Genotoxic and histopathological effects of 6 GHz radiofrequency electromagnetic radiation on rat liver tissue.

IF 1.5 4区生物学 Q3 BIOLOGY

Electromagnetic Biology and Medicine Pub Date : 2025-07-22 DOI:10.1080/15368378.2025.2534381

Nermin Seda Ilgaz, Yasin Karamazı, Mustafa Emre, Tuğba Toyran, Özdem Karaoğlan, Toygar Emre, Meltem Dönmez Kutlu, Hale Öksüz Üçkayabaşı, Çağatay Aydın, M Bertan Yılmaz

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引用次数: 0

Abstract

In this study, the genotoxic and histopathological effects of 6 GHz (0.065 W/kg) Radiofrequency-Electromagnetic Radiation (RF-EMR) on rat liver tissue were investigated. Sham (control) and Radiofrequency Radiation (RFR) groups were formed with 10 adult male rats in each group. Rats in the sham group received no treatment. Rats in the RFR group were exposed to 6 GHz RF-EMR for 4 h/day for 42 days. Immediately after the completion of the exposure, the rats in both groups were sacrificed and liver tissues were removed. Comet Test was performed to determine the genotoxic effect in the samples. Masson Trichrome and Hematoxylin Eosin staining methods were applied histopathologically. According to the Comet Analysis results, the genetic damage index (GDI) and damaged cell percentage (DCP) of the RFR group were higher than the sham group, but this difference was not statistically significant (p > 0.05). In histopathologic examinations, portal inflammation, single cell necrosis, vascularity and congestion were more prominent in the RFR group compared to the sham group. In our study, it was shown that 6 GHz RF-EMR can cause histopathologic and DNA level changes in rat liver tissue. As a result of the literature review, no prior studies have specifically examined the genotoxic and histopathological effects of 6 GHz RF-EMR. This makes our study important as it addresses the biological impacts of the 6 GHz frequency band.

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6ghz射频电磁辐射对大鼠肝组织的遗传毒性和组织病理学影响。

研究了6 GHz （0.065 W/kg）射频电磁辐射（RF-EMR）对大鼠肝组织的遗传毒性和组织病理学影响。随机分为假手术组（对照组）和射频辐射组（RFR），每组10只成年雄性大鼠。假手术组大鼠不接受治疗。RFR组大鼠连续42天，每天4小时暴露于6 GHz RF-EMR。暴露结束后立即处死两组大鼠，取肝组织。采用彗星试验测定样品的遗传毒性作用。组织病理学上采用马松三色法和苏木精伊红染色法。Comet Analysis结果显示，RFR组的遗传损伤指数（GDI）和损伤细胞百分比（DCP）均高于sham组，但差异无统计学意义（p < 0.05）。在组织病理学检查中，与假手术组相比，RFR组门静脉炎症、单细胞坏死、血管扩张和充血更为突出。在我们的研究中，我们发现6ghz RF-EMR可以引起大鼠肝组织的组织病理学和DNA水平的变化。由于文献综述，没有先前的研究专门研究了6 GHz射频电磁辐射的遗传毒性和组织病理学效应。这使得我们的研究很重要，因为它解决了6ghz频段的生物学影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Electromagnetic Biology and Medicine 生物-生物物理

CiteScore

3.60

自引率

11.80%

发文量

审稿时长

>12 weeks

期刊介绍： Aims & Scope: Electromagnetic Biology and Medicine, publishes peer-reviewed research articles on the biological effects and medical applications of non-ionizing electromagnetic fields (from extremely-low frequency to radiofrequency). Topic examples include in vitro and in vivo studies, epidemiological investigation, mechanism and mode of interaction between non-ionizing electromagnetic fields and biological systems. In addition to publishing original articles, the journal also publishes meeting summaries and reports, and reviews on selected topics.