaginosa morphologic features, its nonspecific findings on special stains and the use of adjunct immunohistochemical studies may help avoid misinterpretation and facilitate accurate diagnosis.","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":"786-790"},"PeriodicalIF":0.8,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148334241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessing Nuclear and Nucleolar Areas Between Malignant Melanoma and Benign Nevi. 恶性黑色素瘤和良性痣之间核和核仁区域的评估。

IF 0.8 4区医学

American Journal of Dermatopathology Pub Date : 2026-10-01 Epub Date: 2026-06-18 DOI: 10.1097/DAD.0000000000003355

Carol Stegura, Nolan Steevens, Hannah Neimy, Shakthika Saravanan, Maya Andrade, Hannah Morgan, Luke Broughton, Kathryn Keller, Yousef Almutairi, Yingxue Huang, Tarik Al Nasseri, Mathew J Gregoski, Manuel Valdebran, Dirk Elston

{"title":"Assessing Nuclear and Nucleolar Areas Between Malignant Melanoma and Benign Nevi.","authors":"Carol Stegura, Nolan Steevens, Hannah Neimy, Shakthika Saravanan, Maya Andrade, Hannah Morgan, Luke Broughton, Kathryn Keller, Yousef Almutairi, Yingxue Huang, Tarik Al Nasseri, Mathew J Gregoski, Manuel Valdebran, Dirk Elston","doi":"10.1097/DAD.0000000000003355","DOIUrl":"10.1097/DAD.0000000000003355","url":null,"abstract":"Abstract: Distinguishing malignant melanoma (MM) from benign melanocytic nevi presents a diagnostic challenge that can result in suboptimal management. We sought to assess whether quantifying nuclear and nucleolar areas in histological samples provided utility in differentiation. Our study used deidentified hematoxylin and eosin (H&E)-stained teaching slides, 77 MM cases and 73 benign nevi cases (N = 150). Using ImageJ software, 20 nuclei and their corresponding nucleoli were measured per slide in square pixels and converted to square microns. Nuclei selection was contingent on visualization of the nuclear envelope and a singular nucleolus. Mann-Whitney U tests were applied to compare average nuclear and nucleolar areas between groups. Significant differences were observed in both nuclear and nucleolar areas. The mean nuclear area was significantly larger in MM compared with benign nevi (702.04 ± 236.55 μm 2 vs. 481.18 ± 153.89 μm 2 ; P < 0.001). Similarly, the mean nucleolar area was markedly larger in MM compared with benign nevi (90.88 ± 52.25 μm 2 vs. 58.03 ± 25.35 μm 2 ; P < 0.001).","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":"782-785"},"PeriodicalIF":0.8,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148267114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Herpetic Whitlow in Association With a Cutaneous Infiltrate of Chronic Lymphocytic Leukemia. 疱疹性惠特洛与慢性淋巴细胞白血病皮肤浸润有关。

IF 0.8 4区医学

American Journal of Dermatopathology Pub Date : 2026-10-01 Epub Date: 2026-06-30 DOI: 10.1097/DAD.0000000000003357

Hailey Fike, Shuai Li, Tessa Farnham, Andrew Siref

引用次数: 0

PRAME Immunostaining in Acral Melanocytic Proliferations: A Meta-Analysis. 肢端黑色素细胞增殖的PRAME免疫染色：荟萃分析。

IF 0.8 4区医学

American Journal of Dermatopathology Pub Date : 2026-10-01 Epub Date: 2026-05-12 DOI: 10.1097/DAD.0000000000003299

Ana L Toussaint, Carlos Sánchez-Cárdenas, Ruth Fuentes-García, Yann Charli-Joseph, Sonia Toussaint-Caire

{"title":"PRAME Immunostaining in Acral Melanocytic Proliferations: A Meta-Analysis.","authors":"Ana L Toussaint, Carlos Sánchez-Cárdenas, Ruth Fuentes-García, Yann Charli-Joseph, Sonia Toussaint-Caire","doi":"10.1097/DAD.0000000000003299","DOIUrl":"10.1097/DAD.0000000000003299","url":null,"abstract":"Abstract: Acral cutaneous melanoma is a highly aggressive form of skin cancer that develops in palms, soles, and/or the nail unit. PReferentially expressed Antigen in MElanoma (PRAME) is an immunohistochemical marker that has shown a high degree of expression in cutaneous melanomas. However, no meta-analysis has previously focused on acral melanocytic proliferations. Herein, we performed the first meta-analysis to objectify the utility of PRAME immunohistochemistry, focusing on this understudied subtype of melanocytic proliferations involving acral sites. Thirteen studies were identified, which included 930 lesions (557 malignant and 373 benign). A random-effects model was used to calculate sensitivity, specificity, and likelihood ratios. Summary receiver operating characteristic curves and forest plots were created, and heterogeneity was assessed using Cochran Q and I 2 statistics. PRAME expression in acral melanoma showed the highest diagnostic accuracy at a cutoff value of 3+/50%, pertaining to the optimal balance between sensitivity and specificity (78% and 92%, respectively). Although PRAME immunostaining enhances the accurate diagnosis of acral melanocytic proliferations, its expression in atypical and borderline melanocytic proliferations remains controversial and shows considerable variability. Thus, the definitive diagnosis of acral melanoma still relies on careful clinicopathologic assessment and, occasionally, molecular correlation.","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":"775-781"},"PeriodicalIF":0.8,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148334286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Demonstration of 23-Gene Expression Profile Test Utility Within PRAME Immunohistochemistry Results: A Case Series. 23基因表达谱测试在PRAME免疫组化结果中的应用：一个病例系列。

IF 0.8 4区医学

American Journal of Dermatopathology Pub Date : 2026-10-01 Epub Date: 2026-07-24 DOI: 10.1097/DAD.0000000000003365

Gregory A Hosler, Matthew S Goldberg, Etan Marks

{"title":"Demonstration of 23-Gene Expression Profile Test Utility Within PRAME Immunohistochemistry Results: A Case Series.","authors":"Gregory A Hosler, Matthew S Goldberg, Etan Marks","doi":"10.1097/DAD.0000000000003365","DOIUrl":"10.1097/DAD.0000000000003365","url":null,"abstract":"Abstract: Histopathological examination using hematoxylin and eosin (H&E)-stained tissue is sufficient for diagnosing most melanocytic neoplasms as benign or malignant; however, diagnostic tools such as PRAME (preferentially expressed antigen in melanoma) immunohistochemistry (IHC) and the 23-gene expression profile (23-GEP) test can aid in the analysis of histopathologically ambiguous lesions, which can be referred to as diagnostically challenging, equivocal, indeterminate, or uncertain. When compared with the gold standard of H&E diagnosis by a dermatopathologist, PRAME IHC showed 83.2% sensitivity and 99.3% specificity in an initial validation cohort and 23-GEP showed 91.5% sensitivity and 92.7% specificity in an independent validation cohort. In addition, 23-GEP has been evaluated in 3 studies with patients with known outcomes (eg, metastasis) and has reported metrics of 90.4%-96.3% sensitivity and 87.3%-96.2% specificity in distinguishing benign versus malignant melanocytic neoplasms. In this study, we present the utility of the 23-GEP test within 8 equivocal cases with various PRAME IHC staining patterns. Cases underwent histopathological review and received at least 4 and up to 5 diagnoses each. In samples where PRAME IHC is inconclusive, conflicting, or ambiguous regarding a final diagnosis, the 23-GEP can provide additional diagnostic information to upgrade or downgrade the overall malignant potential of the lesion in question.","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":"791-797"},"PeriodicalIF":0.8,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13585158/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148334225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Look Back at Mercury Soap as a Treatment for Yaws. 水银皂治疗雅司病的回顾。

IF 0.8 4区医学

American Journal of Dermatopathology Pub Date : 2026-10-01 Epub Date: 2026-07-16 DOI: 10.1097/DAD.0000000000003364

John A Papalas

引用次数: 0