Clinical Neurophysiology Practice最新文献

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Facial magnetomyography using an array of optically pumped magnetometers 使用光泵磁强计阵列的面部磁切面术
IF 2
Clinical Neurophysiology Practice Pub Date : 2025-01-01 DOI: 10.1016/j.cnp.2025.03.003
Johannes von Fraunberg , Hongyu Lu , Haodi Yang , Nura Marquetand , Christoph Braun , Lukas Rüttiger , Stephan Wolpert , Marlies Knipper , Markus Siegel , Hubert Löwenheim , Justus Marquetand
{"title":"Facial magnetomyography using an array of optically pumped magnetometers","authors":"Johannes von Fraunberg ,&nbsp;Hongyu Lu ,&nbsp;Haodi Yang ,&nbsp;Nura Marquetand ,&nbsp;Christoph Braun ,&nbsp;Lukas Rüttiger ,&nbsp;Stephan Wolpert ,&nbsp;Marlies Knipper ,&nbsp;Markus Siegel ,&nbsp;Hubert Löwenheim ,&nbsp;Justus Marquetand","doi":"10.1016/j.cnp.2025.03.003","DOIUrl":"10.1016/j.cnp.2025.03.003","url":null,"abstract":"<div><h3>Objective</h3><div>Measuring facial muscle activity is crucial in the diagnosis of facial palsy. This study investigated whether contactless Magnetomyography (MMG) using optically pumped magnetometers (OPM) is feasible for visualizing facial muscle activity.</div></div><div><h3>Methods</h3><div>An anatomically shaped mask featuring eleven OPM was arranged on one side of the face of five healthy subjects. MMG was recorded while they performed different facial expressions. The root mean square of each OPM signal was calculated for each expression and subject and allocated to the individual face. Moreover, the maximum average muscle activity and the signal-to-noise ratio (SNR) were determined.</div></div><div><h3>Results</h3><div>The subjects’ facial muscle activity could be measured individually per facial expression. Mean RMS was 0.6pT (SD 0.4pT), resulting in a mean SNR of 2.2 (SD 1.2).</div></div><div><h3>Conclusions</h3><div>Imaging facial activity via MMG using OPM is possible, although the sensor positioning (sensor geometry and distance to the muscle) is decisive. However, the signal amplitude of the facial muscles is low and the interindividual anatomical variability renders the measurement setup challenging.</div></div><div><h3>Significance</h3><div>As the imaging of facial MMG is feasible, this study paves the way for future studies using OPM for the diagnosis, monitoring, and rehabilitation of facial muscle and facial nerve disorders.</div></div>","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"10 ","pages":"Pages 134-140"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143747941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Electrodiagnostic criteria for neuromuscular transmission disorders suggested by a European consensus group 欧洲共识小组提出的神经肌肉传递障碍的电诊断标准
IF 2
Clinical Neurophysiology Practice Pub Date : 2025-01-01 DOI: 10.1016/j.cnp.2025.02.011
H. Tankisi , K. Pugdahl , B. Johnsen , J.P. Camdessanché , M. de Carvalho , P. Fawcett , A. Labarre-Vila , R. Liguori , W. Nix , I. Schofield , A. Fuglsang-Frederiksen
{"title":"Electrodiagnostic criteria for neuromuscular transmission disorders suggested by a European consensus group","authors":"H. Tankisi ,&nbsp;K. Pugdahl ,&nbsp;B. Johnsen ,&nbsp;J.P. Camdessanché ,&nbsp;M. de Carvalho ,&nbsp;P. Fawcett ,&nbsp;A. Labarre-Vila ,&nbsp;R. Liguori ,&nbsp;W. Nix ,&nbsp;I. Schofield ,&nbsp;A. Fuglsang-Frederiksen","doi":"10.1016/j.cnp.2025.02.011","DOIUrl":"10.1016/j.cnp.2025.02.011","url":null,"abstract":"<div><h3>Objective</h3><div>Electrodiagnostic testing plays an important role in diagnosing disorders of neuromuscular transmission (NMT), especially in seronegative myasthenia gravis. However, electrodiagnostic criteria for the diagnosis are sparse. This study aimed at inferring evidence-based recommendations for the electrodiagnostic examination of NMT disorders.</div></div><div><h3>Methods</h3><div>A total of 164 cases with a consensus diagnosis of NMT disorder obtained by peer review by eight experienced neurophysiologists were analysed for differences in examination strategy, the sensitivity of different tests, and inferring minimal criteria. The diagnostic performance of the suggested criteria was validated on 24 MG patients and 50 patients with neuropathy (17), myopathy (15), or fatigue (18).</div></div><div><h3>Results</h3><div>We recommend as minimal electrodiagnostic criteria for NMT disorders, either (a) 2 abnormal repetitive nerve stimulation (RNS), (b) 1 abnormal RNS and 1 abnormal single fiber electromyography (SFEMG) or (c) 2 abnormal SFEMG. These showed a good diagnostic performance with a sensitivity of 87.5 % and a specificity of 100 %.</div></div><div><h3>Conclusion</h3><div>Recommendations with high diagnostic sensitivity and specificity for the minimum number of RNS and SFEMG studies to diagnose NMT disorders developed by an international consensus group are suggested.</div></div><div><h3>Significance</h3><div>The suggested electrodiagnostic recommendations for diagnosing NMT disorders are reliable and suitable for use at different centres.</div></div>","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"10 ","pages":"Pages 79-83"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143580359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Novel approaches to EEG and MEG in motor neurone disease: IFCN Handbook Chapter 运动神经元疾病EEG和MEG的新方法:IFCN手册章节
IF 2
Clinical Neurophysiology Practice Pub Date : 2025-01-01 DOI: 10.1016/j.cnp.2025.07.001
Stefan Dukic , Rosanne Govaarts , Arjan Hillebrand , Marianne de Visser , Margitta Seeck , Roisin McMackin
{"title":"Novel approaches to EEG and MEG in motor neurone disease: IFCN Handbook Chapter","authors":"Stefan Dukic ,&nbsp;Rosanne Govaarts ,&nbsp;Arjan Hillebrand ,&nbsp;Marianne de Visser ,&nbsp;Margitta Seeck ,&nbsp;Roisin McMackin","doi":"10.1016/j.cnp.2025.07.001","DOIUrl":"10.1016/j.cnp.2025.07.001","url":null,"abstract":"<div><div>Motor neurone diseases (MNDs) are increasingly being acknowledged as network disorders, with cortical dysfunction and degeneration extending beyond the motor cortex. Measures of this broader cortical pathophysiology are providing promising candidates in the search for diagnostic and prognostic biomarkers of the MNDs. Electroencephalography (EEG) and magnetoencephalography (MEG) offer a direct view of neural network activity by detecting changes in electromagnetic fields of the brain. Measurements based on EEG/MEG have often been overlooked in the search for MND biomarkers, largely due to their limited spatial resolution and the perceived challenges associated with noise in these signals. However, with recent developments in sensor technology and source reconstruction algorithms, alongside substantial improvement in pipelines that address noise, EEG/MEG-based measures can now be readily employed for spatiotemporally-precise, economical and non-invasive characterisation of cortical network pathophysiology in MNDs. Here, we provide an overview of how EEG/MEG signals have been employed to quantify neural network function in MND. We outline the advantages and limitations of these measurements, discuss the most clinically promising EEG/MEG studies of MNDs to date, and highlight future directions warranted to harness the full potential of these technologies for understanding and assessing MNDs.</div></div>","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"10 ","pages":"Pages 301-315"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144655220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Asymptomatic tarsal tunnel syndrome in rheumatoid arthritis: An electrophysiological perspective with Insights into clinical and Laboratory correlates 类风湿关节炎的无症状跗骨隧道综合征:电生理观点与临床和实验室相关的见解
IF 2
Clinical Neurophysiology Practice Pub Date : 2025-01-01 DOI: 10.1016/j.cnp.2025.07.003
Hosna Elshony , Mohamed H. Aly , Abdelgaffar Mohammed , Abdulrahman M. Hassan , Abdulrahman A. Alshehri , Mohamed Hedak , Rakan Almuhanna , Abdulaziz Al-Ghamdi , Rasha Elsaadawy
{"title":"Asymptomatic tarsal tunnel syndrome in rheumatoid arthritis: An electrophysiological perspective with Insights into clinical and Laboratory correlates","authors":"Hosna Elshony ,&nbsp;Mohamed H. Aly ,&nbsp;Abdelgaffar Mohammed ,&nbsp;Abdulrahman M. Hassan ,&nbsp;Abdulrahman A. Alshehri ,&nbsp;Mohamed Hedak ,&nbsp;Rakan Almuhanna ,&nbsp;Abdulaziz Al-Ghamdi ,&nbsp;Rasha Elsaadawy","doi":"10.1016/j.cnp.2025.07.003","DOIUrl":"10.1016/j.cnp.2025.07.003","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the prevalence of asymptomatic tarsal tunnel syndrome (TTS) in rheumatoid arthritis (RA) patients and its association with disease activity, inflammation, and electrophysiological changes.</div></div><div><h3>Methods</h3><div>Forty RA patients and 40 age- and sex-matched controls underwent nerve conduction studies assessing medial plantar, lateral plantar, and posterior tibial nerves. Disease activity (DAS28, RASS), inflammatory markers (ESR, CRP), and autoantibodies (RF, anti-CCP) were recorded. Comparisons used t-tests; correlations assessed associations.</div></div><div><h3>Results</h3><div>RA patients showed significantly prolonged sensory latencies and reduced amplitudes and nerve conduction velocities, especially in medial and lateral plantar nerves. Sensory latencies had 100% sensitivity for subclinical TTS; motor parameters demonstrated high specificity. Higher DAS28, longer disease duration, elevated ESR/CRP, joint deformities, and seropositivity predicted TTS.</div></div><div><h3>Conclusions</h3><div>Subclinical TTS is highly prevalent in RA and linked to systemic inflammation, disease severity, and structural damage.</div></div><div><h3>Significance</h3><div>Routine electrophysiological screening may enable early detection and intervention, preserving nerve function and improving long-term mobility and quality of life in RA patients.</div></div><div><h3>Trial Registration</h3><div>The study was approved by the SFHM Institutional Review Board and registered under HAP-02-K-052 in August 2024.</div></div>","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"10 ","pages":"Pages 316-323"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144704111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effects of multi-session dual-tDCS on the bilateral transfer of motor skill learning in patients with stroke 多期双tdcs对脑卒中患者双侧运动技能学习转移的影响
IF 2
Clinical Neurophysiology Practice Pub Date : 2025-01-01 DOI: 10.1016/j.cnp.2025.06.005
Mohammad Mahdi Talimkhani , Ailin Talimkhani , Vida Dinarvand , Somayeh Mohamadi , Hamzeh Baharlouei
{"title":"The effects of multi-session dual-tDCS on the bilateral transfer of motor skill learning in patients with stroke","authors":"Mohammad Mahdi Talimkhani ,&nbsp;Ailin Talimkhani ,&nbsp;Vida Dinarvand ,&nbsp;Somayeh Mohamadi ,&nbsp;Hamzeh Baharlouei","doi":"10.1016/j.cnp.2025.06.005","DOIUrl":"10.1016/j.cnp.2025.06.005","url":null,"abstract":"<div><h3>Objective</h3><div>This study investigates the potential effects of combining motor skill learning transfer from the unaffected to the affected hand with multiple sessions of dual-transcranial direct current stimulation (tDCS) over the primary motor cortex to enhance motor skills in stroke patients.</div></div><div><h3>Methods</h3><div>Eleven stroke patients participated in a randomized, sham-controlled, double-blind crossover study. Over two periods separated by a 3-week washout, participants underwent either sham or dual-tDCS concurrently with serial response time tasks (SRTT). Each intervention included 20 min of stimulation during SRTT for three consecutive days. The skill index, the primary variable, was assessed pre-intervention, immediately post-intervention, and 24 h later.</div></div><div><h3>Results</h3><div>Both groups showed significant improvement in motor skill learning across the three intervention days (P &lt; 0.001). The dual-tDCS group demonstrated significantly greater skill improvement in the affected hand compared to the sham group (P &lt; 0.01), while no significant differences were found for the unaffected hand (P = 0.98).</div></div><div><h3>Conclusions</h3><div>Multi-session dual-tDCS combined with motor learning tasks significantly enhances motor skill transfer to the affected hand in stroke patients, with greater and more durable effects compared to sham stimulation.</div></div><div><h3>Significance</h3><div>This approach may improve bilateral motor skill transfer and hand fatigue management in stroke rehabilitation.</div></div>","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"10 ","pages":"Pages 236-245"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144562781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Triphasic waves: To treat or not to treat? 三相波:治疗还是不治疗?
IF 2
Clinical Neurophysiology Practice Pub Date : 2025-01-01 DOI: 10.1016/j.cnp.2025.06.001
Brin E. Freund , Khalil S. Husari , José L. Fernández-Torre , Philippe Gélisse , Peter W. Kaplan
{"title":"Triphasic waves: To treat or not to treat?","authors":"Brin E. Freund ,&nbsp;Khalil S. Husari ,&nbsp;José L. Fernández-Torre ,&nbsp;Philippe Gélisse ,&nbsp;Peter W. Kaplan","doi":"10.1016/j.cnp.2025.06.001","DOIUrl":"10.1016/j.cnp.2025.06.001","url":null,"abstract":"<div><div>Generalized periodic discharges (GPDs) with triphasic morphology (triphasic waves, TWs) are EEG waveforms that have been a frequent topic of research evaluating their etiology and clinical correlates. More specifically, prior studies have tried to better elucidate their implications regarding seizures to help guide decision making regarding empiric treatment and EEG monitoring and in spite of multiple studies, controversies remain due to disparate findings. In this review we discuss the historical views of TWs and their clinical and radiographic correlates, highlight the typical and atypical features of TWs, discuss the controversy related to the association between TWs and seizures, and propose an approach to their management.</div></div>","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"10 ","pages":"Pages 265-277"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144605722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cortical response to proprioceptive stimulation in primary orthostatic tremor – a magnetoencephalography study 原发性直立性震颤的皮层对本体感觉刺激的反应-脑磁图研究
IF 2
Clinical Neurophysiology Practice Pub Date : 2025-01-01 DOI: 10.1016/j.cnp.2025.04.002
Karolina af Edholm , Mikkel C. Vinding , Christoph Pfeiffer , Anders Svenningsson , Erik Fransén , Mathias Sundgren , Henrik Sjöström , Niklas Edvall , Daniel Lundqvist , Josefine Waldthaler
{"title":"Cortical response to proprioceptive stimulation in primary orthostatic tremor – a magnetoencephalography study","authors":"Karolina af Edholm ,&nbsp;Mikkel C. Vinding ,&nbsp;Christoph Pfeiffer ,&nbsp;Anders Svenningsson ,&nbsp;Erik Fransén ,&nbsp;Mathias Sundgren ,&nbsp;Henrik Sjöström ,&nbsp;Niklas Edvall ,&nbsp;Daniel Lundqvist ,&nbsp;Josefine Waldthaler","doi":"10.1016/j.cnp.2025.04.002","DOIUrl":"10.1016/j.cnp.2025.04.002","url":null,"abstract":"<div><h3>Objective</h3><div>Patients with primary orthostatic tremor (OT) are affected by a strong feeling of instability. Our aim was to investigate whether cortical response to proprioceptive information is altered in OT compared with healthy control subjects (HC) using magnetoencephalography (MEG).</div></div><div><h3>Methods</h3><div>Fifteen OT patients and 15 HCs were examined using whole-head MEG. Proprioceptive stimulation was evoked by passive movements of the right index finger and right foot. Time-frequency responses were extracted in the frequency range of 8–30 Hz. The MEG sensor with the highest amplitude change time-locked to the proprioceptive stimulus was used to calculate the amplitude of event-related desynchronization (ERD) and subsequent event-related re-synchronization (ERS).</div></div><div><h3>Results</h3><div>Finger stimulation induced reliable ERD and ERS, as expected, in both OT patients and HC. Foot stimulation induced weaker ERS in both groups. Cluster-based permutation tests did not reveal any significant differences between the OT and HC groups.</div></div><div><h3>Discussion</h3><div>We did not find evidence supporting a generally altered cortical response to proprioceptive stimulation in patients with OT.</div></div><div><h3>Significance</h3><div>This is the first study on proprioceptive cortical processing in OT. The results do not support the interpretation that the characteristic intense feeling of instability in OT is linked to altered cortical response to proprioceptive information.</div></div>","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"10 ","pages":"Pages 159-166"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143923885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Beyond the triad: Review of Miller Fisher Syndrome in a tertiary neurological centre 超越三联征:三级神经学中心对米勒-费雪综合征的回顾
IF 2
Clinical Neurophysiology Practice Pub Date : 2025-01-01 DOI: 10.1016/j.cnp.2025.06.006
Muhammad Rehman , Chris Gyan , Chinar Osman , Ramamurthy Arunachalam
{"title":"Beyond the triad: Review of Miller Fisher Syndrome in a tertiary neurological centre","authors":"Muhammad Rehman ,&nbsp;Chris Gyan ,&nbsp;Chinar Osman ,&nbsp;Ramamurthy Arunachalam","doi":"10.1016/j.cnp.2025.06.006","DOIUrl":"10.1016/j.cnp.2025.06.006","url":null,"abstract":"","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"10 ","pages":"Pages 234-235"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144548596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Spinal excitability is enhanced by transcranial magnetic stimulation of the motor cortex in children and adolescents 脊髓兴奋性增强经颅磁刺激运动皮层在儿童和青少年
IF 2
Clinical Neurophysiology Practice Pub Date : 2025-01-01 DOI: 10.1016/j.cnp.2025.06.009
Essi J. Marttinen Rossi , Päivi Nevalainen , Jussi Toppila , Helena Mäenpää , Jessica Guzmán-López , Harri Piitulainen , Leena Lauronen
{"title":"Spinal excitability is enhanced by transcranial magnetic stimulation of the motor cortex in children and adolescents","authors":"Essi J. Marttinen Rossi ,&nbsp;Päivi Nevalainen ,&nbsp;Jussi Toppila ,&nbsp;Helena Mäenpää ,&nbsp;Jessica Guzmán-López ,&nbsp;Harri Piitulainen ,&nbsp;Leena Lauronen","doi":"10.1016/j.cnp.2025.06.009","DOIUrl":"10.1016/j.cnp.2025.06.009","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the modulation of spinal excitability to sub-motor threshold transcranial magnetic stimulation (TMS) in healthy children and adolescents.</div></div><div><h3>Methods</h3><div>We paired sub-motor threshold TMS (conditioning) with electrical tibial nerve stimulation (test) to assess changes in the soleus H-reflex at eleven conditioning-test (C-T) intervals. Eleven participants (7.5–16.2 years) were studied under three conditions: rest, voluntary agonist activation (ankle plantar flexion), and voluntary antagonist activation (ankle dorsiflexion).</div></div><div><h3>Results</h3><div>TMS-induced supraspinal volley facilitated the soleus H-reflex amplitude significantly during rest and agonist activation, but not during antagonist activation. The facilitation of H-reflex was similar during rest and agonist activation between C-T intervals from –2 ms (i.e. peripheral stimulation before cortical) to +18 ms (i.e. cortical stimulation before peripheral). Specific to rest condition, a later facilitation occurred at C-T intervals of approximately +60 ms.</div></div><div><h3>Conclusions</h3><div>Spinal excitability modulation in children and adolescents showed similarities to earlier evidence in adults, with the distinction that, unlike in the adults, agonist activity did not further enhance the supraspinal facilitation of the H-reflex compared to the rest condition in children.</div></div><div><h3>Significance</h3><div>These results provide insight into the maturation of motor control and regulation of spinal excitability, offering possibilities to identify typical and atypical developmental trajectories.</div></div>","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"10 ","pages":"Pages 278-285"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144632001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A new method to evaluate staircase phenomenon in skeletal muscle using piezoelectric sensor 一种利用压电传感器评价骨骼肌阶梯现象的新方法。
IF 2
Clinical Neurophysiology Practice Pub Date : 2025-01-01 DOI: 10.1016/j.cnp.2024.12.002
Bungo Hirose , Tomihiro Imai , Kazuna Ikeda , Emiko Tsuda , Rika Yamauchi , Tatsuya Abe , Shin Hisahara
{"title":"A new method to evaluate staircase phenomenon in skeletal muscle using piezoelectric sensor","authors":"Bungo Hirose ,&nbsp;Tomihiro Imai ,&nbsp;Kazuna Ikeda ,&nbsp;Emiko Tsuda ,&nbsp;Rika Yamauchi ,&nbsp;Tatsuya Abe ,&nbsp;Shin Hisahara","doi":"10.1016/j.cnp.2024.12.002","DOIUrl":"10.1016/j.cnp.2024.12.002","url":null,"abstract":"<div><h3>Objective</h3><div>The staircase phenomenon, which refers to the increases in the force of contraction with repetitive stimulation of the muscle, has been studied for many years, but the method is difficult and not widely used. Our objective was to evaluate the staircase phenomenon in skeletal muscle using a piezoelectric sensor.</div></div><div><h3>Methods</h3><div>Thirty-five subjects without neuromuscular diseases (normal controls), 11 patients with Becker muscular dystrophy (BMD), and 19 patients with myotonic dystrophy type 1 (MyD) were studied. Compound muscle action potential (CMAP) and movement-related potential (MRP) waveforms were recorded using piezoelectric sensors during repetitive stimulation of the median nerve, and the amplitudes and durations were measured. Excitation-contraction (E-C) coupling time (ECCT) was calculated from the difference between onset latencies of CMAP and MRP.</div></div><div><h3>Results</h3><div>In normal controls, MRP amplitude ratio (relative to baseline) increased significantly with increase in stimulation duration and with increase in stimulation frequency. In BMD and MyD, however, MRP amplitude ratio did not change significantly with increase in stimulation duration. Especially, in MyD, there was no change in MRP amplitude ratio with increase in frequency.</div></div><div><h3>Conclusion</h3><div>Staircase phenomenon abnormalities can be evaluated easily using piezoelectric sensors, indicating their potential utility for evaluating E-C coupling impairment in myopathies.</div></div><div><h3>Significance</h3><div>Piezoelectric sensors may be a useful tool to evaluate staircase phenomenon in skeletal muscle.</div></div>","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"10 ","pages":"Pages 1-9"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11730597/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143013341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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