Journal of Neuroradiology最新文献

{"title":"Imagerie de la neurosarcoïdose : points forts en IRM (à propose de 16 cas).","authors":"Zineb Gourram,&nbsp;Mohamed Labied,&nbsp;Chorouk Mountassir,&nbsp;Ghizlane Lembarki,&nbsp;Mouna Sabiri,&nbsp;Samira Lezar","doi":"10.1016/j.neurad.2025.101289","DOIUrl":"10.1016/j.neurad.2025.101289","url":null,"abstract":"<div><h3>Objectifs</h3><div>Illustrer les aspects radiologiques caractéristiques de la neurosarcoïdose à travers une revue iconographique.</div><div>Savoir conduire un diagnostic différentiel avec les autres atteintes de la substance blanche du SNC.</div></div><div><h3>Matériels et méthodes</h3><div>- étude descriptive rétrospective portant sur 16 cas colligés au service de radiologie central du CHU Ibn Rochd, Casablanca, entre novembre 2019 et avril 2024</div><div>- Tous les patients ont bénéficié d'une IRM cérébrale et/ou médullaire.</div><div>- L'IRM a été considérée comme pathologique dès lors qu'une lésion compatible avec la neurosarcoïdose était observée en séquences T2 FLAIR ou T1 après injection de gadolinium.</div></div><div><h3>Résultats</h3><div>â<strong>ge des patients</strong> : De 20 à 60 ans, avec une moyenne de 40,5 ans.</div><div><strong>Sexe ratio</strong> : 10H/6F.</div><div><strong>Antécédents de sarcoïdose</strong> : 7 patients avaient un antécédent de sarcoïdose connu.</div><div><strong>Atteinte neurologique inaugurale</strong> chez 9 patients.</div><div><strong>Atteinte des nerfs crâniens</strong> : 3 patients, avec une prédominance pour les nerfs V (trijumeau) et VII (facial).</div><div><strong>Atteinte du système nerveux périphérique</strong> : 4 patients.</div><div><strong>Localisations privilégiées</strong> :</div><div>- Atteinte leptoméningée : Présente dans 8 cas, sous forme d'un épaississement nodulaire des leptoméninges avec prise de contraste diffuse.</div><div>- Atteinte hypothalamo-hypophysaire : 2 cas, avec épaississement de la tige pituitaire et hypertrophie de la glande hypophysaire.</div><div>- Infiltration des nerfs crâniens (V) : 3 cas.</div><div>- Masses intra-axiales nodulaires : 5 cas.</div><div>- Atteinte pachyméningée : 1 cas.</div><div>- Hydrocéphalie : 1 cas.</div><div>- Atteinte médullaire : 4 cas.</div><div><strong>Observations complémentaires</strong> : Polymorphisme des lésions : 10 patients ont présenté au moins 2 types de lésions différentes.</div></div><div><h3>Conclusion</h3><div>â· L'IRM constitue un outil essentiel dans le diagnostic et le suivi de la neurosarcoïdose, permettant d'identifier des caractéristiques radiologiques spécifiques.</div><div>- Les résultats de cette étude illustrent l'importance de la détection précoce des lésions typiques pour poser un diagnostic rapide et initier une prise en charge thérapeutique appropriée.</div></div>","PeriodicalId":50115,"journal":{"name":"Journal of Neuroradiology","volume":"52 2","pages":"Article 101289"},"PeriodicalIF":3.0,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143444378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The brain in oral-facial-digital syndrome type 1: New insights from human and mouse data","authors":"Roman Hossein Khonsari,&nbsp;Leclercq Delphine,&nbsp;Pulh Pernelle,&nbsp;Kogane Nicolas,&nbsp;Franco Brunella,&nbsp;Catala Martin","doi":"10.1016/j.neurad.2025.101334","DOIUrl":"10.1016/j.neurad.2025.101334","url":null,"abstract":"","PeriodicalId":50115,"journal":{"name":"Journal of Neuroradiology","volume":"52 3","pages":"Article 101334"},"PeriodicalIF":3.0,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143445491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experimental study on the mechanism of cerebral edema development and MM-MRI manifestation in burned rats","authors":"Muhammad Usman ,&nbsp;Guiqiong He ,&nbsp;Hong Lu","doi":"10.1016/j.neurad.2025.101323","DOIUrl":"10.1016/j.neurad.2025.101323","url":null,"abstract":"<div><div>Objective: The goal of this study was to investigate post-burn cerebral edema, establish its MM-MRI manifestation, and explore the underlying molecular mechanisms. Methods: Rats were randomly assigned to four groups (8h, 24h, 48h, and 72h post-burn) and subjected to thermal burns to induce skin injury, following the rat burn model. Treatment was administered based on Parkland's formula. At specific time points, rats were evaluated using MM-MRI sequences (T₁ WI, T2 WI, T₂ FLAIR, DWI, and ADC mapping) alongside histological analysis (H&amp;E, TEM) and molecular techniques (IHC, IF, and WB). Results: All experimental groups exhibited significantly increased post-burn cerebral edema compared to the sham control group. While no significant changes were observed on T₁WI, T₂ WI, and T₂ FLAIR images, post-burn cerebral edema was clearly visible on DWI and ADC maps in the region of interest (ROI) the basal ganglia. Histological analysis (H&amp;E, TEM) corroborated these findings. Notably, all experimental groups (8h, 24h, 48h, and 72h) showed upregulated expression of AQP4 compared to controls, as evidenced by IHC, IF, and WB. Further, astrocyte end-feet and endothelial cells exhibited significant swelling may be due to AQP4 overexpression, leading to increased intracellular water content. Conclusion: This study confirms the presence of post-burn cerebral edema in the early stages following burn trauma, might be mediated by AQP4, as supported by histological findings. Radiological results indicate that DWI and ADC mapping are sensitive methods for diagnosing and monitoring post-burn cerebral edema.</div></div>","PeriodicalId":50115,"journal":{"name":"Journal of Neuroradiology","volume":"52 3","pages":"Article 101323"},"PeriodicalIF":3.0,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143442609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"White matter hyperintensities regress at a high rate at three months after minor ischemic stroke or transient ischemic attack","authors":"Yuyun Xu ,&nbsp;Danjiang Huang ,&nbsp;He Zhang ,&nbsp;Qifen Fang ,&nbsp;Yuwei Xia ,&nbsp;Feng Shi ,&nbsp;Xiangyang Gong","doi":"10.1016/j.neurad.2024.101239","DOIUrl":"10.1016/j.neurad.2024.101239","url":null,"abstract":"<div><h3>Background</h3><div>The potential for early white matter hyperintensities(WMH) regression and associated contributory factors remains uncertain. The purpose of this study is to investigate whether WMH regress at early time of three months after minor ischemic stroke (MIS) or transient ischemic attack (TIA), while also identifying factors that may influence this outcome.</div></div><div><h3>Methods</h3><div>A retrospective analysis of a prospective subcohort from the CHANCE trial comprising individuals with MIS and TIA was conducted. All patients underwent brain MRI at the onset and at three months. Deep learning algorithms were employed for the automatic segmentation of WMH volumes in four distinct regions. Scores for lacunes, cerebral microbleeds (CMB), perivascular spaces (PVS), WMH, and overall cerebral small vessel disease (CSVD) burden were quantified. Patients were divided into the stable, regression and progression groups according to change in WMH volume. The demographic, clinical, and imaging data of the participants in the three groups were collected and statistically analyzed.</div></div><div><h3>Results</h3><div>A total of 98 patients with minor ischemic stroke or TIA were included. There were 22 patients in the stable group, 41 patients in the regression group and 35 patients in the progression group. Age and hypertension status were significantly different among the three groups. The lacunes, CMB,WMH, and total CSVD burden scores differed notably among groups, with all the CSVD markers being severely elevated in the progression group, moderately elevated in the regression group, and subtly elevated in the stable group.</div></div><div><h3>Conclusion</h3><div>The findings suggest that WMH could exhibit regression within three months following minor ischemic stroke or TIA. Patients under the age of 65, without a hypertension history, and with a low CSVD burden are more likely to experience WMH regression.</div></div>","PeriodicalId":50115,"journal":{"name":"Journal of Neuroradiology","volume":"52 1","pages":"Article 101239"},"PeriodicalIF":3.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142973064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The art and agony of AI in neuroradiology","authors":"Marc Lenfant","doi":"10.1016/j.neurad.2024.101237","DOIUrl":"10.1016/j.neurad.2024.101237","url":null,"abstract":"","PeriodicalId":50115,"journal":{"name":"Journal of Neuroradiology","volume":"52 1","pages":"Article 101237"},"PeriodicalIF":3.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142824628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FRED-EPI study: Safety and efficacy of FRED/FRED Jr aneurysm treatment in current clinical practice","authors":"Laurent Pierot ,&nbsp;Denis Herbreteau ,&nbsp;Xavier Barreau ,&nbsp;Hervé Brunel ,&nbsp;Jacques Sedat ,&nbsp;Laurent Spelle ,&nbsp;Roberto Riva ,&nbsp;Olivier Heck ,&nbsp;Matthias Gawlitza ,&nbsp;Gaultier Marnat ,&nbsp;Kevin Janot ,&nbsp;Kamel Boubagra ,&nbsp;Omer Eker","doi":"10.1016/j.neurad.2024.101240","DOIUrl":"10.1016/j.neurad.2024.101240","url":null,"abstract":"<div><h3>Objective</h3><div>Flow diversion is increasingly used as an endovascular treatment for intracranial aneurysms. FRED-EPI is a prospective, multicenter, French study, conducted to analyze the safety and efficacy of aneurysm treatment with FRED/FRED Jr (Microvention, AlisoViejo, CA, USA) in current clinical practice.</div></div><div><h3>Patients and methods</h3><div>Patients with intracranial aneurysms treated with FRED and FRED Jr who agreed to participate were prospectively and consecutively included in all French centers using these devices.</div></div><div><h3>Results</h3><div>From June 2020 to January 2022, 135 patients (110 females, 81.5%, and 25 males, 18.5%) with 154 aneurysms were included in 13 French interventional neuroradiology centers. The mean age was 53.9 ± 12.2 years (range: 20 – 77 years). Aneurysm was unruptured in 123 cases (79.9%), ruptured in 4 cases (2.6%), and recanalized in 27 cases (17.5%). Most aneurysms were small (135/154, 87.7%). Aneurysm locations were supraclinoid ICA in 83 (53.9%), cavernous and petrous ICA in 25 (16.2%), anterior cerebral artery or anterior communicating artery in 19 (12.3%), MCA in 7 (4.5%), and posterior circulation in 20 (13.0%). Three patients (2.2%) had hemorrhagic complications (1 delayed aneurysm rupture and 2 delayed remote hematoma) and 3 (2.2%) ischemic complications (2 intrastent thrombosis and 1 stroke related to atherosclerosis) leading to 1-year morbimortality of 4.4%. Complete aneurysm occlusion was reported in 105/139 aneurysms (75.5%).</div></div><div><h3>Conclusions</h3><div>FRED-EPI confirms good safety of aneurysm treatment with FRED/FRED Jr in current clinical practice with 4.4% 1-year morbimortality.</div></div>","PeriodicalId":50115,"journal":{"name":"Journal of Neuroradiology","volume":"52 1","pages":"Article 101240"},"PeriodicalIF":3.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143015326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MRI management of NMOSD and MOGAD: Proposals from the French Expert Group NOMADMUS","authors":"Françoise Durand-Dubief ,&nbsp;Natalia Shor ,&nbsp;Bertrand Audoin ,&nbsp;Bertrand Bourre ,&nbsp;Mickael Cohen ,&nbsp;Stéphane Kremer ,&nbsp;Elisabeth Maillart ,&nbsp;Caroline Papeix ,&nbsp;Aurélie Ruet ,&nbsp;Julien Savatovsky ,&nbsp;Thomas Tourdias ,&nbsp;Xavier Ayrignac ,&nbsp;Jonathan Ciron ,&nbsp;Nicolas Collongues ,&nbsp;David Laplaud ,&nbsp;Laure Michel ,&nbsp;Romain Deschamps ,&nbsp;Eric Thouvenot ,&nbsp;Hélène Zephir ,&nbsp;Romain Marignier ,&nbsp;François Cotton","doi":"10.1016/j.neurad.2024.101235","DOIUrl":"10.1016/j.neurad.2024.101235","url":null,"abstract":"<div><h3>Background</h3><div>Currently, there are no available recommendations or guidelines on how to perform MRI monitoring in the management of neuromyelitis optica spectrum disorder (NMOSD) and myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD). The issue is to determine a valuable MRI monitoring protocol to be applied in the management of NMOSD and MOGAD, as previously proposed for the monitoring of multiple sclerosis.</div></div><div><h3>Objectives</h3><div>The objectives of this work are to establish proposals for a standardized and feasible MRI acquisition protocol, and to propose control time points for systematic MRI monitoring in the management of NMOSD and MOGAD.</div></div><div><h3>Methods</h3><div>A steering committee composed of 7 neurologists and 5 neuroradiologists, experts in NMOSD and MOGAD from the French group NOMADMUS, defined 8 proposals based on their expertise and a review from the literature. These proposals were then submitted to a Rating Group composed of French NMOSD / MOGAD experts.</div></div><div><h3>Results</h3><div>In the management of NMOSD and MOGAD, a consensus has been reached to perform systematic MRI of the brain, optic nerve and spinal cord, including cauda equina nerve roots, at the time of diagnosis, both without and after gadolinium administration. Moreover, it has been agreed to perform a systematic MRI scan 6 months after diagnosis, focusing on the area of interest, both without and after gadolinium administration. For long-term follow-up of NMOSD and MOGAD, and in the absence of clinical activity, it has been agreed to perform gadolinium-free MRI of the brain (+/- optic nerves) and spinal cord, every 36 months. Ideally, these MRI scans should be performed on the same MRI system, preferably a 3T MRI system for brain and optic nerve MRI, and at least a 1.5T MRI system for spinal cord MRI.</div></div><div><h3>Conclusions</h3><div>This expert consensus approach provides physicians with proposals for the MRI management of NMOSD and MOGAD.</div></div>","PeriodicalId":50115,"journal":{"name":"Journal of Neuroradiology","volume":"52 1","pages":"Article 101235"},"PeriodicalIF":3.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142774321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of cerebral collateral recycle status on clinical outcomes in elderly patients with endovascular stroke treatment","authors":"Chen Gong ,&nbsp;Jin Liu ,&nbsp;Ziyang Huang ,&nbsp;Shuyu Jiang ,&nbsp;Liping Huang ,&nbsp;Zhiyuan Wang ,&nbsp;Yankun Chen ,&nbsp;Jinxian Yuan ,&nbsp;You Wang ,&nbsp;Zhiyu Xiong ,&nbsp;Yangmei Chen ,&nbsp;Siyin Gong ,&nbsp;Shengli Chen ,&nbsp;Tao Xu","doi":"10.1016/j.neurad.2024.101236","DOIUrl":"10.1016/j.neurad.2024.101236","url":null,"abstract":"<div><h3>Background</h3><div>Elderly patients are at high risk of acute ischemic stroke caused by large vessel occlusion (AIS-LVO) and usually suffer disability and fatality from stroke even after receiving endovascular treatment (EVT). Previous studies lacked the knowledge of comprehensive cerebral collateral for elderly patients. Hence, we explore the role of cerebral collateral recycle (CCR) status in clinical outcomes in a real-world setting among elderly AIS-LVO patients undergoing EVT.</div></div><div><h3>Methods</h3><div>This was a multicenter retrospective cohort study. Computed tomographic angiography (CTA) at admission was applied to evaluate cerebral venous outflow profiles by the Cortical Vein Opacification Score (COVES) and pial arterial collaterals by the Tan scale. According to the status of cerebral collaterals, enrolled patients were divided into the poor, moderate, and favorable CCR groups. The primary outcome was functional independence (90-day modified Rankin Scale score 0–2).</div></div><div><h3>Results</h3><div>Among 860 AIS-LVO patients receiving EVT, a total of 338 elderly patients were included in the present study after strict screening. Compared with the poor CCR group, the moderate CCR group (31.1 % vs. 10.2 %; adjusted odds ratio[aOR] 3.80; 95 % confidence interval[CI] 1.71–8.44; <em>P</em> = 0.001) and the favorable CCR group (63.3 % vs. 10.2 %; aOR 8.49; 95 % CI 4.02–17.92; <em>P</em> &lt; 0.001) both had a significantly higher rate of functional independence. In subgroup analysis, similar results were found in AIS-LVO patients with older age, large core infarction, or late time window.</div></div><div><h3>Conclusion</h3><div>The cerebral collateral status in elderly patients with AIS-LVO treated by EVT is a strong predictor of functional outcomes and more robust CCR means better outcomes.</div></div>","PeriodicalId":50115,"journal":{"name":"Journal of Neuroradiology","volume":"52 1","pages":"Article 101236"},"PeriodicalIF":3.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142792753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The ARIANES initiative: A vision for a structured regional MRI network in the Hauts-de-France","authors":"J.P. Pruvo,&nbsp;G. Kuchcinski,&nbsp;M. Bretzner,&nbsp;S. Krystal,&nbsp;J. Dumont,&nbsp;B. Le Guellec,&nbsp;Lotfi Hacein-Bey,&nbsp;R. Lopes","doi":"10.1016/j.neurad.2024.101238","DOIUrl":"10.1016/j.neurad.2024.101238","url":null,"abstract":"","PeriodicalId":50115,"journal":{"name":"Journal of Neuroradiology","volume":"52 1","pages":"Article 101238"},"PeriodicalIF":3.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142824627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emerging non-invasive MRI techniques for glymphatic system assessment in neurodegenerative disease","authors":"Daniele Botta ,&nbsp;Ioana Hutuca ,&nbsp;Elyas El Ghoul ,&nbsp;Lukas Sveikata ,&nbsp;Frédéric Assal ,&nbsp;Karl-Olof Lövblad ,&nbsp;Felix T. Kurz","doi":"10.1016/j.neurad.2025.101322","DOIUrl":"10.1016/j.neurad.2025.101322","url":null,"abstract":"<div><div>The discovery of the glymphatic system has revolutionized our understanding of brain physiology, particularly in waste clearance and fluid dynamics within the central nervous system. This pathway, essential for nutrient distribution and waste removal, operates predominantly during sleep and has been implicated in neurodegenerative diseases like Alzheimer's and Parkinson's. Recent advances in non-invasive MRI techniques, including diffusion tensor imaging along the perivascular space (DTI-ALPS), perivascular space (PVS) analysis, and free water (FW) indices, have improved our ability to study glymphatic function and its alterations in disease states. This review discusses the glymphatic system's ultrastructure, physiology, and the latest imaging methods to assess this critical pathway. We highlight how these non-invasive MRI techniques can enhance the understanding of glymphatic function in health and disease, with a focus on neurodegenerative conditions. By integrating insights from current research, this review underscores the diagnostic and therapeutic implications of glymphatic dysfunction. Understanding these mechanisms can pave the way for novel strategies to enhance waste clearance and improve neurological health, offering potential benefits for early diagnosis and intervention in neurodegenerative diseases.</div></div>","PeriodicalId":50115,"journal":{"name":"Journal of Neuroradiology","volume":"52 3","pages":"Article 101322"},"PeriodicalIF":3.0,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143081899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}