Mohammad Hassan Kalantar, Parvin-Dokht Bayat, Sahar Ghaffari Khaligh, Homa Soleimani
{"title":"The role of curcumin during pregnancy on the exposed fetuses' tissues of Wistar rats to electromagnetic field.","authors":"Mohammad Hassan Kalantar, Parvin-Dokht Bayat, Sahar Ghaffari Khaligh, Homa Soleimani","doi":"10.1080/15368378.2024.2315214","DOIUrl":"10.1080/15368378.2024.2315214","url":null,"abstract":"<p><p>To investigate curcumin (CUR) as the protector against the harmful effects of low-frequency electromagnetic field(LF- EMF, 50 Hz) during pregnancy period, 5 males and 15 females of Wistar rat mated and vaginal plaques were observed. Then, the pregnant rats were divided into six groups. During pregnancy(21 days), the EMF group was exposed to EMF for 30 min/day, the CUR group received a single dose of 50 mg/kg/daily CUR intraperitoneal, the EMF+CUR group was injected CUR and exposed to EMF daily. The DMSO(dimethyl sulfoxide) group was injected solvent of CUR (DMSO) intraperitoneal with the same volume of CUR solvent, the sham group was placed through the solenoid in the same conditions as the first group without exposure and the control group was kept in their cage in normal condition. After four weeks, babies born were divided according to the mother groups and sacrificed. Then, the three tissues injuries were investigated. EMF exposure led to an increase in outstanding necrotic areas in hippocampal tissue, an increase in the amount of hyperemia(<i>p</i> = 0.017) and necrotic(<i>p</i> = 0.005) in kidneys, and degeneration in liver tissue(<i>p</i> = 0.007) in the EMF group compared with EMF+CUR groups. A single dose of CUR daily during pregnancy can protect these tissues from injuries caused by LF-EMF exposure in rat fetuses.</p>","PeriodicalId":50544,"journal":{"name":"Electromagnetic Biology and Medicine","volume":" ","pages":"71-80"},"PeriodicalIF":1.7,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139747734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jarosław Pasek, Sebastian Szajkowski, Grzegorz Cieślar
{"title":"Comparison of the therapeutic efficacy of magneto-LED therapy and magnetostimulation applied as the adjuvant treatment of venous leg ulcers - preliminary study.","authors":"Jarosław Pasek, Sebastian Szajkowski, Grzegorz Cieślar","doi":"10.1080/15368378.2024.2325414","DOIUrl":"10.1080/15368378.2024.2325414","url":null,"abstract":"<p><strong>Purpose: </strong>Venous leg ulcers are chronic wounds that are difficult to cure. The aim of the study was to compare the therapeutic efficacy of two methods of physical medicine - magneto-LED therapy and magnetostimulation, applied as adjuvant treatment in the treatment of venous leg ulcers.</p><p><strong>Methods: </strong>The study included 81 patients, 37 male (45.6%) and 44 female (54.3%) ones, age range between 45 and 90 years, with venous leg ulcers. The patients were assigned to two study groups: magneto-LED therapy (group 1) or magnetostimulation (group 2). In both groups, a total of 40 daily procedures were performed. Wound healing was evaluated using computerized planimetry and the pain intensity on numeric rating scale.</p><p><strong>Results: </strong>After treatment, the decrease in healing rate in group 1 was statistically significantly higher in comparison to group 2 (<i>p</i> < 0.001), while a statistically significant reduction in the surface area of ulcers was obtained, amounting on the average from 6.34 ± 1.29 cm<sup>2</sup> to 2.31 ± 1.25 cm<sup>2</sup> in group 1 (<i>p</i> < 0.001), and from 6.52 ± 1.20 cm<sup>2</sup> to 4.79 ± 1.17 cm<sup>2</sup> in group 2 (<i>p</i> < 0.001). The percentage changes of ulcers area in group 1 (64.21 ± 17.94%) were statistically significantly greater as compared to group 2 (25.87 ± 14.07%) (<i>p</i> < 0.001). After treatment, the decrease in pain relief in group 1 was statistically significantly higher in comparison to group 2 (<i>p</i> = 0.006), while pain intensity after treatment decreased statistically significantly in both compared groups of patients (<i>p</i> < 0.001).</p><p><strong>Conclusions: </strong>Magneto-LED therapy and magnetostimulation caused significant reduction of surface area of the treated venous leg ulcers and pain intensity, yet magneto-LED therapy was more efficient. Both evaluated methods also significantly reduced pain intensity.</p>","PeriodicalId":50544,"journal":{"name":"Electromagnetic Biology and Medicine","volume":" ","pages":"95-106"},"PeriodicalIF":1.7,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140050910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The influence of microwave ablation parameters on the positioning of trocar in different cancerous tissues: a numerical study.","authors":"Vellavalapalli Satish, Ramjee Repaka","doi":"10.1080/15368378.2024.2333802","DOIUrl":"10.1080/15368378.2024.2333802","url":null,"abstract":"<p><p>The present study analyzed the microwave ablation of cancerous tumors located in six major cancer-prone organs and estimated the significance of input power and treatment time parameters in the apt positioning of the trocar into the tissue during microwave ablation. The present study has considered a three-dimensional two-compartment tumour-embedded tissue model. FEA based COMSOL Multiphysics software with inbuilt bioheat transfer, electromagnetic waves, heat transfer in solids and fluids, and laminar flow physics has been used to obtain the numerical results. Based on the mortality rates caused by cancer, the present study has considered six major organs affected by cancer, viz. lung, breast, stomach/gastric, liver, liver (with colon metastasis), and kidney for MWA analysis. The input power (100 W) and ablation times (4 minutes) with apt and inapt positioning of the trocar have been considered to compare the ablation volume of various cancerous tissues. The present study addresses one of the major problems clinicians face, i.e. the proper placement of the trocar due to poor imaging techniques and human error, resulting in incomplete tumor ablation and increased surgical procedures. The highest values of the ablation region have been observed for the liver, colon metastatic liver and breast cancerous tissues compared with other organs at the same operating conditions.</p>","PeriodicalId":50544,"journal":{"name":"Electromagnetic Biology and Medicine","volume":" ","pages":"125-134"},"PeriodicalIF":1.7,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140295174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Senthil Pandi S, Senthilselvi A, Kumaragurubaran T, Dhanasekaran S
{"title":"Self-attention-based generative adversarial network optimized with color harmony algorithm for brain tumor classification.","authors":"Senthil Pandi S, Senthilselvi A, Kumaragurubaran T, Dhanasekaran S","doi":"10.1080/15368378.2024.2312363","DOIUrl":"10.1080/15368378.2024.2312363","url":null,"abstract":"<p><p>This paper proposes a novel approach, BTC-SAGAN-CHA-MRI, for the classification of brain tumors using a SAGAN optimized with a Color Harmony Algorithm. Brain cancer, with its high fatality rate worldwide, especially in the case of brain tumors, necessitates more accurate and efficient classification methods. While existing deep learning approaches for brain tumor classification have been suggested, they often lack precision and require substantial computational time.The proposed method begins by gathering input brain MR images from the BRATS dataset, followed by a pre-processing step using a Mean Curvature Flow-based approach to eliminate noise. The pre-processed images then undergo the Improved Non-Sub sampled Shearlet Transform (INSST) for extracting radiomic features. These features are fed into the SAGAN, which is optimized with a Color Harmony Algorithm to categorize the brain images into different tumor types, including Gliomas, Meningioma, and Pituitary tumors. This innovative approach shows promise in enhancing the precision and efficiency of brain tumor classification, holding potential for improved diagnostic outcomes in the field of medical imaging. The accuracy acquired for the brain tumor identification from the proposed method is 99.29%. The proposed BTC-SAGAN-CHA-MRI technique achieves 18.29%, 14.09% and 7.34% higher accuracy and 67.92%,54.04%, and 59.08% less Computation Time when analyzed to the existing models, like Brain tumor diagnosis utilizing deep learning convolutional neural network with transfer learning approach (BTC-KNN-SVM-MRI); M3BTCNet: multi model brain tumor categorization under metaheuristic deep neural network features optimization (BTC-CNN-DEMFOA-MRI), and efficient method depending upon hierarchical deep learning neural network classifier for brain tumour categorization (BTC-Hie DNN-MRI) respectively.</p>","PeriodicalId":50544,"journal":{"name":"Electromagnetic Biology and Medicine","volume":" ","pages":"31-45"},"PeriodicalIF":1.7,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139900728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jun Zhou, Feiyang Jia, Mengjian Qu, Pengyun Ning, Xiarong Huang, Lu Tan, Danni Liu, Peirui Zhong, Qi Wu
{"title":"The prevention effect of pulsed electromagnetic fields treatment on senile osteoporosis in vivo via improving the inflammatory bone microenvironment.","authors":"Jun Zhou, Feiyang Jia, Mengjian Qu, Pengyun Ning, Xiarong Huang, Lu Tan, Danni Liu, Peirui Zhong, Qi Wu","doi":"10.1080/15368378.2024.2314093","DOIUrl":"10.1080/15368378.2024.2314093","url":null,"abstract":"<p><p>This study aimed to assess PEMF in a rat model of senile osteoporosis and its relationship with NLRP3-mediated low-grade inflammation in the bone marrow microenvironment. A total of 24 Sprague Dawley (SD) rats were included in this study. Sixteen of them were 24-month natural-aged male SD rats, which were randomly distributed into the Aged group and the PEMF group (<i>n</i> = 8 per group). The remaining 8 3-month -old rats were used as the Young positive control group (<i>n</i> = 8). Rats in the PEMF group received 12 weeks of PEMF with 40 min/day, five days per week, while the other rats received placebo PEMF intervention. Bone mineral density/microarchitecture, serum levels of CTX-1 and P1CP, and NLRP3-related signaling genes and proteins in rat bone marrow were then analyzed. The 12-week of PEMF showed significant mitigation of aging-induced bone loss and bone microarchitecture deterioration, i.e. PEMF increased the bone mineral density of the proximal femur and L5 vertebral body and improved parameters of the proximal tibia and L4 vertebral body. Further analysis showed that PEMF reversed aging-induced bone turnover, specifically, decreased serum CTX-1 and elevated serum P1CP. Furthermore, PEMF also dramatically inhibited NLRP3-mediated low-grade inflammation in the bone marrow, i.e. PEMF inhibited the levels of NLRP3, proCaspase1, cleaved Caspase1, IL-1β, and GSDMD-N. The study demonstrated that PEMF could mitigate the aging-induced bone loss and reverses the deterioration of bone microarchitecture probably through inhibiting NLRP3-mediated low-grade chronic inflammation to improve the inflammatory bone microenvironment in aged rats.</p>","PeriodicalId":50544,"journal":{"name":"Electromagnetic Biology and Medicine","volume":" ","pages":"46-60"},"PeriodicalIF":1.7,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139703951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jing Liu, Jun Zhou, Xiarong Huang, Linwei Yin, Long Zhou, Yang Liao, Guanghua Sun, Peirui Zhong, Xinke Peng, Zhilu Sun
{"title":"Protective effects of pulsed electromagnetic field therapy attenuates autophagy and apoptosis in osteoporotic osteoarthritis model rats by activating PPARγ.","authors":"Jing Liu, Jun Zhou, Xiarong Huang, Linwei Yin, Long Zhou, Yang Liao, Guanghua Sun, Peirui Zhong, Xinke Peng, Zhilu Sun","doi":"10.1080/15368378.2024.2314108","DOIUrl":"10.1080/15368378.2024.2314108","url":null,"abstract":"<p><p>Osteoporotic osteoarthritis (OPOA) is a specific phenotype of OA with high incidence and severe cartilage damage. This study aimed to explore the protective efficacy of PEMF on the progression of OPOA and observed the effects of PEMF on PPARγ, autophagy- and apoptosis-related proteins in OPOA rats. Rats were randomly divided into three groups: control group, OPOA group, and PEMF group (<i>n</i> = 6). One week after surgery, the rats in PEMF group were subjected to PEMF (3.82 mT, 8 Hz, 40 min/day and 5 day/week) for 12 weeks. Results showed that PEMF retarded cartilage degeneration and bone loss, as evidenced by pathological staining image, decreased MMP-13 expression and increased bone mineral density. PEMF inhibited the serum levels of inflammatory cytokines, and the expressions of caspase-3 and caspase-8, while upregulated the expression of PPARγ. Moreover, PEMF significantly improved the autophagy disorders, represented by decrease expressions of Beclin-1, P62, and LC3B. The research demonstrates that PEMF can effectively prevent cartilage and subchondral bone destruction in OPOA rats. The potential mechanism may be related to upregulation of PPARγ, inhibition of chondrocyte apoptosis and inflammation, and improvement of autophagy disorder. PEMF therapy thus shows promising application prospects in the treatment of postmenopausal OA.</p>","PeriodicalId":50544,"journal":{"name":"Electromagnetic Biology and Medicine","volume":" ","pages":"61-70"},"PeriodicalIF":1.7,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139724847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Lakshmi, Manjunathan Alagarsamy, A. Anbarasa Pandian, Dinesh Paramathi Mani
{"title":"Evolutionary gravitational neocognitron neural network optimized with marine predators optimization algorithm for MRI brain tumor classification","authors":"A. Lakshmi, Manjunathan Alagarsamy, A. Anbarasa Pandian, Dinesh Paramathi Mani","doi":"10.1080/15368378.2024.2301952","DOIUrl":"https://doi.org/10.1080/15368378.2024.2301952","url":null,"abstract":"Magnetic resonance imaging (MRI) is a powerful tool for tumor diagnosis in human brain. Here, the MRI images are considered to detect the brain tumor and classify the regions as meningioma, glioma,...","PeriodicalId":50544,"journal":{"name":"Electromagnetic Biology and Medicine","volume":"12 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139461879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Thermal damage map prediction during irreversible electroporation with U-Net","authors":"Amir Khorasani","doi":"10.1080/15368378.2023.2299212","DOIUrl":"https://doi.org/10.1080/15368378.2023.2299212","url":null,"abstract":"Recent developments in cancer treatment with irreversible electroporation (IRE) have led to a renewed interest in developing a treatment planning system based on Deep-Learning methods. This paper w...","PeriodicalId":50544,"journal":{"name":"Electromagnetic Biology and Medicine","volume":"95 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2023-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139066767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Metamaterial based AMC backed archimedean spiral antenna for in-vitro microwave hyperthermia of skin cancer","authors":"Komalpreet Kaur, Amanpreet Kaur","doi":"10.1080/15368378.2023.2297954","DOIUrl":"https://doi.org/10.1080/15368378.2023.2297954","url":null,"abstract":"This research article presents a study that uses microwave frequencies (ISM band) for treatment of skin cancer by heating the malignant cells on skin with a Microwave Hyperthermia (MWHT) applicator...","PeriodicalId":50544,"journal":{"name":"Electromagnetic Biology and Medicine","volume":"33 4 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2023-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139066821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Shortwave radiation-induced reproductive organ damage in male rats by enhanced expression of molecules associated with the calpain/Cdk5 pathway and oxidative stress.","authors":"Binwei Yao, Junqi Men, Shuchen Liu, Yanxin Bai, Chao Yu, Yabing Gao, Xinping Xu, Li Zhao, Jing Zhang, Hui Wang, Yanyang Li, Ruiyun Peng","doi":"10.1080/15368378.2023.2296896","DOIUrl":"10.1080/15368378.2023.2296896","url":null,"abstract":"<p><p>Shortwave radiation has been reported to have harmful effects on several organs in humans and animals. However, the biological effects of 27 MHz shortwave on the reproductive system are not clear. In this study, we investigated the effects of shortwave whole-body exposure at a frequency of 27 MHz on structural and functional changes in the testis. Male Wistar rats were exposed to 27 MHz continuous shortwaves at average power densities of 0, 5, 10, or 30 mW/cm<sup>2</sup> for 6 min. The levels of insulin-like factor 3 (INSL3) and anti-sperm antibodies (AsAb) in the peripheral serum, sperm motility, sperm malformation rate, and testicular tissue structure of rats were analyzed. Furthermore, the activity of superoxide dismutase (SOD), catalase (CAT), malondialdehyde (MDA) content, calpain, and Cdk5 expression were analyzed at 1, 7, 14, and 28 days after exposure. We observed that the rats after radiation had decreased serum INSL3 levels (<i>p</i> < 0.01), increased AsAb levels (<i>p</i> < 0.05), decreased percentage of class A+B sperm (<i>p</i> < 0.01 or <i>p</i> < 0.05), increased sperm malformation (<i>p</i> < 0.01 or <i>p</i> < 0.05), injured testicular tissue structure, decreased SOD and CAT activities (<i>p</i> < 0.01 or <i>p</i> < 0.05), increased MDA content (<i>p</i> < 0.01), and testicular tissue expressions of calpain1, calpain2, and Cdk5 were increased (<i>p</i> < 0.01 or <i>p</i> < 0.05). In conclusion, Shortwave radiation caused functional and structural damage to the reproductive organs of male rats. Furthermore, oxidative stress and key molecules in the calpain/Cdk5 pathway are likely involved in this process.</p>","PeriodicalId":50544,"journal":{"name":"Electromagnetic Biology and Medicine","volume":" ","pages":"150-162"},"PeriodicalIF":1.7,"publicationDate":"2023-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139059036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}