Clinical Neurophysiology Practice最新文献

{"title":"Spinal lumbar multimodal neurophysiological monitoring in a patient with deep brain Stimulator: A case report","authors":"Daniel San-juan ,&nbsp;Rafael Diaz-Martinez ,&nbsp;Victor Alcocer-Barradas ,&nbsp;Luis Alberto Ortega-Porcayo ,&nbsp;Marcela Amparo Osuna-Zazueta ,&nbsp;Maria Fernanda Tejada-Pineda","doi":"10.1016/j.cnp.2024.10.003","DOIUrl":"10.1016/j.cnp.2024.10.003","url":null,"abstract":"<div><div>Intraoperative neurophysiological monitoring (IONM) is a highly valuable tool in spinal surgery. It allows for real-time evaluation of nervous system function and alerts the surgeon to any warning signs. Among the various techniques used are motor evoked potentials (MEPs) through transcranial electrical stimulation, which involve applying an electrical stimulus to the scalp in the primary motor cortex region and recording it in the corresponding muscles of the corticospinal tract. There are relative contraindications for this technique, such as in patients who have an implantable device. There is no consensus on how to perform this technique in patients with a deep brain stimulator.</div><div>We present the case of a 61-year-old patient with Parkinson’s disease and a deep brain stimulator (DBS), and who underwent spinal surgery for lumbar discopathy. IONM was performed during the procedure using MEPs, necessitating the deactivation of the DBS to protect its function. Upon completion of the surgical procedure, the device was reactivated, confirming its proper function. We demonstrate that this technique can be safe for these patients, weighing the potential risks and benefits. However, it will be necessary to develop specific guidelines for performing these techniques in the future.</div></div>","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"9 ","pages":"Pages 261-265"},"PeriodicalIF":2.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142571621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A 1-month ketogenic diet in patients with migraine gives a clinical beneficial effect associated with increased latency of somatosensory thalamo-cortical activity","authors":"Chiara Abagnale ,&nbsp;Gabriele Sebastianelli ,&nbsp;Francesco Casillo ,&nbsp;Antonio Di Renzo ,&nbsp;Vincenzo Parisi ,&nbsp;Ettore Cioffi ,&nbsp;Mariano Serrao ,&nbsp;Jean Schoenen ,&nbsp;Gianluca Coppola ,&nbsp;Cherubino Di Lorenzo","doi":"10.1016/j.cnp.2024.11.002","DOIUrl":"10.1016/j.cnp.2024.11.002","url":null,"abstract":"<div><h3>Objective</h3><div>Since the habituation deficit of evoked potentials could be related to abnormal thalamocortical drive, we searched for a modulatory effect of ketogenic diet (KD) on somatosensory-evoked thalamo-cortical activity. KD is effective in preventing migraine. Previous studies showed that KD normalises habituation of somatosensory and visual cortical evoked responses in parallel with a decrease in of migraine attack frequency.</div></div><div><h3>Methods</h3><div>We electrically stimulated the median nerve at the wrist to record somatosensory high-frequency oscillations (HFOs) in twenty patients with episodic migraine with and without aura before and after one month of normo- (n = 9) or hypocaloric KD (n = 11). For pre-synaptic thalamocortical and post-synaptic cortical HFOs, we measured the latency of the negative oscillatory maximum, the intra-burst frequency, the number of negative peaks, and the maximum peak-to-peak amplitude.</div></div><div><h3>Results</h3><div>In the total group of patients, the one-month KD significantly increased the latency of the negative oscillatory maximum in pre-synaptic, i.e. thalamocortical activity (t = 2.70, p = 0.015) and in post-synaptic HFOs, i.e. cortical activity (t = 3.08, p = 0.006). This effect could be attributed to hypo-caloric KD, as it was not found after normo-caloric KD. Other HFO parameters, such as amplitude, duration, or number of oscillations, were not affected.</div></div><div><h3>Conclusions</h3><div>A 1-month hypo-caloric KD is able to delay the propagation of neuronal activity through the thalamo-cortical network. This effect does not seem to be correlated with the therapeutic efficacy of KD, but rather to low-calorie intake.</div></div><div><h3>Significance</h3><div>Our results imply that consuming a restricted amount of calories could alter the balance between central excitation and inhibition in migraine.</div></div>","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"9 ","pages":"Pages 292-298"},"PeriodicalIF":2.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142698312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Directional deep brain stimulation of the centromedian thalamic nucleus reduces DBS-induced ataxia and dysarthria in Lennox-Gastaut Syndrome: A single case study","authors":"Stephan Neidhart ,&nbsp;Oona Kohnen ,&nbsp;Lennart Stieglitz ,&nbsp;Lukas Imbach","doi":"10.1016/j.cnp.2024.08.001","DOIUrl":"10.1016/j.cnp.2024.08.001","url":null,"abstract":"<div><h3>Background</h3><p>We present a case of a 46-year-old man with Lennox-Gastaut syndrome and drug-resistant epilepsy. An adjunctive neurostimulation therapy strategy was implemented involving bilateral deep brain stimulation (DBS) of the centromedian thalamic nucleus (CMT).</p></div><div><h3>Methods</h3><p>Robotically assisted implantation of bilateral DBS directional lead system with 8 contacts in the CMT was performed. The clinical course was assessed in repeated in-patient follow-ups.</p></div><div><h3>Results</h3><p>Initial DBS stimulation resulted in progressive ataxia and dysarthria significantly beyond the level seen before surgery. Deactivation of DBS coincided with improvement of dysarthria. A DBS stimulation paradigm with reduction of lateral and superior stimulation resulted in improvement and eventually complete resolution of the stimulation side effect.</p></div><div><h3>Discussion</h3><p>This case suggests that stimulation-induced dysarthria in DBS can be improved by targeted reduction of lateral and/or superior thalamic stimulation. When dysarthria and ataxia occur during DBS, directed stimulation to medial thalamic structures and more inferior electrode contacts offers a promising strategy to reduce side effects while maintaining positive effects.</p></div>","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"9 ","pages":"Pages 233-235"},"PeriodicalIF":2.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2467981X24000222/pdfft?md5=be5e66cca745f2972659627bfc20c150&pid=1-s2.0-S2467981X24000222-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142097607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Visualization of radial nerve activity at the upper arm using magnetoneurography","authors":"Takeyasu Toyama ,&nbsp;Muneharu Ando ,&nbsp;Masaaki Paku ,&nbsp;Shinji Sato ,&nbsp;Yusuke Yamamoto ,&nbsp;Shinichirou Taniguchi ,&nbsp;Nobuo Kohara ,&nbsp;Takanori Saito","doi":"10.1016/j.cnp.2024.11.001","DOIUrl":"10.1016/j.cnp.2024.11.001","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the function of the radial nerve in the upper arm using Magnetoneurography (MNG).</div></div><div><h3>Methods</h3><div>Eight asymptomatic male volunteers (age 25–63 years) and one 67-year-old female patient with radial nerve palsy were included. The radial nerve was electrically stimulated in the right wrist, and the evoked magnetic field was recorded using a 132-channel bio-magnetometer system with a superconducting quantum interference device positioned below the upper arm. The measurements were divided into distal and proximal sessions because of the extensive range of the nerve.</div></div><div><h3>Results</h3><div>MNG recorded the radial nerve’s evoked magnetic field in all cases, and the neural activity of the radial nerve at the upper arm was visualized using reconstructed currents. The mean conduction velocity calculated from the peak latency of the inward currents was 43.9 m/s for distal measurements and 57.9 m/s for proximal measurements. A 67-year-old female patient with radial nerve palsy had a disappearance of the reconstructed inward current and conduction disturbance of the axonal current, facilitating the identification of the lesion site.</div></div><div><h3>Conclusions</h3><div>MNG allowed visualization of the radial nerve activity in the upper arm and facilitated the identification of the lesion site in a patient with radial nerve palsy.</div></div><div><h3>Significance</h3><div>This method could be a useful diagnostic tool for patients with radial nerve palsy.</div></div>","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"9 ","pages":"Pages 283-291"},"PeriodicalIF":2.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142698310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The value of ultrasound-guidance of nerves and muscles for patient tolerance and parameters electrodiagnostic studies","authors":"Marie Laure Inghilleri ,&nbsp;Sandrine Alonso ,&nbsp;Hélène Moron ,&nbsp;Hector Ruiz ,&nbsp;Sophie Bastide ,&nbsp;Sarah Coudray","doi":"10.1016/j.cnp.2024.01.003","DOIUrl":"10.1016/j.cnp.2024.01.003","url":null,"abstract":"<div><h3>Objective</h3><p>To assess impact of ultrasound guidance (USG) on patient’s perception of nerve conduction studies (NCS).</p></div><div><h3>Methods</h3><p>In this single-center, randomized, sham-controlled, parallel, single-blind trial, we evaluated ultrasound (US) in identifying NCS stimulation site. Consecutive adults (18–80 old) without neuropathy referred for NCS were electronically randomized 1:1 to USG or Sham US. The primary outcome was sensory supramaximal intensity (SSMI) for each site/nerve; motor supramaximal intensity (MSMI), amplitudes, number of non-routine muscle punctured, Visual Analogue Scale (VAS), satisfaction were secondary outcomes.</p></div><div><h3>Results</h3><p>290 participants were randomized, with 145 in the USG and 144 Sham US groups, respectively. No difference in SSMI, CMAP or SNAP, VAS, satisfaction was recorded. With USG, the median at the elbow and fibular MMSI were lower (p = 0.04; p = 0.02). With normal NCS or overweight and obese subgroups patients had lower median SSMI (p = 0.05/ p = 0.02), higher median and sural SNAP with normal NCS (p = 0.04; p = 0.007) and the sural SNAP for the expert US subgroup (p = 0.02).</p></div><div><h3>Conclusions</h3><p>USG is useful for nerves, that are anatomically variable or in obesity. The sural SNAP gain with US in the normal NCS subgroup could facilitate routine NCS.</p></div><div><h3>Significance</h3><p>In standard NCS the USG does not modify the patient’s tolerance.</p><p><strong>Trial Registration:</strong> clinicaltrials.gov (NCT03868189).</p></div>","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"9 ","pages":"Pages 78-84"},"PeriodicalIF":1.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2467981X24000064/pdfft?md5=b429328969813cf5ba4ede5768daa0d1&pid=1-s2.0-S2467981X24000064-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139637403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Пepeвoд и aдaптaция для pyccкoгo языкa пepecмoтpeннoгo глoccapия тepминoв, нaибoлee чacтo иcпoльзyeмыx в клиничecкoй элeктpoэнцeфaлoгpaфии, и oбнoвлённoгo пpeдлoжeния пo фopмe зaключeния ЭЭГ (IFCN, 2017 г.)","authors":"Mikhail Sinkin ,&nbsp;Nadezhda Kvaskova ,&nbsp;Vasily Nogovitsyn ,&nbsp;Alexey Troitsky ,&nbsp;Irina Ivanova ,&nbsp;Alexandra Belyakova-Bodina ,&nbsp;Amayak Broutian","doi":"10.1016/j.cnp.2024.01.004","DOIUrl":"10.1016/j.cnp.2024.01.004","url":null,"abstract":"","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"9 ","pages":"Pages 138-161"},"PeriodicalIF":1.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2467981X24000076/pdfft?md5=6770f16b4d4b1ac193d5b3645e4ad0e3&pid=1-s2.0-S2467981X24000076-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139877901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Compound muscle action potential of whole-forearm flexors: A clinical biomarker for inclusion body myositis","authors":"Tomoo Mano ,&nbsp;Naohiko Iguchi ,&nbsp;Naoki Iwasa ,&nbsp;Nanami Yamada ,&nbsp;Kazuma Sugie","doi":"10.1016/j.cnp.2024.03.003","DOIUrl":"https://doi.org/10.1016/j.cnp.2024.03.003","url":null,"abstract":"<div><h3>Objective</h3><p>This study aimed to investigate the potential of whole-forearm flexor muscle (WFFM) compound muscle action potential (CMAP) as a quantitative biomarker for inclusion body myositis (IBM) pathology.</p></div><div><h3>Methods</h3><p>We prospectively enrolled 14 consecutive patients (10 men and 4 women) diagnosed with IBM based on muscle biopsies. We evaluated the baseline-to-peak amplitude of the WFFM CMAP and other quantitative parameters, including grip and pinch strength, Inclusion Body Myositis Functional Rating Scale (IBMFRS) score, and other routine muscle CMAP amplitudes.</p></div><div><h3>Results</h3><p>The WFFM CMAP was strongly correlated with disease duration and the IBMFRS score. The WFFM CMAP on the more affected side was lower than that on the less affected side. Furthermore, grip power was strongly correlated with the WFFM CMAP, whereas lateral pinch strength was strongly correlated with the WFFM and first dorsal interosseous CMAPs. The 3-point pinch strength was also correlated with the WFFM CMAP.</p></div><div><h3>Conclusions</h3><p>This study demonstrates that the WFFM CMAP may serve as a biomarker of severity in IBM.</p></div><div><h3>Significance</h3><p>Identification of this biomarker can support drug development, diagnosis, prognosis, and treatment options for patients with IBM.</p></div>","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"9 ","pages":"Pages 162-167"},"PeriodicalIF":1.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2467981X24000143/pdfft?md5=c5ee443e624833861e41f2e57e89ec24&pid=1-s2.0-S2467981X24000143-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140651037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surface recording of the H-reflex from a relaxed flexor carpi ulnaris: Reliability and normative values for healthy young adults","authors":"Hesham N. Alrowayeh","doi":"10.1016/j.cnp.2024.06.001","DOIUrl":"10.1016/j.cnp.2024.06.001","url":null,"abstract":"<div><p><em>Objective:</em> H-reflex recordings of the relaxed flexor carpi ulnaris (FCU) muscle are not frequently performed in clinical or laboratory settings. There are no normative values or reliability standards. This is most likely because of technical difficulties associated with this technique. This study performed surface recordings of the H-reflex of relaxed FCU muscles to establish the normative values and the reliability of these recordings. <em>Methods:</em> The maximum amplitude and latency of the FCU H-reflex were recorded bilaterally in 53 healthy young adults. Normative values and interclass correlation coefficients (ICCs) were calculated. <em>Results:</em> The amplitude of the relaxed FCU H-reflex were recorded in nearly all participants (96 %). The FCU H-reflex average maximum amplitude was 1.35 mV. The average latency was 18.8 ms. H-reflex amplitude and latency were not statistically different among gender or limb sides. Amplitude and latency were recoded reliably both within and between sessions with ICCs ranging from 0.96 to 0.99. <em>Conclusions:</em> Recordings of the relaxed FCU H-reflex were readily available and could be assessed reliably within and between sessions. <em>Significance:</em> This method might be used more frequently in clinical and laboratory settings to examine C7 and C8 spinal segments and upper limb muscle normal function or neuromuscular pathology.</p></div>","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"9 ","pages":"Pages 205-210"},"PeriodicalIF":2.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2467981X24000179/pdfft?md5=13b4b259c3ef8951cee3bc76e41fad76&pid=1-s2.0-S2467981X24000179-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141402216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Midline non-ictal rhythmic waveforms as possible electroencephalographic biomarkers of Smith-Klingsmore syndrome in children","authors":"Valerio Simonelli ,&nbsp;Anna Rita Ferrari ,&nbsp;Roberta Battini ,&nbsp;Paola Brovedani ,&nbsp;Emanuele Bartolini","doi":"10.1016/j.cnp.2024.02.001","DOIUrl":"https://doi.org/10.1016/j.cnp.2024.02.001","url":null,"abstract":"<div><h3>Introduction</h3><p>Pathogenic variants of the MTOR gene result in the Smith-Kingsmore syndrome, whose phenotypical spectrum includes facial dysmorphisms and neurological features. Expressivity is variable, patients exhibit a combination of intellectual disability, macrocephaly and epilepsy. The diagnosis can be missed, failing to detect the causative pathogenic mutation in patients with somatic mosaicism or even skipping to analyze <em>MTOR</em> when the phenotype is not completely expressed.</p></div><div><h3>Case study</h3><p>Herein, we report two children harboring the same MTOR recurring mutation (c.5395G&gt;A/p.Glu1799Lys) whose EEG displayed a peculiar combination of midline rhythmic waveforms and asynchronous spike-and-wave discharges with anterior fast activity in sleep and wake. <strong>Conclusion</strong>: We suggest these features might be considered as possible hallmarks of the syndrome and could aid to expedite the diagnosis when the phenotype is incomplete.</p></div>","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"9 ","pages":"Pages 102-105"},"PeriodicalIF":1.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2467981X2400009X/pdfft?md5=3a1227099809ea34332686792ca17474&pid=1-s2.0-S2467981X2400009X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140067182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining short interval intracortical inhibition with different transcranial magnetic stimulation-induced current directions in ALS","authors":"Roisin McMackin ,&nbsp;Yasmine Tadjine ,&nbsp;Antonio Fasano ,&nbsp;Matthew Mitchell ,&nbsp;Mark Heverin ,&nbsp;Friedemann Awiszus ,&nbsp;Bahman Nasseroleslami ,&nbsp;Richard G. Carson ,&nbsp;Orla Hardiman","doi":"10.1016/j.cnp.2024.03.001","DOIUrl":"10.1016/j.cnp.2024.03.001","url":null,"abstract":"<div><h3>Objective</h3><p>To establish if induced current direction across the motor cortex alters the sensitivity of transcranial magnetic stimulation (TMS)-evoked short-interval intracortical inhibition (SICI) as an ALS biomarker.</p></div><div><h3>Methods</h3><p>Threshold tracking-TMS was undertaken in 35 people with ALS and 39 controls. Using a coil orientation which induces posterior-anterior (PA)-directed current across the motor cortex, SICI (1 ms and 3 ms interstimulus intervals) and intracortical facilitation (ICF, 10 ms interstimulus interval) were recorded. SICI_3ms was also recorded using a coil orientation which induces anterior-posterior (AP)-directed current across the motor cortex.</p></div><div><h3>Results</h3><p>At group level, SICI_3ms-PA (AUROC = 0.7), SICI_3ms-AP (AUROC = 0.8) and SICI_1ms (AUROC = 0.66) were substantially lower in those with ALS, although there was considerable interindividual heterogeneity. Averaging across interstimulus intervals (ISIs) marginally improved SICI_PA sensitivity (AUROC = 0.76). Averaging SICI values across ISIs and orientations into a single SICI measure did not substantially improve sensitivity (AUROC = 0.81) compared to SICI_3ms-AP alone. SICI_3ms-AP and SICI_3ms-PA did not significantly correlate (rho = 0.19, p = 0.313), while SICI_1ms-PA and SICI_3ms-PA did (rho = 0.37, p = 0.006). Further, those with ALS with the lowest SICI_3ms-PA were not those with the lowest SICI_3ms-AP. ICF was similar between groups (AUROC = 0.50).</p></div><div><h3>Conclusions</h3><p>SICI_PA and SICI_AP are uncorrelated measures of motor cortical inhibitory functions which are useful as distinct, unequally affected, measures of disinhibition in ALS.</p></div><div><h3>Significance</h3><p>Examining both SICI_PA and SICI_AP may facilitate more comprehensive characterisation of motor cortical disinhibition in ALS.</p></div>","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"9 ","pages":"Pages 120-129"},"PeriodicalIF":1.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2467981X2400012X/pdfft?md5=1fae5548e5c18ff04a29ad5b5d8090ce&pid=1-s2.0-S2467981X2400012X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140272102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}