Clinical Neurophysiology Practice最新文献_第3页

Within five weeks: Rapidly grown glioblastoma discovered on repeat MRI after pathologic EEG 5周内：病理脑电图后复查MRI发现快速生长的胶质母细胞瘤

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Clinical Neurophysiology Practice Pub Date : 2025-01-01 DOI: 10.1016/j.cnp.2025.02.002

Zsuzsanna Szankai , Egle Huggenberger , Christoph Metzler , Christian Musahl , Markus Gschwind

引用次数: 0

The role of EEG in the emergency department: Its contribution to the patient’s diagnostic–therapeutic pathway. The EMINENCE study 脑电图在急诊科的作用：它对病人的诊断-治疗途径的贡献。隆起研究

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Clinical Neurophysiology Practice Pub Date : 2025-01-01 DOI: 10.1016/j.cnp.2025.02.010

Scarpino Maenia , Verna Maria Teresa , Grippo Antonello , Lolli Francesco , Piccardi Benedetta , Nazerian Peiman , Nencini Patrizia , Boccardi Cristina , Nencioni Andrea

{"title":"The role of EEG in the emergency department: Its contribution to the patient’s diagnostic–therapeutic pathway. The EMINENCE study","authors":"Scarpino Maenia , Verna Maria Teresa , Grippo Antonello , Lolli Francesco , Piccardi Benedetta , Nazerian Peiman , Nencini Patrizia , Boccardi Cristina , Nencioni Andrea","doi":"10.1016/j.cnp.2025.02.010","DOIUrl":"10.1016/j.cnp.2025.02.010","url":null,"abstract":"<div><h3>Objectives</h3><div>To investigate the utility of the emergency electroencephalogram(emEEG) in the diagnostic work-up of patients admitted to the Emergency Department(ED).</div></div><div><h3>Methods</h3><div>Data from consecutive patients admitted to the ED during a 1-year period. We evaluated the usefulness of emEEGs based on the subsequent patient clinical management.</div></div><div><h3>Results</h3><div>1125 emEEGs from 1018 patients were analyzed. The overall usefulness of an emEEG was 86.7%, mainly influenced by its contribution to diagnosis(75.0%), often excluding initial working diagnosis(50.0%), and to patient management(78.0%). EmEEGs showed their best overall usefulness in Status Epilepticus(SE) and altered level of consciousness both in contributing to the final diagnosis and in patient management and therapeutic pathway. In speech and cognitive/behavioural disorders, emEEGs contributed to the diagnosis(80.6% and 79.8%, respectively), often excluding the initial suspicion of seizures/SE. Normal emEEGs contributed to diagnosis(79.0%), patient management(87.0%) and discharge to home(82.0%).</div></div><div><h3>Conclusions</h3><div>In ED, attending physicians have to make quick decisions about the diagnostic–therapeutic management of patients, and also the ruling out of the initial diagnosis and safely discharging the patient to home are also important goals.</div></div><div><h3>Significance</h3><div>This study provides valuable guidance to ED clinicians in selecting patients for an emEEG and evaluates its contribution to their diagnostic–therapeutic management.</div></div>","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"10 ","pages":"Pages 70-77"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143580355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to “Neurophysiological monitoring during anterior cervical discectomy and fusion for ossification of the posterior longitudinal ligament” [Clin. Neurophysiol. Pract. 6 (2021) 56–62] “颈椎前路椎间盘切除术和融合治疗后纵韧带骨化的神经生理监测”的勘误[临床。Neurophysiol。惯例6 (2021)56-62]

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Clinical Neurophysiology Practice Pub Date : 2025-01-01 DOI: 10.1016/j.cnp.2025.02.001

Jee-Eun Kim , Jun-Soon Kim , Sejin Yang , Jongsuk Choi , Seung-Jae Hyun , Ki-Jeong Kim , Kyung Seok Park

引用次数: 0

Cortical evoked responses to evaluate the effect of spinal cord stimulation on the pain pathways 皮质诱发反应评价脊髓刺激对疼痛通路的影响

IF 2

Clinical Neurophysiology Practice Pub Date : 2025-01-01 DOI: 10.1016/j.cnp.2025.04.003

Laurien J. Reinders, Cecile C. de Vos

{"title":"Cortical evoked responses to evaluate the effect of spinal cord stimulation on the pain pathways","authors":"Laurien J. Reinders, Cecile C. de Vos","doi":"10.1016/j.cnp.2025.04.003","DOIUrl":"10.1016/j.cnp.2025.04.003","url":null,"abstract":"<div><h3>Objectives</h3><div>The mechanisms of spinal cord stimulation (SCS) are insufficiently understood. Conditioned pain modulation (CPM) measures how a painful stimulus is affected by a second painful stimulus. We investigated whether cortical evoked response can be used to evaluate CPM in a patient treated with burst, tonic and sham SCS.</div></div><div><h3>Methods</h3><div>A 40-year-old patient underwent 3 magnetoencephalography sessions (burst, tonic, sham SCS) with 1-week intervals. Painful electrical stimuli were applied to the tibial nerve before, during and after CPM (conditioning: icepack on forearm). Evoked responses were analysed in the primary somatosensory and anterior cingulate cortices.</div></div><div><h3>Results</h3><div>Before CPM, the highest evoked response amplitude occurred under sham SCS, followed by tonic SCS. During CPM pain ratings remained unchanged. However, CPM reduced evoked response amplitudes in the primary somatosensory cortex under tonic and sham SCS and in the anterior cingulate cortex under all SCS paradigms.</div></div><div><h3>Conclusions</h3><div>CPM reduced evoked response amplitudes, while pain ratings were unaffected, suggesting neurophysiological measures provide additional insights into CPM effects. Tonic and burst SCS both appeared to reduce cortical capacity to attend to stimuli, with burst showing the greatest effect.</div></div><div><h3>Significance</h3><div>Cortical responses offer a valuable tool to assess pain pathways. Larger scale studies are needed to enhance our understanding of SCS mechanisms.</div></div>","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"10 ","pages":"Pages 167-171"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143935730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlation analysis between excitability in the somatosensory cortex and structural changes in amyotrophic lateral sclerosis 肌萎缩性侧索硬化症体感觉皮层兴奋性与结构变化的相关性分析

IF 2

Clinical Neurophysiology Practice Pub Date : 2025-01-01 DOI: 10.1016/j.cnp.2025.06.003

Aysegul Gunduz , Tuba Akıncı , Osman Aykan Kargın , Melih Tutuncu , Serdar Arslan , Nurten Uzun

{"title":"Correlation analysis between excitability in the somatosensory cortex and structural changes in amyotrophic lateral sclerosis","authors":"Aysegul Gunduz , Tuba Akıncı , Osman Aykan Kargın , Melih Tutuncu , Serdar Arslan , Nurten Uzun","doi":"10.1016/j.cnp.2025.06.003","DOIUrl":"10.1016/j.cnp.2025.06.003","url":null,"abstract":"<div><h3>Objective</h3><div>We aimed to investigate the excitability of the somatosensory cortex and its relationship to structural changes in motor and sensory pathways, and motor excitability in amyotrophic lateral sclerosis (ALS).</div></div><div><h3>Patients and method</h3><div>We included all consecutive individuals with ALS, fulfilling the “definite” or “probable” ALS criteria. We recorded surround inhibition (SI) and recovery function (RC) of somatosensory evoked potentials (SEPs), resting motor threshold, and cortical silent period (cSP), and performed volumetric analysis and diffusion tensor imaging (DTI).</div></div><div><h3>Results</h3><div>We included 15 patients with ALS and 12 healthy individuals of similar age and sex. At the group level, the mean SEP-RC% at ISI 5 ms was higher in the ALS group than in healthy participants (all SEP-RC% at 5 ms p < 0.001). SEP-SI was lost in one-third of individuals with ALS. A negative correlation was found between the duration of the cSP and SEP-RC%, whereas no correlations were observed between SEP parameters and radiological volumetric analysis of the corticospinal tract, medial lemniscus, or cortical thickness of the precentral and postcentral gyri.</div></div><div><h3>Conclusion</h3><div>Somatosensory hyperexcitability is present in ALS, and SI is lost in a subset of patients with ALS.</div></div><div><h3>Significance</h3><div>Somatosensory hyperexcitability correlates well with cSP but not with structural changes.</div></div>","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"10 ","pages":"Pages 202-208"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144366657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Methotrexate-induced neurotoxicity: Diagnostic challenges and the role of neurophysiological testing 甲氨蝶呤诱导的神经毒性：诊断挑战和神经生理测试的作用

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Clinical Neurophysiology Practice Pub Date : 2025-01-01 DOI: 10.1016/j.cnp.2025.06.004

Pauline D’hoore , Joke Terryn

{"title":"Methotrexate-induced neurotoxicity: Diagnostic challenges and the role of neurophysiological testing","authors":"Pauline D’hoore , Joke Terryn","doi":"10.1016/j.cnp.2025.06.004","DOIUrl":"10.1016/j.cnp.2025.06.004","url":null,"abstract":"<div><div>Methotrexate (MTX) is widely used in the treatment of acute lymphocytic leukemia (ALL) and other onco-hematological conditions. Although subacute MTX-related neurotoxicity is relatively rare, it can present with dramatic, fluctuating neurological deficits that mimic other serious conditions. Diagnosis may be complicated by the frequent presence of asymptomatic white matter abnormalities on MRI, commonly attributed to chronic MTX toxicity.</div><div>We report an 18-year-old ALL patient who developed severe, fluctuating neurological symptoms 11 days after the third intrathecal administration of MTX. MRI showed bilateral, symmetric diffusion-restrictive white matter lesions. Absent cortical motor evoked potentials (MEPs) with preserved responses to spinal stimulation indicated corticospinal tract involvement localized to the brain, supporting a diagnosis of MTX-induced neurotoxicity. Treatment with high-dose dextromethorphan led to rapid and complete recovery.</div><div>This case underscores the value of early neurophysiological testing – particularly MEPs – in identifying corticospinal tract involvement and differentiating symptomatic neurotoxicity from chronic, asymptomatic MRI findings. Prompt recognition can accelerate diagnosis, guide treatment, and prevent unnecessary interventions.</div></div>","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"10 ","pages":"Pages 218-221"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144501197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multiple factors contribute to pupillary light reflex: implications for screening of traumatic brain injury in military service members 多种因素影响瞳孔光反射：对军人创伤性脑损伤筛查的意义

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Clinical Neurophysiology Practice Pub Date : 2025-01-01 DOI: 10.1016/j.cnp.2025.07.002

Michael N. Dretsch , Katie M. Williams , Diana P. Evans , Katrina S. Monti , Brian J. Guise , Mark L. Ettenhofer , Jamie N. Hershaw

{"title":"Multiple factors contribute to pupillary light reflex: implications for screening of traumatic brain injury in military service members","authors":"Michael N. Dretsch , Katie M. Williams , Diana P. Evans , Katrina S. Monti , Brian J. Guise , Mark L. Ettenhofer , Jamie N. Hershaw","doi":"10.1016/j.cnp.2025.07.002","DOIUrl":"10.1016/j.cnp.2025.07.002","url":null,"abstract":"<div><h3>Objectives</h3><div>This study aimed to assess the contribution of demographics, medical history, and psychological health to pupillary light reflex (PLR) indices in Service members with and without a history of mild traumatic brain injury (mTBI).</div></div><div><h3>Methods</h3><div>PLR data from NeurOptics NPi-300 were analyzed on 216 participants who were categorized as non-injured controls (NIC), mTBI with no loss of consciousness (mTBI<sup>LOC-</sup>), or mTBI with LOC (mTBI<sup>LOC+</sup>). Multiple independent regression models were conducted for each PLR index to assess the contribution of these factors to the variability of PLR indices by group.</div></div><div><h3>Results</h3><div>There were no significant group differences on the PLR indices. Age was a significant factor across groups, but more robust for those with mTBI. Sleep duration, injury characteristics, and psychological health effects on PLR indices were primarily observed in the mTBI<sup>LOC+</sup> group. Posttraumatic stress and sex were not significant predictors in any of the models.</div></div><div><h3>Conclusions</h3><div>When using PLR for screening of mTBI, an individual’s age, history of prior mTBI, total lifetime TBI-related alterations in consciousness, sleep, and anxiety and depression symptoms should be considered when interpreting PLR metrics.</div></div><div><h3>Significance</h3><div>Controlling for these factors is essential for validating the use of PLR for screening of mTBI.</div></div>","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"10 ","pages":"Pages 256-264"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144605723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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The eastern Association of EEG: A Legacy with Contemporary lessons 东部脑电图协会：具有当代教训的遗产

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Clinical Neurophysiology Practice Pub Date : 2025-01-01 DOI: 10.1016/j.cnp.2025.08.003

Stefano Meletti , Margitta Seeck

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Averted weakness from a large Martin-Gruber anastomosis 避免了马丁-格鲁伯吻合术造成的虚弱。

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Clinical Neurophysiology Practice Pub Date : 2025-01-01 DOI: 10.1016/j.cnp.2024.12.003

Emily Cheung, Karl Ng

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Comparative analysis of signal quality and usability for a novel wireless, wearable EEG sensor 一种新型无线可穿戴脑电图传感器的信号质量和可用性对比分析

IF 2

Clinical Neurophysiology Practice Pub Date : 2025-01-01 DOI: 10.1016/j.cnp.2025.05.004

Vamshi K. Muvvala , Avidor B. Kazen , Tyler J. Newton , Zoë Tosi , Michael Elwood , Mark J. Lehmkuhle , Tobias Loddenkemper , Mark C. Spitz , Laura Strom , Daniel Friedman , Mitchell A. Frankel

{"title":"Comparative analysis of signal quality and usability for a novel wireless, wearable EEG sensor","authors":"Vamshi K. Muvvala , Avidor B. Kazen , Tyler J. Newton , Zoë Tosi , Michael Elwood , Mark J. Lehmkuhle , Tobias Loddenkemper , Mark C. Spitz , Laura Strom , Daniel Friedman , Mitchell A. Frankel","doi":"10.1016/j.cnp.2025.05.004","DOIUrl":"10.1016/j.cnp.2025.05.004","url":null,"abstract":"<div><h3>Objective</h3><div>This study details the design, efficacy, and usability of a novel wearable, wireless electroencephalography (EEG) sensor designed for extended-duration clinical monitoring in any environment.</div></div><div><h3>Methods</h3><div>Simultaneous EEG recordings from REMI sensors and a conventional scalp-EEG recording system were conducted across two cohorts: 1) participants undergoing routine epilepsy seizure monitoring and 2) healthy volunteers performing tasks to induce common EEG artifacts. Comparative time and spectral-based analyses were conducted between the recording modalities. Sensor usability was also evaluated.</div></div><div><h3>Results</h3><div>The temporal dynamics and signal morphology of artifacts and electrographic seizures were visually similar between the REMI sensor and conventional scalp-EEG. Additionally, spectral correlation between the two systems was high across all event types, ranging from 0.86 to 0.94. Patient-reported acceptance was also strong, with 69% of participants rating the sensors as comfortable to wear.</div></div><div><h3>Conclusions</h3><div>The REMI sensor showed strong agreement with conventional scalp-EEG in the signal characteristics of physiological artifacts and electrographic seizures. The positive comfort feedback further supports the REMI sensors’ everyday utility.</div></div><div><h3>Significance</h3><div>Although limited in electrode coverage compared to conventional scalp-EEG recording systems, the REMI sensor records comparable high-fidelity EEG data in both time and spectral domains. REMI sensor’s recording quality and wearability facilitate extended-duration monitoring in everyday environments.</div></div>","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"10 ","pages":"Pages 292-300"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144655230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0