{"title":"Superficial ALK-Rearranged Myxoid Spindle Cell Neoplasm With Aberrant Keratin Expression and a Rare Gene Fusion Partner.","authors":"Bethany Batson, Shaymaa Hegazy, Rana Naous","doi":"10.1097/DAD.0000000000003132","DOIUrl":null,"url":null,"abstract":"<p><strong>Abstract: </strong>Superficial ALK-rearranged myxoid spindle cell neoplasms/epithelioid fibrous histiocytoma (SAMS/EFH) are newly defined hybrid soft tissue tumors within the broader class of S100 and CD34 coexpressing spindle cell tumors that harbor receptor tyrosine kinase fusions. Several research groups have contributed to describing and characterizing the morphologic and immunophenotypic spectrum of SAMS/EFH and exploring its relationship with other similar appearing and molecularly driven neoplasms. To further expand the knowledge of this entity, we present a unique hybrid case of superficial ALK-rearranged myxoid spindle cell neoplasm/EFH with novel aberrant cytokeratin expression and rare ALK::PRKAR1A fusion, thus, adding to the spectrum of such unique and newly emerging tumors.</p>","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":""},"PeriodicalIF":1.0000,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"American Journal of Dermatopathology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/DAD.0000000000003132","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"DERMATOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Abstract: Superficial ALK-rearranged myxoid spindle cell neoplasms/epithelioid fibrous histiocytoma (SAMS/EFH) are newly defined hybrid soft tissue tumors within the broader class of S100 and CD34 coexpressing spindle cell tumors that harbor receptor tyrosine kinase fusions. Several research groups have contributed to describing and characterizing the morphologic and immunophenotypic spectrum of SAMS/EFH and exploring its relationship with other similar appearing and molecularly driven neoplasms. To further expand the knowledge of this entity, we present a unique hybrid case of superficial ALK-rearranged myxoid spindle cell neoplasm/EFH with novel aberrant cytokeratin expression and rare ALK::PRKAR1A fusion, thus, adding to the spectrum of such unique and newly emerging tumors.
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The American Journal of Dermatopathology offers outstanding coverage of the latest diagnostic approaches and laboratory techniques, as well as insights into contemporary social, legal, and ethical concerns. Each issue features review articles on clinical, technical, and basic science advances and illuminating, detailed case reports.
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