发布求助
文献互助 智能选刊 最新文献

American Journal of Dermatopathology最新文献

筛选
英文 中文
Vesiculobullous Eruption in Patient With Mycosis Fungoides. 蕈样真菌病患者的囊泡性爆发。
IF 1 4区 医学
American Journal of Dermatopathology Pub Date : 2025-09-23 DOI: 10.1097/DAD.0000000000003135
Feifan Chen, Robin H Wang, Jenna J Lullo, Sarah B Cadden, Hunter Koster, Jackson Schaeffer, Jodi J Speiser
{"title":"Vesiculobullous Eruption in Patient With Mycosis Fungoides.","authors":"Feifan Chen, Robin H Wang, Jenna J Lullo, Sarah B Cadden, Hunter Koster, Jackson Schaeffer, Jodi J Speiser","doi":"10.1097/DAD.0000000000003135","DOIUrl":"https://doi.org/10.1097/DAD.0000000000003135","url":null,"abstract":"<p><strong>Abstract: </strong>Mycosis fungoides bullosa is a rare clinical subtype of mycosis fungoides, with less than 40 cases reported in the literature. We report a case of a 66-year-old female with a history of stage IIB folliculotrophic mycosis fungoides with large cell transformation, currently being treated with romidepsin and gemcitabine, transferred to our institution due to worsening cutaneous involvement. On exam, there were large, erythematous, crusted and eroded plaques of the neck, trunk, and bilateral upper and lower extremities, some with overlying tense bullae. Punch biopsy showed a marked infiltrate of atypical CD3+ lymphocytes with epidermotropism of predominantly CD4+ cells (CD4:CD8 ratio of 8:1), loss of CD5 and CD7, and scattered CD30+ cells. Direct immunofluorescence showed a non-diagnostic staining pattern. Blood cultures were negative. Given the clinical and histopathologic findings, a diagnosis of mycosis fungoides bullosa was made. Mycosis fungoides is the most common type of cutaneous T-cell lymphoma. Mycosis fungoides bullosa, a vesiculobullous presentation of mycosis fungoides, is a rare variant first described by Dr. Moritz Kaposi in 1887. Proposed mechanisms of bullae formation include confluence of Pautrier's microabscesses or loss of keratinocyte cohesion due to proliferation of atypical lymphocytes. Diagnosis is based on the presence of vesiculobullous lesions among typical lesions of mycosis fungoides, histopathologic features consistent with mycosis fungoides, and negative evaluation for other causes of vesiculobullous lesions such as infection and autoimmune blistering diseases. Recognition is important as mycosis fungoides bullosa carries poor prognosis, with 50% of reported patients expiring within 1 year of bullae appearance.</p>","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145132516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Venous Malformation-Like Kaposi Sarcoma: Revisiting a Known Variant. 静脉畸形样卡波西肉瘤：重访一种已知变异。
IF 1 4区 医学
American Journal of Dermatopathology Pub Date : 2025-09-22 DOI: 10.1097/DAD.0000000000003134
Victoria Martínez-Sernández, José Antonio Oliva-Fernández, Andrea Beatriz Jiménez-Pérez, Diego López-Martínez, Carmen García-Moronta, Alberto Romo-Melgar, Ángel Santos-Briz
{"title":"Venous Malformation-Like Kaposi Sarcoma: Revisiting a Known Variant.","authors":"Victoria Martínez-Sernández, José Antonio Oliva-Fernández, Andrea Beatriz Jiménez-Pérez, Diego López-Martínez, Carmen García-Moronta, Alberto Romo-Melgar, Ángel Santos-Briz","doi":"10.1097/DAD.0000000000003134","DOIUrl":"https://doi.org/10.1097/DAD.0000000000003134","url":null,"abstract":"","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145114477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vulvar Nocardiosis in the Setting of dVIN: A High-Risk Infection. dVIN背景下的外阴诺卡菌病：一种高风险感染。
IF 1 4区 医学
American Journal of Dermatopathology Pub Date : 2025-09-19 DOI: 10.1097/DAD.0000000000003130
Morgan Parker, Kristen Delans, Douglas J Grider
{"title":"Vulvar Nocardiosis in the Setting of dVIN: A High-Risk Infection.","authors":"Morgan Parker, Kristen Delans, Douglas J Grider","doi":"10.1097/DAD.0000000000003130","DOIUrl":"https://doi.org/10.1097/DAD.0000000000003130","url":null,"abstract":"<p><strong>Abstract: </strong>Nocardia is a Gram positive, aerobic, partially acid-fast filamentous bacteria of the order Actinomycetales. It is a saprophytic organism found in environmental contaminants such as soil and decomposing organic matter. Primary cutaneous nocardiosis is uncommon and may occur through contamination of a wound or through inhalation of the organism with dissemination to multiple organ systems, including the skin. Vulvar nocardiosis is an exceedingly rare manifestation of Nocardia. Described is a patient with a history of lichen sclerosus, differentiated vulvar intraepithelial neoplasia (dVIN), and recurrent vulvar squamous cell carcinoma requiring multiple resections and biopsies who presented with recurrent firm, white, nodular lesions on the right labia and right inferior clitoris. Histopathology of the right inferior clitoral lesion demonstrated dVIN. The right labia majora lesion also revealed dVIN and a dermal epithelioid granuloma with central vacuoles filled with filamentous to small, fragmented forms suggestive of bacteria. Ziehl-Neelsen AFB stain was negative. Gram stain, Gomori methenamine silver (GMS), and FITE stains were positive. The staining pattern of the filamentous and beaded forms supports a diagnosis of Nocardia. Vulvar nocardiosis in the setting of dVIN and history of multiple vulvar surgeries has not been described in the literature to date. This case demonstrates the importance of maintaining atypical infections on the differential for nonhealing vulvar wounds. Timely treatment is crucial to improve outcomes, particularly in the setting of multiple surgical procedures in patients at high risk for infectious complications.</p>","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145092708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Superficial ALK-Rearranged Myxoid Spindle Cell Neoplasm With Aberrant Keratin Expression and a Rare Gene Fusion Partner. 浅表alk重排黏液样梭形细胞肿瘤伴异常角蛋白表达和罕见的基因融合伴侣。
IF 1 4区 医学
American Journal of Dermatopathology Pub Date : 2025-09-16 DOI: 10.1097/DAD.0000000000003132
Bethany Batson, Shaymaa Hegazy, Rana Naous
{"title":"Superficial ALK-Rearranged Myxoid Spindle Cell Neoplasm With Aberrant Keratin Expression and a Rare Gene Fusion Partner.","authors":"Bethany Batson, Shaymaa Hegazy, Rana Naous","doi":"10.1097/DAD.0000000000003132","DOIUrl":"https://doi.org/10.1097/DAD.0000000000003132","url":null,"abstract":"<p><strong>Abstract: </strong>Superficial ALK-rearranged myxoid spindle cell neoplasms/epithelioid fibrous histiocytoma (SAMS/EFH) are newly defined hybrid soft tissue tumors within the broader class of S100 and CD34 coexpressing spindle cell tumors that harbor receptor tyrosine kinase fusions. Several research groups have contributed to describing and characterizing the morphologic and immunophenotypic spectrum of SAMS/EFH and exploring its relationship with other similar appearing and molecularly driven neoplasms. To further expand the knowledge of this entity, we present a unique hybrid case of superficial ALK-rearranged myxoid spindle cell neoplasm/EFH with novel aberrant cytokeratin expression and rare ALK::PRKAR1A fusion, thus, adding to the spectrum of such unique and newly emerging tumors.</p>","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145076651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Teenager With a Painful Arm Nodule: Challenge. 手臂结节疼痛的青少年：挑战。
IF 1 4区 医学
American Journal of Dermatopathology Pub Date : 2025-09-12 DOI: 10.1097/DAD.0000000000003075
Lauren C Morehead, Atif Ahmed, Tyler Ketterl, Markus D Boos
{"title":"A Teenager With a Painful Arm Nodule: Challenge.","authors":"Lauren C Morehead, Atif Ahmed, Tyler Ketterl, Markus D Boos","doi":"10.1097/DAD.0000000000003075","DOIUrl":"https://doi.org/10.1097/DAD.0000000000003075","url":null,"abstract":"","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145042157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Myoepithelial Neoplasm of the Eyelid Harboring a Novel HAS2::PLAG1 Fusion and Aberrant ALK Expression: A Case Report. 眼睑肌上皮肿瘤包含一种新的HAS2::PLAG1融合和异常ALK表达：1例报告。
IF 1 4区 医学
American Journal of Dermatopathology Pub Date : 2025-09-12 DOI: 10.1097/DAD.0000000000003128
Francesco Fortarezza, Tito Brambullo, Gerardo Cazzato, Franco Bassetto, Angelo Paolo Dei Tos
{"title":"Myoepithelial Neoplasm of the Eyelid Harboring a Novel HAS2::PLAG1 Fusion and Aberrant ALK Expression: A Case Report.","authors":"Francesco Fortarezza, Tito Brambullo, Gerardo Cazzato, Franco Bassetto, Angelo Paolo Dei Tos","doi":"10.1097/DAD.0000000000003128","DOIUrl":"https://doi.org/10.1097/DAD.0000000000003128","url":null,"abstract":"<p><strong>Abstract: </strong>We report an exceptional case of a neoplasm with myoepithelial differentiation arising in the eyelid of a 50-year-old woman, representing the first documented instance of a HAS2::PLAG1 gene fusion in this anatomical location. The tumor exhibited a biphasic morphology with both spindle and epithelioid cell components and demonstrated aberrant immunohistochemical expression of ALK protein, although molecular analysis did not reveal any ALK gene rearrangements. This case underscores the importance of comprehensive molecular diagnostics in resolving immunophenotypic ambiguities and accurately classifying rare adnexal tumors.</p>","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145042192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unmasking a Persistent Rash: Challenge. 揭开持久皮疹的面纱：挑战。
IF 1 4区 医学
American Journal of Dermatopathology Pub Date : 2025-09-12 DOI: 10.1097/DAD.0000000000003085
Karima M Osman, John J Fowler, Sabrina A Newman, Shyam S Raghavan
{"title":"Unmasking a Persistent Rash: Challenge.","authors":"Karima M Osman, John J Fowler, Sabrina A Newman, Shyam S Raghavan","doi":"10.1097/DAD.0000000000003085","DOIUrl":"https://doi.org/10.1097/DAD.0000000000003085","url":null,"abstract":"","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145042127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fever, Weight Loss, and Cutaneous Nodules in an Immunocompromised Host: Challenge. 免疫功能低下宿主的发热、体重减轻和皮肤结节：挑战。
IF 1 4区 医学
American Journal of Dermatopathology Pub Date : 2025-09-12 DOI: 10.1097/DAD.0000000000003062
Satyatejas G Reddy, Katherine B Kemple, Kathryn A Potter, Matthew R Powell
{"title":"Fever, Weight Loss, and Cutaneous Nodules in an Immunocompromised Host: Challenge.","authors":"Satyatejas G Reddy, Katherine B Kemple, Kathryn A Potter, Matthew R Powell","doi":"10.1097/DAD.0000000000003062","DOIUrl":"https://doi.org/10.1097/DAD.0000000000003062","url":null,"abstract":"","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145042179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bland Spindle Cell Lesion on the Leg of a 43-Year-Old Man: Challenge. 一名43岁男性腿部无明显梭形细胞病变：挑战。
IF 1 4区 医学
American Journal of Dermatopathology Pub Date : 2025-09-12 DOI: 10.1097/DAD.0000000000003049
Chase T Trybula, Daniel D Wong, Benjamin A Wood
{"title":"Bland Spindle Cell Lesion on the Leg of a 43-Year-Old Man: Challenge.","authors":"Chase T Trybula, Daniel D Wong, Benjamin A Wood","doi":"10.1097/DAD.0000000000003049","DOIUrl":"https://doi.org/10.1097/DAD.0000000000003049","url":null,"abstract":"","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145042210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multiple Exophytic and Ulcerated Plaques and Nodules: Challenge. 多发性外生性和溃疡斑块和结节：挑战。
IF 1 4区 医学
American Journal of Dermatopathology Pub Date : 2025-09-12 DOI: 10.1097/DAD.0000000000003067
Kinan M Hayani, Rute F Lellis, Omar P Sangüeza
{"title":"Multiple Exophytic and Ulcerated Plaques and Nodules: Challenge.","authors":"Kinan M Hayani, Rute F Lellis, Omar P Sangüeza","doi":"10.1097/DAD.0000000000003067","DOIUrl":"https://doi.org/10.1097/DAD.0000000000003067","url":null,"abstract":"","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145042143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：604180095
Book学术官方微信