34βE12是角蛋白来源的皮肤淀粉样蛋白最可靠的标志物：一项比较研究

IF 1.1 4区医学 Q4 DERMATOLOGY

American Journal of Dermatopathology Pub Date : 2025-06-01 Epub Date: 2025-02-19 DOI:10.1097/DAD.0000000000002942

Maged Daruish, Ghada Al-Sharbatee, Corrado D'Arrigo, Saleem Taibjee

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引用次数: 0

摘要

摘要：刚果红（CR）是病理学家检测淀粉样蛋白沉积最常用的染色方法。然而，CR有局限性，包括可变的敏感性和假阴性结果的可能性。我们研究了CR的染色强度，并将其与市购的细胞角蛋白免疫组化标记物进行了比较，这些标记物是由角蛋白丝引起的原发性皮肤淀粉样变性。

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34βE12 is the Most Reliable Marker for Keratin-Derived Cutaneous Amyloid: A Comparative Study.

Abstract: Congo red (CR) remains the most commonly used stain by pathologists to detect amyloid deposition. CR, however, has limitations including variable sensitivity with potential of false negative results. We investigated the staining intensity of CR in comparison to commercially available cytokeratin immunohistochemical markers in a series of primary cutaneous amyloidosis originating from keratin filaments.

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来源期刊

American Journal of Dermatopathology 医学-皮肤病学

CiteScore

1.80

自引率

9.10%

发文量

453

审稿时长

3 months

期刊介绍： The American Journal of Dermatopathology offers outstanding coverage of the latest diagnostic approaches and laboratory techniques, as well as insights into contemporary social, legal, and ethical concerns. Each issue features review articles on clinical, technical, and basic science advances and illuminating, detailed case reports. With the The American Journal of Dermatopathology you''ll be able to: -Incorporate step-by-step coverage of new or difficult-to-diagnose conditions from their earliest histopathologic signs to confirmatory immunohistochemical and molecular studies. -Apply the latest basic science findings and clinical approaches to your work right away. -Tap into the skills and expertise of your peers and colleagues the world over peer-reviewed original articles, "Extraordinary cases reports", coverage of practical guidelines, and graphic presentations. -Expand your horizons through the Journal''s idea-generating forum for debating controversial issues and learning from preeminent researchers and clinicians