Massooma Pirbhai, Nora Wagner, Cora Ferguson, Cody Belden, Ana Y Estevez
{"title":"Orientation-dependent effects of a 1 mT static magnetic field on HT22 neural cell proliferation.","authors":"Massooma Pirbhai, Nora Wagner, Cora Ferguson, Cody Belden, Ana Y Estevez","doi":"10.1080/15368378.2026.2652926","DOIUrl":"10.1080/15368378.2026.2652926","url":null,"abstract":"<p><p>This study examines how the vertical orientation of a moderate-intensity static magnetic field (1 mT) influences the proliferation of HT22 mouse hippocampal cells. Static magnetic fields (SMFs) offer potential for biomedical applications due to their ability to influence cellular processes in a non-invasive manner. However, their effects on neural cell proliferation remain poorly understood, particularly with respect to magnetic field orientation. Cells were exposed to SMFs in two orientations: downward and upward. SMF exposure was associated with significantly higher proliferation relative to both incubator and sham controls, with the downward orientation producing the most consistent increase. This trend was observed across multiple experimental conditions, including exposure duration and antibiotic use. Ion substitution experiments further showed that replacing extracellular K<sup>+</sup> with Cs<sup>+</sup> attenuated the orientation-dependent response, suggesting that ion conductance may contribute to SMF sensitivity. These findings emphasize the importance of magnetic field orientation in low-intensity SMF studies and indicate that directional exposure can modulate neural cell proliferation under well-controlled conditions.</p>","PeriodicalId":50544,"journal":{"name":"Electromagnetic Biology and Medicine","volume":" ","pages":"273-279"},"PeriodicalIF":1.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147624565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jarosław Pasek, Sebastian Szajkowski, Grzegorz Cieślar
{"title":"Interaction between variable magnetic field with low magnetic induction value and body tattoos - a preliminary observational single center study.","authors":"Jarosław Pasek, Sebastian Szajkowski, Grzegorz Cieślar","doi":"10.1080/15368378.2025.2562431","DOIUrl":"10.1080/15368378.2025.2562431","url":null,"abstract":"<p><strong>Purpose: </strong>Low-induction variable magnetic fields are widely used in various fields of medicine. However, it is worth raising the issue whether treatments using low-induction variable magnetic fields applied to patients can affect the condition of tattooed skin.</p><p><strong>Methods: </strong>In the study, 24 volunteers were enrolled (12 men and 12 women) their age range was 30-60 years (average age: 43 years), they were assigned to two groups. The study group included people with a black ink (7 people) or colored (5 people) tattoo on the skin of the upper limb. The control group included 12 participants without tattoos. The participants were exposed to variable magnetic field with low magnetic induction value applied to the upper limb area, in form of magnetostimulation procedures performed once a day, 5 days a week for 3 weeks. Using an original questionnaire, it was assessed whether the subjects experienced any disturbing symptoms related to the physical treatments during and after the treatments.</p><p><strong>Results: </strong>After the magnetic stimulation, 2 patients from the study group (with a colored tattoo) indicated that during the procedures they felt a feeling of warmth and slight itching of the skin in the place of exposure to magnetic field. In the control group, no side effects of the procedures were noted. Dermatological evaluation did not reveal any pathological changes in the skin area exposed to magnetic field in any participant from both groups.</p><p><strong>Conclusions: </strong>Treatments using low-induction variable magnetic fields in people with tattoos did not show any significant adverse effects on the skin in the tattoo area exposed to the magnetic field.</p>","PeriodicalId":50544,"journal":{"name":"Electromagnetic Biology and Medicine","volume":" ","pages":"86-93"},"PeriodicalIF":1.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145076548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xavier Andres Figueroa, Lucas Lacambra, Michael Prados, B Michael Butters
{"title":"Tumor inhibition in xenograft model of diffuse intrinsic pontine glioma via ultra-low and low-frequency magnetic field therapy.","authors":"Xavier Andres Figueroa, Lucas Lacambra, Michael Prados, B Michael Butters","doi":"10.1080/15368378.2025.2599291","DOIUrl":"10.1080/15368378.2025.2599291","url":null,"abstract":"<p><p>A low-frequency (DC-22.05 kHz), time-varying magnetic field signal (rfe_A1A) was tested against the human-derived SF8628 cell line, a diffuse intrinsic pontine glioma (DIPG). This study was done to determine the efficacy and mechanism of action of the rfe_A1A signal, <i>in vitro</i> and <i>in vivo</i>. <i>In vitro</i>, an acellular tubulin polymerization assay and an SF8628 cell culture assay increased tubulin polymerization rates and reduced cell division, respectively. Mouse survival models of DIPG, subsequently exposed to the rfe_A1A signal, demonstrated significantly longer survival times and biomarker changes in Ki67 expression, consistent with a slowdown in cell-division rates. The rfe_A1A signal significantly increased survival time in a DIPG model, a novel strategy tested in clinical studies and compassionate use cases.</p>","PeriodicalId":50544,"journal":{"name":"Electromagnetic Biology and Medicine","volume":" ","pages":"206-221"},"PeriodicalIF":1.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145745397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A static magnetic field applied during cancer chemotherapy: Results of a clinical investigation.","authors":"Andrea Bailey, Joseph R Salvatore","doi":"10.1080/15368378.2025.2551593","DOIUrl":"10.1080/15368378.2025.2551593","url":null,"abstract":"<p><p>A Static Magnetic Field in the form of a permanent magnet was applied to participants in an investigational protocol to determine the toxicity and safety profile of the magnetic field in participants receiving antineoplastic chemotherapy for advanced cancer. The magnet was placed 15 minutes prior to starting the antineoplastic chemotherapy and then remained in place for three levels following completion of the therapy for 0, 15, and 30 minutes. The data showed that overall, the presence of a static magnetic field could be applied safely to individuals receiving antineoplastic chemotherapy for advanced cancer, and for participants in the Level 3 Group (magnet applied for 30 minutes), there was a statistically significant decrease in toxicity compared to matched controls. We were not able to determine if the static magnet field had an effect on survival. Our data suggests that applying a static magnetic field to individuals receiving antineoplastic chemotherapy for advanced cancer is safe and may, under certain parameters, decrease the toxicity of the therapy. Further studies should be conducted.</p>","PeriodicalId":50544,"journal":{"name":"Electromagnetic Biology and Medicine","volume":" ","pages":"1-10"},"PeriodicalIF":1.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144977336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Quantitative analysis and trends in the study of the effects of electromagnetic radiation on the nervous system from a bibliometric perspective.","authors":"Ketao Liang, Wenying Zhou, Xueqin Li, Jianjun Wu, Dekui Li, Yahui Xie, Xingmin Wei","doi":"10.1080/15368378.2025.2568667","DOIUrl":"10.1080/15368378.2025.2568667","url":null,"abstract":"<p><p>With the rapid development of communication technology, the potential health risk of electromagnetic radiation (EMR) to the nervous system has aroused widespread concern. This study systematically reviews the research progress in the field of EMR-neurological interactions during 2013-2024, revealing its research hotspots and future trends. Based on WOS database, this study adopts bibliometric method combined with visualization technology for multidimensional analysis. The construction of visual maps of countries, institutions, authors, keywords and other elements is realized through CiteSpace and VOSviewer software, which systematically reveals the developmental lineage and knowledge structure of the research field. The study reveals that the field has been growing continuously, with China, Iran and the United States as the core research countries, the Chinese Academy of Military Medical Sciences and other organizations contributing prominently, and Environment International leading the list with an impact factor of 21.90. High-frequency keywords include \"adolescents,\"hippocampus\" and \"synaptic plasticity\", reflecting the focus of research on neurodevelopmental and functional impairments. The study points out that although the mechanism of the neurological effects of electromagnetic radiation has been achieved, its molecular mechanisms and therapeutic interventions still need to be further explored. This study provides a systematic reference for scholars around the world, helps to promote the development of the field of neural effects of electromagnetic radiation, and provides a scientific basis for public health protection.</p>","PeriodicalId":50544,"journal":{"name":"Electromagnetic Biology and Medicine","volume":" ","pages":"123-136"},"PeriodicalIF":1.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145214290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Huan Zhou, Xiao-Yu Peng, Weijun Wang, Chengbin Zhao, Peng Zhang, Jie Liu, Peng Li, Julia Li Zhong, Xianqin Luo, Biyong Ren, De-Sheng Pei
{"title":"Biological effects on breast cancer cells of strong terahertz waves from a terahertz free-electron laser.","authors":"Huan Zhou, Xiao-Yu Peng, Weijun Wang, Chengbin Zhao, Peng Zhang, Jie Liu, Peng Li, Julia Li Zhong, Xianqin Luo, Biyong Ren, De-Sheng Pei","doi":"10.1080/15368378.2025.2577314","DOIUrl":"10.1080/15368378.2025.2577314","url":null,"abstract":"<p><p>It is of great importance to study the biological effects of terahertz (THz) waves on human cancer cells for their potential future applications in cancer therapy. However, only a few examples of distinct biological effects have been reported due to the lack of strong THz radiation sources. Here, we report our preliminary investigation using a strong THz source at 1.56 THz with an average power of ~ 10 W and an average intensity of ~129.1 mW/cm<sup>2</sup> working at a repetition rate of 10 Hz for its macro pulses with duration of ~1 ms and micro pulse duration of ~ 1 ps at a repetition rate of 54.17 MHz from a THz free-electron laser to investigate its biological effects on breast cancer cells in vitro. We observed significant morphological changes in breast cancer cells after 2 hours irradiation and apoptosis after 3 hours irradiation. Most notably, after 4 hours irradiation, we observed obvious cytolysis and the disappearance of most breast cancer cells in the center of the THz beam spot. It is suggested that these biological effects could be attributed mainly to the non-thermal effect of the strong THz waves according to our separate experimental results on the morphological changes of the breast cancer cells induced solely by heat. Our results indicate the potential to leverage the apoptosis and cytolysis of cancer cells induced by strong THz waves for future cancer treatment applications.</p>","PeriodicalId":50544,"journal":{"name":"Electromagnetic Biology and Medicine","volume":" ","pages":"149-159"},"PeriodicalIF":1.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145337920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
B S Rohan Charles, M D Alexander Vlasak, M D Travis Turner, M D Joshua Romero, D P M Elizabeth Bondi
{"title":"Extracorporeal magnetotransduction therapy as an adjunctive and primary modality for bone healing: a scoping review of current evidence.","authors":"B S Rohan Charles, M D Alexander Vlasak, M D Travis Turner, M D Joshua Romero, D P M Elizabeth Bondi","doi":"10.1080/15368378.2026.2648306","DOIUrl":"10.1080/15368378.2026.2648306","url":null,"abstract":"<p><strong>Background: </strong>Delayed or improper bone healing causes significant physical and socioeconomic burdens. Pulsed electromagnetic field therapy aims to improve fracture repair but shows inconsistent results. Extracorporeal Magnetotransduction Therapy offers higher oscillation frequencies and magnetic field strengths than PEMF, potentially enhancing bone regeneration through deeper tissue penetration and stronger cellular stimulation.</p><p><strong>Methods: </strong>A scoping review identified nine studies on EMTT for fracture healing: two in vitro, six case reports, and one pilot clinical trial.</p><p><strong>Results: </strong>In vitro, EMTT upregulated osteogenic genes and accelerated matrix mineralization without harming cell viability, demonstrating a biological role in bone formation. Clinical reports and the pilot trial showed faster bone union, pain relief, and functional improvement when EMTT was used alone or with extracorporeal shockwave therapy.</p><p><strong>Conclusion: </strong>Preliminary evidence supports EMTT as a safe and potentially viable non-operative modality, primarily as an adjunct to established treatments such as ESWT. These studies also illustrate EMTT's potential to enhance angiogenesis, osteogenic gene expression, and clinical bone healing. Clinical cases of delayed union and non-union fractures demonstrating healing with EMTT, resulting in successful union and return to sport for all patients reported. While results suggest synergistic effects with Extracorporeal Shockwave Therapy (ESWT), the evidence remains limited by small sample sizes, publication bias, and confounding adjunct therapies. Future randomized controlled trials are required to establish standardized protocols and isolate EMTT's efficacy as monotherapy.</p>","PeriodicalId":50544,"journal":{"name":"Electromagnetic Biology and Medicine","volume":" ","pages":"313-320"},"PeriodicalIF":1.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147516274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Lawn bowling and potential interference of a cardiovascular implantable electronic device (CIED): case report.","authors":"E De Waegeneer, B Corteville, L Braeckman","doi":"10.1080/15368378.2025.2553647","DOIUrl":"10.1080/15368378.2025.2553647","url":null,"abstract":"<p><p>Cardiovascular implantable electronic devices (CIEDs), including cardiac pacemakers and implantable cardioverter-defibrillators, are extensively utilized across diverse patient populations. These devices are susceptible to electromagnetic interference (EMI), which may result in functional disturbances such as pacing inhibition, misinterpretation of extraneous signals as intrinsic cardiac activity, or inappropriate mode switching. Neodymium-iron-boron (NdFeB) magnets, known for their high magnetic flux density, are commonly employed in various industrial and consumer applications. This case report highlights a previously undocumented source of EMI-namely, the magnet embedded in lawn bowling equipment-and its potential to disrupt CIED functionality. The underlying mechanism of interference is examined, and recommendations for risk mitigation and patient safety are proposed.</p>","PeriodicalId":50544,"journal":{"name":"Electromagnetic Biology and Medicine","volume":" ","pages":"119-121"},"PeriodicalIF":1.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144977309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"An intelligent model approach for dynamic prediction of magnetized Jeffrey blood flow carrying penta-hybrid nanoparticles in a catheterized electrified arterial annulus.","authors":"Puja Paul, Sanatan Das, Poly Karmakar, Asgar Ali, Tilak Kumar Pal","doi":"10.1080/15368378.2025.2561033","DOIUrl":"10.1080/15368378.2025.2561033","url":null,"abstract":"<p><p>This research paper presents an artificial intelligence (AI) framework to predict magnetized penta-nanoparticle-enhanced Jeffrey blood flow dynamics in a catheterized electrified arterial annulus. The work addresses critical gaps in modeling non-Newtonian blood rheology with multi-physics interactions. Employing Jeffrey's fluid model to encapsulate the non-Newtonian rheological properties of blood mixed with nanoparticles. This analysis combines diverse factors influencing heat sources, Joule heating, interfacial nanolayers, and porous media drag. The flow system is streamlined via lubrication theory and Debye-Hückel linearization and then solved using homotopy perturbation method (HPM). Visualization of indispensable flow metrics is conducted using tools in Mathematica and Matlab. Computational results indicate electro-osmotic forces significantly alter the streaming patterns of penta-hybrid nanoparticle-infused blood in catheterized arterial geometry. Blood temperature lowers in the catheterized regions for the expanded thickness of nanolayer, and the axial blood pressure gradient elevates with an upsurge in the electro-osmotic factor while wall shear stress (WSS) abates. Heat transfer coefficient (HTC) improves with thicker nanolayers. AI-driven artificial neural network (ANN) model achieves 97-100% accuracy in predicting WSS and HTC. The research findings highlight potential improvements in patient-specific treatment strategies and contribute to the broader field of biomedical engineering by enhancing the efficacy and precision of non-invasive therapies.</p>","PeriodicalId":50544,"journal":{"name":"Electromagnetic Biology and Medicine","volume":" ","pages":"48-85"},"PeriodicalIF":1.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145087885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kader Gülmez, Ayşe Demirkazık, Ahmet Şevki Taşkıran
{"title":"Effect of ELF-EMF on cognitive functions, analgesia, and oxidative stress in rats with PTZ-induced epilepsy.","authors":"Kader Gülmez, Ayşe Demirkazık, Ahmet Şevki Taşkıran","doi":"10.1080/15368378.2025.2593267","DOIUrl":"10.1080/15368378.2025.2593267","url":null,"abstract":"<p><p>This study aimed to examine the impacts of extremely low-frequency (ELF)-electromagnetic field (EMF) on cognitive functions and analgesia in terms of total oxidant status (TOS) and total antioxidant status (TAS) in the experimental pentylenetetrazole (PTZ)-induced epilepsy model. Twenty-four Wistar albino male rats were categorized into four groups: sham, EMF, PTZ, and EMF+PTZ. The rats were repeatedly exposed to alternating 50-Hz and 5-mT EMF for 165 min a day for 7 days. Epileptic seizures were induced with PTZ. The levels of oxidative stress markers were measured. Univariate multifactorial one-way analysis of variance and post hoc Tukey's test were used for pairwise comparisons between groups. A statistically significant difference was observed in the learning and short-term memory levels in the EMF + PTZ group compared with the PTZ group (<i>p</i> < 0.001). Analgesia latency statistically significantly increased in the ELF-EMF and ELF-EMF+PTZ groups compared with both the control and epilepsy groups (<i>p</i> < 0.001). A statistically significant increase in TOS was found in the prefrontal cortex in the PTZ group compared with the sham group (<i>p</i> < 0.001). Also, TOS statistically significantly increased in the hippocampus in both PTZ and ELF-EMF+ PTZ groups compared with the sham group (<i>p</i> < 0.001). ELF-EMF decreased the increased TOS in the hippocampus of rats in the PTZ group.</p>","PeriodicalId":50544,"journal":{"name":"Electromagnetic Biology and Medicine","volume":" ","pages":"186-196"},"PeriodicalIF":1.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145642358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}