Journal of Neuroradiology最新文献

{"title":"The ARIANES initiative: A vision for a structured regional MRI network in the Hauts-de-France","authors":"J.P. Pruvo, G. Kuchcinski, M. Bretzner, S. Krystal, J. Dumont, B. Le Guellec, Lotfi Hacein-Bey, R. Lopes","doi":"10.1016/j.neurad.2024.101238","DOIUrl":"10.1016/j.neurad.2024.101238","url":null,"abstract":"","PeriodicalId":50115,"journal":{"name":"Journal of Neuroradiology","volume":"52 1","pages":"Article 101238"},"PeriodicalIF":3.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142824627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emerging non-invasive MRI techniques for glymphatic system assessment in neurodegenerative disease","authors":"Daniele Botta ,&nbsp;Ioana Hutuca ,&nbsp;Elyas El Ghoul ,&nbsp;Lukas Sveikata ,&nbsp;Frédéric Assal ,&nbsp;Karl-Olof Lövblad ,&nbsp;Felix T. Kurz","doi":"10.1016/j.neurad.2025.101322","DOIUrl":"10.1016/j.neurad.2025.101322","url":null,"abstract":"<div><div>The discovery of the glymphatic system has revolutionized our understanding of brain physiology, particularly in waste clearance and fluid dynamics within the central nervous system. This pathway, essential for nutrient distribution and waste removal, operates predominantly during sleep and has been implicated in neurodegenerative diseases like Alzheimer's and Parkinson's. Recent advances in non-invasive MRI techniques, including diffusion tensor imaging along the perivascular space (DTI-ALPS), perivascular space (PVS) analysis, and free water (FW) indices, have improved our ability to study glymphatic function and its alterations in disease states. This review discusses the glymphatic system's ultrastructure, physiology, and the latest imaging methods to assess this critical pathway. We highlight how these non-invasive MRI techniques can enhance the understanding of glymphatic function in health and disease, with a focus on neurodegenerative conditions. By integrating insights from current research, this review underscores the diagnostic and therapeutic implications of glymphatic dysfunction. Understanding these mechanisms can pave the way for novel strategies to enhance waste clearance and improve neurological health, offering potential benefits for early diagnosis and intervention in neurodegenerative diseases.</div></div>","PeriodicalId":50115,"journal":{"name":"Journal of Neuroradiology","volume":"52 3","pages":"Article 101322"},"PeriodicalIF":3.0,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143081899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The apparent diffusion coefficient color Map for evaluating a large ischemic core","authors":"Takeru Umemura ,&nbsp;Yuko Tanaka ,&nbsp;Toru Kurokawa ,&nbsp;Ryo Miyaoka ,&nbsp;Masaru Idei ,&nbsp;Hirotsugu Ohta ,&nbsp;Junkoh Yamamoto","doi":"10.1016/j.neurad.2025.101315","DOIUrl":"10.1016/j.neurad.2025.101315","url":null,"abstract":"<div><h3>Introduction</h3><div>Our previous work demonstrated that evaluating large ischemic cores using the apparent diffusion coefficient (ADC) could predict EVT outcomes, with the most frequent ADC (peak ADC) ≥520×10^–6 mm²/s associated with better clinical results. Since the degree of ADC reduction reflects the severity of ischemic stress, this study aimed to assess the utility of an ADC color map in visualizing this stress.</div></div><div><h3>Patients and methods</h3><div>This retrospective cohort study included consecutive patients with a low Alberta Stroke Program Early Computed Tomography Score (ASPECTS) using diffusion-weighted imaging (DWI) who underwent successful EVT recanalization between April 2014 and March 2023. To create a visual representation of ischemic stress, we assigned different colors to diffusion-weighted image (DWI) lesions based on their ADC values: ≥520×10^–6 mm²/s, 520–440×10^–6 mm²/s, and &lt;440×10^–6 mm²/s. We compared patients with peak ADC ≥520×10^–6 mm²/s to those with lower peak ADC to identify factors associated with the higher value.</div></div><div><h3>Results</h3><div>A total of 78 patients were enrolled, with 34 having a peak ADC ≥520×10^–6 mm²/s. The optimal ratio for discriminating peak ADC ≥520×10^–6 mm²/s was found to be 60 % for the volume of the lesion with ADC ≥520×10^–6 mm²/s (ADC₅₂₀) relative to the total DWI lesion volume. This ratio demonstrated a sensitivity of 86 % and a specificity of 82 %.</div></div><div><h3>Discussion and conclusion</h3><div>The ADC color map effectively portrays the depth of ischemic stress. A large ischemic core with an ADC₅₂₀/DWI ratio &gt;60 % may be salvageable with EVT. This approach offers a visual means for assessing EVT suitability in acute large ischemic stroke.</div></div>","PeriodicalId":50115,"journal":{"name":"Journal of Neuroradiology","volume":"52 2","pages":"Article 101315"},"PeriodicalIF":3.0,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perivascular enhancement pattern: Identification, diagnostic spectrum and practical approach – A pictorial review","authors":"Matthias Babin ,&nbsp;Marianne Golse ,&nbsp;Manel Khaterchi ,&nbsp;Blanche Bapst ,&nbsp;Claire Ancelet ,&nbsp;Ghaidaa Nasser ,&nbsp;Farida Benoudiba","doi":"10.1016/j.neurad.2025.101242","DOIUrl":"10.1016/j.neurad.2025.101242","url":null,"abstract":"<div><div>Perivascular spaces (PVS) are fluid-filled structures that form the immediate peripheral environment of small cerebral vessels. They are a central component of the glymphatic system, which plays a crucial role in maintaining cerebral homeostasis. Their involvement in central nervous system diseases is currently a major focus of research, particularly in neuroimaging. Pathological enhancement of PVS on post-contrast MRI sequences creates a distinctive pattern due to their topography. As with other intracranial enhancement patterns, a differential diagnosis approach can be applied to perivascular enhancement (PVE). However, it is particularly challenging due to the rarity and complexity of the conditions involved. This article aims to facilitate the recognition of PVE pattern, to highlight the various causal conditions and to propose a practical diagnostic approach.</div></div>","PeriodicalId":50115,"journal":{"name":"Journal of Neuroradiology","volume":"52 2","pages":"Article 101242"},"PeriodicalIF":3.0,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143015328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The number of recanalization attempts, procedure time and endovascular therapy outcomes in acute large core stroke patients","authors":"Yapeng Guo ,&nbsp;Changwei Guo ,&nbsp;Dahong Yang ,&nbsp;Shitao Fan ,&nbsp;Xu Xu ,&nbsp;Jinfu Ma ,&nbsp;Zibao Li ,&nbsp;Shihai Yang ,&nbsp;Xiaolei Shi ,&nbsp;Zhixi Wang ,&nbsp;Wenjie Zi ,&nbsp;Guoyong Zeng ,&nbsp;Xianjun Huang","doi":"10.1016/j.neurad.2024.101241","DOIUrl":"10.1016/j.neurad.2024.101241","url":null,"abstract":"<div><h3>Introduction</h3><div>Landmark thrombectomy trials demonstrated improved functional outcomes after endovascular therapy (EVT) for large core strokes (LCSs). This study explored the impact of recanalization attempts and procedure time (PT) on outcomes in LCS patients.</div></div><div><h3>Patients and Methods</h3><div>This was a retrospective study of patients with LCSs who underwent EVT from a prospective multicentre cohort. LCS was defined as an Alberta Stroke Program Early Computed Tomography Score of 0 to 5. Patients were divided into 6 groups (unsuccessful reperfusion [modified Thrombolysis in Cerebral Infarction Scale (mTICI) 0–2a] and successful reperfusion [mTICI, 2b/3]) after 1, 2, 3, 4, or &gt;4 attempts. The primary outcome was a favorable 90-day mRS score of 0–3. Secondary outcomes included mRS 0–4, 90-day mortality, and 48-hour rates of symptomatic (sICH) and any intracranial hemorrhage (aICH).</div></div><div><h3>Results</h3><div>A total of 447 patients were analysed. 388 with successful reperfusion, 59 without.Successful reperfusion during the first 3 passes increased the odds of favourable functional outcomes [attempt 1: aOR, 4.454 (1.723–11.514),p=0.002; 2: aOR, 3.762 (1.437–9.847),p=0.07; or 3: aOR, 3.619 (1.254–10.440),p=0.017] and decreased mortality at 90 days [(attempt 1: aOR, 0.336 (0.155–0.727),p=0.006; 2: aOR, 0.346 (0.160–0.746),p=0.007; or 3: aOR, 0.395 (0.164–0.953),p=0.039]. A shorter PT increased the odds of a favourable functional outcome [aOR, 0.991 (0.985–0.997),p=0.002]. PT may reduce the association between the number of attempts and patient outcomes. No associations were found between the number of attempts and sICH or aICH, whereas there was an increasing trend in the proportion of aICH or sICH when the number of attempts was more than two.</div></div><div><h3>Conclusion</h3><div>In patients with LCSs who underwent EVT, successful reperfusion within the first 3 attempts and a shorter PT were associated with favourable functional outcomes. However, the effect size of the association between the number of attempts and clinical outcomes may gradually decrease with extension of the PT.</div></div>","PeriodicalId":50115,"journal":{"name":"Journal of Neuroradiology","volume":"52 2","pages":"Article 101241"},"PeriodicalIF":3.0,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143025545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative efficacy, safety, and DMSO compatibility of detachable vs. non-detachable tip microcatheters in neurointerventional procedures: A systematic review and meta-analysis","authors":"Atakan Orscelik ,&nbsp;Basel Musmar ,&nbsp;Esref Alperen Bayraktar ,&nbsp;Jonathan Cortese ,&nbsp;Yigit Can Senol ,&nbsp;Sherief Ghozy ,&nbsp;Muhammed Amir Essibayi ,&nbsp;Gokce Belge Bilgin ,&nbsp;Madona Pakkam ,&nbsp;Cem Bilgin ,&nbsp;Waleed Brinjikji ,&nbsp;David F. Kallmes","doi":"10.1016/j.neurad.2024.101234","DOIUrl":"10.1016/j.neurad.2024.101234","url":null,"abstract":"<div><h3>Background</h3><div>The evolution of embolic agents necessitates the use of microcatheters compatible with dimethyl sulfoxide (DMSO), with detachable tip microcatheters (DTMs) emerging as a significant innovation aimed at reducing the risk of catheter entrapment in embolization procedures. This study aims to compare the efficacy, safety, and DMSO compatibility of DTMs with non-detachable tip microcatheters (Non-DTMs) in the context of embolization treatments for neurovascular diseases.</div></div><div><h3>Method</h3><div>Following PRISMA guidelines, a systematic literature search was conducted across PubMed, Scopus, Embase, and Web of Science databases until February 25, 2024. Primary outcomes included technical success and microcatheter-related complications, with a meta-analysis performed using a random-effects model to calculate proportions and odds ratios (OR) with 95 % confidence intervals (Cl).</div></div><div><h3>Results</h3><div>Forty-five studies involving 2185 patients and 3758 catheters (995 DTMs and 2763 Non-DTMs) were analyzed. Our analysis revealed that DTMs were associated with comparable rates of technical success (98.3 % vs. 97.6 %, <em>p</em> = 0.68), favorable outcomes (93.9 % vs. 93.6 %, <em>p =</em> 0.89), and microcatheter-related complications compared to Non-DTMs. Specifically, DTMs showed a 0.0 % rate of microcatheter entrapment and hemorrhagic complications. Intended detachment was achieved in 41.7 % (95 % CI = 27.02–57.98) of cases and premature detachment was rare (0.1 %; 95 % %CI = 0.00–1.23). In the analysis of comparative studies, microcatheter-related complications did not defer between DTM and Non-DTM groups.</div></div><div><h3>Conclusion</h3><div>Our study demonstrates the safety and efficacy of DTMs in embolization treatments, emphasizing their compatibility with DMSO-based embolic agents and their potential to enhance patient outcomes in neurointerventional procedures. Future research should focus on well-designed, larger, prospective, comparative multi-center studies to strengthen the evidence base and further optimize the use of DTMs in endovascular interventions.</div></div>","PeriodicalId":50115,"journal":{"name":"Journal of Neuroradiology","volume":"52 1","pages":"Article 101234"},"PeriodicalIF":3.0,"publicationDate":"2024-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142734350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impaired iron metabolism and cerebral perfusion patterns in unilateral middle cerebral artery stenosis or occlusion: Insights from quantitative susceptibility mapping","authors":"Yu Guo ,&nbsp;Huimin Mao ,&nbsp;Kunjian Chen ,&nbsp;Weiqiang Dou ,&nbsp;Xinyi Wang","doi":"10.1016/j.neurad.2024.101233","DOIUrl":"10.1016/j.neurad.2024.101233","url":null,"abstract":"<div><h3>Background and purpose</h3><div>Cerebral hypoperfusion caused by stenosis or occlusion of the middle cerebral artery (MCA) may be followed by impaired iron metabolism. We explored the association between iron changes of gray matter (GM) nuclei subregions and different cerebral perfusion patterns in patients with chronic unilateral middle cerebral artery (MCA) stenosis or occlusion using quantitative susceptibility imaging (QSM).</div></div><div><h3>Methods</h3><div>Sixty-one patients with unilateral MCA stenosis or occlusion were recruited and scored with Alberta-Stroke-Program-Early-CT-Score (ASPECTS) based on relative cerebral blood flow (rCBF) measurements to calculate the number of corresponding hypoperfusion subregions, and then divided into an extensive-hypoperfusion group (EH group), regional-hypoperfusion group (RH group), and normal-perfusion group (Control group) accordingly. The measured magnetic susceptibility of GM nuclei subregions was compared between the lesion and contralateral side for each group and among the three groups. Correlation analysis was performed to assess the relationships of magnetic susceptibility of GM nuclei with mean rCBF, National-Institutes-of-Health-stroke-scale (NIHSS) and modified-Rankin-scale (mRS) scores.</div></div><div><h3>Results</h3><div>Magnetic susceptibility in the putamen (PU) and globus pallidus (GP) at the lesion side was higher in the EH and RH groups compared with the contralateral side (all P &lt; 0.05). Susceptibility in the lesion side PU and GP showed negative correlations with mean rCBF and positive correlations with NIHSS and mRS scores (all P &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>Our findings demonstrate that chronic cerebral hypoperfusion might be one cause of cerebral abnormal iron metabolism. In addition, magnetic susceptibility of PU and GP seems to be correlated with stroke scale scores, suggesting that iron deposition may play an important role in neurologic deficits after ischemic stroke.</div></div>","PeriodicalId":50115,"journal":{"name":"Journal of Neuroradiology","volume":"52 1","pages":"Article 101233"},"PeriodicalIF":3.0,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142640153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep learning segmentation-based bone removal from computed tomography of the brain improves subdural hematoma detection","authors":"Masis Isikbay ,&nbsp;M.Travis Caton ,&nbsp;Jared Narvid ,&nbsp;Jason Talbott ,&nbsp;Soonmee Cha ,&nbsp;Evan Calabrese","doi":"10.1016/j.neurad.2024.101231","DOIUrl":"10.1016/j.neurad.2024.101231","url":null,"abstract":"<div><h3>Purpose</h3><div>Timely identification of intracranial blood products is clinically impactful, however the detection of subdural hematoma (SDH) on non-contrast CT scans of the head (NCCTH) is challenging given interference from the adjacent calvarium. This work explores the utility of a NCCTH bone removal algorithm for improving SDH detection.</div></div><div><h3>Methods</h3><div>A deep learning segmentation algorithm was designed/trained for bone removal using 100 NCCTH. Segmentation accuracy was evaluated on 15 NCCTH from the same institution and 22 NCCTH from an independent external dataset using quantitative overlap analysis between automated and expert manual segmentations. The impact of bone removal on detecting SDH by junior radiology trainees was evaluated with a reader study comparing detection performance between matched cases with and without bone removal applied.</div></div><div><h3>Results</h3><div>Average Dice overlap between automated and manual segmentations from the internal and external test datasets were 0.9999 and 0.9957, which was superior to other publicly available methods. Among trainee readers, SDH detection was statistically improved using NCCTH with and without bone removal applied compared to standard NCCTH alone (P value &lt;0.001). Additionally, 12/14 (86 %) of participating trainees self-reported improved detection of extra axial blood products with bone removal, and 13/14 (93 %) indicated that they would like to have access to NCCTH bone removal in the on-call setting.</div></div><div><h3>Conclusion</h3><div>Deep learning segmentation-based NCCTH bone removal is rapid, accurate, and improves detection of SDH among trainee radiologists when used in combination with standard NCCTH. This study highlights the potential of bone removal for improving confidence and accuracy of SDH detection.</div></div>","PeriodicalId":50115,"journal":{"name":"Journal of Neuroradiology","volume":"52 1","pages":"Article 101231"},"PeriodicalIF":3.0,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142631410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intra-operative use of Augmented Reality for 3D visualisation of rotational angiography data: Feasibility and workflow demonstration using a PCOM aneurysm case","authors":"Mikkel V. Petersen,&nbsp;Mia H. Christiansen,&nbsp;Ronni Mikkelsen","doi":"10.1016/j.neurad.2024.101232","DOIUrl":"10.1016/j.neurad.2024.101232","url":null,"abstract":"<div><div>In this Neuro-Interventional Video, we demonstrate a novel Augmented Reality (AR) platform for visualising vascular imaging data during interventional procedures. The platform allows clinicians to interact with 3D patient data through head-mounted displays while remaining sterile. Our workflow converts rotational angiography data to 3D models in real-time, and enables intuitive hand-tracked manipulation of patient data, including tools for cropping, size measurement, and C-arm projection assessment. We show how AR can enhance understanding of patient vascular pathology.</div></div>","PeriodicalId":50115,"journal":{"name":"Journal of Neuroradiology","volume":"52 1","pages":"Article 101232"},"PeriodicalIF":3.0,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142606860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progressive T1 high-intensity plaques in carotid stenosis: Comparative MRI analyses in asymptomatic and symptomatic phases of low-grade stenosis","authors":"Yoshitaka Kurosaki ,&nbsp;Masanori Kinosada ,&nbsp;Hiroyuki Ikeda ,&nbsp;Haruki Yamashita ,&nbsp;Kazumichi Yoshida ,&nbsp;Masaki Chin","doi":"10.1016/j.neurad.2024.101223","DOIUrl":"10.1016/j.neurad.2024.101223","url":null,"abstract":"<div><h3>Background and Purpose</h3><div>Carotid artery stenosis, particularly the progression from asymptomatic to symptomatic lesions, is a key factor in cerebrovascular events. This study identifies predictors of symptom development in low-grade carotid stenosis (&lt;50%), focusing on intraplaque hemorrhage (IPH) and dynamic plaque changes.</div></div><div><h3>Materials and Methods</h3><div>We conducted a retrospective study analyzing 30 cases of symptomatic low-grade carotid stenosis, using carotid MRI before and after symptom onset. Key measures included relative plaque signal intensity (rSI) and high-intensity plaque (HI plaque) volume. Stepwise regression analysis examined the influence of these factors on Symptomatic rSI, Symptomatic plaque volume, and NIHSS scores.</div></div><div><h3>Results</h3><div>Significant increases were observed in rSI (1.32 ± 0.32 to 1.69 ± 0.25, p &lt; 0.001) and HI plaque volume (296.4 ± 362.7 mm³ to 717.5 ± 554.9 mm³, p &lt; 0.001) from asymptomatic to symptomatic phases. Past smoking (p = 0.008) and statin use (p = 0.04) were associated with higher Symptomatic rSI, while poor risk factor control (p = 0.03) was negatively associated. Female sex (p = 0.007) and current smoking (p = 0.009) were linked to smaller Symptomatic plaque volumes, while ischemic heart disease (p = 0.0002) and poor risk factor control (p = 0.002) predicted larger plaque volumes. Larger plaques were correlated with higher NIHSS scores (p = 0.002).</div></div><div><h3>Conclusions</h3><div>IPH and plaque volume are key markers of progression in low-grade carotid stenosis. Poor control of cardiovascular risk factors and a history of ischemic heart disease contribute to plaque burden and stroke severity. Continuous monitoring and strict risk management are essential in reducing stroke severity in these patients.</div></div>","PeriodicalId":50115,"journal":{"name":"Journal of Neuroradiology","volume":"51 6","pages":"Article 101223"},"PeriodicalIF":3.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142479309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}