Clinical Neurophysiology Practice最新文献_第3页

Shear wave elastography as a marker of anisotropy in denervated muscle tissue 剪切波弹性图作为去神经支配肌肉组织各向异性的标志

IF 2

Clinical Neurophysiology Practice Pub Date : 2025-01-01 DOI: 10.1016/j.cnp.2025.02.007

Olli Kutvonen , Sari-Leena Himanen , Katri Mäkelä

{"title":"Shear wave elastography as a marker of anisotropy in denervated muscle tissue","authors":"Olli Kutvonen , Sari-Leena Himanen , Katri Mäkelä","doi":"10.1016/j.cnp.2025.02.007","DOIUrl":"10.1016/j.cnp.2025.02.007","url":null,"abstract":"<div><h3>Objectives</h3><div>To assess the capability of shear wave elastography (SWE) to detect muscle denervation.</div></div><div><h3>Methods</h3><div>36 patients underwent electrodiagnostic studies (EDX) of the lower limbs and volunteered to undergo ultrasound examination of the Tibialis anterior (TA) and the Gastrocnemius medialis (GCM) muscles. A variable reflecting the level of anisotropy was created by calculating the difference between the longitudinal and transverse shear wave velocity (SWE-D).</div></div><div><h3>Results</h3><div>In the TA muscles, SWE-D correlated negatively with the quantity of fibrillation potentials (FP) and the degree of interference pattern (IP) reduction (p = 0.032, r = -0.185 and p = 0.006, r = -0.236, respectively). In the GCM muscles, SWE-D only correlated with the amount of IP reduction among patients of normal weight (p = 0.030, r = -0.285). There was also a significant difference in the overall SWE-D values in the GCM muscles between patients of normal weight and obese patients (p = 0.007).</div></div><div><h3>Conclusions</h3><div>Loss of anisotropy caused by denervation of muscle tissue may be measured quantitatively by calculating the differences between longitudinal and transverse shear wave velocities. However, obesity seems to hinder the SWE-based assessment of muscle denervation.</div></div><div><h3>Significance</h3><div>Being able to measure anisotropy caused by denervation acts as a base for further development of SWE methods to evaluate neurogenic injury.</div></div>","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"10 ","pages":"Pages 95-103"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143619967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The diagnostic yield of a first EEG in children with suspected epilepsy: A retrospective age-related comparison between awake and sleep recordings 怀疑癫痫的儿童首次脑电图的诊断率：清醒和睡眠记录之间的回顾性年龄相关比较

IF 2

Clinical Neurophysiology Practice Pub Date : 2025-01-01 DOI: 10.1016/j.cnp.2025.05.002

Greta Gustafsson , Anders Broström , Eva Svanborg , Magnus Vrethem , Martin Ulander

{"title":"The diagnostic yield of a first EEG in children with suspected epilepsy: A retrospective age-related comparison between awake and sleep recordings","authors":"Greta Gustafsson , Anders Broström , Eva Svanborg , Magnus Vrethem , Martin Ulander","doi":"10.1016/j.cnp.2025.05.002","DOIUrl":"10.1016/j.cnp.2025.05.002","url":null,"abstract":"<div><h3>Objectives</h3><div>Previous research has indicated a low diagnostic yield of initial EEGs in epilepsy diagnosis in children. This study aimed at exploring factors affecting the diagnostic yield of a first EEG in different ages, and factors affecting the choice of EEG method.</div></div><div><h3>Methods</h3><div>1097 EEGs performed as first recordings in children with suspected epilepsy were retrospectively analysed and divided into age groups: ≤ 5, 6–11 and 12–17 years. EEGs were classified as wake recordings with or without provocations, and sleep recordings: spontaneous sleep, sleep induced by deprivation or by melatonin premedication.</div></div><div><h3>Results</h3><div>Epileptiform activity was found in 18 % of all patients, most common (30 %) in children 6–11 years old. It was more likely to be detected in melatonin-induced sleep EEGs compared to other types of sleep EEG. Presence of epileptiform discharges were positively associated to age, sleep, neurological and/or intellectual comorbidity in all children.</div></div><div><h3>Conclusions</h3><div>The prevalence of epileptiform activity varies depending on the child́s age. Sleep EEG is advantageous as first recording, especially in very young children or with neurological comorbidity.</div></div><div><h3>Significance</h3><div>Melatonin-induced sleep EEG has higher diagnostic yield compared to other types of sleep EEG. Age, seizure semiology and comorbidity affect the choice of EEG method.</div></div>","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"10 ","pages":"Pages 181-187"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144290883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effects of stimulation waveform and carrier frequency on tolerance and motor thresholds elicited by transcutaneous spinal cord stimulation in stroke 刺激波形和载波频率对脑卒中经皮脊髓刺激引起的耐受性和运动阈值的影响

IF 2

Clinical Neurophysiology Practice Pub Date : 2025-01-01 DOI: 10.1016/j.cnp.2025.04.001

Chen Yang , Nicole C. Veit , Kelly A. McKenzie , Shreya Aalla , Ameen Kishta , Kyle Embry , Elliot J. Roth , Richard L. Lieber , Arun Jayaraman

{"title":"The effects of stimulation waveform and carrier frequency on tolerance and motor thresholds elicited by transcutaneous spinal cord stimulation in stroke","authors":"Chen Yang , Nicole C. Veit , Kelly A. McKenzie , Shreya Aalla , Ameen Kishta , Kyle Embry , Elliot J. Roth , Richard L. Lieber , Arun Jayaraman","doi":"10.1016/j.cnp.2025.04.001","DOIUrl":"10.1016/j.cnp.2025.04.001","url":null,"abstract":"<div><h3>Objective</h3><div>With growing interest in translating transcutaneous spinal cord stimulation (tSCS) into rehabilitation for different neurologic injuries, understanding the effects of various combinations of stimulation parameters becomes essential.</div></div><div><h3>Methods</h3><div>Twenty-one participants post-stroke completed an assessment to determine their resting motor threshold (RMT) (minimum current required to elicit a muscle response) and tolerance levels (uncomfortable current intensity) to 12 stimulation configurations: two square waveforms, biphasic and monophasic, paired with six carrier frequencies (unmodulated: 0, and modulated: 1, 3, 5, 7, and 10 kHz).</div></div><div><h3>Results</h3><div>The results demonstrated that increasing carrier frequency increased participants’ tolerance level and RMTs. Carrier frequency nor waveform type significantly altered discomfort when tolerance was normalized to the motor threshold, with 57 ± 23 % tolerated across all configurations. However, higher carrier frequencies, particularly biphasic waveforms at frequencies > 5 kHz, required more charge to reach a muscle activation and activated fewer muscles compared to unmodulated waveforms. No significant differences in discomfort relative to RMT were found between monophasic and biphasic waveforms.</div></div><div><h3>Conclusions</h3><div>Higher carrier frequency allows stimulation to be more comfortable at a given intensity, but it also requires more current to reach RMTs.</div></div><div><h3>Significance</h3><div>This study provides an essential feasibility assessment of tSCS configurations in a neurological population.</div></div>","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"10 ","pages":"Pages 150-158"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143876696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Contralateral R1 response in blink reflex in patients with amyotrophic lateral sclerosis 肌萎缩性侧索硬化症患者眨眼反射对侧R1反应

IF 2

Clinical Neurophysiology Practice Pub Date : 2025-01-01 DOI: 10.1016/j.cnp.2025.02.005

Julian Theuriet , Adrien Bohic , Maxime Bonjour , Emilien Bernard , Florent Cluse , Juliette Svahn , Laurent Jomir , Anne-Evelyne Vallet , Marion Demia , Lucie Roux , Ioana Cristina Bârsan , Léa Alves , Matthias Dion , Lionel Meens , Martin Moussy , Françoise Bouhour , Yann Péréon , Antoine Pegat

{"title":"Contralateral R1 response in blink reflex in patients with amyotrophic lateral sclerosis","authors":"Julian Theuriet , Adrien Bohic , Maxime Bonjour , Emilien Bernard , Florent Cluse , Juliette Svahn , Laurent Jomir , Anne-Evelyne Vallet , Marion Demia , Lucie Roux , Ioana Cristina Bârsan , Léa Alves , Matthias Dion , Lionel Meens , Martin Moussy , Françoise Bouhour , Yann Péréon , Antoine Pegat","doi":"10.1016/j.cnp.2025.02.005","DOIUrl":"10.1016/j.cnp.2025.02.005","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to compare the frequency of blink reflex’s contralateral R1 responses (R1′) between patients with amyotrophic lateral sclerosis (ALS), non-ALS motor deficit patients, and healthy volunteers.</div></div><div><h3>Methods</h3><div>A total of 120 participants were prospectively recruited: 40 with ALS, 40 with a non-ALS motor deficit, and 40 healthy volunteers. Blink reflexes were recorded from orbicularis oculi muscles following supraorbital nerve stimulation.</div></div><div><h3>Results</h3><div>R1′ was more frequent in the ALS group (42.5 %) compared to healthy volunteers (12.5 %, p = 0.00588), and compared to non-ALS patients (7.5 %, p = 0.000789). Bilateral R1′ was observed only in ALS patients (22.5 %). No clinically significant difference was found in the latencies or amplitudes of the R1, R2, or R1′ responses among groups. R1′ was more frequent in ALS patients with pseudobulbar affect (71.4 %) compared to those without (36.4 %).</div></div><div><h3>Conclusions</h3><div>The higher frequency of R1′ in ALS highlights its potential role in distinguishing ALS from other motor disorders. Its sensitivity was low, but bilateral R1′ was specific to ALS. The higher frequency of R1′ among ALS patients with pseudobulbar affect potentially reflects corticobulbar neuron degeneration.</div></div><div><h3>Significance</h3><div>The R1′, especially when bilateral, could serve as an additional diagnostic biomarker for ALS, although its clinical relevance should be considered within the broader diagnostic context.</div></div>","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"10 ","pages":"Pages 47-51"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143509107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Motor and parietal cortex activity responses to mirror visual feedback in patients with subacute stroke: An EEG study 亚急性中风患者的运动和顶叶皮层活动对镜像视觉反馈的反应：一项脑电图研究。

IF 2

Clinical Neurophysiology Practice Pub Date : 2025-01-01 DOI: 10.1016/j.cnp.2024.12.004

Jinyang Zhuang , Xiyuan Lei , Xiaoli Guo , Li Ding , Jie Jia

{"title":"Motor and parietal cortex activity responses to mirror visual feedback in patients with subacute stroke: An EEG study","authors":"Jinyang Zhuang , Xiyuan Lei , Xiaoli Guo , Li Ding , Jie Jia","doi":"10.1016/j.cnp.2024.12.004","DOIUrl":"10.1016/j.cnp.2024.12.004","url":null,"abstract":"<div><h3>Objective</h3><div>To elucidate the immediate electrophysiological effects of mirror visual feedback (MVF) combined with or without touch task in subacute stroke.</div></div><div><h3>Methods</h3><div>Subacute stroke patients and healthy controls were recruited to participate in four grasping tasks (MVF or no MVF, combined with rubber ball or no ball) under electroencephalogram (EEG) monitoring. Event-related desynchronization (ERD) /event-related synchronization (ERS) and the lateralization index (LI) were utilized to observe the electrophysiological effects.</div></div><div><h3>Results</h3><div>MVF reduced ERD suppression in the contralateral primary motor cortex (M1) of stroke patients. This reduction was observed in the low mu band for the contralateral parietal cortex during pure MVF. The laterality effects in the low mu band under MVF was noted in M1 for stroke patients and in the parietal cortex for all participants.</div></div><div><h3>Conclusions</h3><div>MVF inhibits the excitability of the contralateral M1 for subacute stroke. MVF inhibit activities in the contralateral M1 and parietal cortex, and reestablished hemispheric balance in the low mu band.</div></div><div><h3>Significance</h3><div>MVF has an instantaneous effect on subacute stroke by inhibiting the excitability of the contralateral sensorimotor cortex. The attenuated ERD in the low mu band in contralateral M1 and parietal cortex may serve as biomarkers of MVF for stroke rehabilitation.</div></div>","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"10 ","pages":"Pages 12-21"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11743862/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143013284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognostic models for seizures and epilepsy after stroke, tumors and traumatic brain injury 脑卒中、肿瘤和创伤性脑损伤后癫痫发作的预后模型

IF 2

Clinical Neurophysiology Practice Pub Date : 2025-01-01 DOI: 10.1016/j.cnp.2025.02.008

Kai Michael Schubert, Anton Schmick, Miranda Stattmann, Marian Galovic

{"title":"Prognostic models for seizures and epilepsy after stroke, tumors and traumatic brain injury","authors":"Kai Michael Schubert, Anton Schmick, Miranda Stattmann, Marian Galovic","doi":"10.1016/j.cnp.2025.02.008","DOIUrl":"10.1016/j.cnp.2025.02.008","url":null,"abstract":"<div><div>Epilepsy is a frequent consequence of acute brain injuries, such as stroke, brain tumors, and traumatic brain injury (TBI). Accurate prediction of epilepsy is essential for early intervention and improved patient outcomes. This review evaluates the best-established prognostic models, including the SeLECT and CAVE scores, which estimate the risk of developing seizures and epilepsy following these injuries. The review highlights their clinical applicability, predictive accuracy, and limitations for different etiologies. In addition to providing practical tables for risk estimation, we also offer user-friendly online calculators for these models at <span><span>www.predictepilepsy.com</span><svg><path></path></svg></span> to facilitate clinical implementation. These tools help identify high-risk patients and support decision-making for follow-up and treatment. Furthermore, we discuss the potential of integrating electrophysiological data, including EEG biomarkers, to further enhance prediction accuracy and patient care. These insights highlight the need for further refinement and validation of predictive models, enabling more personalized treatment strategies and better patient care.</div></div>","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"10 ","pages":"Pages 116-128"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143628171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Case report: Potential physiological sources of the late response in epidural spinal recordings induced by spinal cord stimulation during intraoperative neuromonitoring 病例报告：术中神经监测中脊髓刺激引起的硬膜外脊髓记录延迟反应的潜在生理来源。

IF 2

Clinical Neurophysiology Practice Pub Date : 2025-01-01 DOI: 10.1016/j.cnp.2024.12.005

Steven Falowski , Mingyue Tang , Ashlesha Deshmukh , Ameya Nanivadekar , David Page , Mingming Zhang

{"title":"Case report: Potential physiological sources of the late response in epidural spinal recordings induced by spinal cord stimulation during intraoperative neuromonitoring","authors":"Steven Falowski , Mingyue Tang , Ashlesha Deshmukh , Ameya Nanivadekar , David Page , Mingming Zhang","doi":"10.1016/j.cnp.2024.12.005","DOIUrl":"10.1016/j.cnp.2024.12.005","url":null,"abstract":"<div><h3>Objective</h3><div>This study aims to investigate the sources of later response in epidural spinal recordings (ESRs) obtained from implanted leads during spinal cord stimulation, a topic has not been widely studied in previous research.</div></div><div><h3>Methods</h3><div>Two patients with lower back and lower extremity pain underwent SCS implantation with intraoperative neuromonitoring (IONM). The timing of extracted peaks in ESRs and intramuscular electromyography (EMG) recordings were analyzed and compared to a Monte Carlo simulation for synchronization analysis.</div></div><div><h3>Results</h3><div>Our data show that, when using two most caudal electrodes for stimulation, late response in ESRs collected from SCS leads was not synchronized with EMG recordings from lower extremity muscles. However, parts of the late responses were synchronized with EMG recordings from abdominal muscle groups.</div></div><div><h3>Conclusions</h3><div>Late response in ESRs is believed to result from muscle contractions, although the exact sources have not been fully identified. They are likely to originate from muscles near the implanted leads.</div></div><div><h3>Significance</h3><div>This research indicates that components of the late response may originate beyond the abdominal region, potentially offering additional information for current IONM practice. Additionally, understanding the sources of the late response may be useful for emerging clinical applications in neurorehabilitation.</div></div>","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"10 ","pages":"Pages 22-29"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11760812/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143048233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Age-dependent changes in the power spectrum conflate composite scores to assess brain frailty 功率谱随年龄的变化与综合评分相结合，以评估大脑的脆弱性

IF 2

Clinical Neurophysiology Practice Pub Date : 2025-01-01 DOI: 10.1016/j.cnp.2025.06.002

Julian Ostertag , Aleksandra Migal , David P. Obert , Gerhard Schneider , Pablo Sepúlveda , Matthias Kreuzer

{"title":"Age-dependent changes in the power spectrum conflate composite scores to assess brain frailty","authors":"Julian Ostertag , Aleksandra Migal , David P. Obert , Gerhard Schneider , Pablo Sepúlveda , Matthias Kreuzer","doi":"10.1016/j.cnp.2025.06.002","DOIUrl":"10.1016/j.cnp.2025.06.002","url":null,"abstract":"<div><h3>Objective</h3><div>Evaluating age-related dependencies in the electroencephalogram (EEG) during induction of general anesthesia and their impact on composite scores used to assess frailty.</div></div><div><h3>Methods</h3><div>A composite score was derived from spectral edge frequency, total power, alpha power, and the effect-site concentration (Ce) of propofol. All these parameters are influenced by age, brain health, and dosage and speed of drug administration. Correlation coefficients and variance inflation factors were used to determine multicollinearity. Differences in the spectral EEG features of patients with “high” and “low” composite scores were assessed by the area under the receiver operator characteristic curve (AUC) as the statistical test.</div></div><div><h3>Results</h3><div>The EEG features, total power and alpha power, were strongly correlated (<em>ρ</em> = 0.82). But alpha power (<em>ρ</em> = 0.17) and total power (<em>ρ</em> = 0.2) were only weakly correlated with propofol, indicating a weak model. Additionally, the composite score showed a moderate negative correlation with age (<em>ρ</em> = -0.44). We also observed significant and strong (AUC <em><</em> 0.3) differences in total power and the power of all EEG bands except gamma between patients with a ”high” and a ”low” score before loss of responsiveness (LOR).</div></div><div><h3>Conclusion</h3><div>Patient age significantly influences EEG-based parameters within the score. Importantly, significant differences in spectral EEG features between the groups were already observable before LOR. These differences could allow for early assessment of a patient’s brain state and to titrate anesthetic dose before LOR. The study also shows that age should be considered as it can drive models for ”frailty”.</div></div><div><h3>Significance</h3><div>Age moderately influenced all subcomponents and should consequently be factored into score interpretation.</div></div>","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"10 ","pages":"Pages 209-217"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144480200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multimodal tele-epileptology: Challenges on the way to interoperable medical data 多模式远程癫痫学：实现医疗数据互操作的挑战

IF 2

Clinical Neurophysiology Practice Pub Date : 2025-01-01 DOI: 10.1016/j.cnp.2025.02.004

Sigrid Mues , Arndt Ebert , Marc Kämmerer , Marcus Kremers , Ulrich Sliwka , Rüdiger Hilker-Roggendorf , Dirk Woitalla , Iris Adelt , Thomas Günnewig , Ana Miron , Sulev Haldre , Tipakorn Tumnark , Kanjana Unnwongse , Wenke Grönheit , Tim Wehner , Vanessa Behrens , Jörg Wellmer

{"title":"Multimodal tele-epileptology: Challenges on the way to interoperable medical data","authors":"Sigrid Mues , Arndt Ebert , Marc Kämmerer , Marcus Kremers , Ulrich Sliwka , Rüdiger Hilker-Roggendorf , Dirk Woitalla , Iris Adelt , Thomas Günnewig , Ana Miron , Sulev Haldre , Tipakorn Tumnark , Kanjana Unnwongse , Wenke Grönheit , Tim Wehner , Vanessa Behrens , Jörg Wellmer","doi":"10.1016/j.cnp.2025.02.004","DOIUrl":"10.1016/j.cnp.2025.02.004","url":null,"abstract":"<div><h3>Objective</h3><div>To realize multi-modal data exchange for telemedicine in epilepsy.</div></div><div><h3>Methods</h3><div>TE Ruhr is a multicenter, prospective pilot study. Primary endpoint of the study was the technical implementation of a platform between an epilepsy center and regional neurological departments and international cooperating epilepsy centers, respectively. A multi-professional board was established to develop technical workflows. After completion of the study a survey was conducted among users of the regional arm.</div></div><div><h3>Results</h3><div>Two workflows were developed, 1) a combination of web-application and use of an established teleradiology network, and 2) a web-application only data exchange. Technical workflow 1 comprised local EEG conversion into to a standard format (.besa) and its shipping as DICOM RAW object. Technically, both workflows could be implemented. Yet, workflow 1 was not realisable in peripheral hospitals. Via workflow 2, 149 consults for 144 patients were completed. Users of the regional arm were satisfied (1.6 on a grading scale of 1–6 (1-very good, 6- very bad)).</div></div><div><h3>Conclusion</h3><div>Technical feasibility alone does not determine the actual use of telemedicine. Web applications enables multimodal data exchange, but usability is limited due to lack of interoperability.</div></div><div><h3>Significance</h3><div>Genuine interoperability of medical data remains the desired goal for multi modal data exchange.</div></div>","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"10 ","pages":"Pages 56-62"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143552404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Muscle excitability testing: Age and sex dependency of normative data 肌肉兴奋性测试：规范数据的年龄和性别依赖性

IF 2

Clinical Neurophysiology Practice Pub Date : 2025-01-01 DOI: 10.1016/j.cnp.2025.03.002

Matthias Thomas Exl , Belén Rodriguez , Karl Ng , Stella Veronica Tan , James Howells , Hugh Bostock , Hatice Tankisi , Werner J. Z’Graggen

{"title":"Muscle excitability testing: Age and sex dependency of normative data","authors":"Matthias Thomas Exl , Belén Rodriguez , Karl Ng , Stella Veronica Tan , James Howells , Hugh Bostock , Hatice Tankisi , Werner J. Z’Graggen","doi":"10.1016/j.cnp.2025.03.002","DOIUrl":"10.1016/j.cnp.2025.03.002","url":null,"abstract":"<div><h3>Objective</h3><div>To establish normative data for muscle excitability testing in the tibialis anterior muscle of a healthy population, and to determine their dependence on age and sex.</div></div><div><h3>Methods</h3><div>Parameters of muscle velocity recovery cycle recordings with 1, 2 and 5 conditioning stimuli of 197 healthy subjects and frequency ramp recordings of 151 healthy subjects were retrospectively analysed for age and sex differences.</div></div><div><h3>Results</h3><div>There were no differences by sex and only small age differences were found in healthy subjects older than 60 years for the muscle excitability parameters muscle relative refractory period, early supernormality and latency to the first response in a train at 15 Hz and 30 Hz.</div></div><div><h3>Conclusions</h3><div>In this study, based on a large sample of muscle velocity recovery cycle and frequency ramp recordings, we have provided normative data and shown that muscle excitability testing is not influenced by sex, and that age only has an influence from the age of 60 years onwards on parameters reflecting muscle membrane potential.</div></div><div><h3>Significance</h3><div>Our results suggest that future studies no longer need to control for sex when using a healthy control group.</div></div>","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"10 ","pages":"Pages 129-133"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143681141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0