Clinical Epidemiology and Global Health最新文献

{"title":"Acceptance of booster dose of COVID-19 vaccine and factors influencing it among health care workers at Tikur Anbessa specialized hospital, in Addis Ababa, Ethiopia","authors":"Bahja Ahmed Mohammed,&nbsp;Zelalem Tilahun Tesfaye,&nbsp;Fikreselam Habte Hailemariam,&nbsp;Chalelgn Kassaw Belete","doi":"10.1016/j.cegh.2025.102027","DOIUrl":"10.1016/j.cegh.2025.102027","url":null,"abstract":"<div><h3>Background</h3><div>The COVID-19 booster dose (BD) was introduced to enhance protection after the initial vaccination series. However, its acceptance remains low, particularly among healthcare workers (HCWs). This study aimed to assess BD acceptance among HCWs at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia, and identify the factors influencing their decision.</div></div><div><h3>Methodology</h3><div>A cross-sectional study was conducted among 423 HCWs from May to June 2022. Data were collected using a self-administered questionnaire and a convenient sampling technique. Descriptive and inferential analyses were performed using SPSS version 25. Binary logistic regression was applied to identify factors associated with BD acceptance.</div></div><div><h3>Results</h3><div>A total of 399 HCWs completed the survey, with 51.4 % male, 80.5 % health professionals, and 60.2 % aged 18–30 years. More than half had no prior COVID-19 infection. Despite 86.5 % holding favorable attitudes toward BD, only 28.6 % accepted it. BD acceptance was significantly higher among HCWs aged 31–40 years (AOR = 2.21), 41–50 years (AOR = 4.14), and over 50 years (AOR = 6.00) compared to those aged 18–30 years. Married individuals (AOR = 1.82), those with post-vaccination COVID-19 infection (AOR = 1.94), and those with a favorable attitude toward BD (AOR = 16.74) were more likely to accept it.</div></div><div><h3>Conclusion</h3><div>Less than one-third of HCWs accepted the COVID-19 BD. Older age, marital status, prior post-vaccination COVID-19 infection, and positive attitudes toward vaccination were significant predictors. Low acceptance among HCWs may influence public confidence in immunization, necessitating targeted interventions to improve uptake.</div></div>","PeriodicalId":46404,"journal":{"name":"Clinical Epidemiology and Global Health","volume":"33 ","pages":"Article 102027"},"PeriodicalIF":2.3,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143863407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mapping the research landscape of lifestyle modification in PCOS management: A 10 year bibliometric analysis","authors":"Rohit Gautam ,&nbsp;Asmitha Bhateja ,&nbsp;Neena Malhotra ,&nbsp;Taruna Arora","doi":"10.1016/j.cegh.2025.102024","DOIUrl":"10.1016/j.cegh.2025.102024","url":null,"abstract":"<div><h3>Objective</h3><div>Polycystic Ovary Syndrome (PCOS) is a prevalent endocrine disorder affecting women of reproductive age, with significant implications for metabolic, reproductive, and psychological health. The objective of the study is to conduct a 10-year bibliometric analysis of research trends on lifestyle modifications in PCOS treatment.</div></div><div><h3>Methodology</h3><div>This bibliometric analysis examines the 10-year research landscape (2015–2024) on lifestyle modification for PCOS management, analyzing global trends, key contributors, and thematic advancements using Web of Science data and VOS viewer tool. A total 2214 studies has been selected for bibliometric analysis.</div></div><div><h3>Result</h3><div>Results indicate a steady increase in research output, highest between 2022 and 2023, underscoring the growing recognition of lifestyle interventions. Monash University emerged as the leading institution, driving high-impact research, and fostering global collaborations. The USA, China, and England dominates the research landscape, while emerging nations like India and Iran contribute culturally tailored interventions. Key authors, including Helena Teede and Lisa Moran, play central roles, reflected in their high publication counts and citation impacts. Keyword analysis highlights weight loss, obesity, insulin resistance, and quality of life as primary research focuses, with recent trends (2021–2024) exploring gut micro biota optimization, oxidative stress, and mindfulness-based interventions.</div></div><div><h3>Conclusion</h3><div>Despite progress, contributions from Africa and South America highlight the need for global equity in research. This analysis highlights dynamic research shifts, emerging trends, and the critical need for global equity and collaboration to advance evidence-based lifestyle interventions for PCOS management.</div></div>","PeriodicalId":46404,"journal":{"name":"Clinical Epidemiology and Global Health","volume":"33 ","pages":"Article 102024"},"PeriodicalIF":2.3,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143859899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating Compliance with National Guidelines for Urinary Tract Infection Treatment in Lebanese Hospitals: A Multicenter Cross-Sectional Study","authors":"Deema Rahme ,&nbsp;Hania Nakkash Chmaisse ,&nbsp;Rabih Hallit ,&nbsp;Pascale Salameh","doi":"10.1016/j.cegh.2025.102032","DOIUrl":"10.1016/j.cegh.2025.102032","url":null,"abstract":"<div><h3>Background</h3><div>Inappropriate antibiotic prescribing for urinary tract infections (UTIs) is a major issue in Lebanon, leading to increased antimicrobial resistance (AMR). This study assesses antibiotic-prescribing practices and evaluates physicians' adherence to national guidelines for UTI management in hospitalized patients, while also identifying factors linked to inappropriate prescribing.</div></div><div><h3>Methods</h3><div>This cross-sectional study was conducted in five university hospitals across Lebanon from March 2022 to December 2023. Prescribed antibiotics were compared against the Lebanese national guidelines for UTIs. Data analysis utilized IBM SPSS® version 27, incorporating descriptive statistics, bivariate analysis, and multivariable logistic regression, with significance set at p ≤ 0.05.</div></div><div><h3>Results</h3><div>The study included 401 patients (61.8 % females), with a mean age of 64.81 years. Appropriate antibiotic prescribing occurred in 52.4 % of cases, highest in complicated pyelonephritis (62.3 %) and lowest in uncomplicated pyelonephritis (38.7 %). Bivariate analysis linked older age (p = 0.042), flank pain (p &lt; 0.001), nausea/vomiting (p = 0.001), and frequency/urgency (p = 0.007) to appropriate treatment. Physician position significantly impacted adherence (consultants: 81.8 % vs. residents: 32.4 %, p &lt; 0.001). Multivariable analysis showed that carbapenems (OR: 1.76, p = 0.032) and fluoroquinolones (OR: 9.49, p &lt; 0.001) were associated with inappropriate prescribing.</div></div><div><h3>Conclusions</h3><div>The study reveals widespread non-compliance with UTI treatment guidelines in Lebanon, leading to inappropriate antibiotic use and AMR. It is recommended that educational programs, prescribing audits, and improved residency training be implemented. Reinforcement of Antimicrobial Stewardship Programs, the use of clinical decision support tools, and the enhancement of regulatory frameworks are key steps to improve guideline adherence and combat <span>AMR</span>.</div></div>","PeriodicalId":46404,"journal":{"name":"Clinical Epidemiology and Global Health","volume":"33 ","pages":"Article 102032"},"PeriodicalIF":2.3,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143852098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of health literacy tool for hypertension and determinants of limited health literacy in rural Myanmar: Implications for targeted public health interventions","authors":"Roshan Kumar Mahato,&nbsp;Saw San Myint Htun,&nbsp;Kyaw Min Htike,&nbsp;Rajitra Nawawonganun,&nbsp;Kittipong Sornlorm","doi":"10.1016/j.cegh.2025.102018","DOIUrl":"10.1016/j.cegh.2025.102018","url":null,"abstract":"<div><h3>Background &amp; objectives</h3><div>Health literacy (HL) is essential for managing chronic diseases like hypertension. However, limited health literacy is common in many populations leading to poor health outcomes. This study aimed to develop hypertension-specific health literacy tool and identify factors associated with limited health literacy (LHL) among individuals with and without hypertension.</div></div><div><h3>Methods</h3><div>A cross-sectional study was conducted in rural Karen State, Myanmar from December 2023 to November 2024. Descriptive statistics and multivariable analysis using the logistic regression were employed to investigate the associations between LHL and hypertension-related factors.</div></div><div><h3>Results</h3><div>Among 487 participants, the developed tool demonstrated strong reliability with Cronbach's alpha values of 0.923 (access), 0.879 (understand), 0.902 (appraise) and 0.889 (apply). The overall prevalence of LHL was 85.82 % (95 % CI: 82.02–89.08) in the no-hypertension group and 83.53 % (95 % CI: 73.91–90.69) in the hypertension group. Key factors associated with LHL in individuals with hypertension included employment in agriculture, farming, self-employment or non-government sectors (AOR: 4.85, 95 % CI: 1.18–19.91), a family history of hypertension (AOR: 5.42, 95 % CI: 1.28–22.84) and poor or average knowledge about hypertension (AOR: 5.21, 95 % CI: 1.20–22.57).</div></div><div><h3>Conclusion</h3><div>Four out of five individuals in rural Myanmar had LHL highlighting disparities compared to urban populations. Employment type, family history of hypertension and insufficient hypertension knowledge were significant predictors of LHL. A context-specific tool was developed to ensure accurate assessment and inform targeted interventions.</div></div>","PeriodicalId":46404,"journal":{"name":"Clinical Epidemiology and Global Health","volume":"33 ","pages":"Article 102018"},"PeriodicalIF":2.3,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143826018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of bronchitis in children at Latin America's largest open-pit coal mine","authors":"Heli A. Arregocés ,&nbsp;Roberto Rojano","doi":"10.1016/j.cegh.2025.102022","DOIUrl":"10.1016/j.cegh.2025.102022","url":null,"abstract":"<div><h3>Background/objectives</h3><div>Air pollution, the presence of substances that harm other living organisms, results from human activity. Open-pit coal mines are notable sources of particulate matter emissions, which spread over considerable distances and affect surrounding communities. This study aimed to evaluate the influence of prolonged exposure to particulate matter with a diameter of ≤10 μm (PM₁₀) emissions from Latin America's largest open-pit coal mine on bronchitis incidence in children aged 0–4 years.</div></div><div><h3>Methods</h3><div>We collected daily PM₁₀ concentration data from 25 stations between January 2011 and December 2019, monitored every three working days. The AirQ + model was used to estimate the human health impacts of long-term exposure to ambient PM₁₀ using the bronchitis prevalence data from the National Institute of Colombia.</div></div><div><h3>Results</h3><div>From 2011 to 2019, the average daily PM₁₀ levels for the zones directly and indirectly impacted by mining were 37.52 and 31.54 μg/m³, respectively. Approximately 500 bronchitis cases were attributed to PM₁₀ pollution. Moreover, an average reduction of 15 μg/m³ in the annual mean PM₁₀ concentration could prevent 56 bronchitis cases annually in children near the mines.</div></div><div><h3>Conclusions</h3><div>From 2011 to 2019, all monitoring stations consistently recorded more than the World Health Organization's annual average reference of 15 μg/m³. Our findings on the long-term effects of PM₁₀ on bronchitis prevalence underscore the health impact of air pollution, emphasizing the importance of stringent air quality standards, particularly in industrial mining zones. This information is vital for developing, monitoring, and assessing air pollution policies while safeguarding public health.</div></div>","PeriodicalId":46404,"journal":{"name":"Clinical Epidemiology and Global Health","volume":"33 ","pages":"Article 102022"},"PeriodicalIF":2.3,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143826016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adapting global tools for local realities: Linguistic validation of the BREAST-Q BCT module in Hindi and Marathi for breast cancer surgical management in India","authors":"Jisha John ,&nbsp;Anjali Joshi ,&nbsp;Vishesha Lulla ,&nbsp;Justin Scarimbolo ,&nbsp;Pradnya Rotithor ,&nbsp;Shalaka Joshi ,&nbsp;Rupa Mishra ,&nbsp;C.B. Koppiker ,&nbsp;Sneha Joshi","doi":"10.1016/j.cegh.2025.102021","DOIUrl":"10.1016/j.cegh.2025.102021","url":null,"abstract":"<div><h3>Background</h3><div>Patient-Reported Outcome Measures (PROMs) like BREAST-Q are vital for understanding patients' health and QoL after breast cancer treatment. However, its English-only format limits use in India, where cultural and language barriers affect data accuracy. With an 80 % breast-conserving surgery (BCS) rate at our center, far above the national average, capturing the unique socio-cultural experiences of Indian patients is crucial. This study focused on translating and validating the BREAST-Q BCT module into Hindi and Marathi to enhance its relevance in India.</div></div><div><h3>Methods</h3><div>Following Q-Portfolio guidelines, the BREAST-Q BCT module underwent a rigorous linguistic validation process. This included two forward translations, reconciliation, back-translation, and cognitive debriefing with 15 native speakers each for Hindi and Marathi. Patients reviewed the clarity and cultural appropriateness of the translations, providing feedback that informed refinements to ensure conceptual equivalence.</div></div><div><h3>Results</h3><div>The final translated versions of the BREAST-Q BCT module were completed and tested with a test cohort of 70 patients who underwent BCS. Patients were given the choice of their preferred language: 40 chose Marathi, 20 Hindi, and 10 English. Response rates improved significantly, from 83 % in previous cohorts to 94 % with the translated versions. Internal consistency and psycho-sociometric assessment for translated versions is ongoing.</div></div><div><h3>Conclusion</h3><div>The linguistic validation of the BREAST-Q BCT module is a key step in breaking language barriers in India. However, a PROMs tool tailored to India's unique socio-cultural context is essential to fully capture the experiences of breast cancer patients.</div></div>","PeriodicalId":46404,"journal":{"name":"Clinical Epidemiology and Global Health","volume":"34 ","pages":"Article 102021"},"PeriodicalIF":2.3,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144070652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hepatitis B virus immunoprophylaxis for newborns of rural women living with hepatitis B virus infection: The moderating role of knowledge, perceived susceptibility and severity","authors":"Okasha Mohammed ,&nbsp;Vivian Efua Senoo-Dogbey ,&nbsp;Charles Ampong Adjei","doi":"10.1016/j.cegh.2025.102029","DOIUrl":"10.1016/j.cegh.2025.102029","url":null,"abstract":"<div><h3>Background</h3><div>Mother-To-Child Transmission (MTCT) of Hepatitis B Virus (HBV) poses a significant public health threat, particularly in high-prevalence regions like sub-Saharan Africa. Effective interventions, including Hepatitis B Immunoglobulin (HBIG) and hepatitis B vaccine, can substantially reduce vertical transmission risk. However, disease transmission knowledge, perceptions of risk and severity are factors in the face of other personal factors that collectively shape the decision-making process of immunoprophylaxis utilization for exposed newborns. This study investigated knowledge of disease transmission, perceptions of risk and severity and their impact on the utilization of HBV immunoprophylaxis for exposed newborns of rural women living with HBV infection in Ghana's North-East Region.</div></div><div><h3>Methods</h3><div>A descriptive cross-sectional design was employed, involving 213 mothers who had been diagnosed with hepatitis B virus infection and had given birth within the past 6 weeks. Sampling was done using random sampling procedures following proportional allocation to the selected facilities. The women were interviewed in a face-to-face interaction using a structured pretested questionnaire. Data were analyzed using SPSS version 26 employing descriptive statistics, Chi-Square test and logistic regression analysis with the level of significance set at 0.05.</div></div><div><h3>Results</h3><div>The mean age of the participants was 28 years (±1.5). A total of 56.3 % of the mothers had good knowledge. Higher education and religious affiliation were significantly associated with good knowledge of HBV disease transmission and newborn immunoprophylaxis. Mothers with good overall knowledge of HBV had significantly higher odds of uptake (aOR: 2.23, 95 % CI: 1.12–4.45, p-value: 0.023). There was no significant association between (aOR: 0.97, 95 % CI: 0.46–2.07, p-value: 0.941) perceived susceptibility and immunoprophylaxis uptake. Mothers who perceived HBV severity as high had higher odds of immunoprophylaxis uptake for their newborns (aOR: 1.36, 95 % CI: 0.15–0.87, p-value: 0.023).</div></div><div><h3>Conclusion</h3><div>This study highlights the pivotal role of knowledge of HBV disease and its prevention and perceived severity in determining HBV immunoprophylaxis uptake among rural women. Addressing barriers surrounding education and perceptions through targeted education, improved healthcare accessibility, and culturally sensitive interventions is critical for enhancing MTCT prevention in similar settings.</div></div>","PeriodicalId":46404,"journal":{"name":"Clinical Epidemiology and Global Health","volume":"33 ","pages":"Article 102029"},"PeriodicalIF":2.3,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143816348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal postnatal depression, bonding, and health care practices in providing essential services for preterm and low birth weight infants in Indonesia","authors":"Ricvan Dana Nindrea ,&nbsp;Long Chiau Ming ,&nbsp;Nissa Prima Sari","doi":"10.1016/j.cegh.2025.102028","DOIUrl":"10.1016/j.cegh.2025.102028","url":null,"abstract":"<div><h3>Background</h3><div>Preterm and low birth weight (LBW) infants face higher health risks and need specialized care. Maternal postnatal depression, mother-infant bonding, and healthcare practices are key to providing proper care for these vulnerable infants. This study aims to explore the role of maternal postnatal depression and bonding in enhancing healthcare practices for providing essential health care to preterm and LBW infants.</div></div><div><h3>Methods</h3><div>This community-based cross-sectional study was conducted from July to December 2024 in three regions of West Sumatra, Indonesia: the operational areas of the Health Offices in Padang City, Padang Pariaman Regency, and Solok Regency. A total of 246 mothers of LBW or preterm infants born between January and December 2023 were selected through multistage random sampling. Data analysis was conducted using structural equation modeling (SEM).</div></div><div><h3>Results</h3><div>Most respondents were aged 20–34 years (71.5 %), with a median of two pregnancies and one delivery. Preterm births (63.0 %) and cesarean deliveries (59.3 %) were common. SEM analysis revealed that maternal postnatal depression had a direct effect on healthcare practices (β = 0.278, P = 0.004) and an indirect effect mediated by mother-infant bonding (β = 0.172, P = 0.007). Furthermore, mother-infant bonding was significantly associated with better healthcare practices (β = 0.181, P = 0.005).</div></div><div><h3>Conclusion</h3><div>Maternal postnatal depression significantly influences healthcare practices both directly and indirectly through its effect on mother-infant bonding. These findings highlight the importance of addressing maternal mental health and fostering strong mother-infant bonds to enhance caregiving practices and improve health outcomes for vulnerable infants.</div></div>","PeriodicalId":46404,"journal":{"name":"Clinical Epidemiology and Global Health","volume":"33 ","pages":"Article 102028"},"PeriodicalIF":2.3,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143816346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical characteristics and potential biomarkers predicting disease progression in severe adenoviral pneumonia: A pediatric intensive care unit experience","authors":"Bijay Kumar Meher ,&nbsp;Sovesh Ranjan Behera ,&nbsp;Sarthak Naik ,&nbsp;Pravakar Mishra ,&nbsp;Deepti Damayanty Pradhan","doi":"10.1016/j.cegh.2025.102026","DOIUrl":"10.1016/j.cegh.2025.102026","url":null,"abstract":"<div><h3>Background</h3><div>Respiratory tract infections (RTIs) are a major global threat to children, with adenovirus being a leading cause of severe RTIs in this age group. Treatment options are limited, and understanding the factors affecting mortality is essential for developing effective management strategies. This study aims to analyze adenovirus infections in critically ill children and identify biomarkers associated with a poor outcomes.</div></div><div><h3>Methods</h3><div>This prospective observational study was conducted in children aged 1 month to 14 years with severe adenoviral RTI. Demographic information and clinical data were collected; polymerase chain reaction (PCR) testing was conducted on nasopharyngeal swabs. Survival and non-survival groups were compared using the Mann-Whitney <em>U</em> test and independent sample t tests. Associations with outcomes were evaluated using the chi-square test, and diagnostic evaluation was conducted using receiver operating characteristics (ROC) analysis.</div></div><div><h3>Results</h3><div>In 70 children with severe adenoviral infection, common symptoms included fever, cough, and respiratory distress. Most patients required respiratory support, including invasive mechanical ventilation support. Chest radiograph findings revealed patchy infiltration and right upper lobar consolidation. Forty percent of the cases resulted in death. Children with lower hemoglobin and lymphocyte counts and higher CRP, LDH, and ferritin levels had poorer outcomes. Hemoglobin (≤9 gm/dL), serum ferritin (&gt;897 ng/mL), and serum LDH (&gt;1172 U/L) showed high sensitivity and specificity, making them good outcome markers.</div></div><div><h3>Conclusion</h3><div>Low hemoglobin, high serum ferritin, and high LDH in the second week are markers of disease progression and poor prognostic markers in severe adenoviral infections, emphasizing further research and targeted interventions.</div></div>","PeriodicalId":46404,"journal":{"name":"Clinical Epidemiology and Global Health","volume":"33 ","pages":"Article 102026"},"PeriodicalIF":2.3,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143820615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"Knowledge of primary health care physicians about clinical governance in Mansoura district, Egypt: A cross-sectional study\"","authors":"Shymaa Mamdouh Mohamed Abdu ,&nbsp;Abdel-Hady El-Gilany ,&nbsp;Sahar Mohamed Youness","doi":"10.1016/j.cegh.2025.102019","DOIUrl":"10.1016/j.cegh.2025.102019","url":null,"abstract":"<div><h3>Background</h3><div>Clinical governance (CG) serves as a crucial mechanism for enhancing service quality in primary health care (PHC) facilities in Egypt. Little is known about knowledge of PHC physicians about CG. The aim of this study was to assess the knowledge of PHC physicians about the concepts of CG and to identify its determinants.</div></div><div><h3>Methods</h3><div>A cross-sectional study was conducted on 108 PHC physicians selected through a convenience sampling technique. The data were collected through a validated questionnaire including data related to knowledge of PHC physicians about the concepts, principles of CG, and barriers affecting their engagement in CG. Binary logistic regression analysis was used to detect the predictors of knowledge about CG.</div></div><div><h3>Results</h3><div>More than half of participants (52.8 %) had high knowledge about CG with a total mean score of (3.61 ± 0.73). 65.7 % and 61.1 % of PHC physicians knew continuous quality improvement (CQI) and responsibility as CG principles, respectively. Multiple regression analysis revealed that those with diploma (AOR = 9.72, P = 0.007), those who had postgraduate studies (AOR = 3.99, p = 0.007), and those who previously heard about CG (AOR = 5.78, P = 0.019) significantly predicted PHC physicians' knowledge of CG.</div></div><div><h3>Conclusion</h3><div>More than half of PHC physicians are knowledgeable about CG. Level of education is the strongest predictor of PHC physician's knowledge. Less than half of rural physicians have high knowledge about CG, and no statistically significant difference has been detected. Thus, conducting educational and training programs, and increasing human and financial resources are crucial for improving PHC physicians' engagement in CG.</div></div>","PeriodicalId":46404,"journal":{"name":"Clinical Epidemiology and Global Health","volume":"33 ","pages":"Article 102019"},"PeriodicalIF":2.3,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143816349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}