Journal of Neuroradiology最新文献

{"title":"L'IRM MUSCULAIRE AU COURS DES MYOPATHIES HEREDITAIRES : EVALUATION D'ALGORITHME","authors":"Insaf Dkhil ,&nbsp;Soumaya Jelassi ,&nbsp;Meriem Ben Hafsa ,&nbsp;Thouraya Ben Younes ,&nbsp;Hanene Benrhouma ,&nbsp;Ichraf Kraoua ,&nbsp;Sonia Nagi","doi":"10.1016/j.neurad.2025.101312","DOIUrl":"10.1016/j.neurad.2025.101312","url":null,"abstract":"<div><h3>Introduction</h3><div>Les myopathies sont caractérisées par une grande hétérogénéité. L'IRM musculaire peut contribuer à l'approche diagnostique et guider l’étude génétique.</div></div><div><h3>Objectifs</h3><div>Appliquer et évaluer l'algorithme proposé par Aivazoglou at al, 2021 dans l'interprétation de l'IRM musculaire</div></div><div><h3>Méthodes</h3><div>Nous avons mené une étude rétrospective à l'Institut National de Neurologie de Tunis sur une période allant de janvier 2018 à novembre 2024, incluant des patients atteints de myopathies héréditaires. Dans tous les cas, la biopsie musculaire, l’étude génétique ou les deux ont permis de confirmer le diagnostic. Une relecture des examens a été réalisée par un neuroradiologue senior. Nous avons appliqué l'algorithme proposé par Aivazoglou et al et nous avons confronté le diagnostic proposé par l'imagerie au résultat final. Résultats : Nous avons colligé 12 cas (5 de sexe masculin, 7 de sexe féminin). L’âge moyen est de17,5 ans (de 2 ans à 73 ans). Tous les patients ont bénéficié d'une IRM corps entier incluant des séquences axiales T1 pour étudier l'infiltration graisseuse et STIR pour détecter l'oedème. En suivant l'algorithme d'Adivazoglou et al, l'IRM musculaire était concordante au diagnostic moléculaire, (LGMD 2A, LGMD2B, LGMD2L, SEPN1, RYR1, UCMD et maladie de Pompe) dans 75% des cas.</div></div><div><h3>Discussion</h3><div>Les résultats de l'IRM musculaire corps entier présentent certaines caractéristiques et varient selon le sous-type de la myopathie héréditaire. Les études antérieures ne fournissent pas une démarche valable pour tous les sous types. Cependant, l'algorithme proposé par Aivazoglou et al permet d'orienter le diagnostic étiologique de ces myopathies indépendamment de leur présentation clinique.</div></div><div><h3>Conclusion</h3><div>La confrontation des résultats de l'IRM musculaire aux manifestations cliniques permet de fournir des informations utiles pour une meilleure orientation génétique, aidant ainsi les cliniciens dans l’établissement d'un diagnostic précis.</div></div>","PeriodicalId":50115,"journal":{"name":"Journal of Neuroradiology","volume":"52 2","pages":"Article 101312"},"PeriodicalIF":3.0,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143444688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomarqueur généré par IA pour quantifier le mismatch flair-diffusion dans l'AVC.","authors":"Joseph Benzakoun ,&nbsp;Anke Wouters ,&nbsp;Bertrand Lapergue ,&nbsp;Grégoire Boulouis ,&nbsp;Alice Le Berre ,&nbsp;Wagih Ben Hassen ,&nbsp;Olivier Naggara ,&nbsp;Robin Lemmens ,&nbsp;Catherine Oppenheim","doi":"10.1016/j.neurad.2025.101268","DOIUrl":"10.1016/j.neurad.2025.101268","url":null,"abstract":"<div><h3>Contexte</h3><div>Dans 15 % des AVC ischémiques, l'heure de début des symptômes est inconnue, excluant les patients concernés de la fenêtre de thrombolyse intraveineuse (0 à 4,5 heures après l'AVC). Le mismatch entre les séquences de diffusion (DWI) et FLAIR permet d'identifier les patients éligibles au traitement, mais sa reproductibilité inter- et intra-observateur est faible.</div></div><div><h3>Objectif</h3><div>Développer et valider un biomarqueur d'imagerie quantitatif basé sur l'intelligence artificielle, appelé ‘FLAIR Visibility Area’ (FVA), dérivé uniquement de la DWI, afin de prédire le mismatch DWI-FLAIR.</div></div><div><h3>Méthodes</h3><div>Étude rétrospective incluant des patients AVC des cohortes ETIS (cohorte de développement, 2018-2024) et WAKE-UP (cohorte de validation, 2012-2017). Le mismatch DWI-FLAIR a été évalué visuellement. Un modèle prédictif a été entraîné pour estimer le volume des zones FLAIR visibles (FVA) segmentées manuellement sur les IRM initiales (H0) et de suivi (H24), en utilisant uniquement la séquence DWI. Les performances, l'aire sous la courbe ROC (AUC) et le seuil optimal de FVA pour prédire le mismatch ont été évaluées sur les IRM H0.</div></div><div><h3>Résultats</h3><div>La cohorte de développement comprenait 3605 IRM (2922 patients, âge moyen : 70,5ans), et la cohorte de validation 844 IRM (844 patients, âge moyen : 65,5ans). Le FVA a montré une bonne capacité prédictive du mismatch DWI-FLAIR dans les IRM H0 des cohortes de développement (n=2453, AUC=0,85 [IC95%:0,84-0,87]) et de validation (n=844, AUC=0,86 [IC95%:0,84-0,89]). Avec un seuil optimal de 0,5 mL, la sensibilité et la spécificité pour la détection du mismatch étaient respectivement de 70% [IC95%:66-74%] et 88% [IC95%:83-91%] dans la cohorte de validation. (Fig. 1,2)</div></div><div><h3>Conclusion</h3><div>Le FVA, dérivé uniquement des séquences DWI, permet de prédire le mismatch DWI-FLAIR chez les patients présentant un AVC ischémique avec heure de début inconnue. Il pourrait aider les cliniciens en cas de difficultés d’évaluation visuelle ou d'absence de séquence FLAIR.</div></div>","PeriodicalId":50115,"journal":{"name":"Journal of Neuroradiology","volume":"52 2","pages":"Article 101268"},"PeriodicalIF":3.0,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143444854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Essential palatal tremor following COVID-19 Vaccine : a case report.","authors":"Khalil Toumi,&nbsp;Yahya Naji,&nbsp;Sara Laadami,&nbsp;Nawal Adali","doi":"10.1016/j.neurad.2025.101304","DOIUrl":"10.1016/j.neurad.2025.101304","url":null,"abstract":"<div><div>Palatal tremor (PT) is an infrequent disorder characterized by abnormal movement distinguished into symptomatic palatal tremor (SPT) and essential palatal tremor (EPT). SPT can have various causes, including damage to the Guillain-Mollaret triangle (GMT) and hypertrophy of the inferior olive. In contrast, EPT is often associated with clicking sounds in the ears with normal imaging results and may have a functional origin. We describe the case of a 20-year-old girl presenting with clinical symptoms of palatal tremor 2 days after receiving the SARS-CoV-2 AstraZeneca vaccine. The patient had persistent audible clicks associated with rhythmic contractions of the soft palate. Complete resolution of symptoms occurred 2 days after the administration of oral clonazepam. This is the first known case of palatal tremor caused by the SARS-CoV-2 AstraZeneca vaccine.</div></div>","PeriodicalId":50115,"journal":{"name":"Journal of Neuroradiology","volume":"52 2","pages":"Article 101304"},"PeriodicalIF":3.0,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143444303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Imagerie de la neurosarcoïdose : points forts en IRM (à propose de 16 cas).","authors":"Zineb Gourram,&nbsp;Mohamed Labied,&nbsp;Chorouk Mountassir,&nbsp;Ghizlane Lembarki,&nbsp;Mouna Sabiri,&nbsp;Samira Lezar","doi":"10.1016/j.neurad.2025.101289","DOIUrl":"10.1016/j.neurad.2025.101289","url":null,"abstract":"<div><h3>Objectifs</h3><div>Illustrer les aspects radiologiques caractéristiques de la neurosarcoïdose à travers une revue iconographique.</div><div>Savoir conduire un diagnostic différentiel avec les autres atteintes de la substance blanche du SNC.</div></div><div><h3>Matériels et méthodes</h3><div>- étude descriptive rétrospective portant sur 16 cas colligés au service de radiologie central du CHU Ibn Rochd, Casablanca, entre novembre 2019 et avril 2024</div><div>- Tous les patients ont bénéficié d'une IRM cérébrale et/ou médullaire.</div><div>- L'IRM a été considérée comme pathologique dès lors qu'une lésion compatible avec la neurosarcoïdose était observée en séquences T2 FLAIR ou T1 après injection de gadolinium.</div></div><div><h3>Résultats</h3><div>â<strong>ge des patients</strong> : De 20 à 60 ans, avec une moyenne de 40,5 ans.</div><div><strong>Sexe ratio</strong> : 10H/6F.</div><div><strong>Antécédents de sarcoïdose</strong> : 7 patients avaient un antécédent de sarcoïdose connu.</div><div><strong>Atteinte neurologique inaugurale</strong> chez 9 patients.</div><div><strong>Atteinte des nerfs crâniens</strong> : 3 patients, avec une prédominance pour les nerfs V (trijumeau) et VII (facial).</div><div><strong>Atteinte du système nerveux périphérique</strong> : 4 patients.</div><div><strong>Localisations privilégiées</strong> :</div><div>- Atteinte leptoméningée : Présente dans 8 cas, sous forme d'un épaississement nodulaire des leptoméninges avec prise de contraste diffuse.</div><div>- Atteinte hypothalamo-hypophysaire : 2 cas, avec épaississement de la tige pituitaire et hypertrophie de la glande hypophysaire.</div><div>- Infiltration des nerfs crâniens (V) : 3 cas.</div><div>- Masses intra-axiales nodulaires : 5 cas.</div><div>- Atteinte pachyméningée : 1 cas.</div><div>- Hydrocéphalie : 1 cas.</div><div>- Atteinte médullaire : 4 cas.</div><div><strong>Observations complémentaires</strong> : Polymorphisme des lésions : 10 patients ont présenté au moins 2 types de lésions différentes.</div></div><div><h3>Conclusion</h3><div>â· L'IRM constitue un outil essentiel dans le diagnostic et le suivi de la neurosarcoïdose, permettant d'identifier des caractéristiques radiologiques spécifiques.</div><div>- Les résultats de cette étude illustrent l'importance de la détection précoce des lésions typiques pour poser un diagnostic rapide et initier une prise en charge thérapeutique appropriée.</div></div>","PeriodicalId":50115,"journal":{"name":"Journal of Neuroradiology","volume":"52 2","pages":"Article 101289"},"PeriodicalIF":3.0,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143444378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The brain in oral-facial-digital syndrome type 1: New insights from human and mouse data","authors":"Roman Hossein Khonsari,&nbsp;Leclercq Delphine,&nbsp;Pulh Pernelle,&nbsp;Kogane Nicolas,&nbsp;Franco Brunella,&nbsp;Catala Martin","doi":"10.1016/j.neurad.2025.101334","DOIUrl":"10.1016/j.neurad.2025.101334","url":null,"abstract":"","PeriodicalId":50115,"journal":{"name":"Journal of Neuroradiology","volume":"52 3","pages":"Article 101334"},"PeriodicalIF":3.0,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143445491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experimental study on the mechanism of cerebral edema development and MM-MRI manifestation in burned rats","authors":"Muhammad Usman ,&nbsp;Guiqiong He ,&nbsp;Hong Lu","doi":"10.1016/j.neurad.2025.101323","DOIUrl":"10.1016/j.neurad.2025.101323","url":null,"abstract":"<div><div>Objective: The goal of this study was to investigate post-burn cerebral edema, establish its MM-MRI manifestation, and explore the underlying molecular mechanisms. Methods: Rats were randomly assigned to four groups (8h, 24h, 48h, and 72h post-burn) and subjected to thermal burns to induce skin injury, following the rat burn model. Treatment was administered based on Parkland's formula. At specific time points, rats were evaluated using MM-MRI sequences (T₁ WI, T2 WI, T₂ FLAIR, DWI, and ADC mapping) alongside histological analysis (H&amp;E, TEM) and molecular techniques (IHC, IF, and WB). Results: All experimental groups exhibited significantly increased post-burn cerebral edema compared to the sham control group. While no significant changes were observed on T₁WI, T₂ WI, and T₂ FLAIR images, post-burn cerebral edema was clearly visible on DWI and ADC maps in the region of interest (ROI) the basal ganglia. Histological analysis (H&amp;E, TEM) corroborated these findings. Notably, all experimental groups (8h, 24h, 48h, and 72h) showed upregulated expression of AQP4 compared to controls, as evidenced by IHC, IF, and WB. Further, astrocyte end-feet and endothelial cells exhibited significant swelling may be due to AQP4 overexpression, leading to increased intracellular water content. Conclusion: This study confirms the presence of post-burn cerebral edema in the early stages following burn trauma, might be mediated by AQP4, as supported by histological findings. Radiological results indicate that DWI and ADC mapping are sensitive methods for diagnosing and monitoring post-burn cerebral edema.</div></div>","PeriodicalId":50115,"journal":{"name":"Journal of Neuroradiology","volume":"52 3","pages":"Article 101323"},"PeriodicalIF":3.0,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143442609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"White matter hyperintensities regress at a high rate at three months after minor ischemic stroke or transient ischemic attack","authors":"Yuyun Xu ,&nbsp;Danjiang Huang ,&nbsp;He Zhang ,&nbsp;Qifen Fang ,&nbsp;Yuwei Xia ,&nbsp;Feng Shi ,&nbsp;Xiangyang Gong","doi":"10.1016/j.neurad.2024.101239","DOIUrl":"10.1016/j.neurad.2024.101239","url":null,"abstract":"<div><h3>Background</h3><div>The potential for early white matter hyperintensities(WMH) regression and associated contributory factors remains uncertain. The purpose of this study is to investigate whether WMH regress at early time of three months after minor ischemic stroke (MIS) or transient ischemic attack (TIA), while also identifying factors that may influence this outcome.</div></div><div><h3>Methods</h3><div>A retrospective analysis of a prospective subcohort from the CHANCE trial comprising individuals with MIS and TIA was conducted. All patients underwent brain MRI at the onset and at three months. Deep learning algorithms were employed for the automatic segmentation of WMH volumes in four distinct regions. Scores for lacunes, cerebral microbleeds (CMB), perivascular spaces (PVS), WMH, and overall cerebral small vessel disease (CSVD) burden were quantified. Patients were divided into the stable, regression and progression groups according to change in WMH volume. The demographic, clinical, and imaging data of the participants in the three groups were collected and statistically analyzed.</div></div><div><h3>Results</h3><div>A total of 98 patients with minor ischemic stroke or TIA were included. There were 22 patients in the stable group, 41 patients in the regression group and 35 patients in the progression group. Age and hypertension status were significantly different among the three groups. The lacunes, CMB,WMH, and total CSVD burden scores differed notably among groups, with all the CSVD markers being severely elevated in the progression group, moderately elevated in the regression group, and subtly elevated in the stable group.</div></div><div><h3>Conclusion</h3><div>The findings suggest that WMH could exhibit regression within three months following minor ischemic stroke or TIA. Patients under the age of 65, without a hypertension history, and with a low CSVD burden are more likely to experience WMH regression.</div></div>","PeriodicalId":50115,"journal":{"name":"Journal of Neuroradiology","volume":"52 1","pages":"Article 101239"},"PeriodicalIF":3.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142973064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The art and agony of AI in neuroradiology","authors":"Marc Lenfant","doi":"10.1016/j.neurad.2024.101237","DOIUrl":"10.1016/j.neurad.2024.101237","url":null,"abstract":"","PeriodicalId":50115,"journal":{"name":"Journal of Neuroradiology","volume":"52 1","pages":"Article 101237"},"PeriodicalIF":3.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142824628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FRED-EPI study: Safety and efficacy of FRED/FRED Jr aneurysm treatment in current clinical practice","authors":"Laurent Pierot ,&nbsp;Denis Herbreteau ,&nbsp;Xavier Barreau ,&nbsp;Hervé Brunel ,&nbsp;Jacques Sedat ,&nbsp;Laurent Spelle ,&nbsp;Roberto Riva ,&nbsp;Olivier Heck ,&nbsp;Matthias Gawlitza ,&nbsp;Gaultier Marnat ,&nbsp;Kevin Janot ,&nbsp;Kamel Boubagra ,&nbsp;Omer Eker","doi":"10.1016/j.neurad.2024.101240","DOIUrl":"10.1016/j.neurad.2024.101240","url":null,"abstract":"<div><h3>Objective</h3><div>Flow diversion is increasingly used as an endovascular treatment for intracranial aneurysms. FRED-EPI is a prospective, multicenter, French study, conducted to analyze the safety and efficacy of aneurysm treatment with FRED/FRED Jr (Microvention, AlisoViejo, CA, USA) in current clinical practice.</div></div><div><h3>Patients and methods</h3><div>Patients with intracranial aneurysms treated with FRED and FRED Jr who agreed to participate were prospectively and consecutively included in all French centers using these devices.</div></div><div><h3>Results</h3><div>From June 2020 to January 2022, 135 patients (110 females, 81.5%, and 25 males, 18.5%) with 154 aneurysms were included in 13 French interventional neuroradiology centers. The mean age was 53.9 ± 12.2 years (range: 20 – 77 years). Aneurysm was unruptured in 123 cases (79.9%), ruptured in 4 cases (2.6%), and recanalized in 27 cases (17.5%). Most aneurysms were small (135/154, 87.7%). Aneurysm locations were supraclinoid ICA in 83 (53.9%), cavernous and petrous ICA in 25 (16.2%), anterior cerebral artery or anterior communicating artery in 19 (12.3%), MCA in 7 (4.5%), and posterior circulation in 20 (13.0%). Three patients (2.2%) had hemorrhagic complications (1 delayed aneurysm rupture and 2 delayed remote hematoma) and 3 (2.2%) ischemic complications (2 intrastent thrombosis and 1 stroke related to atherosclerosis) leading to 1-year morbimortality of 4.4%. Complete aneurysm occlusion was reported in 105/139 aneurysms (75.5%).</div></div><div><h3>Conclusions</h3><div>FRED-EPI confirms good safety of aneurysm treatment with FRED/FRED Jr in current clinical practice with 4.4% 1-year morbimortality.</div></div>","PeriodicalId":50115,"journal":{"name":"Journal of Neuroradiology","volume":"52 1","pages":"Article 101240"},"PeriodicalIF":3.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143015326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MRI management of NMOSD and MOGAD: Proposals from the French Expert Group NOMADMUS","authors":"Françoise Durand-Dubief ,&nbsp;Natalia Shor ,&nbsp;Bertrand Audoin ,&nbsp;Bertrand Bourre ,&nbsp;Mickael Cohen ,&nbsp;Stéphane Kremer ,&nbsp;Elisabeth Maillart ,&nbsp;Caroline Papeix ,&nbsp;Aurélie Ruet ,&nbsp;Julien Savatovsky ,&nbsp;Thomas Tourdias ,&nbsp;Xavier Ayrignac ,&nbsp;Jonathan Ciron ,&nbsp;Nicolas Collongues ,&nbsp;David Laplaud ,&nbsp;Laure Michel ,&nbsp;Romain Deschamps ,&nbsp;Eric Thouvenot ,&nbsp;Hélène Zephir ,&nbsp;Romain Marignier ,&nbsp;François Cotton","doi":"10.1016/j.neurad.2024.101235","DOIUrl":"10.1016/j.neurad.2024.101235","url":null,"abstract":"<div><h3>Background</h3><div>Currently, there are no available recommendations or guidelines on how to perform MRI monitoring in the management of neuromyelitis optica spectrum disorder (NMOSD) and myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD). The issue is to determine a valuable MRI monitoring protocol to be applied in the management of NMOSD and MOGAD, as previously proposed for the monitoring of multiple sclerosis.</div></div><div><h3>Objectives</h3><div>The objectives of this work are to establish proposals for a standardized and feasible MRI acquisition protocol, and to propose control time points for systematic MRI monitoring in the management of NMOSD and MOGAD.</div></div><div><h3>Methods</h3><div>A steering committee composed of 7 neurologists and 5 neuroradiologists, experts in NMOSD and MOGAD from the French group NOMADMUS, defined 8 proposals based on their expertise and a review from the literature. These proposals were then submitted to a Rating Group composed of French NMOSD / MOGAD experts.</div></div><div><h3>Results</h3><div>In the management of NMOSD and MOGAD, a consensus has been reached to perform systematic MRI of the brain, optic nerve and spinal cord, including cauda equina nerve roots, at the time of diagnosis, both without and after gadolinium administration. Moreover, it has been agreed to perform a systematic MRI scan 6 months after diagnosis, focusing on the area of interest, both without and after gadolinium administration. For long-term follow-up of NMOSD and MOGAD, and in the absence of clinical activity, it has been agreed to perform gadolinium-free MRI of the brain (+/- optic nerves) and spinal cord, every 36 months. Ideally, these MRI scans should be performed on the same MRI system, preferably a 3T MRI system for brain and optic nerve MRI, and at least a 1.5T MRI system for spinal cord MRI.</div></div><div><h3>Conclusions</h3><div>This expert consensus approach provides physicians with proposals for the MRI management of NMOSD and MOGAD.</div></div>","PeriodicalId":50115,"journal":{"name":"Journal of Neuroradiology","volume":"52 1","pages":"Article 101235"},"PeriodicalIF":3.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142774321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}