肌萎缩性侧索硬化症体感觉皮层兴奋性与结构变化的相关性分析

IF 2 Q3 NEUROSCIENCES

Clinical Neurophysiology Practice Pub Date : 2025-01-01 DOI:10.1016/j.cnp.2025.06.003

Aysegul Gunduz , Tuba Akıncı , Osman Aykan Kargın , Melih Tutuncu , Serdar Arslan , Nurten Uzun

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引用次数: 0

摘要

目的探讨肌萎缩性侧索硬化症（ALS）患者体感觉皮层的兴奋性及其与运动和感觉通路结构变化的关系。患者和方法我们纳入了所有符合“明确”或“可能”ALS标准的连续ALS患者。我们记录了体感诱发电位（sep）、静息运动阈值和皮质沉默期（cSP）的环绕抑制（SI）和恢复功能（RC），并进行了体积分析和扩散张量成像（DTI）。结果纳入15例ALS患者和12例年龄、性别相近的健康人。在组水平上，ALS组在ISI 5ms时SEP-RC%的平均值高于健康参与者(所有SEP-RC%在5ms时p <；0.001)。三分之一的ALS患者失去了SEP-SI。cSP持续时间与SEP- rc %呈负相关，而SEP参数与皮质脊髓束、内侧小网膜或中央前和后回皮质厚度的放射学体积分析无相关性。结论肌萎缩侧索硬化症患者存在躯体感觉亢奋性，而部分肌萎缩侧索硬化症患者的躯体感觉亢奋性缺失。意义：体感高兴奋性与cSP相关，但与cSP的结构变化无关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Correlation analysis between excitability in the somatosensory cortex and structural changes in amyotrophic lateral sclerosis

Objective

We aimed to investigate the excitability of the somatosensory cortex and its relationship to structural changes in motor and sensory pathways, and motor excitability in amyotrophic lateral sclerosis (ALS).

Patients and method

We included all consecutive individuals with ALS, fulfilling the “definite” or “probable” ALS criteria. We recorded surround inhibition (SI) and recovery function (RC) of somatosensory evoked potentials (SEPs), resting motor threshold, and cortical silent period (cSP), and performed volumetric analysis and diffusion tensor imaging (DTI).

Results

We included 15 patients with ALS and 12 healthy individuals of similar age and sex. At the group level, the mean SEP-RC% at ISI 5 ms was higher in the ALS group than in healthy participants (all SEP-RC% at 5 ms p < 0.001). SEP-SI was lost in one-third of individuals with ALS. A negative correlation was found between the duration of the cSP and SEP-RC%, whereas no correlations were observed between SEP parameters and radiological volumetric analysis of the corticospinal tract, medial lemniscus, or cortical thickness of the precentral and postcentral gyri.

Conclusion

Somatosensory hyperexcitability is present in ALS, and SI is lost in a subset of patients with ALS.

Significance

Somatosensory hyperexcitability correlates well with cSP but not with structural changes.

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来源期刊

Clinical Neurophysiology Practice NEUROSCIENCES-

CiteScore

3.90

自引率

0.00%

发文量

审稿时长

71 days

期刊介绍： Clinical Neurophysiology Practice (CNP) is a new Open Access journal that focuses on clinical practice issues in clinical neurophysiology including relevant new research, case reports or clinical series, normal values and didactic reviews. It is an official journal of the International Federation of Clinical Neurophysiology and complements Clinical Neurophysiology which focuses on innovative research in the specialty. It has a role in supporting established clinical practice, and an educational role for trainees, technicians and practitioners.