产前900 mhz电磁场对大鼠周围神经形态及功能的影响。

IF 1.5 4区 生物学 Q3 BIOLOGY
Electromagnetic Biology and Medicine Pub Date : 2025-01-01 Epub Date: 2025-03-18 DOI:10.1080/15368378.2025.2479517
Hatice Hancı, Engin Yenilmez, Selim Demir, Mehmet Yıldırım, Öznur Gedikli, Haydar Kaya
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引用次数: 0

摘要

本研究的目的是探讨900兆赫电磁场(EMF)在产前施加对大鼠周围神经形态、神经传导速度和运动活动的影响。9只怀孕的斯普拉格·道利大鼠被分为三组。第一组(对照组)未做任何处理。第二组(假)在整个实验期间(怀孕第1-21天)每天被放置在EMF笼中1小时,但不暴露于EMF。第三组(EMF)在整个实验期间(怀孕第1-21天)每天放置在EMF笼内1小时,并暴露于900 MHz的EMF。在出生后第21天之前,未对新生幼犬进行任何处理,并从这些幼犬中组成新组。所有新建立的组在PN第21天和第60天进行开场和旋转试验,之后根据研究方案对各组进行电生理测量。对PN第60天处死的动物坐骨神经进行组织病理学、组织形态学、免疫组织化学和生化分析。根据研究结果,我们得出结论,产前应用900 MHz EMF会对大鼠周围神经发育产生不利影响,并且这些影响持续到成年,例如在坐骨神经形态学中可以检测到,但这些形态学变化不足以严重影响与坐骨神经相关的功能。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The effect on rat peripheral nerve morphology and function of a 900-MHz electromagnetic field applied in the prenatal period.

The purpose of this study was to investigate the effects of a 900 megahertz (MHz) electromagnetic field (EMF) applied in the prenatal period on rat peripheral nerve morphology, nerve conduction velocity, and locomotor activity. Nine pregnant Sprague Dawley rats were assigned into three groups. No procedure was applied to the first group (control). The second (sham) group was placed inside an EMF cage for 1 h a day throughout the experiment (days 1-21 of pregnancy), but was not exposed to EMF. The third group (EMF) was placed inside the EMF cage for 1 h a day throughout the experiment (days 1-21 of pregnancy) and exposed to a 900 MHz EMF. No procedure was applied to the newborn pups until postnatal (PN) day 21, and new groups were constituted from among these. All the newly established groups were subjected to the open field and rotarod tests on PN days 21 and 60, after which electrophysiological measurements were performed on the groups in line with the study protocol. Sciatic nerves obtained from the animals sacrificed on PN day 60 were subjected to histopathological, histomorphometric, immunohistochemical, and biochemical analyses. In light of the study results, we concluded that prenatal application of a 900 MHz EMF adversely affects rat peripheral nerve development, and that these effects persist up to adulthood such as to be detectable in the sciatic nerve morphology, but that these morphological changes are not sufficiently severe to affect functional associated with the sciatic nerve.

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来源期刊
CiteScore
3.60
自引率
11.80%
发文量
33
审稿时长
>12 weeks
期刊介绍: Aims & Scope: Electromagnetic Biology and Medicine, publishes peer-reviewed research articles on the biological effects and medical applications of non-ionizing electromagnetic fields (from extremely-low frequency to radiofrequency). Topic examples include in vitro and in vivo studies, epidemiological investigation, mechanism and mode of interaction between non-ionizing electromagnetic fields and biological systems. In addition to publishing original articles, the journal also publishes meeting summaries and reports, and reviews on selected topics.
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