Clinical Epidemiology and Global Health最新文献

{"title":"Functional disability among the older adult population in Kedah, Malaysia","authors":"","doi":"10.1016/j.cegh.2024.101673","DOIUrl":"10.1016/j.cegh.2024.101673","url":null,"abstract":"<div><h3>Background</h3><p>Functional disability, defined as acquired difficulty in performing basic daily tasks or more complex tasks needed for independent living. Functional assessment among community dwelling elderly is critical due to the changes taking place during the normal aging process, acute illness, worsening chronic illness, and hospitalization which compromises their performances necessary to live independently. Measuring their functional ability can provide objective data to assist with targeting individualized care plan for older adults being the highest consumers of medications due to greater burden of medical conditions in addition to being vulnerable to the effects of medications. It is crucial for the pharmacists to be aware of the geriatric functional disability as pharmacies are often the first point-of-care this elderly group may encounter in community settings.</p></div><div><h3>Methods</h3><p>This study was conducted to estimate the prevalence of functional disability and the common difficulties in the daily task performance among elderly from a state in the Northern region of Malaysia. Besides, the differences in terms of functional disability in both genders were also explored. Among a total of 266 elderly participants.</p></div><div><h3>Results</h3><p>Around 42 % was estimated to face at least one difficulty with Activities of Daily Living while more than half, 57 %, had at least one difficulty with Instrumental Activities of Daily Living. The most common difficulties reported with Activities of Daily Living and Instrumental Activities of Daily Living were transferring (22 %) and transportation (33 %), respectively.</p></div><div><h3>Conclusion</h3><p>In order to deliver effective pharmaceutical care plan emphatically, both senior-friendly pharmacy curricula and pharmacy settings are imperative to address the most common difficulties faced by this vulnerable group.</p></div>","PeriodicalId":46404,"journal":{"name":"Clinical Epidemiology and Global Health","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213398424001696/pdfft?md5=044950f2dd948c9ba547d6cee58b2bd4&pid=1-s2.0-S2213398424001696-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141853473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of SLEDAI score changes in systemic lupus erythematosus patients under low-dose interleukin-2 therapy: A meta-analysis","authors":"","doi":"10.1016/j.cegh.2024.101704","DOIUrl":"10.1016/j.cegh.2024.101704","url":null,"abstract":"<div><h3>Background</h3><p>Interleukin-2 is being investigated as a potential therapeutic option in systemic lupus erythematosus (SLE), but the current findings regarding its effectiveness remained inconclusive.</p></div><div><h3>Objectives</h3><p>To assess the association between the administration of low-dose interleukin-2 and the SLE Disease Activity Index (SLEDAI) score among SLE patients.</p></div><div><h3>Methods</h3><p>A meta-analysis was conducted by gathering articles from Scopus, Pubmed, and Embase databases (PROSPERO registration ID: 451971). Essential data from each study was extracted, and the impact of administering low-dose interleukin-2 on the SLEDAI score in SLE patients was assessed using the inverse variance method.</p></div><div><h3>Results</h3><p>We conducted an analysis of 7 articles involving 194 patients. Our study revealed that the administration of low-dose interleukin-2 was associated with a decrease in the SLEDAI score, showing an average reduction of −4.3 points from baseline. Furthermore, when comparing SLE patients treated with standard of care plus low-dose interleukin-2 to those receiving standard of care alone, we observed a significantly greater improvement in the SLEDAI score, with an average difference of 2.91 points.</p></div><div><h3>Conclusion</h3><p>Our results indicate the potential beneficial impact of low-dose interleukin-2 in reducing disease activity and enhancing outcomes in SLE management.</p></div>","PeriodicalId":46404,"journal":{"name":"Clinical Epidemiology and Global Health","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213398424002008/pdfft?md5=931666fd634ed1d9c5d6a6e06a528bde&pid=1-s2.0-S2213398424002008-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141839699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors associated with tuberculosis among PLHIV: An observational study in a Government Medical College in West Bengal, India","authors":"","doi":"10.1016/j.cegh.2024.101729","DOIUrl":"10.1016/j.cegh.2024.101729","url":null,"abstract":"<div><h3>Background</h3><p>Tuberculosis (TB) is one of the leading causes of significant morbidity and mortality among the People Living with Human Immune-deficiency Virus (PLHIV) in India. Reducing TB burden among PLHIV is a priority area under the National TB Elimination Program (NTEP).</p></div><div><h3>Methodology</h3><p>We analyzed the routinely collected data from an Anti-Retro-viral Treatment Centre (ARTC) of Malda Medical College, West Bengal with an aim of identifying the factors associated with TB prevalence among the PLHIV. All 739 PLHIV who attended the ARTC during 2020–2022, were included in this study.</p></div><div><h3>Results</h3><p>Mean age of the study participants was 34 years (SD:13). 47.9 % PLHIV received Co-trimoxazole Prophylaxis Treatment (CPT) whereas 67.7 % PLHIV received TB preventive treatment (TPT). Transgender [2.9 (1.4–6)], Males [3.7 (1.8–7.9)], Widow/Separated [2.5 (1.2–5.4)], Living with 2–4 Family members [1.6 (1–2.7)], CD4 count less than 200 [1.9 (1.1–3.2)], those who received CPT [17 (7.1–40.8)] and those who didn't receive TPT [1.6 (1–2.6)] were independently associated with increased risk of developing TB. There was no significant association of Age with TB diagnosis among the PLHIV.</p></div><div><h3>Conclusions</h3><p>It is evident from this study, that introduction of TPT and improving CD4 count by Anti-retroviral Treatment is the key intervention to reduce TB burden among PLHIV. The study found significant association of CPT with TB. Further study may be conducted to determine the actual reason for such association.</p></div>","PeriodicalId":46404,"journal":{"name":"Clinical Epidemiology and Global Health","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213398424002252/pdfft?md5=f38a501f28727864059c5bfb749323bc&pid=1-s2.0-S2213398424002252-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141839696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimising Indian healthcare delivery with standard treatment workflows","authors":"","doi":"10.1016/j.cegh.2024.101732","DOIUrl":"10.1016/j.cegh.2024.101732","url":null,"abstract":"<div><h3>Background</h3><p>Standard treatment workflows (STWs) indeed play a crucial role in enhancing healthcare delivery by providing structured guidelines for managing prevalent diseases. These guidelines are particularly beneficial in primary and secondary healthcare settings, where they help standardize treatment protocols, streamline referrals, and ultimately improve healthcare efficiency.</p></div><div><h3>Methods</h3><p>Indian Council of Medical Research, in collaboration with the National Health Authority and the World Health Organisation India country office developed the STWs. The broad medical specialities were identified and speciality expert groups each of 5–12 experienced members led by an eminent chairperson were constituted. Priority disease conditions were identified and the speciality experts deliberated on the evidence available for various recommendations and developed the content for the STW. These were then converted to a one-pager infographic. The draft STWs were reviewed by relevant experts for internal and external validation of content.</p></div><div><h3>Results</h3><p>125 STWs in 23 specialties have been developed.</p></div><div><h3>Conclusion</h3><p>STWs are one-page summaries of clinical guidelines designed to improve healthcare delivery in India. Training healthcare profesionals and collaboration with medical bodies are crucial for successful implementation. This can ensure standardized, evidence-based care throughout India's healthcare system.</p></div>","PeriodicalId":46404,"journal":{"name":"Clinical Epidemiology and Global Health","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213398424002288/pdfft?md5=a91ce8ca2b355d6d4d8060f2298306dc&pid=1-s2.0-S2213398424002288-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141842843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased socioeconomic vulnerability in breast cancer diagnosis during the COVID-19 pandemic in Brazil","authors":"","doi":"10.1016/j.cegh.2024.101735","DOIUrl":"10.1016/j.cegh.2024.101735","url":null,"abstract":"<div><h3>Objective</h3><p>To evaluate the impact of the coronavirus disease (COVID-19) pandemic on the time of breast cancer diagnosis in Brazil and associated socioeconomic factors.</p></div><div><h3>Methods</h3><p>This population-based retrospective study examined breast cancer diagnoses in women between 2019 and 2020 (n = 12,597). Two periods were evaluated: the pre-pandemic (March–December 2019) and pandemic periods (March–December 2020). Logistic regression was performed to calculate odds ratios and 95 % confidence intervals (CIs).</p></div><div><h3>Results</h3><p>There was a 50.2 % reduction (<em>p</em> &lt; 0.01) in the number of diagnoses, and the average time from the first consultation to diagnosis increased from 28 to 36 days during the first six months of the COVID-19 pandemic (<em>p</em> = 0.006). Before the pandemic, the regression model indicated an increased possibility of delay in breast cancer diagnosis in women with lower education levels (OR = 1.30; 95 % CI:1.14–1.48); who were residents in the north, northeast, or midwest regions (OR = 1.56; 95 % CI:1.35–1.81); and who presented staging I or II (OR = 1.96; 95 % CI:1.71–2.24). During the pandemic, there was an increase in the odds ratios for all variables: education, an increase of 10.8 %; region of residence, 20.5 %; and staging, 9.2 %.</p></div><div><h3>Conclusion</h3><p>The COVID-19 pandemic exacerbated pre-existing socioeconomic disparities during the early detection of breast cancer. It is important that, at critical moments in health, interventions be carried out for patients in vulnerable circumstances, thus minimizing the effects of possible delays in diagnosis.</p></div>","PeriodicalId":46404,"journal":{"name":"Clinical Epidemiology and Global Health","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213398424002318/pdfft?md5=20f21b0cdcc149d477e1897f2f8afa8f&pid=1-s2.0-S2213398424002318-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141841457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic accuracy of Xpert MTB/RIF and Xpert ultra tests in pulmonary and extrapulmonary tuberculosis compared to Löwenstein-Jensen culture","authors":"","doi":"10.1016/j.cegh.2024.101730","DOIUrl":"10.1016/j.cegh.2024.101730","url":null,"abstract":"<div><h3>Background</h3><p>Tuberculosis (TB) is one of the leading causes of death worldwide. However, an accurate diagnosis contributes to timely treatment, reducing its adverse consequences. The aim of this research was to determine the diagnostic accuracy of the molecular test Xpert MTB/RIF and Xpert MTB/RIF Ultra (Xpert Ultra) for the diagnosis of pulmonary and extrapulmonary TB compared to Löwenstein-Jensen culture.</p></div><div><h3>Methods</h3><p>We conducted a cross-sectional study of diagnostic accuracy. We included samples from patients who attended a Peruvian laboratory between 2011 and 2022. The index test was the Xpert MTB/RIF and Xpert Ultra and the reference standard was Löwenstein-Jensen solid culture for <em>Mycobacterium tuberculosis</em>. We calculated sensitivity, specificity, and positive and negative likelihood ratios.</p></div><div><h3>Results</h3><p>We evaluated 1023 samples, of which 737 were pulmonary samples, 197 tested positive for the Xpert MTB/RIF and Xpert Ultra tests; and 151 tested positive for culture. The Xpert (MTB/RIF and Ultra) showed a joint sensitivity and specificity of: 97 % (95%CI: 93–99) and 93 % (95%CI: 91–95) in pulmonary samples, 100 % (95%CI: 29.2–100) and 98.3 % (95%CI: 94.1–99.8) in cerebrospinal fluid, 66.7 % (95%CI: 22.3–95.7) and 96.8 % (95%CI: 91–99.3) in pleural fluid, 100 % (95%CI: 15.8–100) and 94.3 % (95%CI: 80.8–99.3) in urine. For the detection of pulmonary TB, the Xpert MTB/RIF had a sensitivity and specificity of 97.1 % (95%CI: 89.9–99.6) and 95.6 % (95%CI: 92.9–97.5) and the Xpert Ultra of 97 % (95%CI: 88.5–99.6) 89.5 % (95%CI: 84.9–93.1) respectively.</p></div><div><h3>Conclusion</h3><p>Our results suggest that the Xpert MTB/RIF and the Xpert Ultra are tests with high diagnostic performance for the detection of pulmonary TB and adequate specificity in pulmonary, cerebrospinal fluid, pleural, and urine samples. However, the results for other samples were imprecise.</p></div>","PeriodicalId":46404,"journal":{"name":"Clinical Epidemiology and Global Health","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213398424002264/pdfft?md5=a30709977ef40c2bbab41f653e67a270&pid=1-s2.0-S2213398424002264-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141960170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Breast cancer screening in Lebanon: Understanding knowledge, attitudes and barriers","authors":"","doi":"10.1016/j.cegh.2024.101733","DOIUrl":"10.1016/j.cegh.2024.101733","url":null,"abstract":"<div><h3>Background</h3><p>Breast cancer (BC) has been increasing in both prevalence and incidence in Lebanon. Knowing the positive impact mammographic screening has on reducing mortality rates, we sought to investigate the knowledge, attitudes and barriers towards BC screening amongst Lebanese women across all districts.</p></div><div><h3>Methods</h3><p>We conducted a cross-sectional study with 400 Lebanese women aged 35–75, with no prior or current diagnosis of BC, employing an online questionnaire filled face-to-face with participants to gather sociodemographic data and assess BC history and screening practices. We utilized the Breast Cancer Screening Beliefs Questionnaire (BCSBQ) and Champion Health Belief Model Scale (CHBMS) to evaluate knowledge, attitudes, and barriers.</p></div><div><h3>Results</h3><p>Findings revealed inadequate attitudes towards general health check-ups (77.5 %) and insufficient BC screening knowledge (56.4 %). Furthermore, 38.5 % encountered obstacles to mammography screening. Education significantly affected BC knowledge. Interestingly, increased knowledge of BC reduced barriers to mammographic screening. Participants with healthcare connections or background exhibited better attitudes towards health check-ups and encountered fewer screening obstacles.</p></div><div><h3>Conclusion</h3><p>This is the first study that endeavors to comprehensively investigate Lebanese women's knowledge, attitudes, and barriers concerning BC screening, encompassing all demographics and regions using validated scales (BCSBQ and CHBMS). Our data highlight the crucial role of education in advocating for early BC screening and the necessity to reevaluate national campaigns, particularly in communication methods, to ensure equitable access to screening across Lebanon.</p></div>","PeriodicalId":46404,"journal":{"name":"Clinical Epidemiology and Global Health","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S221339842400229X/pdfft?md5=7de630de6cd922c738b900740dbc9724&pid=1-s2.0-S221339842400229X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141960144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Financial impact of needle stick injury on a tertiary care teaching hospital","authors":"","doi":"10.1016/j.cegh.2024.101726","DOIUrl":"10.1016/j.cegh.2024.101726","url":null,"abstract":"<div><h3>Background</h3><p>Accidental needle stick injuries (NSIs) are an occupational hazard for healthcare workers (HCWs). Despite the implementation of preventive measures, NSIs still continue to occur in health care settings. The cost incurred by an institute for the management of occupational exposure to blood borne pathogen is a significant economic burden.This retrospective study was aimed to estimate the prevalence, factors associated with NSIs and cost burden on hospital due to NSIs.</p></div><div><h3>Material and methods</h3><p>Retrospective data of all reported NSIs among HCWs between January 2019 and December 2021 in a tertiary care hospital was collected and analyzed. CDC definition was used to calculate direct &amp; indirect cost.</p></div><div><h3>Results</h3><p>&amp; Discussion- A total 205 NSIs were reported between January 2019 and December 2021. Nurses were the most affected category of HCWs. The maximum number of NSI cases (18.54 %) occurred during handling of biomedical waste. Both the source and the affected HCWs were tested and it was found that the source was seropositive in 30(14.63 %), seronegative in 128 (62.44 %) cases and in 47(22.93 %) cases there was an unknown source resulting in NSI. A total of 13, 21,206 INR, which included both direct and indirect cost, spent by hospital in the management of NSI's, over a period of 3yrs.</p></div><div><h3>Conclusion</h3><p>Surveillance and analysis of NSI is very crucial for the planning of both preventive measures and training modules. Managing NSI generates significant cost. Hepatitis B vaccination for all healthcare workers plays major role in reducing cost of managing NSIs.</p></div>","PeriodicalId":46404,"journal":{"name":"Clinical Epidemiology and Global Health","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213398424002227/pdfft?md5=e36a32c0b8e829563a7ae29d7c559103&pid=1-s2.0-S2213398424002227-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141850488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unraveling patient satisfaction, associated factors, and dissatisfaction reasons in the provision of health care services for rural communities in Bangladesh: A cross-sectional investigation","authors":"","doi":"10.1016/j.cegh.2024.101724","DOIUrl":"10.1016/j.cegh.2024.101724","url":null,"abstract":"<div><h3>Background</h3><p>Access to high-quality healthcare is a fundamental right, but rural communities in Bangladesh face challenges in accessing such services. Patient satisfaction plays a crucial role in healthcare outcomes. Identifying factors influencing satisfaction is vital for targeted interventions.</p></div><div><h3>Methods</h3><p>A cross-sectional investigation was conducted in rural areas of Sirajganj, Rajshahi, Bangladesh, from April to June 2023. Convenient sampling was employed, and face-to-face interviews were conducted using a semi-structured questionnaire. A total of 411 participants were included in the final analysis. Descriptive statistics, as well as bivariate and multivariable logistic regression analyses, were carried out using SPSS software.</p></div><div><h3>Results</h3><p>Most unmarried participants (mean age: 41.93 ± 14.54 years; age range: 18–88 years) had primary education and a family income below 15,000 BDT. Among them, 80.3 % reported dissatisfaction with treatment. Significant factors linked to dissatisfaction included low education, being a businessman, living in nuclear families, daily physical exercise, difficulty accessing healthcare, average doctor-patient communication, high treatment costs, long waiting times, government hospital services, proximity to healthcare centers, lack of follow-up services, and absence of Telemedicine or M-health services.</p></div><div><h3>Conclusion</h3><p>This study identifies key factors affecting patient satisfaction in rural Bangladesh. Interventions should focus on improving doctor-patient communication, reducing treatment costs and waiting times, enhancing access to healthcare and follow-up services, and incorporating Telemedicine or M-health services. Special attention is needed for businessmen, nuclear family residents, those who exercise daily, and patients using government hospitals or living near healthcare centers, as these groups report higher dissatisfaction.</p></div>","PeriodicalId":46404,"journal":{"name":"Clinical Epidemiology and Global Health","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213398424002203/pdfft?md5=429c52f1d16bc20a08d78701f9a6a410&pid=1-s2.0-S2213398424002203-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141852057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification and resolution of drug-related problems among neonates in neonatal intensive care unit (NICU): A prospective longitudinal observational study","authors":"","doi":"10.1016/j.cegh.2024.101728","DOIUrl":"10.1016/j.cegh.2024.101728","url":null,"abstract":"<div><h3>Background</h3><p>Drug related problems (DRPs) can interfere with the desired therapeutic outcomes. Neonates are susceptible for DRP occurrence due to clinical heterogeneity, inappropriate formulations, complexity of drug regimens and polypharmacy. Thus, the objective of this study was to characterize the DRP, their resolutions and associated risk factors among neonates in the Neonatal Intensive Care Unit (NICU).</p></div><div><h3>Methods</h3><p>A cross-sectional study was carried out in NICU ward at tertiary care teaching hospital for 18 months. Clinical pharmacists participated on daily basis to collect patient information and assess their medication therapy for DRPs. DRPs were classified into problems and their causes according to Pharmaceutical Care Network Europe (PCNE) Version 9.1. Clinical pharmacist implicated evidence-based interventions to resolve DRPs. SPSS V.25 was used for the statistical analysis. Univariate logistic regression analysis was used for the determination of risk factors for DRPs, with a p-value &lt;0.05 for associations that were statistically significant.</p></div><div><h3>Results</h3><p>A total of 426 neonates were enrolled with a mean gestational age of 35.2 ± 7.5 weeks and a mean birth weight of 2316 ± 1814 g. A total of 486 DRPs were found among 55.6 % neonates. Among them, majority of DRPs were belongs to treatment effectiveness [n = 427 (87.8 %)]. In total, 559 interventions were made, resulting in the resolution of 87.4 % of the DRPs. Furthermore, neonates staying in hospital for more than 5 days identified as most significant risk factor of DRPs.</p></div><div><h3>Conclusion</h3><p>DRPs are common in neonates admitted to NICU. Clinical Pharmacist can play significant roles in identifying, preventing and resolving DRPs among neonates.</p></div>","PeriodicalId":46404,"journal":{"name":"Clinical Epidemiology and Global Health","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213398424002240/pdfft?md5=a49c2d9d804bfdc71ec2f6650f1024db&pid=1-s2.0-S2213398424002240-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141849910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}