Electromagnetic Biology and Medicine最新文献_第4页

Assessing the potential of carbon fibre reinforced polymer shielding in protecting male reproductive health from mobile phone radiation. 评估碳纤维增强聚合物屏蔽在保护男性生殖健康免受移动电话辐射方面的潜力。

IF 1.5 4区生物学

Electromagnetic Biology and Medicine Pub Date : 2026-01-01 Epub Date: 2025-10-10 DOI: 10.1080/15368378.2025.2571658

Irmawan Farindra, Soetjipto, Viskasari P Kalanjati, Alya Putri Sakinah, Warda Elmaida Rusdi, Andi Roesbiantoro, Bambang Edi Suwito, Irsandi Rizki Farmananda

{"title":"Assessing the potential of carbon fibre reinforced polymer shielding in protecting male reproductive health from mobile phone radiation.","authors":"Irmawan Farindra, Soetjipto, Viskasari P Kalanjati, Alya Putri Sakinah, Warda Elmaida Rusdi, Andi Roesbiantoro, Bambang Edi Suwito, Irsandi Rizki Farmananda","doi":"10.1080/15368378.2025.2571658","DOIUrl":"10.1080/15368378.2025.2571658","url":null,"abstract":"Purpose: This study evaluates the protective potential of carbon fibre-reinforced polymer (CFRP) shielding against the adverse effects of 1800 MHz electromagnetic radiation (EMR) from mobile phones on male reproductive indicators in Wistar rats.Materials and methods: Twenty-four adult male Wistar rats were randomly assigned to three groups (n = 8): i. control (no treatment); ii. EMR exposure; iii. EMR exposure with CFRP shielding. The exposure groups were exposed to EMR from an activated 1800 MHz and Specific Absorption Rate (SAR) = 0.897 W/Kg mobile phone for 2 hours/day for 30 days. The shielding consisted of four CFRP prepreg layers (two layers of 210 g/m² and two layers of 450 g/m²), with a total thickness of 2 mm. After the exposure period, sperm analysis (motility, viability, and morphology), serum testosterone, testicular histology, and malondialdehyde (MDA) levels were examined.Results: EMR significantly reduced testosterone levels, sperm viability, sperm morphology, diameter of the seminiferous tubule (ST) (p < 0.05), and interstitial cells of Leydig counts compared to the control groups (p < 0.05). The results also revealed a significant increase in MDA levels in the EMR-exposed group compared to the control group (p < 0.05). Furthermore, the treatment had a positive effect on the CFRP shield group, as these variables were actually better compared to the EMR group without shield.Conclusions: CFRP shielding is proven to reduce the negative impacts of 1800 MHz EMR emitted from mobile phone exposure on sperm quality, testosterone levels, histological testicular, and MDA levels of male Wistar rats.","PeriodicalId":50544,"journal":{"name":"Electromagnetic Biology and Medicine","volume":" ","pages":"137-148"},"PeriodicalIF":1.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145259796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Changes in miR-21, -138, -141, -135 expression and apoptosis/necrosis levels in HCT116 colon cancer cells under 50 Hz ELF-EMF exposure at 0.4 and 0.8 mT. 在0.4和0.8 mT的50 Hz ELF-EMF暴露下，HCT116结肠癌细胞中miR-21、-138、-141、-135表达和凋亡/坏死水平的变化

IF 1.5 4区生物学

Electromagnetic Biology and Medicine Pub Date : 2026-01-01 Epub Date: 2026-02-23 DOI: 10.1080/15368378.2026.2635039

Mehdi Miladi, Javad Behroozi, Ali Shakerimoghaddam, Mohammad Foad Heidari, Soheila Abdi, Arezoo Farhadi, Hamed Naghoosi, Mohsen Chamanara, Mehrdad Hashemi, Mahmoud Vahidi

{"title":"Changes in miR-21, -138, -141, -135 expression and apoptosis/necrosis levels in HCT116 colon cancer cells under 50 Hz ELF-EMF exposure at 0.4 and 0.8 mT.","authors":"Mehdi Miladi, Javad Behroozi, Ali Shakerimoghaddam, Mohammad Foad Heidari, Soheila Abdi, Arezoo Farhadi, Hamed Naghoosi, Mohsen Chamanara, Mehrdad Hashemi, Mahmoud Vahidi","doi":"10.1080/15368378.2026.2635039","DOIUrl":"10.1080/15368378.2026.2635039","url":null,"abstract":"In this study, we investigated the effect of extremely low-frequency electromagnetic fields (ELF-EMF) on colorectal cancer cells. HCT116 colorectal carcinoma cells were exposed to an electromagnetic field under various conditions encompassing three variables: time (9 and 18 hours), field intensity (0.4 and 0.8 milliTesla), and continuity (continuous and discontinuous), resulting in eight distinct irradiated groups alongside control groups (untreated cancer cells). The levels of apoptosis and necrosis in the different groups were measured and compared using flow cytometry. Furthermore, changes in the expression of miR-21, miR-141, miR-135, and miR-138 were evaluated using RT-qPCR, with the results indicating a significant alteration in the expression of these microRNAs under exposure to electromagnetic fields. Considering previous studies on the effects of these microRNA expressions in cancer cells and our study's findings, the observed expression changes under our applied irradiation conditions - specifically, the downregulation of miR-135 and miR-21, and the upregulation of miR-141-suggested a positive role in controlling and suppressing tumor growth and cancer cells. Conversely, the downregulation of miR-138 appeared to be a negative factor. Additionally, flow cytometry results demonstrated an increase in the rates of apoptosis and necrosis under the employed electromagnetic fields.","PeriodicalId":50544,"journal":{"name":"Electromagnetic Biology and Medicine","volume":" ","pages":"251-262"},"PeriodicalIF":1.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147277596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Performance evaluation and personalized electric field prediction of the deep H1 coil in the human brain based on simulation and machine learning. 基于仿真和机器学习的人脑深H1线圈性能评价与个性化电场预测

IF 1.5 4区生物学

Electromagnetic Biology and Medicine Pub Date : 2026-01-01 Epub Date: 2025-09-23 DOI: 10.1080/15368378.2025.2561001

Xinhua Tan, Ao Guo, Yifan Wang, Jiasheng Tian, Jian Shi, Yingwei Li

{"title":"Performance evaluation and personalized electric field prediction of the deep H1 coil in the human brain based on simulation and machine learning.","authors":"Xinhua Tan, Ao Guo, Yifan Wang, Jiasheng Tian, Jian Shi, Yingwei Li","doi":"10.1080/15368378.2025.2561001","DOIUrl":"10.1080/15368378.2025.2561001","url":null,"abstract":"Deep transcranial magnetic stimulation (DTMS) has been increasingly used to treat neurological disorders in recent years. However, owing to the complicated configuration of DTMS coils, such as the H1 coil, the electric field induced by it in the personalized human brain is so varied and complex that its transcranial magnetic stimulation performances, especially focusing behavior and depth characteristics, have to be studied and evaluated further before clinical application. Therefore, besides the effects of the excitation frequency of the H1 coils, two types of magnetic shielding blocks (MSBs) with various dimensions were analyzed, and the H1 coil circuit structure with flexible length adjustment and its coil spacing were also investigated in this study. Finally, a machine learning model based on an optimizable tree algorithm was established to rapidly predict the induced electric field in the personalized human brain. Results demonstrated that the half-value depth D1/2 of the electric field induced by the H1 coil could reach 3.67 cm, which was deeper than that by the figure-of-eight (FOE) coil (<1.6 cm), but its focusing (half-value) volume V1/2 was 567.94 cm3, larger than that of the FOE coil. After introducing MSBs, reasonably adjusting the coil circuit length and the coil spacing, V1/2 was reduced to 81.748 cm3, with a slight increase in D1/2. The proposed machine learning model exhibited a good prediction performance (R2 = 0.99, etc.) and only took about 0.014 s to finish predicting the induced electric field in the personalized human brain for rapidly evaluating the H1 coil performance in clinical practices.","PeriodicalId":50544,"journal":{"name":"Electromagnetic Biology and Medicine","volume":" ","pages":"22-47"},"PeriodicalIF":1.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145126394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

One-year follow-up of thyroid status in rats exposed to 2.45 Ghz radiofrequency radiation during the prenatal period. 产前暴露于2.45 Ghz射频辐射的大鼠甲状腺状态的一年随访。

IF 1.5 4区生物学

Electromagnetic Biology and Medicine Pub Date : 2026-01-01 Epub Date: 2025-10-22 DOI: 10.1080/15368378.2025.2577318

Cemal Özyılmaz, Süleyman Daşdağ, Mehmet Faruk Oktay, Engin Ulukaya, Merve Erkısa Genel, Funda Emre, Korkut Yeğin

{"title":"One-year follow-up of thyroid status in rats exposed to 2.45 Ghz radiofrequency radiation during the prenatal period.","authors":"Cemal Özyılmaz, Süleyman Daşdağ, Mehmet Faruk Oktay, Engin Ulukaya, Merve Erkısa Genel, Funda Emre, Korkut Yeğin","doi":"10.1080/15368378.2025.2577318","DOIUrl":"10.1080/15368378.2025.2577318","url":null,"abstract":"The aim of this study is to investigate the thyroid status of offspring exposed to prenatal 2.45 GHz radiofrequency radiation (RFR). In this study, which is the second phase of our previous study, the thyroids of rats exposed to prenatal 2.45 GHz RFR were examined one year after birth. The mothers of the offspring in the experimental group (n = 8) were exposed to 2.45 GHz RFR (whole-body specific absorption rate (SAR): 12 mW/kg; maximum point SAR: 25 mW/kg) 24 hours per day throughout pregnancy. The mothers in the sham group (n = 8) were kept under the same experimental conditions except for RFR exposure. The offspring in this study were not exposed to RFR after birth and continued their daily lives for one year. When the offspring reached one year of age, they were sacrificed and their thyroids were removed and evaluated. Mann-Whitney U and t tests were used for statistical analysis. Increases in fibrosis (p = 0.038), atypical thyrocytes (p = 0.002) and degenerated follicles (p = 0.007) and colloid reduction (p = 0.002) were found to be significant in the experimental group compared to the sham group. However, the increase in the percentage of apoptosis positive cells (p = 0.006) and H2A.X antibody levels (p = 0.007) showed a statistically significant difference in the experimental group compared to the sham group. This study provides evidence that prenatal exposure to 2.45 GHz RFR can induce persistent histological changes, increase apoptosis, and cause DNA double-strand breaks in thyroid tissue observed one year after birth. These results underscore the importance of further long-term studies to assess developmental risks associated with prenatal RFR exposure.","PeriodicalId":50544,"journal":{"name":"Electromagnetic Biology and Medicine","volume":" ","pages":"160-169"},"PeriodicalIF":1.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145349910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Radiofrequency electromagnetic fields in Alzheimer's therapy: emerging evidence and future prospects. 射频电磁场在阿尔茨海默病治疗中的应用：新证据和未来展望。

IF 1.5 4区生物学

Electromagnetic Biology and Medicine Pub Date : 2026-01-01 Epub Date: 2026-02-06 DOI: 10.1080/15368378.2026.2627962

Wenjia Liu, Xin Rao, Wen Sun, Xiaodong Chen, Liyang Yu, Jiangtao Zhang

引用次数: 0

Effects of exposure to nearby mobile phone base stations and mobile phone usage on human blood parameters. 接触附近移动电话基站和使用移动电话对人体血液参数的影响。

IF 1.5 4区生物学

Electromagnetic Biology and Medicine Pub Date : 2026-01-01 Epub Date: 2026-02-06 DOI: 10.1080/15368378.2026.2623473

Laldinpuii, Lalhruaitluangi Sailo, Steven Weller, C Lalfamkima Varte, Lalchhandami Tochhawng, Priyanka Bandara, Julie E McCredden, Zothansiama

{"title":"Effects of exposure to nearby mobile phone base stations and mobile phone usage on human blood parameters.","authors":"Laldinpuii, Lalhruaitluangi Sailo, Steven Weller, C Lalfamkima Varte, Lalchhandami Tochhawng, Priyanka Bandara, Julie E McCredden, Zothansiama","doi":"10.1080/15368378.2026.2623473","DOIUrl":"10.1080/15368378.2026.2623473","url":null,"abstract":"The present study investigates the impact of RF-EMF (900 and 1800 MHz) emissions from mobile phone base stations (MPBS) as well as from mobile phone usage on the hematological parameters and stress markers of exposed individuals. Members of MPBS highly exposed (N = 50) and a reference group (N = 51) were tested using a complete blood count and two stress markers, amylase and cortisol. Different effects were found for different blood parameters, based on various combinations of exposure type, demographics, and lifestyle behaviors. Subsequent stepwise regression analysis revealed that exposure from MPBS contributed significantly to TLC, while various combinations of gender, age and power density contributed significantly to differential and absolute basophil counts and absolute monocyte counts. MPBS exposures contributed to absolute monocytes similar to smoking. Furthermore, hours of daily mobile phone exposure together with age contributed significantly to absolute and differential basophil counts and absolute lymphocyte counts. Of concern, almost a quarter of those with high MPBS exposures had basophil counts above the clinical reference limits, while over half of those with heavy daily mobile phone use (4 to 6 hours) had lymphocyte counts above the limits, and most were under 30 years old. While smoking and age contributed to amylase levels, no exposure variables contributed to amylase or cortisol levels. Altogether, there is an indication that RF-EMF from mobile phones and MPBS together with age and gender can differentially impact leucocytes, indicating biological stress and potentially affecting health. These results suggest the necessity for increasing awareness regarding adverse effects of RF-EMF exposures.","PeriodicalId":50544,"journal":{"name":"Electromagnetic Biology and Medicine","volume":" ","pages":"231-250"},"PeriodicalIF":1.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146127308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biological responses to 30 mT static magnetic field in young and 36-month-old rats. 幼龄和36月龄大鼠对30mt静磁场的生物学反应。

IF 1.5 4区生物学

Electromagnetic Biology and Medicine Pub Date : 2026-01-01 Epub Date: 2026-01-19 DOI: 10.1080/15368378.2026.2617536

Mirjana Jovanović, Mihailo Ille, Andrija Vuković, Ivan D Milovanovich, Dragana Mitić, Silvio R De Luka

{"title":"Biological responses to 30 mT static magnetic field in young and 36-month-old rats.","authors":"Mirjana Jovanović, Mihailo Ille, Andrija Vuković, Ivan D Milovanovich, Dragana Mitić, Silvio R De Luka","doi":"10.1080/15368378.2026.2617536","DOIUrl":"10.1080/15368378.2026.2617536","url":null,"abstract":"This study aimed to investigate the effects of subchronic exposure to a 30 mT static magnetic field (SMF) on hematological parameters, spleen and tibia cellularity in 36-month-old and young rats. A total of 27 rats were divided into four groups (Young, Young SMF, Old, Old SMF) and two groups were exposed to SMF for 10 weeks. After exposure period, blood counts, neutrophil-to-lymphocyte ratio (NLR, an index of systemic inflammation), platelet-to-lymphocyte ratio (PLR, a platelet-based inflammatory marker) and cellularity of immune-related organs were analyzed. SMF exposure reduced lymphocyte counts and increased NLR in both age groups, while PLR increased only in young rats. In 36-month-old rats, SMF significantly reduced platelet counts, whereas this effect was not observed in young animals. SMF exposure also enhanced tibial and splenic cellularity in both groups but exerted opposite effects on the proportions of lymphocytes and erythrocytes depending on age. These findings suggest age-dependent immune modulation by SMF. In young animals, SMF likely promoted a proinflammatory shift, reflected by elevated NLR and PLR. In contrast, in 36-month-old rats, SMF may act as a nonspecific physiological stressor, potentially triggering the General Adaptation Syndrome (three-stage stress response), leading to corticosterone-mediated immunosuppression and cell redistribution. To our knowledge, this is the first study demonstrating age-dependent differential modulation of NLR and PLR by subchronic SMF exposure, linking proinflammatory shifts in youth with stress-related immunosuppression in aging. Overall, age appears to be a critical factor in determining the biological responses to SMF, underscoring the need for age-specific evaluation of SMF exposure.","PeriodicalId":50544,"journal":{"name":"Electromagnetic Biology and Medicine","volume":" ","pages":"222-230"},"PeriodicalIF":1.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145999584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Magnetic disc enhances resilience and over-winter survival of honeybees (Apis mellifera). 磁性 圆盘增强蜜蜂（Apis mellifera）的适应力和越冬存活率。

IF 1.5 4区生物学

Electromagnetic Biology and Medicine Pub Date : 2026-01-01 Epub Date: 2026-04-16 DOI: 10.1080/15368378.2026.2644215

Magda Havas

{"title":"Magnetic disc enhances resilience and over-winter survival of honeybees (Apis mellifera).","authors":"Magda Havas","doi":"10.1080/15368378.2026.2644215","DOIUrl":"10.1080/15368378.2026.2644215","url":null,"abstract":"Honeybee losses continue to threaten ecological and agricultural stability worldwide. This field study evaluated whether a static neodymium magnetic disc placed beneath beehives could enhance colony resilience and overwinter survival. Two commercial apiaries (≈60 hives total) under identical management in Ontario, Canada, were monitored in late summer 2023, spring 2024 and after a mid‑season partial crossover in August 2024. One yard received magnetic discs, while the second served as control. Treated hives (i.e. with magnets) compared with the control hives exhibited significantly higher overwinter survival, stronger spring populations, better hygiene and fewer queen replacements than controls (p < 0.001). After discs were added to the control yard, colony performance improved within 8 weeks, reaching parity with the initially treated hives. Static magnetic arrays positioned beneath hives appear to enhance colony health and stability, possibly through modulation of bioelectromagnetic or redox processes known to influence cellular energy metabolism. Although magnetic modulation of bioenergetic and redox processes is hypothesized, direct electrical or biochemical measurements were not performed and should be prioritized in future studies. This approach provides a simple, low-cost intervention to improve apicultural outcomes and pollinator resilience. Future studies could investigate the effectiveness of these magnets in areas with known environmental stressors.","PeriodicalId":50544,"journal":{"name":"Electromagnetic Biology and Medicine","volume":" ","pages":"263-272"},"PeriodicalIF":1.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147693634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

When biology meets polarity: Toward a unified framework for sex-dependent responses to magnetic polarity in living systems. 当生物学遇到极性：迈向生命系统中对磁极性的性别依赖反应的统一框架。

IF 1.5 4区生物学

Electromagnetic Biology and Medicine Pub Date : 2026-01-01 Epub Date: 2026-01-31 DOI: 10.1080/15368378.2026.2621660

Igor Nelson

{"title":"When biology meets polarity: Toward a unified framework for sex-dependent responses to magnetic polarity in living systems.","authors":"Igor Nelson","doi":"10.1080/15368378.2026.2621660","DOIUrl":"10.1080/15368378.2026.2621660","url":null,"abstract":"The human body emits a bioelectromagnetic field primarily generated by the electrical activity of the heart, with additional contributions from the brain, muscles, and peripheral nerves. These endogenous fields are not isolated and can be modulated by external electromagnetic and magnetic influences. Current evidence suggests that the main mechanisms underlying such interactions include modulation of ion channels, radical pair dynamics, and ion cyclotron resonance. Several studies report sex-specific differences in responses to magnetic exposure. The main factors implicated in these differences include heart orientation and position, heart mass, tissue conductivity, hormonal modulation, autonomic balance, and cortical field organization. Beyond sex, consistent findings demonstrate that biological effects depend not only on field intensity and frequency but also on polarity (north/south), and direction (vector angle). These parameters are often overlooked or unreported in published works. Some observations even suggest a direct relationship between polarity and sex, with divergent physiological and behavioral outcomes. Recognizing these interactions is crucial to refining models of magnetoreception, resolving inconsistencies, and advancing therapeutic applications of electromagnetic fields. This review integrates evidence from magnetobiology and sex-based physiology to propose that hormonal and structural dimorphism may modulate biological responses to magnetic field. Potential mechanisms involving ion-channel modulation, magnetite orientation, and radical-pair dynamics are outlined and experimental paradigms to test these interactions are proposed. Together, these insights establish a framework for studying sex-dependent magnetic sensitivity in living systems.","PeriodicalId":50544,"journal":{"name":"Electromagnetic Biology and Medicine","volume":" ","pages":"280-294"},"PeriodicalIF":1.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146094897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative study of spectral properties of the bovine serum albumin complexes with acridine orange and methylene blue under the effect of millimeter range electromagnetic waves. 毫米波作用下牛血清白蛋白与吖啶橙和亚甲基蓝配合物光谱特性的比较研究。

IF 1.5 4区生物学

Electromagnetic Biology and Medicine Pub Date : 2026-01-01 Epub Date: 2025-09-09 DOI: 10.1080/15368378.2025.2558669

A P Antonyan, M A Shahinyan, M S Mikaelyan, A H Karapetyan, V P Kalantaryan, P O Vardevanyan

{"title":"Comparative study of spectral properties of the bovine serum albumin complexes with acridine orange and methylene blue under the effect of millimeter range electromagnetic waves.","authors":"A P Antonyan, M A Shahinyan, M S Mikaelyan, A H Karapetyan, V P Kalantaryan, P O Vardevanyan","doi":"10.1080/15368378.2025.2558669","DOIUrl":"10.1080/15368378.2025.2558669","url":null,"abstract":"Effect of millimeter range electromagnetic waves (MM EMW) with the frequency 51.8 GHz on the interaction of DNA-specific ligands-intercalators acridine orange (AO) and methylene blue (MB) with bovine serum albumin (BSA) has been studied. The measurements were implemented by the spectroscopic methods that open new opportunities for such goals. The methods of absorption, differential and fluorescence spectroscopies were applied. The obtained data permit revealing several peculiarities of MM EMW effect on the interaction of these ligands with BSA, as well as possible sites and modes for the binding. AO and MB were found out to bind to BSA by two modes, moreover, under the effect of MM EMW, one of these modes for MB disappears. The values of the quenching constant - KSV were determined for the types that compose 4.7⋅104 and 9.2⋅104 L/mole for non-irradiated and 4.6⋅104 and 11.0⋅104 L/mole for irradiated complexes AO-BSA, respectively. For the non-irradiated complexes MB-BSA the values of KSV were equal to 4.0⋅104 and 0.87⋅104 L/mole, respectively. Because of the irradiation, the first type of the binding disappears, while for the second type the value 0.43⋅104 L/mole was obtained. It was also revealed that MM EMW invokes structural transformations in BSA molecule that touch those sites to which AO and MB bind. Moreover, for AO it results in an increase of preferable binding to this site; though, for MB, vice versa, it leads to the disappearance of stronger (specific) binding mode, while the electrostatic interaction appears for both non-irradiated and irradiated protein.","PeriodicalId":50544,"journal":{"name":"Electromagnetic Biology and Medicine","volume":" ","pages":"11-21"},"PeriodicalIF":1.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145024627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0