多期双tdcs对脑卒中患者双侧运动技能学习转移的影响

IF 2 Q3 NEUROSCIENCES

Clinical Neurophysiology Practice Pub Date : 2025-01-01 DOI:10.1016/j.cnp.2025.06.005

Mohammad Mahdi Talimkhani , Ailin Talimkhani , Vida Dinarvand , Somayeh Mohamadi , Hamzeh Baharlouei

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引用次数: 0

摘要

目的探讨脑卒中患者运动技能学习转移与多期双经颅直流电刺激（tDCS）对初级运动皮质的潜在影响。方法采用随机、假对照、双盲交叉研究。在为期3周的洗脱期中，参与者接受假tdcs或双tdcs同时进行系列反应时间任务（SRTT）。每次干预包括连续三天SRTT期间20分钟的刺激。主要变量技能指数分别在干预前、干预后和24小时后进行评估。结果两组在干预3天内运动技能学习均有显著改善(P <；0.001)。与假手术组相比，双tdcs组在患手的技能提高明显更大(P <；0.01)，而未受影响的手无显著差异（P = 0.98）。结论多阶段双tdcs联合运动学习任务可显著提高脑卒中患者患手的运动技能转移，且效果比假刺激更显著、更持久。意义该方法可改善脑卒中康复患者的双侧运动技能转移和手部疲劳管理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The effects of multi-session dual-tDCS on the bilateral transfer of motor skill learning in patients with stroke

Objective

This study investigates the potential effects of combining motor skill learning transfer from the unaffected to the affected hand with multiple sessions of dual-transcranial direct current stimulation (tDCS) over the primary motor cortex to enhance motor skills in stroke patients.

Methods

Eleven stroke patients participated in a randomized, sham-controlled, double-blind crossover study. Over two periods separated by a 3-week washout, participants underwent either sham or dual-tDCS concurrently with serial response time tasks (SRTT). Each intervention included 20 min of stimulation during SRTT for three consecutive days. The skill index, the primary variable, was assessed pre-intervention, immediately post-intervention, and 24 h later.

Results

Both groups showed significant improvement in motor skill learning across the three intervention days (P < 0.001). The dual-tDCS group demonstrated significantly greater skill improvement in the affected hand compared to the sham group (P < 0.01), while no significant differences were found for the unaffected hand (P = 0.98).

Conclusions

Multi-session dual-tDCS combined with motor learning tasks significantly enhances motor skill transfer to the affected hand in stroke patients, with greater and more durable effects compared to sham stimulation.

Significance

This approach may improve bilateral motor skill transfer and hand fatigue management in stroke rehabilitation.

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来源期刊

Clinical Neurophysiology Practice NEUROSCIENCES-

CiteScore

3.90

自引率

0.00%

发文量

审稿时长

71 days

期刊介绍： Clinical Neurophysiology Practice (CNP) is a new Open Access journal that focuses on clinical practice issues in clinical neurophysiology including relevant new research, case reports or clinical series, normal values and didactic reviews. It is an official journal of the International Federation of Clinical Neurophysiology and complements Clinical Neurophysiology which focuses on innovative research in the specialty. It has a role in supporting established clinical practice, and an educational role for trainees, technicians and practitioners.