Clinical Neurophysiology Practice最新文献

{"title":"Morphine exposure and prematurity affect flash visual evoked potentials in preterm infants","authors":"Caterina Coviello ,&nbsp;Silvia Lori ,&nbsp;Giovanna Bertini ,&nbsp;Simona Montano ,&nbsp;Simonetta Gabbanini ,&nbsp;Maria Bastianelli ,&nbsp;Cesarina Cossu ,&nbsp;Sara Cavaliere ,&nbsp;Clara Lunardi ,&nbsp;Carlo Dani","doi":"10.1016/j.cnp.2023.12.005","DOIUrl":"10.1016/j.cnp.2023.12.005","url":null,"abstract":"<div><h3>Objective</h3><p>The present study aimed to explore first the impact of perinatal risk factors on flash-VEP waves and morphology in a group of preterm infants studied at term equivalent age (TEA). Second, to correlate VEP morphology with neurological outcome at 2 years corrected age (CA).</p></div><div><h3>Methods</h3><p>Infants with a gestational age (GA) at birth &lt;32 weeks, without major brain injury, were enrolled. Multivariate regression analyses were performed, and the models were run separately for each dependent variable N2, P2, N3 latencies and P2 amplitude. Logistic regression was applied to study N4 component (present/absent) and VEP morphology (regular/irregular). The predictors were GA, bronchopulmonary dysplasia (BPD), postmenstrual age at VEP registration, cumulative morphine and fentanyl dose, and painful procedures. Lastly, linear regression models were performed to assess the relation between the Bayley-III cognitive and motor scores at 2 years CA and VEP morphology, in relation to GA, BPD, painful procedures and cumulative morphine dose.</p></div><div><h3>Results</h3><p>Eighty infants were enrolled. Morphine was the predictor of N2 (R² = 0.09, <em>p</em> = 0.006), P2 (R² = 0.11, <em>p</em> = 0.002), and N3 (R² = 0.13, <em>p</em> = 0.003) latencies. Younger GA was associated with lower amplitude (R² = 0.05, <em>p</em> = 0.029). None of the independent variables predicted the presence of N4 component, nor VEP morphology in the logistic analysis. VEP morphology was not associated with cognitive and motor scores at 2 years.</p></div><div><h3>Conclusions</h3><p>Morphine treatment and prematurity were risk factors for altered VEPs parameters at TEA. In our cohort VEP morphology did not predict neurological outcome.</p></div><div><h3>Significance</h3><p>Morphine administration should be evaluated according to potential risks and benefits, and dosage individually accustomed, according to pain and comfort scores, considering the possible risk for neurodevelopmental impairment.</p></div>","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"9 ","pages":"Pages 85-93"},"PeriodicalIF":1.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2467981X24000040/pdfft?md5=19636996dbe6798a1a0be137990c1c31&pid=1-s2.0-S2467981X24000040-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139638835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of clinical neurophysiology in the definition and assessment of fatigue and fatigability","authors":"Hatice Tankisi ,&nbsp;Viviana Versace ,&nbsp;Annapoorna Kuppuswamy ,&nbsp;Jonathan Cole","doi":"10.1016/j.cnp.2023.12.004","DOIUrl":"10.1016/j.cnp.2023.12.004","url":null,"abstract":"<div><p>Though a common symptom, fatigue is difficult to define and investigate, occurs in a wide variety of neurological and systemic disorders, with differing pathological causes. It is also often accompanied by a psychological component. As a symptom of long-term COVID-19 it has gained more attention.</p><p>In this review, we begin by differentiating fatigue, a perception, from fatigability, quantifiable through biomarkers. Central and peripheral nervous system and muscle disorders associated with these are summarised. We provide a comprehensive and objective framework to help identify potential causes of fatigue and fatigability in a given disease condition. It also considers the effectiveness of neurophysiological tests as objective biomarkers for its assessment. Among these, twitch interpolation, motor cortex stimulation, electroencephalography and magnetencephalography, and readiness potentials will be described for the assessment of central fatigability, and surface and needle electromyography (EMG), single fibre EMG and nerve conduction studies for the assessment of peripheral fatigability.</p><p>The purpose of this review is to guide clinicians in how to approach fatigue, and fatigability, and to suggest that neurophysiological tests may allow an understanding of their origin and interactions. In this way, their differing types and origins, and hence their possible differing treatments, may also be defined more clearly.</p></div>","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"9 ","pages":"Pages 39-50"},"PeriodicalIF":1.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2467981X23000367/pdfft?md5=598322e61ca375a5dcff79f4baba5e5a&pid=1-s2.0-S2467981X23000367-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139015879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stereo-electroencephalographic seizure localization in patients with mesial temporal sclerosis: A single center experience","authors":"Bill Zhang ,&nbsp;Irina Podkorytova ,&nbsp;Ryan Hays ,&nbsp;Ghazala Perven ,&nbsp;Mark Agostini ,&nbsp;Jay Harvey ,&nbsp;Rodrigo Zepeda ,&nbsp;Sasha Alick-Lindstrom ,&nbsp;Marisara Dieppa ,&nbsp;Alex Doyle ,&nbsp;Rohit Das ,&nbsp;Bradley Lega ,&nbsp;Kan Ding","doi":"10.1016/j.cnp.2024.02.002","DOIUrl":"https://doi.org/10.1016/j.cnp.2024.02.002","url":null,"abstract":"<div><h3>Objective</h3><p>Epilepsy patients with mesial temporal sclerosis (MTS) on imaging who are drug-resistant usually undergo epilepsy surgery without previous invasive evaluation. However, up to one-third of patients are not seizure-free after surgery. Prior studies have identified risk factors for surgical failure, but it is unclear if they are associated with bilateral or discordant seizure onset.</p></div><div><h3>Methods</h3><p>In this retrospective case series, we identified 17 epilepsy patients who had MRI-confirmed MTS but received invasive stereo-EEG (SEEG) evaluation before definitive intervention. We analyzed their presurgical risk factors in relation to SEEG seizure onset localization and MRI/SEEG concordance.</p></div><div><h3>Results</h3><p>SEEG ictal onset was concordant with MTS localization (i.e. seizures started only from the hippocampus with MTS) in 5 out of 13 patients with unilateral MTS (UMTS) and in 3 out of 4 patients with bilateral MTS.</p><p>No statistically significant association regarding concordance of SEEG ictal onset and MTS location was found in patients with such risk factors as a history of non-mesial temporal aura, frequent focal to bilateral tonic-clonic seizures, prior viral brain infection, or family history of epilepsy. Nine out of 13 UMTS patients had resective surgery only, 5 out of 9 (56 %) have Engel class I outcome at most recent follow-up (median 46.5 months, range 22–91 months). In Engel class I cohort, the SEEG ictal onset was concordant with MTS location in 3 out of 5 patients, and 2 patients had ipsilateral temporal neocortical ictal onset.</p></div><div><h3>Conclusions</h3><p>Our findings suggest that patients with MTS might have discordant SEEG ictal onset (in 61.5% patients with UMTS in presented cohort), which may explain poor surgical outcome after destructive surgery in these cases.</p></div><div><h3>Significance</h3><p>Although no statistically significant association was found in this under-powered study, these findings could be potentially valuable for future <em>meta</em>-analyses.</p></div>","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"9 ","pages":"Pages 106-111"},"PeriodicalIF":1.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2467981X24000106/pdfft?md5=a49a4443f8ef4720e1d0e21ef06d1ff5&pid=1-s2.0-S2467981X24000106-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140134380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using jitter analysis with concentric needle electrodes to assess disease status and treatment responses in myasthenia gravis","authors":"Vinaya Bhandari,&nbsp;Ajith Sivadasan,&nbsp;Carolina Barnett-Tapia,&nbsp;Hans Katzberg,&nbsp;Vera Bril","doi":"10.1016/j.cnp.2024.06.004","DOIUrl":"10.1016/j.cnp.2024.06.004","url":null,"abstract":"<div><h3>Objective</h3><p>This study assesses the utility of jitter analysis with concentric needles to evaluate disease severity in myasthenia gravis (MG), correlate changes in jitter with clinical status as well as identify reasons for any discordance.</p></div><div><h3>Methods</h3><p>We performed a retrospective chart review of 82 MG patients and extracted data on demographics, MG subtype, antibody status, clinical scales, electrophysiology, and interventions at baseline and follow-up.</p></div><div><h3>Results</h3><p>Baseline MGII scores correlated with jitter (r = 0.25, p = 0.024) and abnormal pairs (r = 0.24, p = 0.03). After 28 months, MGII scores correlated with jitter (r = 0.31, p = 0.006), abnormal pairs (r = 0.29, p = 0.009), and pairs with blocks (r = 0.35, p = 0.001). Changes in MGII scores correlated with changes in jitter (r = 0.35, p = 0.002), abnormal pairs (r = 0.27, p = 0.014), and pairs with blocks (r = 0.36, p = 0.001).</p></div><div><h3>Conclusions</h3><p>Concentric needle jitter analysis may have the potential to evaluate baseline and sequential disease severity in MG.</p></div><div><h3>Significance</h3><p>This study highlights the potential for improved MG patient care through precise assessment and management using concentric needle jitter analysis to improve the accuracy of MG diagnosis and monitoring of disease activity.</p></div>","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"9 ","pages":"Pages 227-232"},"PeriodicalIF":2.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2467981X24000210/pdfft?md5=59272c4e18875518856fda2ac22a2f39&pid=1-s2.0-S2467981X24000210-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141712780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary progressive aphasia with focal periodic sharp wave complexes: An unusual manifestation of Creutzfeldt-Jakob disease","authors":"Amayak Broutian,&nbsp;Yuliya Shpilyukova,&nbsp;Alexandra Belyakova-Bodina,&nbsp;Anna Abramova,&nbsp;Olga Korepina,&nbsp;Rodion Konovalov","doi":"10.1016/j.cnp.2023.12.002","DOIUrl":"10.1016/j.cnp.2023.12.002","url":null,"abstract":"<div><h3>Background</h3><p>Creutzfeldt-Jakob disease (CJD) is a devastating degenerative brain disorder caused by an abnormal isoform of a cellular glycoprotein which is known as the prion protein. A diagnosis of CJD is usually based on specific clinical signs, EEG and MRI findings, as well as the presence of the 14–3-3 protein in the cerebrospinal fluid. Although end-stage CJD usually has a typical clinical presentation, early symptoms may be variable.</p></div><div><h3>Case presentation</h3><p>We present an uncommon case of CJD which manifested with primary progressive aphasia, leading to an incorrect diagnosis of frontotemporal dementia. EEG performed eight months after symptom onset revealed focal periodic sharp wave complexes that later evolved into diffuse EEG abnormalities characteristic of CJD. Brain MRI also suggested the diagnosis of CJD. Later, the patient developed rapidly progressive dementia, visual symptoms, ataxia, extrapyramidal symptoms, followed by dysphagia and mutism, and died 34 months after disease onset.</p></div><div><h3>Discussion and conclusion</h3><p>PPA is a relatively uncommon first manifestation of CJD, occurring only in about 1% of all CJD cases. Our case is also remarkable because we were able to capture focal periodic sharp wave complexes at the stage of the CJD when aphasia was the only clinical manifestation. We demonstrate that both brain MRI and wake and sleep EEG should be a mandatory part of the diagnostic workup for patients presenting with primary progressive aphasia.</p></div>","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"9 ","pages":"Pages 21-26"},"PeriodicalIF":1.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2467981X23000343/pdfft?md5=c61340249e33901fd37c593b8d656299&pid=1-s2.0-S2467981X23000343-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138986039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Without ENMG, detecting pediatric vincristine neuropathy is a challenge","authors":"Kreeta Viinikainen ,&nbsp;Pirjo Isohanni ,&nbsp;Jukka Kanerva ,&nbsp;Tuula Lönnqvist ,&nbsp;Leena Lauronen","doi":"10.1016/j.cnp.2024.01.005","DOIUrl":"10.1016/j.cnp.2024.01.005","url":null,"abstract":"<div><h3>Objective</h3><p>Vincristine, a widely used anticancer chemotherapy drug, may cause polyneuropathy (PNP), potentially resulting in permanent functional impairment. We characterized the occurrence and development of vincristine-induced neuropathy (VIPN) in early treatment of childhood leukemia.</p></div><div><h3>Methods</h3><p>This prospective study of 35 pediatric acute lymphoblastic leukemia (ALL) patients comprised systematic clinical and electrophysiological studies at both the time of diagnosis and at least one time point during the first months of treatment.</p></div><div><h3>Results</h3><p>After vincristine treatment, all patients had axonal sensorimotor PNP on electroneuromyography (ENMG) In 34/35 patients, the motor and in 24/35 the sensory responses were decreased. Interestingly, in 3 patients PNP was most prominent in the upper limb. However, some children had no PNP symptoms despite moderate ENMG findings, and not all clinical symptoms were correlated with abnormal ENMG.</p></div><div><h3>Conclusions</h3><p>Pediatric VIPN is a sensorimotor, predominantly motor axonal neuropathy. VIPN can be detected even in its early phase by ENMG, but it is difficult to detect by symptoms and clinical examination only<strong>.</strong></p></div><div><h3>Significance</h3><p>Pediatric ALL patients treated with vincristine are at risk of developing VIPN. Since the clinical signs of PNP in acutely ill children are difficult to identify, VIPN can easily be overlooked if ENMG is not performed.</p></div>","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"9 ","pages":"Pages 94-101"},"PeriodicalIF":1.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2467981X24000088/pdfft?md5=f27f079ff1cde8bd16298532ac00e844&pid=1-s2.0-S2467981X24000088-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139885844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Importance of changes in abnormal muscle responses during microvascular decompression for hemifacial spasm","authors":"Masafumi Fukuda ,&nbsp;Yosuke Ito ,&nbsp;Tomoyoshi Ota ,&nbsp;Makoto Oishi","doi":"10.1016/j.cnp.2024.02.003","DOIUrl":"https://doi.org/10.1016/j.cnp.2024.02.003","url":null,"abstract":"<div><h3>Objective</h3><p>To determine if compression sites of the facial nerve correlate with immediate postoperative outcomes in patients with hemifacial spasm (HFS), and if changes in the waveform of abnormal muscle response (AMR) during microvascular decompression (MVD) for HFS can predict the postoperative course.</p></div><div><h3>Methods</h3><p>In this retrospective review, we evaluated 50 patients with HFS who underwent AMR monitoring during MVD. The ratios of amplitude and duration of AMR waveforms were computed by comparing baseline with final examinations. Vascular compression sites were categorized into four portions of the facial nerve. Postoperatively, we classified patients into two groups based on symptom relief as those whose symptoms disappeared immediately (DI group), and those whose symptoms disappeared gradually (DG group).</p></div><div><h3>Results</h3><p>The compression sites significantly correlated with postoperative outcomes at discharge (p &lt; 0.001) but not with outcomes after 6 months of MVD. Lower duration ratios of AMRs from the mentalis muscle were significantly associated with an increased chance of classification into the DI group based on the results of multivariate logistic regression analysis (p = 0.017).</p></div><div><h3>Conclusions</h3><p>Relationship between compression sites and immediate outcomes could provide useful information to surgeons for predicting if symptoms will resolve over long term. Moreover, changes in AMRs recorded from the mentalis muscle could predict the postoperative course of HFS.</p></div><div><h3>Significance</h3><p>These findings can help surgeons evaluate the changes in AMR amplitude and duration during MVD for HFS.</p></div>","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"9 ","pages":"Pages 112-119"},"PeriodicalIF":1.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2467981X24000118/pdfft?md5=85a4f93eaf3d48646a18f134acda6338&pid=1-s2.0-S2467981X24000118-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140192031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Reappraisal on cortical myoclonus and brief Remarks on myoclonus of different Origins","authors":"Laura Canafoglia ,&nbsp;Stefano Meletti ,&nbsp;Francesca Bisulli ,&nbsp;Lara Alvisi ,&nbsp;Giovanni Assenza ,&nbsp;Giuseppe d’Orsi ,&nbsp;Raffaele Dubbioso ,&nbsp;Edoardo Ferlazzo ,&nbsp;Lorenzo Ferri ,&nbsp;Silvana Franceschetti ,&nbsp;Antonio Gambardella ,&nbsp;Alice Granvillano ,&nbsp;Laura Licchetta ,&nbsp;Bruna Nucera ,&nbsp;Ferruccio Panzica ,&nbsp;Marco Perulli ,&nbsp;Federica Provini ,&nbsp;Guido Rubboli ,&nbsp;Gionata Strigaro ,&nbsp;Antonio Suppa ,&nbsp;Gaetano Cantalupo","doi":"10.1016/j.cnp.2024.10.001","DOIUrl":"10.1016/j.cnp.2024.10.001","url":null,"abstract":"<div><div>Myoclonus has multiple clinical manifestations and heterogeneous generators and etiologies, encompassing a spectrum of disorders and even physiological events. This paper, developed from a teaching course conducted by the Neurophysiology Commission of the Italian League against Epilepsy, aims to delineate the main types of myoclonus, identify potential underlying neurological disorders, outline diagnostic procedures, elucidate pathophysiological mechanisms, and discuss appropriate treatments.</div><div>Neurophysiological techniques play a crucial role in accurately classifying myoclonic phenomena, by means of simple methods such as EEG plus polymyography (EEG + Polymyography), evoked potentials, examination of long-loop reflexes, and often more complex protocols to study intra-cortical inhibition-facilitation<strong>.</strong> In clinical practice, EEG + Polymyography often represents the first step to identify myoclonus, acquire signals for off-line studies and plan the diagnostic work-up.</div></div>","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"9 ","pages":"Pages 266-278"},"PeriodicalIF":2.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142578310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical neurophysiology of functional motor disorders: IFCN Handbook Chapter","authors":"M.J. Edwards ,&nbsp;L.H. Koens ,&nbsp;J. Liepert ,&nbsp;J. Nonnekes ,&nbsp;P. Schwingenschuh ,&nbsp;A.M.M. van de Stouwe ,&nbsp;F. Morgante","doi":"10.1016/j.cnp.2023.12.006","DOIUrl":"10.1016/j.cnp.2023.12.006","url":null,"abstract":"<div><p>Functional Motor Disorders are common and disabling. Clinical diagnosis has moved from one of exclusion of other causes for symptoms to one where positive clinical features on history and examination are used to make a “rule in” diagnosis wherever possible. Clinical neurophysiological assessments have developed increasing importance in assisting with this positive diagnosis, not being used simply to demonstrate normal sensory-motor pathways, but instead to demonstrate specific abnormalities that help to positively diagnose these disorders. Here we provide a practical review of these techniques, their application, interpretation and pitfalls. We also highlight particular areas where such tests are currently lacking in sensitivity and specificity, for example in people with functional dystonia and functional tic-like movements.</p></div>","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"9 ","pages":"Pages 69-77"},"PeriodicalIF":1.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2467981X24000052/pdfft?md5=9f3bf0aee161e81024ab78fb8c49d976&pid=1-s2.0-S2467981X24000052-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139635676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"E-norms and AI in clinical neurophysiology","authors":"Joe F. Jabre","doi":"10.1016/j.cnp.2024.12.001","DOIUrl":"10.1016/j.cnp.2024.12.001","url":null,"abstract":"<div><h3>Objective</h3><div>To describe the use of Artificial Intelligence (AI) to automate the e-norms method, a technique used to derive normative data from patient studies, mixed datasets that contain both normal and abnormal data. Multiple studies have shown that normal values collected with the e-norms method compare favorably with those collected from healthy volunteers using traditional methods.</div></div><div><h3>Methods</h3><div>OpenAI’s ChatGPT was used by the author to build a Python script to automate the e-norms method’s plateau identification, the area of the e-norms curve where a variable’s normal values lie. To date, e-norms plateau identification has been done visually using an Excel Macro developed for that purpose.</div></div><div><h3>Results</h3><div>E-norms normal values derived from the visual e-norms plateau identification with the Excel Macro compared favorably with those derived from the OpenAI’s Python script developed by the author to automate the e-norms plateau identification.</div></div><div><h3>Conclusions</h3><div>OpenAI’s ChatGPT Python scripts can be developed by users with little to no experience in programming to automate the collection of e-norms normal values.</div></div><div><h3>Significance</h3><div>A Neurologist with no experience in programming, and a limited knowledge of statistics was able to develop this on his own without the help of any programmers or statisticians.</div></div>","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"9 ","pages":"Pages 299-304"},"PeriodicalIF":2.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11696621/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142933086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}