Clinical Epidemiology and Global Health最新文献

{"title":"Attack rate and determinants of malaria outbreak in Ethiopia: A systematic review and meta-analysis","authors":"Diriba Etana Tola ,&nbsp;Azeb Haile Tesfaye ,&nbsp;Lencho Kajela Solbana ,&nbsp;Shalama Lekasa Nagari ,&nbsp;Zenebu Begna Bayissa ,&nbsp;Eshetu Ejeta Chaka","doi":"10.1016/j.cegh.2025.102045","DOIUrl":"10.1016/j.cegh.2025.102045","url":null,"abstract":"<div><h3>Background</h3><div>Malaria remains a public health challenge in Ethiopia. Despite progress in reducing cases and deaths, there has been a resurgence. This highlights the need to identify driving factors for malaria outbreaks and sustain progress toward elimination. This study aims to determine the overall attack rate of malaria outbreaks and identify the key determinants.</div></div><div><h3>Methods</h3><div>The study was registered with PROSPERO with the registration code CRD42025645940. Databases, including PubMed, EMBASE, Google Scholar, Google, and Web of Science. Analyzed using R version 4.2.3 and Stata version 17.0.</div></div><div><h3>Results</h3><div>In this study, the pooled estimated attack rate of malaria outbreaks in Ethiopia was 3 % (95 % CI: 2 %–5 %). Presence of stagnant water (OR = 3.45; 95 % CI: 2.06, 4.84), staying outside at night (OR = 3.79; 95 % CI: 2.39, 5.20), not using insecticide-treated bed nets (OR = 3.52; 95 % CI: 3.13, 3.92), lack of knowledge about transmission and preventions methods (OR = 4.73; 95 % CI: 1.67, 7.80), knowing transmission and prevention methods (OR = 0.38; 0.13, 0.64), presence of breeding sites (OR = 3.40; 95 % CI: 1.35, 5.44), not using indoor chemical sprays (OR = 3.19; 1.76, 4.63).</div></div><div><h3>Conclusion</h3><div>To combat these outbreaks, a comprehensive approach is recommended, involving environmental management to eliminate mosquito breeding sites, public health education, and increasing access to preventive tools such as ITNs and indoor residual spraying. Addressing these determinants effectively can reduce malaria outbreaks, leading to a decrease in morbidity and mortality, and improve public health outcomes.</div></div>","PeriodicalId":46404,"journal":{"name":"Clinical Epidemiology and Global Health","volume":"33 ","pages":"Article 102045"},"PeriodicalIF":2.3,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143873701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circulating Asprosin and Neuregulin-4 in metabolic dysfunction-associated steatotic liver disease (MASLD): A systematic review and meta-analysis","authors":"Roshan Kumar Mahat ,&nbsp;Vedika Rathore","doi":"10.1016/j.cegh.2025.102041","DOIUrl":"10.1016/j.cegh.2025.102041","url":null,"abstract":"<div><h3>Background</h3><div>Adipokines, such as asprosin and neuregulin 4 (Nrg4), are implicated in the pathogenesis of metabolic dysfunction-associated steatotic liver disease (MASLD) and may function as potential diagnostic biomarkers and therapeutic targets. The objective of this meta-analysis is to compare the circulating levels of asprosin and Nrg4 between populations with MASLD and those without the condition.</div></div><div><h3>Methods</h3><div>A systematic review and meta-analysis were conducted in accordance with the PRISMA guidelines. Databases including PubMed, Scopus, and Europe PMC were systematically searched for observational studies published until October 7, 2024. Inclusion criteria consisted of studies that reported extractable data on circulating asprosin and Nrg4 in populations with and without MASLD. Random-effects models were employed to calculate standardized mean differences (SMDs) and mean differences (MDs) with 95 % confidence intervals (CIs). Heterogeneity among studies was assessed using Cochrane's Q test, as well as <em>I</em>^<em>2</em> and Tau² statistics. Furthermore, sensitivity analysis and publication bias were evaluated to ensure the robustness of the findings.</div></div><div><h3>Results</h3><div>Ten studies were included, with four analysing asprosin and six analysing Nrg4. Patients with MASLD exhibited significantly higher circulating asprosin levels (SMD = 0.82, 95 % CI: 0.49–1.15; <em>p</em> &lt; 0.01; <em>I</em>^<em>2</em> = 65 %) and lower Nrg4 levels (SMD = −1.12, 95 % CI: 1.77 to −0.46; <em>p</em> &lt; 0.01; <em>I</em>^<em>2</em> = 94 %) compared to non-MASLD individuals. Sensitivity analyses confirmed the robustness of these findings.</div></div><div><h3>Conclusions</h3><div>Elevated asprosin and reduced Nrg4 levels are associated with MASLD, highlighting their potential as biomarkers and therapeutic targets. Further studies are warranted to validate these findings.</div></div>","PeriodicalId":46404,"journal":{"name":"Clinical Epidemiology and Global Health","volume":"33 ","pages":"Article 102041"},"PeriodicalIF":2.3,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143873699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between age, obesity indices, and cardiometabolic risk factors in Women: Findings from a point-of-care health screening in South Sulawesi, Indonesia","authors":"Ika Yustisia ,&nbsp;Liong Boy Kurniawan ,&nbsp;Tenri Esa ,&nbsp;Syahrijuita ,&nbsp;Sri Astuti Thamrin","doi":"10.1016/j.cegh.2025.102048","DOIUrl":"10.1016/j.cegh.2025.102048","url":null,"abstract":"<div><h3>Background</h3><div>Metabolic syndrome (MetS) significantly increases the risk of diabetes mellitus and cardiovascular disease. The prevalence of MetS is higher in women due to factors such as pregnancy, menopause, and lifestyle habits. In Indonesia, MetS affects 21.66 % of the population, with women being disproportionately affected. Biomarkers may improve diagnosis; early detection is essential for care and prevention. This study evaluates health screening results among women in South Sulawesi, Indonesia, to provide insights into MetS prevalence and risk factors.</div></div><div><h3>Methods</h3><div>Using point-of-care devices, this study analyzed data sources on health examination results from a community service activity attended by 139 female participants undergoing a comprehensive health assessment, including anthropometric, blood pressure, and biochemical measurements.</div></div><div><h3>Results</h3><div>The study's findings revealed a range of significant health concerns among the female participants, including hypertension, hyperuricemia, hypercholesterolemia, and obesity. These conditions were found to increase with age. The study also identified specific cutoff values for body weight and body mass index that could predict hypertension, 57.7 kg and 24.8 kg/m2, respectively, and the visceral fat index that could indicate potential hyperuricemia was 8.8.</div></div><div><h3>Conclusion</h3><div>Metabolic health screening identifies obesity, hypertension, hypercholesterolemia, and hyperuricemia as key concerns for women's health in South Sulawesi, Indonesia. These findings highlight the need for further validation and targeted interventions to improve women's metabolic health<strong>.</strong></div></div>","PeriodicalId":46404,"journal":{"name":"Clinical Epidemiology and Global Health","volume":"33 ","pages":"Article 102048"},"PeriodicalIF":2.3,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143869178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in overweight and obesity among reproductive-age women in sub-Saharan African countries from 1990 to 2030: Progress towards 2030 SDG nutrition targets","authors":"A.A. Tareke ,&nbsp;A. Mohammed ,&nbsp;Y. Ali ,&nbsp;A. Muche","doi":"10.1016/j.cegh.2025.102044","DOIUrl":"10.1016/j.cegh.2025.102044","url":null,"abstract":"<div><h3>Objective</h3><div>We aimed to determine the trends of overweight and obesity among women of reproductive age (WRA) in sub-Saharan countries from 1990 to 2030. We also calculated the likelihood of achieving the Sustainable Development Goals (SDGs) in this region.</div></div><div><h3>Study design</h3><div>Repeated cross-sectional study.</div></div><div><h3>Methods</h3><div>The study employed 122 nationally representative cross-sectional survey datasets from 32 countries within sub-Saharan Africa. A Bayesian linear regression model was employed to determine overweight and obesity estimates, complete with 95 % credible intervals, based on data from 769,724 women.</div></div><div><h3>Results</h3><div>Twenty-eight countries (87.5 %) showed an increasing trend compared with the 1990 overweight value. Only four countries (Burundi, Congo, Lesotho, and Sierra Leone) showed a decreasing trend. In all countries except Lesotho, the proportion of overweight has increased since 2015. From 2024 to 2030, no country is expected to experience a decline in overweight prevalence. Of the 32 countries, 31 (96.88 %) have an increasing obesity rate. Only Sierra Leone shows a decreasing trend from 1990 to 2024. The prevalence of obesity has increased in all 32 countries since the start of the SDGs. No country is on track to meet the SDG target of eliminating all forms of malnutrition related overweight and obesity by 2030.</div></div><div><h3>Conclusions</h3><div>The increasing prevalence of overweight and obesity among WRA in SSA is a significant concern. Aggressive interventions are required to address this problem. New initiatives beyond the SDG era may also be needed to prevent the ongoing surge.</div></div>","PeriodicalId":46404,"journal":{"name":"Clinical Epidemiology and Global Health","volume":"33 ","pages":"Article 102044"},"PeriodicalIF":2.3,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143876515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of young-onset diabetes and associated physical activity profile in southern India","authors":"Anupama Harihar ,&nbsp;G. Arun Maiya ,&nbsp;Sahana Shetty ,&nbsp;Shivashankar K.N. ,&nbsp;Shyamasunder Bhat N.","doi":"10.1016/j.cegh.2025.102040","DOIUrl":"10.1016/j.cegh.2025.102040","url":null,"abstract":"<div><h3>Background/objective</h3><div>A temporal shift is noticed in the age of diagnosis of type 2 diabetes mellitus among young adults globally. Physical inactivity is a significant contributor to the higher prevalence of young-onset diabetes in India. This study aims to estimate the prevalence of young-onset diabetes in southern India and to identify the physical activity level and barriers in young adults.</div></div><div><h3>Methods</h3><div>This is a cross-sectional study including individuals aged 18–40 years. A total of 273 participants were included by random selection of individuals attending a tertiary hospital for routine checkups. In the first stage, the prevalence of type 2 diabetes was estimated using capillary blood glucose level evaluation. The second stage includes the profiling of physical activity &amp; identification of barriers to physical activity among physically inactive individuals using a self-reported questionnaire.</div></div><div><h3>Result</h3><div>The overall prevalence of young-onset type 2 diabetes was found to be 17.2 %. Pre-existing type 2 diabetes was 11.3 %, while 5.8 % of new cases were found with no previous history of diabetes. In males, the prevalence was 10.6 %, whereas in females, it was 6.5 %. The majority of individuals with young-onset type 2 diabetes were physically inactive, and the most common barriers identified were lack of time, willpower, and energy.</div></div><div><h3>Conclusion</h3><div>This study reveals a high prevalence of type 2 diabetes below the age of 40 years in India. Screening for diabetes by the age of 25 years is highly recommended. Management strategies are needed to overcome the identified barriers and promote physical activity in young adults.</div></div>","PeriodicalId":46404,"journal":{"name":"Clinical Epidemiology and Global Health","volume":"33 ","pages":"Article 102040"},"PeriodicalIF":2.3,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143873700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiological profile and treatment of cystic echinococcosis hospitalized cases in Morocco between 2011 and 2021","authors":"Ilham Benmoujjane ,&nbsp;Souad Bouhout ,&nbsp;Aicha mehdioui ,&nbsp;Houda Chebli ,&nbsp;Meryem Zabarra ,&nbsp;Mohammed Akrim ,&nbsp;Hassan Chrifi ,&nbsp;Touria Benamar","doi":"10.1016/j.cegh.2025.102035","DOIUrl":"10.1016/j.cegh.2025.102035","url":null,"abstract":"<div><h3>Background/objective</h3><div>Cystic Echinococcosis (CE) is a globally spread zoonotic disease. In Morocco, CE is endemic. The objective was to study Morocco's epidemiological profile and management of hospitalized patients with CE.</div></div><div><h3>Methods</h3><div>This research was done retrospectively over 11 years (2011–2021). It included 7385 cases from all regions of Morocco.</div></div><div><h3>Results</h3><div>Between 2011 and 2021, the annual incidence decreased from 4.55 to 1.18 (per 100,000 population). The patients' ages varied from one to 115 years. The sex ratio of women to men was 1.54. Rural areas accounted for 62.96 % of the patients. The diagnostic method commonly used was the ultrasound (67.62 %). The liver (80.85 %) was the most affected organ, followed by the lungs (15.68 %). Type I cysts accounted for 56.35 % of all HC cases. Surgery was performed in 97.33 % of the patients, with 57.01 % being conservative. The outcome was favorable for 98.48 % of the cases. The Average Length of Stay (ALOS) in the hospital for CE patients was 11 days.</div></div><div><h3>Conclusion</h3><div>Significant progress has been made towards achieving the goal of CE eradication by 2030, but Morocco still faces a significant threat due to the high number of hospitalized cases and resulting deaths.</div></div>","PeriodicalId":46404,"journal":{"name":"Clinical Epidemiology and Global Health","volume":"33 ","pages":"Article 102035"},"PeriodicalIF":2.3,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143869177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between parental nationalities and childhood overweight/obesity in Japan: An analysis of nationally representative survey data","authors":"Tasuku Okui,&nbsp;Naoki Nakashima","doi":"10.1016/j.cegh.2025.102042","DOIUrl":"10.1016/j.cegh.2025.102042","url":null,"abstract":"<div><h3>Background</h3><div>Few studies have investigated the association between nativity or nationality and childhood overweight/obesity in Japan. Therefore, this study aimed to assess the association between parental nationalities and childhood overweight/obesity in Japan using nationally representative survey data.</div></div><div><h3>Methods</h3><div>Data from the Longitudinal Survey of Newborns in the 21st Century (2010 Cohort) in Japan, which longitudinally monitored height and weight of children from 2.5 years to 12 years, were used. Parental nationalities were categorized as Japanese and non-Japanese. The prevalence of overweight/obesity was calculated according to combinations of parental nationalities for each age. In addition, the generalized estimating equation was used to investigate the association between parental nationalities and overweight/obesity, and the sociodemographic characteristics of children were adjusted.</div></div><div><h3>Results</h3><div>The analysis utilized data on 37,190 children. Results showed that the proportions of overweight/obesity in children born to non-Japanese mother and Japanese father and those whose parents were both non-Japanese were higher than the proportion in children whose parents were both Japanese regardless of age, and the proportion in children whose parents were both non-Japanese was the highest in many cases. The generalized estimating equation analysis showed that children born to non-Japanese mother had a significantly higher risk for overweight/obesity than those born to Japanese mother.</div></div><div><h3>Conclusions</h3><div>In conclusion, the risk of childhood overweight/obesity differed based on maternal nationality in Japan. The study highlights the need for investigating health-related behaviors and statuses of non-Japanese children more in Japan in the future.</div></div>","PeriodicalId":46404,"journal":{"name":"Clinical Epidemiology and Global Health","volume":"33 ","pages":"Article 102042"},"PeriodicalIF":2.3,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143878726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unmet needs to achieve disease control among patients with hypertension and diabetes, Pathanamthitta, Kerala, India, 2023: A mixed methods study.","authors":"Abey Sushan,&nbsp;Malu Mohan,&nbsp;Aby Robinson,&nbsp;Anjali Krishna,&nbsp;Boopathi Kangusamy,&nbsp;Sendhilkumar Muthappan,&nbsp;Abdulkader Suliankatchi Rizwan","doi":"10.1016/j.cegh.2025.102036","DOIUrl":"10.1016/j.cegh.2025.102036","url":null,"abstract":"<div><h3>Background</h3><div>This study addresses unmet needs in managing hypertension and diabetes at public health institutions in Pathanamthitta district, Kerala, India, highlighting the significance of non-pharmacological approaches and psychosocial support.</div></div><div><h3>Methods</h3><div>This mixed-methods cross-sectional study was conducted in two phases: a quantitative phase followed by a qualitative phase. 18 Primary Health Centers (PHCs), one urban PHC, and six Community Health Centers (CHCs) were selected through simple random sampling. Patients were interviewed using a structured, interviewer-administered questionnaire. Quantitative data were analyzed and presented as frequencies and percentages, while qualitative data were transcribed and thematically analyzed to identify key themes.</div></div><div><h3>Results</h3><div>We interviewed 346 patients, of whom 144 (41.6 %) had only hypertension, 57 (16.5 %) had only diabetes, and 145 (41.9 %) had both conditions. Hypertension was under control in 89 (31.4 %) patients, while diabetes was under control in 51 (27.7 %) patients. Among the 89 patients with controlled hypertension, most had unmet needs for information about their condition (91.0 %), diet (90.9 %), and exercise (88.8 %). Unmet need for information about disease condition was reported by 44 (88·0 %) of 50 patients who achieved control of diabetes compared to 127 (94·8 %) among 134 patients who did not achieve control. Qualitative data identified meal preparation and household chores as major barriers to effective disease management.</div></div><div><h3>Conclusion</h3><div>Unmet needs are high across domains like information about disease, drug, and exercise. Establishment of community-based support groups for patients with hypertension and/or diabetes to enable collective motivation for sustained lifestyle changes can be explored to achieve better control.</div></div>","PeriodicalId":46404,"journal":{"name":"Clinical Epidemiology and Global Health","volume":"33 ","pages":"Article 102036"},"PeriodicalIF":2.3,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143869176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of swallow fatigue and its relationship with self reported swallowing difficulties among community dwelling older adults in the Indian population","authors":"Uzair Chilwan ,&nbsp;K. Vijaya Kumar ,&nbsp;Sudhin Karuppali ,&nbsp;Venkataraja U. Aithal ,&nbsp;Thejaswi Dodderi ,&nbsp;Sahlah Shameer ,&nbsp;Radish Kumar Balasubramanium","doi":"10.1016/j.cegh.2025.102034","DOIUrl":"10.1016/j.cegh.2025.102034","url":null,"abstract":"<div><h3>Problem considered</h3><div>Swallowing fatigue significantly impacts older adults, affecting daily activities and increasing the risk of disability. This study explored the prevalence of swallowing fatigue among healthy young, middle-aged, and older adults and its relationship with self-reported swallowing difficulties.</div></div><div><h3>Method</h3><div>A cross-sectional study was conducted with 389 participants. The Swallowing and Eating-Related Fatigue Scale in Kannada (SERF-K) and self-reported scales (EAT-10K, DHI-K) were used. Reliability was assessed through internal consistency and test-retest reproducibility.</div></div><div><h3>Results</h3><div>SERF-K demonstrated good internal consistency (Cronbach's α = 0.752), with individual item consistency ranging from 0.729 to 0.849. Older adults had a mean SERF-K score of 12.1, with 41.5 % reporting swallowing fatigue. A moderate correlation (r = 0.56) was observed between swallowing fatigue and self-reported difficulties.</div></div><div><h3>Conclusion</h3><div>These findings emphasize the necessity of recognizing swallow fatigue as a crucial factor in understanding swallowing difficulties across different age groups. While older adults exhibited a higher prevalence of swallowing fatigue, the presence of this symptom in young and middle aged adults also highlights the importance of early identification and early intervention. Addressing swallowing fatigue can contribute to improving overall quality of life and reducing the risk of disability related to swallowing in the general population.</div></div>","PeriodicalId":46404,"journal":{"name":"Clinical Epidemiology and Global Health","volume":"33 ","pages":"Article 102034"},"PeriodicalIF":2.3,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143850445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acceptance of booster dose of COVID-19 vaccine and factors influencing it among health care workers at Tikur Anbessa specialized hospital, in Addis Ababa, Ethiopia","authors":"Bahja Ahmed Mohammed,&nbsp;Zelalem Tilahun Tesfaye,&nbsp;Fikreselam Habte Hailemariam,&nbsp;Chalelgn Kassaw Belete","doi":"10.1016/j.cegh.2025.102027","DOIUrl":"10.1016/j.cegh.2025.102027","url":null,"abstract":"<div><h3>Background</h3><div>The COVID-19 booster dose (BD) was introduced to enhance protection after the initial vaccination series. However, its acceptance remains low, particularly among healthcare workers (HCWs). This study aimed to assess BD acceptance among HCWs at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia, and identify the factors influencing their decision.</div></div><div><h3>Methodology</h3><div>A cross-sectional study was conducted among 423 HCWs from May to June 2022. Data were collected using a self-administered questionnaire and a convenient sampling technique. Descriptive and inferential analyses were performed using SPSS version 25. Binary logistic regression was applied to identify factors associated with BD acceptance.</div></div><div><h3>Results</h3><div>A total of 399 HCWs completed the survey, with 51.4 % male, 80.5 % health professionals, and 60.2 % aged 18–30 years. More than half had no prior COVID-19 infection. Despite 86.5 % holding favorable attitudes toward BD, only 28.6 % accepted it. BD acceptance was significantly higher among HCWs aged 31–40 years (AOR = 2.21), 41–50 years (AOR = 4.14), and over 50 years (AOR = 6.00) compared to those aged 18–30 years. Married individuals (AOR = 1.82), those with post-vaccination COVID-19 infection (AOR = 1.94), and those with a favorable attitude toward BD (AOR = 16.74) were more likely to accept it.</div></div><div><h3>Conclusion</h3><div>Less than one-third of HCWs accepted the COVID-19 BD. Older age, marital status, prior post-vaccination COVID-19 infection, and positive attitudes toward vaccination were significant predictors. Low acceptance among HCWs may influence public confidence in immunization, necessitating targeted interventions to improve uptake.</div></div>","PeriodicalId":46404,"journal":{"name":"Clinical Epidemiology and Global Health","volume":"33 ","pages":"Article 102027"},"PeriodicalIF":2.3,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143863407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}