Clinical Epidemiology and Global Health最新文献

{"title":"Gestational diabetes mellitus and its association with ABO blood group type among pregnant women with pregnancy-induced hypertension in Northwest Ethiopia: A comparative study","authors":"","doi":"10.1016/j.cegh.2024.101788","DOIUrl":"10.1016/j.cegh.2024.101788","url":null,"abstract":"<div><h3>Background</h3><p>Gestational diabetes mellitus (GDM), a form of diabetes occurring during pregnancy in non-diabetic women, can lead to complications such as preeclampsia, gestational hypertension, and cesarean section delivery. This study aimed to investigate the incidence of GDM and its association with blood group type among pregnant women with pregnancy-induced hypertension in Northwest Ethiopia.</p></div><div><h3>Methods</h3><p>A cross-sectional comparative study was conducted in Northwest Ethiopia from December 2021 to April 2022, involving 240 pregnant women. Convenience sampling was used to select 120 women diagnosed with pregnancy-induced hypertension (PIH) and 120 women without PIH. Data on demographics, dietary habits, and BMI were collected using a structured questionnaire, and blood samples were analyzed for glucose levels. Statistical analysis was performed with a 95 % confidence interval.</p></div><div><h3>Results</h3><p>Among the total of 240 pregnant women included in the study, 16.25 % (95 % CI: 18.3–34.6) were diagnosed with gestational diabetes mellitus. Of these, 12.9 % had pregnancy-induced hypertension, while 3.35 % did not have pregnancy-induced hypertension. Several risk factors were identified for the development of GDM, including a BMI greater than 25 kg/m2, rural residence, family history of diabetes, previous history of GDM, blood types AB and O, and Rh positive.</p></div><div><h3>Conclusions</h3><p>The study findings demonstrate a significantly higher incidence of gestational diabetes mellitus among pregnant women with pregnancy-induced hypertension (25.8 %) compared to those without pregnancy-induced hypertension (6.7 %). These results highlight the importance of considering blood group type and other identified risk factors in assessing the risk and management of GDM in pregnant women with pregnancy-induced hypertension.</p></div>","PeriodicalId":46404,"journal":{"name":"Clinical Epidemiology and Global Health","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213398424002859/pdfft?md5=862e825a2496ff94285029a1daeece64&pid=1-s2.0-S2213398424002859-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142244145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distribution and risk factors of Trichomonas vaginalis infection with relevance to interleukin profile among population in Duhok city, Iraq","authors":"","doi":"10.1016/j.cegh.2024.101784","DOIUrl":"10.1016/j.cegh.2024.101784","url":null,"abstract":"<div><h3>Background</h3><p>Vaginal trichomoniasis is a sexually transmitted disease causes adverse health outcomes, the causative agent is Tichomonas vaginalis. Infected women develop abnormal vaginal discharge with vaginitis. While, men mostly suffer from prostatitis and urethritis.</p></div><div><h3>Objectives</h3><p>This study aimed to detect the rate of T.vaginalis infection in association with risk factors, measurement of blood parameters, interleukine-2 (IL-2) and interleukine-8(IL-8) levels among individuals.</p></div><div><h3>Methods</h3><p>A total of 500 females were tested, a vaginal swab and blood were collected from the participants, and they were within the age range of 18–70 years old. High vaginal swabs were examined microscopically using wet mount preparation, the blood used for measurement of blood parameters using coulter count machine and IL-2 and IL-8 levels were evaluated using ELISA technique.</p></div><div><h3>Results</h3><p>Out of 500 individuals, the prevalence of <em>T. vaginalis</em> infection was 45(9.0 %). The maximum infection rates were reported among age group (18–28) years, rural residents, illiterates, married women (16.7 %), (15.9 %),(30.0 %),(11.7 %),respectively. Moreover, high positivity of infection revealed among low economical level 12.5 % compared to only 1.7 % in high economy group. Unemployed women, those with bad vaginal hygiene showed high incidence of infection 10.5 % and 6.3 %, respectively. It was noted a significant decrease in red blood cells and hemoglobin concentration, however, there was a significantly increased in white blood cells among infected subjects. Furthermore, the levels of both interleukin-2 and interleukin-8 were significantly higher among infected individuals compared to healthy ones.</p></div><div><h3>Conclusions</h3><p>Effective strategies for disease awareness are needed and should include health promotion, education, and prevention.</p></div>","PeriodicalId":46404,"journal":{"name":"Clinical Epidemiology and Global Health","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213398424002811/pdfft?md5=4f3c21f137ea0b29d84718f46ed1dafb&pid=1-s2.0-S2213398424002811-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142230477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"“Community-based intervention to dengue prevention: Insights from urban residents in Pune, using the health belief model\"","authors":"","doi":"10.1016/j.cegh.2024.101779","DOIUrl":"10.1016/j.cegh.2024.101779","url":null,"abstract":"<div><h3>Background</h3><p>Dengue infection is increasingly recognized as one of the world's emerging infectious diseases. The present study was carried out with the aim of assessing knowledge and health beliefs regarding Dengue fever among community in an urban slum area of Pune. This cross-sectional study was undertaken in an urban slum area of Urban Health Centre, Pashan, which is a field practice area of Department of Community Medicine.</p></div><div><h3>Aim &amp; objectives</h3><p>This study is aimed at understanding the perception towards the Dengue Prevention using the Health Belief Model (HBM) approach, prevention measures adopted, their knowledge, opinion and confidence towards various control measures.</p></div><div><h3>Methods</h3><p>A Cross-Sectional Study using a pre-tested, semi-structured questionnaire was conducted for assessing on knowledge, health beliefs and practice of dengue control.</p></div><div><h3>Results</h3><p>About 26.1 % knew the causes of dengue, 56.2 % had poor knowledge on the severity of dengue. The knowledge on causes (69.9 %), signs and symptoms (77.1 %), treatment (51.2 %) and carriers (86.3 %) of dengue was poor. The knowledge regarding insects breeding spots, potential breeding spots inside (26.1 %) and outside (38.1 %) and prevention was almost poor. The data was collected from the questionnaire, entered and analysed using Statistical Package for Social Sciences (SPSS) version 21.0.</p></div><div><h3>Conclusion</h3><p>Most people living across the community behaved in a similar manner, irrespective of age, education and socio-economic status. Perceptions of the community as explained by Health Belief Model was greatly influenced by their approach to the available health care services and for the subsequent behavioural change.</p></div>","PeriodicalId":46404,"journal":{"name":"Clinical Epidemiology and Global Health","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213398424002768/pdfft?md5=e142486ad5919d3eaa99c3bb428ee4e3&pid=1-s2.0-S2213398424002768-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142230478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of cardiometabolic index, lipid accumulation product, visceral adiposity index and waist-to-thigh ratio for the early diagnosis of diabetes in young females at childbearing age who were obese or non-obese","authors":"","doi":"10.1016/j.cegh.2024.101783","DOIUrl":"10.1016/j.cegh.2024.101783","url":null,"abstract":"<div><h3>Aim</h3><p>To explore the effectiveness of the cardiometabolic index (CMI), lipid accumulation product (LAP), and waist-to-thigh ratio (WTR) in identifying insulin resistance (IR) in females who are clinically not having diabetes mellitus (DM).</p></div><div><h3>Methods</h3><p>This cross-sectional study was conducted in Sri Lanka between 2020 and 2023. A total of 282 female participants aged 18 to 35 were recruited. Their anthropometric measurements, fasting blood sugar (FBS) levels, IR by HOMA-IR, lipid profile, and blood pressure were assessed. All females with FBS levels &gt;100 mg/dl were excluded from the study.</p></div><div><h3>Results</h3><p>The study participants were divided into two groups, normal-weight controls (N = 142, BMI:18.0–22.9 kg/m²) and overweight/obese cases (N = 140, BMI:23.0–24.9 kg/m², Obesity: &gt;25 kg/m²), based on their BMI values. The mean values of CMI, LAP, and WTR in cases were 3.56 ± 0.63, 49.97 ± 17.75, and 1.88 ± 0.17, respectively. Significant associations were identified between all adiposity indexes, IR and lipid profile parameters (p &lt; 0.05). In this female cohort, despite being clinically non DM, the prevalence of IR was significantly higher (52.83 %). ROC analysis results showed greater sensitivities for detecting IR with higher AUC as follows: CMI = 0.854(0.811–0.899), LAP = 0.869(0.829–0.910), and WTR = 0.828(0.779–0.877). The normal-weight controls were assessed to check the prevalence of metabolically-obese normal-weights (MONW,65.5 %) and metabolically-healthy normal-weights (MHNW,35.5 %) among the population, given the higher prevalence of IR. The detection accuracy of MONW females in the ROC assay was; CMI &gt; LAP &gt; WTR &gt; VAI.</p></div><div><h3>Conclusions</h3><p>CMI had the highest accuracy for detecting IR, with the accuracy of all four indexes ranked as follows: CMI &gt; LAP &gt; WTR &gt; VAI.</p></div>","PeriodicalId":46404,"journal":{"name":"Clinical Epidemiology and Global Health","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S221339842400280X/pdfft?md5=59869fae5da6f40257792c0585e5e1c2&pid=1-s2.0-S221339842400280X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142173269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparative study to assess Hba1c levels in antenatal non diabetic women with anemia and without anemia","authors":"","doi":"10.1016/j.cegh.2024.101777","DOIUrl":"10.1016/j.cegh.2024.101777","url":null,"abstract":"<div><h3>Background</h3><p>Glycosylated hemoglobin (HbA1c) has a glucose residue attached to the terminal NH2 group (valine residue) of one or both HbA beta chains. HbA1c levels are not affected by blood glucose levels alone. HbA1c results are affected by several factors, such as anemia, structural hemoglobinopathies and thalassemia syndromes. HbA1c concentrations are affected by conditions that affect erythrocyte turnover. Iron deficiency anemia is the most common form of anemia. The prevalence of anemia among pregnant women in India is above 50 %. Although many forms of anemia are associated with the lowering of HbA1c, iron deficiency has been shown to shift HbA1c slightly upward. Research on this topic has yielded a variety of findings. In some research, there was no association observed between anemia and HbA1c levels; in other investigations, there was a rise or fall in this number. Iron deficiency anemia and HbA1c′s relationship is therefore still unclear. Therefore, this study aims to determine the correlation between Iron deficiency anemia and HbA1c levels among non diabetic pregnant women with anemia.</p></div><div><h3>Methodology</h3><p>This prospective observational study was conducted among singleton pregnant women attending antenatal clinic OPD in a private tertiary hospital in Chengalpattu, Kanchipuram district. After the complete review of their obstetric record, blood was collected in 5 ml sterile syringes and transferred equally to the two separate test tubes containing ethylene-diamine-tetra acetic acid (EDTA) anticoagulant for determining RBC indices and HbA1c levels. The difference in mean between two independent samples (between Anemia and Non-anemia) was determined using an independent sample <em>t</em>-test, and the difference between two independent proportions was calculated using a z-test. Bivariate Pearson's correlation analysis was used to adjudicate the relationship between red blood cell indices and HbA1c level, and correlation coefficient (r)was calculated, and the p-value of &lt;0.05* was considered statistically significant.</p></div><div><h3>Results</h3><p>Bivariate Pearson's correlation analysis was done to determine the relationship between HbA1c levels and red blood cells in anemic pregnant women. HbA1c levels negatively correlated with Hemoglobin (r = −0.875, p &lt; 0.01*), PCV (r = −0.732, p =&lt;0.01*) and transferrin saturation (r = 0.224, p &lt; 0.01*) and it was statistically significant. Other indices, such as serum iron concentration and TIBC, demonstrated no correlation with HbA1c level.</p></div><div><h3>Conclusion</h3><p>This study shows that the reliability of Hba1c in diagnosing diabetes among pregnant women with iron deficiency anemia is misguiding and can be considered after treating the condition. Also, more studies are needed to improve our understanding of this topic.</p></div>","PeriodicalId":46404,"journal":{"name":"Clinical Epidemiology and Global Health","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213398424002744/pdfft?md5=d201940137f3efba330e1842a491696c&pid=1-s2.0-S2213398424002744-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142173268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adoption and factors associated with 7.1% chlorhexidine digluconate cord care standards in public health facilities in Kiambu County, Kenya","authors":"","doi":"10.1016/j.cegh.2024.101781","DOIUrl":"10.1016/j.cegh.2024.101781","url":null,"abstract":"<div><h3>Background</h3><p>The Government of Kenya adopted the practice of 7.1% chlorhexidine digluconate (CHX) application for all newborns. However, challenges in implementation have arisen, as some counties in Kenya do not align with the underlying criteria for this recommendation. Therefore, we aimed to evaluate CHX adoption and associated factors in Kiambu County, Kenya.</p></div><div><h3>Methods</h3><p>A cross-sectional survey was conducted among 434 caregivers attending their 6-week well-child clinics using multistage sampling. Descriptive statistics summarized sociodemographic data and CHX cord care uptake, while logistic regression analyzed associations between variables and CHX uptake.</p></div><div><h3>Results</h3><p>The prevalence of use of CHX in Kiambu county was 41.0%. Twenty-two percent (22%) of the mothers were provided CHX post-delivery and 100% used it. Of the 78% who weren't provided CHX post-delivery, 39% were given prescriptions for CHX. The 61% who were not issued a prescription resorted to the use of surgical spirit (34.8%), dry cord care (9.2%) and saliva (3%). In public facilities, being married [AOR 0.19 (0.11–0.33)] and index use of CHX [AOR 0.17 (0.08–0.35)] were associated with non-adherence. Being employed [AOR 2.46 (1.26–4.77)] and delivering in hospital [COR 3.29 (1.69–7.08)] increased the likelihood of using CHX.</p></div><div><h3>Conclusion</h3><p>Weak prescription and adherence to the CHX cord care policy in Kiambu county has led to women turning to alternative substances for cord care. Quality improvement strategies are necessary to enhance adherence to guidelines, such as refining county-specific recommendations for cord care and providing corresponding patient education, or issuing definitive prescriptions for CHX post-delivery.</p></div>","PeriodicalId":46404,"journal":{"name":"Clinical Epidemiology and Global Health","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213398424002781/pdfft?md5=cc98ba0c3ce3b3b337dcb440392020d2&pid=1-s2.0-S2213398424002781-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142151556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What caregiver’ count as neonatal danger signs? A systematic review and meta-analysis of South East Asian countries","authors":"","doi":"10.1016/j.cegh.2024.101766","DOIUrl":"10.1016/j.cegh.2024.101766","url":null,"abstract":"<div><h3>Objective</h3><p>To assess the prevalence of Knowledge of caregivers for neonatal danger signs. Registered in PROSPERO [CDR42022338605.]</p></div><div><h3>Methodology</h3><p>PubMed, Embase, Scopus and Google Scholar were searched, Cochrane I² statistics for heterogeneity and Random effects model for reporting the results was used. Egger tests with funnel plots were used to investigate publication bias.</p></div><div><h3>Result</h3><p>Overall pooled prevalence of caregiver's knowledge towards IMNCI and other neonatal danger signs was 36.6 % (95 % CI = 28, 46.1) and 55.1 % [95 % CI = 46.9, 53] respectively.</p></div><div><h3>Conclusion</h3><p>The knowledge of caregivers towards neonatal danger signs was inadequate.</p></div>","PeriodicalId":46404,"journal":{"name":"Clinical Epidemiology and Global Health","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S221339842400263X/pdfft?md5=d4089ece49d35f7d5546cc86899ec2e8&pid=1-s2.0-S221339842400263X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142099606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"“Something must kill a man”: Beliefs about condom use in prevention of Human Papilloma Virus among men at Kpong community","authors":"","doi":"10.1016/j.cegh.2024.101773","DOIUrl":"10.1016/j.cegh.2024.101773","url":null,"abstract":"<div><h3>Background</h3><p>Human papillomavirus (HPV) infection is highly prevalent among sexually active individuals. A report by the Ghana Aids Commission highlights low condom usage among Ghana's sexually active youth. Despite this, there has been no exploration of views regarding condom use for preventing HPV infection. The purpose of the study was to examine the beliefs about condom use in preventing the human papillomavirus among men at Kpong community.</p></div><div><h3>Methods</h3><p>The study utilized a qualitative approach with an exploratory design, employing purposive sampling to select 40 participants. Data collection involved face-to-face interviews using a semi-structured interview guide. The interviews were recorded, transcribed verbatim, and analyzed through content analysis.</p></div><div><h3>Results</h3><p>The study produced three main themes and 8 subthemes. Despite most participants having used condoms before, primarily once (57.5 %) with a preference for “kiss condoms\" (42.5 %). The primary reason for condom use was pregnancy prevention (45 %), instead of HPV infections (22.5 %). Most participants rarely used condoms, aiming to enhance sexual pleasure or assuming their partners were HPV-free. Some cited religious reasons, viewing condom use as sinful.</p></div><div><h3>Conclusion</h3><p>Participants commonly do not use condoms to prevent HPV infections. Additionally, men have various religious and personal reasons for not using condoms to protect against HPV and other infections. This underscores the need for increased awareness of HPV transmission among men.</p></div>","PeriodicalId":46404,"journal":{"name":"Clinical Epidemiology and Global Health","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213398424002707/pdfft?md5=e2152dfc3e1591ed5a0067f2fd0aa9e2&pid=1-s2.0-S2213398424002707-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142151555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling the menstrual mind: Exploring proprioceptive proficiency, reaction responsiveness, and motor mastery in premenstrual syndrome versus Non-PMS cohorts: A two-arm parallel non-blinded cross-sectional study","authors":"","doi":"10.1016/j.cegh.2024.101782","DOIUrl":"10.1016/j.cegh.2024.101782","url":null,"abstract":"<div><h3>Introduction</h3><p>Premenstrual syndrome (PMS) is characterized by cyclical physical and mood disturbances during the luteal phase. Symptoms gradually intensify during this phase and typically subside a few days after menstruation begins. PMS encompasses neuromuscular and psychological symptoms that can significantly affect the quality of life of affected females. This study aims to compare proprioception, reaction time, and coordination between females with PMS and those with non-PMS.</p></div><div><h3>Material and methods</h3><p>A cross-sectional study, conducted in accordance with the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) guidelines, recruited 998 females with PMS and without PMS, aged 18–40 years based on premenstrual dysphoric disorder criteria. Participants underwent assessments of proprioception and reaction time using the Sensbalance Miniboard. Coordination was assessed using Lower Extremity Motor Coordination Test. Data analysis utilized the Kolmogorov-Smirnov test to determine the normality of the data while Mann Whitney-U test was used to compare the between group differences of the variables.</p></div><div><h3>Results</h3><p>Significant differences were observed with p-value &lt;0.05 for all the variables, proprioception (front, back, right and left), reaction time (front, back, right and left), coordination (right and left) between the PMS and non-PMS groups.</p></div><div><h3>Conclusions</h3><p>Females with PMS were associated with great variation in proprioception, reaction time and coordination when compared with females without PMS.</p></div>","PeriodicalId":46404,"journal":{"name":"Clinical Epidemiology and Global Health","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213398424002793/pdfft?md5=1c3d5fd5f8092b9b8fac4dce6c71ed8e&pid=1-s2.0-S2213398424002793-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142163905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study association of urinary Club Cell Protein with air pollution-related pulmonary function compromised among children","authors":"","doi":"10.1016/j.cegh.2024.101776","DOIUrl":"10.1016/j.cegh.2024.101776","url":null,"abstract":"<div><h3>Background</h3><p>Childhood exposure to air pollution exacerbates respiratory conditions and even carries deleterious effects on lung functions in adulthood. It is desirable to establish a non-invasive screening test for children to predict early lung insult with air pollution exposure. The association between serum club cell protein (CC16) and obstructive airway diseases is known, but the same is not explored with air-pollution-related lung insult and pulmonary function test (PFT) parameters.</p></div><div><h3>Aim</h3><p>To investigate the association between urinary CC16 and PFT parameters in children exposed to differing levels of air pollution.</p></div><div><h3>Methods</h3><p>This cross-sectional study recruited 107 children from critically-polluted area (CPA) and 96 age-sex-matched children from non-polluted area (NPA). PFT and urinary CC16 were determined with standard techniques. Air quality parameters were estimated with adherence to National Ambient Air Quality Standards (NAAQS).</p></div><div><h3>Results</h3><p>CPA was observed with 2.5 times poorer Air-Quality-Index compared to NPA. Urinary CC16 levels of children were four-fold higher in CPA compared to NPA (<em>p</em> &lt; 0.001). CPA children were significantly deprived in PFT parameters [FVC(L)-1.86 v/s 2.02, <em>p</em> = 0.01; FEV₁(L/s)-1.71 v/s 1.86, <em>p</em> = 0.01 &amp; PEFR(L/s)- 3.25 v/s 3.69, <em>p</em> &lt; 0.001]. While adjusted for physiological parameters, urinary CC16 observed with significant negative association with PFT parameters (FVC: <em>β</em> = −0.02, <em>p=0.03;</em> FEV₁: <em>β</em> = −0.03, <em>p=0.001 &amp;</em> FEF_25–75 %: <em>β</em> = −0.05, <em>p=0.04</em>).</p></div><div><h3>Conclusion</h3><p>The significant decline in lung function parameters and elevated urinary CC16 levels among children in polluted areas underscore the need for further research to validate urinary CC16 as a reliable screening tool for respiratory health monitoring among children.</p></div>","PeriodicalId":46404,"journal":{"name":"Clinical Epidemiology and Global Health","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213398424002732/pdfft?md5=37aa02e47801f48f67f2bae0e9d502c4&pid=1-s2.0-S2213398424002732-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142129790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}