{"title":"Extracellular volume fraction of liver and pancreas using spectral CT in hypertensive patients: A comparative study.","authors":"Xiaoming Huang, Zhen Zhang, Jiansheng Wang, Yaqing Yang, Tianqi Hao, Shuai Zhang, Ling Liu, Guohua Wang","doi":"10.3233/XST-240130","DOIUrl":"https://doi.org/10.3233/XST-240130","url":null,"abstract":"<p><strong>Background: </strong>Besides the direct impact on the cardiovascular system, hypertension is closely associated with organ damage in the kidneys, liver, and pancreas. Chronic liver and pancreatic damage in hypertensive patients may be detectable via imaging.</p><p><strong>Objective: </strong>To explore the correlation between hypertension-related indicators and extracellular volume fraction (ECV) of liver and pancreas measured by iodine maps, and to evaluate corresponding clinical value in chronic damage of liver and pancreas in hypertensive patients.</p><p><strong>Methods: </strong>A prospective study from June to September 2023 included abdominal patients who underwent contrast-enhanced spectral CT. Normal and various grades of hypertensive blood pressure groups were compared. Upper abdominal iodine maps were constructed, and liver and pancreatic ECVs calculated. Kruskal-Wallis and Spearman analyses evaluated ECV differences and correlations with hypertension indicators.</p><p><strong>Results: </strong>In 300 patients, hypertensive groups showed significantly higher liver and pancreatic ECV than the normotensive group, with ECV rising alongside hypertension severity. ECVliver displayed a stronger correlation with hypertension stages compared to ECVpancreas. Regression analysis identified hypertension severity as an independent predictor for increased ECV.</p><p><strong>Conclusions: </strong>ECVliver and ECVpancreas positively correlates with hypertension indicators and serves as a potential clinical marker for chronic organ damage due to hypertension, with ECVliver being more strongly associated than ECVpancreas.</p>","PeriodicalId":49948,"journal":{"name":"Journal of X-Ray Science and Technology","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142141626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
V. Moock, Darien E. Arce Chávez, Crescencio García-Segundo, L. Ruiz-Huerta
{"title":"Photothermal effect in X-ray images for computed tomography of metallic parts: Stainless steel spheres","authors":"V. Moock, Darien E. Arce Chávez, Crescencio García-Segundo, L. Ruiz-Huerta","doi":"10.3233/xst-230260","DOIUrl":"https://doi.org/10.3233/xst-230260","url":null,"abstract":"BACKGROUND: The environmental impact on industrial X-ray tomography systems has gained its attention in terms of image precision and metrology over recent years, yet is still complex due to the variety of applications. OBJECTIVE: The current study explores the photothermal repercussions of the overall radiation exposure time. It shows the emerging dimensional uncertainty when measuring a stainless steel sphere by means of circular tomography scans. METHODS: The authors develop a novel frame difference method for X-ray radiographies to evaluate the spatial changes induced in the projected absorption maps on the X-ray panel. The object of interest has a simple geometry for the purpose of proof of concept. The dominant source of the observed radial uncertainty is the photothermal effect due to high-energy X-ray scattering at the metal workpiece. Thermal variations are monitored by an infrared camera within the industrial tomography system, which confines that heat in the industrial grade X-ray system. RESULTS: The authors demonstrate that dense industrial computed tomography programs with major X-ray power notably affect the uncertainty of digital dimensional measurements. The registered temperature variations are consistent with dimensional changes in radiographies and hence form a source of error that might result in visible artifacts within the 3D image reconstruction. CONCLUSIONS: This contribution is of fundamental value to reach the balance between the number of projections and radial uncertainty tolerance when performing analysis with X-ray dimensional exploration in precision measurements with industrial tomography.","PeriodicalId":49948,"journal":{"name":"Journal of X-Ray Science and Technology","volume":"43 36","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139442549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"An adaptive weighted ensemble learning network for diabetic retinopathy classification","authors":"Panpan Wu, Yue Qu, Ziping Zhao, Yue Cui, Yurou Xu, Peng An, Hengyong Yu","doi":"10.3233/xst-230252","DOIUrl":"https://doi.org/10.3233/xst-230252","url":null,"abstract":"Diabetic retinopathy (DR) is one of the leading causes of blindness. However, because the data distribution of classes is not always balanced, it is challenging for automated early DR detection using deep learning techniques. In this paper, we propose an adaptive weighted ensemble learning method for DR detection based on optical coherence tomography (OCT) images. Specifically, we develop an ensemble learning model based on three advanced deep learning models for higher performance. To better utilize the cues implied in these base models, a novel decision fusion scheme is proposed based on the Bayesian theory in terms of the key evaluation indicators, to dynamically adjust the weighting distribution of base models to alleviate the negative effects potentially caused by the problem of unbalanced data size. Extensive experiments are performed on two public datasets to verify the effectiveness of the proposed method. A quadratic weighted kappa of 0.8487 and an accuracy of 0.9343 on the DRAC2022 dataset, and a quadratic weighted kappa of 0.9007 and an accuracy of 0.8956 on the APTOS2019 dataset are obtained, respectively. The results demonstrate that our method has the ability to enhance the ovearall performance of DR detection on OCT images.","PeriodicalId":49948,"journal":{"name":"Journal of X-Ray Science and Technology","volume":"58 7","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139449386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bo Liu, Shaima Haithem Zaki, Eduardo García, Amanda Bonilla, D. Thabit, Aya Hussein Adab
{"title":"The investigation of dose rate and photon beam energy dependence of optimized PASSAG polymer gel dosimeter using magnetic resonance imaging","authors":"Bo Liu, Shaima Haithem Zaki, Eduardo García, Amanda Bonilla, D. Thabit, Aya Hussein Adab","doi":"10.3233/xst-230282","DOIUrl":"https://doi.org/10.3233/xst-230282","url":null,"abstract":"OBJECTIVE: It seems that dose rate (DR) and photon beam energy (PBE) may influence the sensitivity and response of polymer gel dosimeters. In the current project, the sensitivity and response dependence of optimized PASSAG gel dosimeter (OPGD) on DR and PBE were assessed. MATERIALS AND METHODS: We fabricated the OPGD and the gel samples were irradiated with various DRs and PBEs. Then, the sensitivity and response (R 2) of OPGD were obtained by MRI at various doses and post-irradiation times. RESULTS: Our analysis showed that the sensitivity and response of OPGD are not affected by the evaluated DRs and PBEs. It was also found that the dose resolution values of OPGD ranged from 9 to 33 cGy and 12 to 34 cGy for the evaluated DRs and PBEs, respectively. Additionally, the data demonstrated that the sensitivity and response dependence of OPGD on DR and PBE do not vary over various times after the irradiation. CONCLUSIONS: The findings of this research project revealed that the sensitivity and response dependence of OPGD are independent of DR and PBE.","PeriodicalId":49948,"journal":{"name":"Journal of X-Ray Science and Technology","volume":"56 20","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139449477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shi Bo Jiang, Yue Wen Sun, Shuo Xu, Hua Xia Zhang, Zhi Fang Wu
{"title":"Semi-supervised segmentation of metal-artifact contaminated industrial CT images using improved CycleGAN","authors":"Shi Bo Jiang, Yue Wen Sun, Shuo Xu, Hua Xia Zhang, Zhi Fang Wu","doi":"10.3233/xst-230233","DOIUrl":"https://doi.org/10.3233/xst-230233","url":null,"abstract":"Accurate segmentation of industrial CT images is of great significance in industrial fields such as quality inspection and defect analysis. However, reconstruction of industrial CT images often suffers from typical metal artifacts caused by factors like beam hardening, scattering, statistical noise, and partial volume effects. Traditional segmentation methods are difficult to achieve precise segmentation of CT images mainly due to the presence of these metal artifacts. Furthermore, acquiring paired CT image data required by fully supervised networks proves to be extremely challenging. To address these issues, this paper introduces an improved CycleGAN approach for achieving semi-supervised segmentation of industrial CT images. This method not only eliminates the need for removing metal artifacts and noise, but also enables the direct conversion of metal artifact-contaminated images into segmented images without the requirement of paired data. The average values of quantitative assessment of image segmentation performance can reach 0.96645 for Dice Similarity Coefficient(Dice) and 0.93718 for Intersection over Union(IoU). In comparison to traditional segmentation methods, it presents significant improvements in both quantitative metrics and visual quality, provides valuable insights for further research.","PeriodicalId":49948,"journal":{"name":"Journal of X-Ray Science and Technology","volume":"53 12","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139449293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Md Sayed Tanveer, Christopher Wiedeman, Mengzhou Li, Yongyi Shi, Bruno De Man, Jonathan S. Maltz, Ge Wang
{"title":"Deep-silicon photon-counting x-ray projection denoising through reinforcement learning","authors":"Md Sayed Tanveer, Christopher Wiedeman, Mengzhou Li, Yongyi Shi, Bruno De Man, Jonathan S. Maltz, Ge Wang","doi":"10.3233/xst-230278","DOIUrl":"https://doi.org/10.3233/xst-230278","url":null,"abstract":"BACKGROUND: In recent years, deep reinforcement learning (RL) has been applied to various medical tasks and produced encouraging results. OBJECTIVE: In this paper, we demonstrate the feasibility of deep RL for denoising simulated deep-silicon photon-counting CT (PCCT) data in both full and interior scan modes. PCCT offers higher spatial and spectral resolution than conventional CT, requiring advanced denoising methods to suppress noise increase. METHODS: In this work, we apply a dueling double deep Q network (DDDQN) to denoise PCCT data for maximum contrast-to-noise ratio (CNR) and a multi-agent approach to handle data non-stationarity. RESULTS: Using our method, we obtained significant image quality improvement for single-channel scans and consistent improvement for all three channels of multichannel scans. For the single-channel interior scans, the PSNR (dB) and SSIM increased from 33.4078 and 0.9165 to 37.4167 and 0.9790 respectively. For the multichannel interior scans, the channel-wise PSNR (dB) increased from 31.2348, 30.7114, and 30.4667 to 31.6182, 30.9783, and 30.8427 respectively. Similarly, the SSIM improved from 0.9415, 0.9445, and 0.9336 to 0.9504, 0.9493, and 0.0326 respectively. CONCLUSIONS: Our results show that the RL approach improves image quality effectively, efficiently, and consistently across multiple spectral channels and has great potential in clinical applications.","PeriodicalId":49948,"journal":{"name":"Journal of X-Ray Science and Technology","volume":"61 48","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139449258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dehua Wang, Hayder Jasim Taher, Murtadha Al-Fatlawi, Badr Ahmed Abdullah, Munojat Khayatovna Ismailova, R. Abedi-Firouzjah
{"title":"Multi-parametric assessment of cardiac magnetic resonance images to distinguish myocardial infarctions: A tensor-based radiomics feature","authors":"Dehua Wang, Hayder Jasim Taher, Murtadha Al-Fatlawi, Badr Ahmed Abdullah, Munojat Khayatovna Ismailova, R. Abedi-Firouzjah","doi":"10.3233/xst-230307","DOIUrl":"https://doi.org/10.3233/xst-230307","url":null,"abstract":"AIM: This study assessed the myocardial infarction (MI) using a novel fusion approach (multi-flavored or tensor-based) of multi-parametric cardiac magnetic resonance imaging (CMRI) at four sequences; T1-weighted (T1W) in the axial plane, sense-balanced turbo field echo (sBTFE) in the axial plane, late gadolinium enhancement of heart short axis (LGE-SA) in the sagittal plane, and four-chamber views of LGE (LGE-4CH) in the axial plane. METHODS: After considering the inclusion and exclusion criteria, 115 patients (83 with MI diagnosis and 32 as healthy control patients), were included in the present study. Radiomic features were extracted from the whole left ventricular myocardium (LVM). Feature selection methods were Least Absolute Shrinkage and Selection Operator (Lasso), Minimum Redundancy Maximum Relevance (MRMR), Chi-Square (Chi2), Analysis of Variance (Anova), Recursive Feature Elimination (RFE), and SelectPersentile. The classification methods were Support Vector Machine (SVM), Logistic Regression (LR), and Random Forest (RF). Different metrics, including receiver operating characteristic curve (AUC), accuracy, F1- score, precision, sensitivity, and specificity were calculated for radiomic features extracted from CMR images using stratified five-fold cross-validation. RESULTS: For the MI detection, Lasso (as the feature selection) and RF/LR (as the classifiers) in sBTFE sequences had the best performance (AUC: 0.97). All features and classifiers of T1 + sBTFE sequences with the weighted method (as the fused image), had a good performance (AUC: 0.97). In addition, the results of the evaluated metrics, especially mean AUC and accuracy for all models, determined that the T1 + sBTFE-weighted fused method had strong predictive performance (AUC: 0.93±0.05; accuracy: 0.93±0.04), followed by T1 + sBTFE-PCA fused method (AUC: 0.85±0.06; accuracy: 0.84±0.06). CONCLUSION: Our selected CMRI sequences demonstrated that radiomics analysis enables to detection of MI accurately. Among the investigated sequences, the T1 + sBTFE-weighted fused method with the highest AUC and accuracy values was chosen as the best technique for MI detection.","PeriodicalId":49948,"journal":{"name":"Journal of X-Ray Science and Technology","volume":"56 2","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139449526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A hybrid thyroid tumor type classification system using feature fusion, multilayer perceptron and bonobo optimization.","authors":"B Shankarlal, S Dhivya, K Rajesh, S Ashok","doi":"10.3233/XST-230430","DOIUrl":"10.3233/XST-230430","url":null,"abstract":"<p><strong>Background: </strong>Thyroid tumor is considered to be a very rare form of cancer. But recent researches and surveys highlight the fact that it is becoming prevalent these days because of various factors.</p><p><strong>Objectives: </strong>This paper proposes a novel hybrid classification system that is able to identify and classify the above said four different types of thyroid tumors using high end artificial intelligence techniques. The input data set is obtained from Digital Database of Thyroid Ultrasound Images through Kaggle repository and augmented for achieving a better classification performance using data warping mechanisms like flipping, rotation, cropping, scaling, and shifting.</p><p><strong>Methods: </strong>The input data after augmentation goes through preprocessing with the help of bilateral filter and is contrast enhanced using dynamic histogram equalization. The ultrasound images are then segmented using SegNet algorithm of convolutional neural network. The features needed for thyroid tumor classification are obtained from two different algorithms called CapsuleNet and EfficientNetB2 and both the features are fused together. This process of feature fusion is carried out to heighten the accuracy of classification.</p><p><strong>Results: </strong>A Multilayer Perceptron Classifier is used for classification and Bonobo optimizer is employed for optimizing the results produced. The classification performance of the proposed model is weighted using metrics like accuracy, sensitivity, specificity, F1-score, and Matthew's correlation coefficient.</p><p><strong>Conclusion: </strong>It can be observed from the results that the proposed multilayer perceptron based thyroid tumor type classification system works in an efficient manner than the existing classifiers like CANFES, Spatial Fuzzy C means, Deep Belief Networks, Thynet and Generative adversarial network and Long Short-Term memory.</p>","PeriodicalId":49948,"journal":{"name":"Journal of X-Ray Science and Technology","volume":" ","pages":"651-675"},"PeriodicalIF":1.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139941063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jarrod Cortez, Ignacio Romero, Jason Ngo, Md Sayed Tanveer Azam, Chuang Niu, Cássio Luiz Coutinho Almeida-da-Silva, Leticia Ferreira Cabido, David M Ojcius, Wei-Chun Chin, Ge Wang, Changqing Li
{"title":"Multiple energy X-ray imaging of metal oxide particles inside gingival tissues.","authors":"Jarrod Cortez, Ignacio Romero, Jason Ngo, Md Sayed Tanveer Azam, Chuang Niu, Cássio Luiz Coutinho Almeida-da-Silva, Leticia Ferreira Cabido, David M Ojcius, Wei-Chun Chin, Ge Wang, Changqing Li","doi":"10.3233/XST-230175","DOIUrl":"10.3233/XST-230175","url":null,"abstract":"<p><strong>Background: </strong>Periodontal disease affects over 50% of the global population and is characterized by gingivitis as the initial sign. One dental health issue that may contribute to the development of periodontal disease is foreign body gingivitis (FBG), which can result from exposure to some kinds of foreign metal particles from dental products or food.</p><p><strong>Objective: </strong>We design a novel, portable, affordable, multispectral X-ray and fluorescence optical microscopic imaging system dedicated to detecting and differentiating metal oxide particles in dental pathological tissues. A novel denoising algorithm is applied. We verify the feasibility and optimize the performance of the imaging system with numerical simulations.</p><p><strong>Methods: </strong>The designed imaging system has a focused X-ray tube with tunable energy spectra and thin scintillator coupled with an optical microscope as detector. A simulated soft tissue phantom is embedded with 2-micron thick metal oxide discs as the imaged object. GATE software is used to optimize the systematic parameters such as energy bandwidth and X-ray photon number. We have also applied a novel denoising method, Noise2Sim with a two-layer UNet structure, to improve the simulated image quality.</p><p><strong>Results: </strong>The use of an X-ray source operating with an energy bandwidth of 5 keV, X-ray photon number of 108, and an X-ray detector with a 0.5 micrometer pixel size in a 100 by 100-pixel array allowed for the detection of particles as small as 0.5 micrometer. With the Noise2Sim algorithm, the CNR has improved substantially. A typical example is that the Aluminum (Al) target's CNR is improved from 6.78 to 9.72 for the case of 108 X-ray photons with the Chromium (Cr) source of 5 keV bandwidth.</p><p><strong>Conclusions: </strong>Different metal oxide particles were differentiated using Contrast-to-Noise ratio (CNR) by utilizing four different X-ray spectra.</p>","PeriodicalId":49948,"journal":{"name":"Journal of X-Ray Science and Technology","volume":" ","pages":"87-103"},"PeriodicalIF":3.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138048318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Multiple semantic X-ray medical image retrieval using efficient feature vector extracted by FPN.","authors":"Lijia Zhi, Shaoyong Duan, Shaomin Zhang","doi":"10.3233/XST-240069","DOIUrl":"10.3233/XST-240069","url":null,"abstract":"<p><strong>Objective: </strong>Content-based medical image retrieval (CBMIR) has become an important part of computer-aided diagnostics (CAD) systems. The complex medical semantic information inherent in medical images is the most difficult part to improve the accuracy of image retrieval. Highly expressive feature vectors play a crucial role in the search process. In this paper, we propose an effective deep convolutional neural network (CNN) model to extract concise feature vectors for multiple semantic X-ray medical image retrieval.</p><p><strong>Methods: </strong>We build a feature pyramid based CNN model with ResNet50V2 backbone to extract multi-level semantic information. And we use the well-known public multiple semantic annotated X-ray medical image data set IRMA to train and test the proposed model.</p><p><strong>Results: </strong>Our method achieves an IRMA error of 32.2, which is the best score compared to the existing literature on this dataset.</p><p><strong>Conclusions: </strong>The proposed CNN model can effectively extract multi-level semantic information from X-ray medical images. The concise feature vectors can improve the retrieval accuracy of multi-semantic and unevenly distributed X-ray medical images.</p>","PeriodicalId":49948,"journal":{"name":"Journal of X-Ray Science and Technology","volume":" ","pages":"1297-1313"},"PeriodicalIF":1.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141731580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}