运动促进计划对妊娠期糖尿病胰岛素抵抗和血糖控制的影响：一项随机对照试验

IF 1.7 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Clinical Epidemiology and Global Health Pub Date : 2025-07-24 DOI:10.1016/j.cegh.2025.102143

Savni Apte , Preetha Ramachandra , Shyamala Guruvare , Shashikala K Bhat , G Arun Maiya

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引用次数: 0

摘要

背景：胎盘激素引起的胰岛素抵抗（IR）升高和胰腺β细胞功能障碍引起的胰岛素分泌不足共同作用可导致妊娠糖尿病（GDM）。随着孕龄的增加，与妊娠相关的不适和对活动安全性的担忧导致身体活动（PA）水平降低。这种减少进一步增加IR和损害血糖控制。因此，本研究的目的是确定体育活动促进（PAP）计划对GDM患者IR和血糖控制的影响。方法在本随机对照试验中，120例GDM患者被随机分为干预组和对照组。两组的参与者都接受了医院提供的定期产前护理。干预组的参与者接受了为期八周的体育活动促进（PAP）计划。在基线和8周结束时评估IR、空腹血糖（FBG）、餐后血糖（PPBG）和PA水平。采用随机效应作为参与者的混合模型分析结果。结果所有纳入研究的患者平均年龄为29.8±3.66岁，平均胎龄为26.4±1.38周。IR差异有统计学意义(F = 44.62, p <；0.001), FGB (F = 25.2, p <；各组间PPBG随时间变化（F = 6.98, p = 0.009）。结论PAP治疗可有效降低糖尿病患者IR，改善血糖控制。

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Effect of physical activity promotion program on insulin resistance and glycemic control in gestational diabetes mellitus: a randomized controlled trial

Background

A combined effect of increased insulin resistance (IR) due to placental hormones and insufficient insulin production due to pancreatic β-cell dysfunction leads to gestational diabetes mellitus (GDM). As gestational age progresses, pregnancy-related discomfort and concerns related to the safety of performing activities lead to reduced physical activity (PA) levels. This reduction further increases IR and impairs glycemic control. Thus, the objective of this study was to determine the effects of the Physical Activity Promotion (PAP) program on IR and glycemic control in GDM.

Methods

In this randomized controlled trial, 120 participants with GDM were randomly assigned to either an intervention group or a control group. The participants in both groups received regular prenatal care provided at the hospital. The participants in the intervention group received a physical activity promotion (PAP) program for eight weeks. IR, fasting blood glucose (FBG), postprandial blood glucose (PPBG), and PA levels were assessed at baseline and the end of eight weeks. A mixed model with random effects as participants was used for the analysis of outcomes.

Results

The mean age of all the included participants in the study was 29.8 ± 3.66 years, and the gestational age was 26.4 ± 1.38 weeks. Significant differences in IR (F = 44.62, p < 0.001), FGB (F = 25.2, p < 0.001), and PPBG (F = 6.98, p = 0.009) were detected between the groups over time.

Conclusion

The PAP program effectively reduced IR and improved glycemic control in GDM.

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来源期刊

Clinical Epidemiology and Global Health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-

CiteScore

4.60

自引率

7.70%

发文量

218

审稿时长

66 days

期刊介绍： Clinical Epidemiology and Global Health (CEGH) is a multidisciplinary journal and it is published four times (March, June, September, December) a year. The mandate of CEGH is to promote articles on clinical epidemiology with focus on developing countries in the context of global health. We also accept articles from other countries. It publishes original research work across all disciplines of medicine and allied sciences, related to clinical epidemiology and global health. The journal publishes Original articles, Review articles, Evidence Summaries, Letters to the Editor. All articles published in CEGH are peer-reviewed and published online for immediate access and citation.