类风湿关节炎的无症状跗骨隧道综合征：电生理观点与临床和实验室相关的见解

IF 2 Q3 NEUROSCIENCES

Clinical Neurophysiology Practice Pub Date : 2025-01-01 DOI:10.1016/j.cnp.2025.07.003

Hosna Elshony , Mohamed H. Aly , Abdelgaffar Mohammed , Abdulrahman M. Hassan , Abdulrahman A. Alshehri , Mohamed Hedak , Rakan Almuhanna , Abdulaziz Al-Ghamdi , Rasha Elsaadawy

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引用次数: 0

摘要

目的探讨无症状跗骨隧道综合征（TTS）在类风湿关节炎（RA）患者中的患病率及其与疾病活动度、炎症和电生理变化的关系。方法40例RA患者和40例年龄和性别匹配的对照组接受了神经传导研究，评估了足底内侧神经、足底外侧神经和胫后神经。记录疾病活动性（DAS28、RASS）、炎症标志物（ESR、CRP）和自身抗体（RF、抗ccp）。比较采用t检验；相关性评估关联。结果ra患者感觉潜伏期明显延长，振幅和神经传导速度明显降低，尤以内侧和外侧足底神经明显。感觉潜伏期对亚临床TTS的敏感性为100%；电机参数具有高特异性。较高的DAS28、较长的病程、升高的ESR/CRP、关节畸形和血清阳性预测TTS。结论亚临床TTS在RA中非常普遍，并与全身性炎症、疾病严重程度和结构损伤有关。常规电生理筛查可以早期发现和干预，保护神经功能，改善RA患者的长期活动能力和生活质量。试验注册该研究已获得SFHM机构审查委员会的批准，并于2024年8月根据HAP-02-K-052注册。

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Asymptomatic tarsal tunnel syndrome in rheumatoid arthritis: An electrophysiological perspective with Insights into clinical and Laboratory correlates

Objective

To evaluate the prevalence of asymptomatic tarsal tunnel syndrome (TTS) in rheumatoid arthritis (RA) patients and its association with disease activity, inflammation, and electrophysiological changes.

Methods

Forty RA patients and 40 age- and sex-matched controls underwent nerve conduction studies assessing medial plantar, lateral plantar, and posterior tibial nerves. Disease activity (DAS28, RASS), inflammatory markers (ESR, CRP), and autoantibodies (RF, anti-CCP) were recorded. Comparisons used t-tests; correlations assessed associations.

Results

RA patients showed significantly prolonged sensory latencies and reduced amplitudes and nerve conduction velocities, especially in medial and lateral plantar nerves. Sensory latencies had 100% sensitivity for subclinical TTS; motor parameters demonstrated high specificity. Higher DAS28, longer disease duration, elevated ESR/CRP, joint deformities, and seropositivity predicted TTS.

Conclusions

Subclinical TTS is highly prevalent in RA and linked to systemic inflammation, disease severity, and structural damage.

Significance

Routine electrophysiological screening may enable early detection and intervention, preserving nerve function and improving long-term mobility and quality of life in RA patients.

Trial Registration

The study was approved by the SFHM Institutional Review Board and registered under HAP-02-K-052 in August 2024.

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来源期刊

Clinical Neurophysiology Practice NEUROSCIENCES-

CiteScore

3.90

自引率

0.00%

发文量

审稿时长

71 days

期刊介绍： Clinical Neurophysiology Practice (CNP) is a new Open Access journal that focuses on clinical practice issues in clinical neurophysiology including relevant new research, case reports or clinical series, normal values and didactic reviews. It is an official journal of the International Federation of Clinical Neurophysiology and complements Clinical Neurophysiology which focuses on innovative research in the specialty. It has a role in supporting established clinical practice, and an educational role for trainees, technicians and practitioners.