Vascular mechanoreceptor magnetic activation, hemodynamic evidence and potential clinical outcomes.

Abstract

There is sufficient proof that static magnetic fields (SMFs) of different parameters have a significant effect on the cardiovascular system. The sometimes contradictory, opposite-directional nature of SMF's hemodynamic effect generates uncertainty; therefore, an explanation of the underlying mechanisms is required. Following SMF selective carotid baroreceptors or microvascular net exposure, both high and low blood pressure (BP)/vascular tone starting conditions showed a return to normal. Beyond the previous descriptions of SMF's simple hemodynamic results, the current study aims to clarify the physiology of the SMF BP/vascular tone normalizing effects. The examination of available literature and hemodynamic tracings provided strong evidence that mechanoreceptor magnetic activation is concealed behind SMF vascular tone adjustment (increasing or decreasing as needed), filling in the knowledge gap regarding SMF opposite directional vascular tone normalizing outcomes. It has been proposed that cytoskeletal actin filament rearrangement, mechanically-gated Ca²⁺ influx, and nitric oxide (NO) activity may strengthen SMF's vascular mechanoreceptor sensing/regulation ability, modifying BP and vascular tone features in a hemodynamic normalizing pattern. It is suggested that baro/mechanoreceptor magnetic activation physiology is a unique mechanism of the magneto-cardiovascular interaction with substantial potential for cardiovascular protection.