Clinical Neurophysiology Practice最新文献_第10页

The diagnostic yield of a first EEG in children with suspected epilepsy: A retrospective age-related comparison between awake and sleep recordings 怀疑癫痫的儿童首次脑电图的诊断率：清醒和睡眠记录之间的回顾性年龄相关比较

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Clinical Neurophysiology Practice Pub Date : 2025-01-01 Epub Date: 2025-06-08 DOI: 10.1016/j.cnp.2025.05.002

Greta Gustafsson , Anders Broström , Eva Svanborg , Magnus Vrethem , Martin Ulander

{"title":"The diagnostic yield of a first EEG in children with suspected epilepsy: A retrospective age-related comparison between awake and sleep recordings","authors":"Greta Gustafsson , Anders Broström , Eva Svanborg , Magnus Vrethem , Martin Ulander","doi":"10.1016/j.cnp.2025.05.002","DOIUrl":"10.1016/j.cnp.2025.05.002","url":null,"abstract":"<div><h3>Objectives</h3><div>Previous research has indicated a low diagnostic yield of initial EEGs in epilepsy diagnosis in children. This study aimed at exploring factors affecting the diagnostic yield of a first EEG in different ages, and factors affecting the choice of EEG method.</div></div><div><h3>Methods</h3><div>1097 EEGs performed as first recordings in children with suspected epilepsy were retrospectively analysed and divided into age groups: ≤ 5, 6–11 and 12–17 years. EEGs were classified as wake recordings with or without provocations, and sleep recordings: spontaneous sleep, sleep induced by deprivation or by melatonin premedication.</div></div><div><h3>Results</h3><div>Epileptiform activity was found in 18 % of all patients, most common (30 %) in children 6–11 years old. It was more likely to be detected in melatonin-induced sleep EEGs compared to other types of sleep EEG. Presence of epileptiform discharges were positively associated to age, sleep, neurological and/or intellectual comorbidity in all children.</div></div><div><h3>Conclusions</h3><div>The prevalence of epileptiform activity varies depending on the child́s age. Sleep EEG is advantageous as first recording, especially in very young children or with neurological comorbidity.</div></div><div><h3>Significance</h3><div>Melatonin-induced sleep EEG has higher diagnostic yield compared to other types of sleep EEG. Age, seizure semiology and comorbidity affect the choice of EEG method.</div></div>","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"10 ","pages":"Pages 181-187"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144290883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlation between decremental responses in repetitive nerve stimulation and disease progression rate in patients with amyotrophic lateral sclerosis 肌萎缩性脊髓侧索硬化症患者重复性神经刺激的递减反应与疾病进展率之间的相关性

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Clinical Neurophysiology Practice Pub Date : 2025-01-01 Epub Date: 2025-02-22 DOI: 10.1016/j.cnp.2025.02.003

Yuki Fujii , Takamichi Kanbayashi , Kazusa Takahashi , Yuichi Hamada , Shunsuke Kobayashi , Masahiro Sonoo

{"title":"Correlation between decremental responses in repetitive nerve stimulation and disease progression rate in patients with amyotrophic lateral sclerosis","authors":"Yuki Fujii , Takamichi Kanbayashi , Kazusa Takahashi , Yuichi Hamada , Shunsuke Kobayashi , Masahiro Sonoo","doi":"10.1016/j.cnp.2025.02.003","DOIUrl":"10.1016/j.cnp.2025.02.003","url":null,"abstract":"<div><h3>Objective</h3><div>Decrement responses in repetitive nerve stimulation (RNS) are theoretically expected to correlate with the disease progression speed in amyotrophic lateral sclerosis (ALS). However, actual results have been controversial. We investigated this issue using ΔFS calculated from the ALS functional rating scale revised version (ALSFRS-R) and the duration of illness.</div></div><div><h3>Methods</h3><div>RNS results of the abductor pollicis brevis, trapezius, and deltoid muscles in our previous study were reviewed. We investigated correlations and multiple regressions regarding decremental percentage (Decr%), the amplitude of the initial compound muscle action potential (Amp), and progression speed parameters, i.e. ΔFS or ΔUL-FS, the latter being the ΔFS for the upper-limb questions in ALSFRS-R.</div></div><div><h3>Results</h3><div>Included subjects were 124 patients with ALS, 47 of whom were upper-limb onset. Multiple regression analyses revealed that Decr% is largely determined by Amp and that Δ FS or ΔUL-FS showed no or little contributions to Decr%.</div></div><div><h3>Conclusions</h3><div>Decremental responses in RNS does not predict the speed of progression of the functional impairment in patients with ALS.</div></div><div><h3>Significance</h3><div>This study suggests that the decremental responses in RNS in ALS are contributed by the impaired neuromuscular transmission in chronic sprouts following extensive reinnervation, as well as by the immature sprouts.</div></div>","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"10 ","pages":"Pages 40-46"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143488300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Shear wave elastography as a marker of anisotropy in denervated muscle tissue 剪切波弹性图作为去神经支配肌肉组织各向异性的标志

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Clinical Neurophysiology Practice Pub Date : 2025-01-01 Epub Date: 2025-03-05 DOI: 10.1016/j.cnp.2025.02.007

Olli Kutvonen , Sari-Leena Himanen , Katri Mäkelä

{"title":"Shear wave elastography as a marker of anisotropy in denervated muscle tissue","authors":"Olli Kutvonen , Sari-Leena Himanen , Katri Mäkelä","doi":"10.1016/j.cnp.2025.02.007","DOIUrl":"10.1016/j.cnp.2025.02.007","url":null,"abstract":"<div><h3>Objectives</h3><div>To assess the capability of shear wave elastography (SWE) to detect muscle denervation.</div></div><div><h3>Methods</h3><div>36 patients underwent electrodiagnostic studies (EDX) of the lower limbs and volunteered to undergo ultrasound examination of the Tibialis anterior (TA) and the Gastrocnemius medialis (GCM) muscles. A variable reflecting the level of anisotropy was created by calculating the difference between the longitudinal and transverse shear wave velocity (SWE-D).</div></div><div><h3>Results</h3><div>In the TA muscles, SWE-D correlated negatively with the quantity of fibrillation potentials (FP) and the degree of interference pattern (IP) reduction (p = 0.032, r = -0.185 and p = 0.006, r = -0.236, respectively). In the GCM muscles, SWE-D only correlated with the amount of IP reduction among patients of normal weight (p = 0.030, r = -0.285). There was also a significant difference in the overall SWE-D values in the GCM muscles between patients of normal weight and obese patients (p = 0.007).</div></div><div><h3>Conclusions</h3><div>Loss of anisotropy caused by denervation of muscle tissue may be measured quantitatively by calculating the differences between longitudinal and transverse shear wave velocities. However, obesity seems to hinder the SWE-based assessment of muscle denervation.</div></div><div><h3>Significance</h3><div>Being able to measure anisotropy caused by denervation acts as a base for further development of SWE methods to evaluate neurogenic injury.</div></div>","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"10 ","pages":"Pages 95-103"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143619967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Eastern Association of Electroencephalographers: A Canadian/USA success story 东部脑电图医师协会：加拿大/美国的成功故事

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Clinical Neurophysiology Practice Pub Date : 2025-01-01 Epub Date: 2025-09-01 DOI: 10.1016/j.cnp.2025.08.002

Michael H. Goodman , Paul Hwang , Carole D. Burnham , Solomon L. Moshé , Jeremy M. Barry , Gregory L. Holmes

{"title":"The Eastern Association of Electroencephalographers: A Canadian/USA success story","authors":"Michael H. Goodman , Paul Hwang , Carole D. Burnham , Solomon L. Moshé , Jeremy M. Barry , Gregory L. Holmes","doi":"10.1016/j.cnp.2025.08.002","DOIUrl":"10.1016/j.cnp.2025.08.002","url":null,"abstract":"<div><h3>Objective/methods</h3><div>The Eastern Association of Electroencephalographers (EAEEG), founded in 1946, is recognized as the world’s oldest EEG society. This review traces its history, highlighting contributions from notable members and the significance of the Kirshman and Milner lectureships in advancing the field.</div></div><div><h3>Results</h3><div>Although established in Hartford, Connecticut, the society’s intellectual roots lie at the Montreal Neurological Institute, home to pioneering EEG researchers Wilder Penfield and Herbert Jasper. Over more than seven decades, the EAEEG has played a pivotal role in fostering research, education, and collaboration across the United States and Canada. Its conferences have featured distinguished keynote lectures, including presentations by three Nobel Laureates, emphasizing the society’s prominence in neurophysiological advancements. The society has successfully facilitated transnational collaboration, offering a platform for both trainees and experienced clinicians and scientists to exchange knowledge and promote progress in clinical and basic neurophysiology.</div></div><div><h3>Conclusions/Significance</h3><div>Despite the prominence of large international conferences, the EAEEG’s influence underscores the importance of smaller, multinational societies in shaping neurophysiological research and practice. Its history exemplifies how collaborative efforts between the US and Canada can drive scientific innovation and education within a supportive, collegial environment, reinforcing the enduring impact of specialized professional societies on the field.</div></div>","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"10 ","pages":"Pages 404-425"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145158044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Asymptomatic tarsal tunnel syndrome in rheumatoid Arthritis: An electrophysiological perspective with insights into clinical and laboratory correlates 类风湿关节炎的无症状跗骨隧道综合征：电生理观点与临床和实验室相关的见解

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Clinical Neurophysiology Practice Pub Date : 2025-01-01 Epub Date: 2025-09-02 DOI: 10.1016/j.cnp.2025.08.005

Hosna Elshony , Mohamed H. Aly , Abdelgaffar Mohammed , Abdulrahman M. Hassan , Abdulrahman A. Alshehri , Mohamed Hedak , Rakan Almuhanna , Abdulaziz Al-Ghamdi , Rasha Elsaadawy

引用次数: 0

Brachial radiculopathy with intact central nervous system imaging following carbon monoxide poisoning: A case report 一氧化碳中毒后神经根病伴完整中枢神经系统影像学1例

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Clinical Neurophysiology Practice Pub Date : 2025-01-01 Epub Date: 2025-07-26 DOI: 10.1016/j.cnp.2025.07.004

Zhiyong Lin , Jierong Mo , Peiyi Liu , Zhiquan Li , Ran Zhan , Jun Jiang , Tianen Zhou

{"title":"Brachial radiculopathy with intact central nervous system imaging following carbon monoxide poisoning: A case report","authors":"Zhiyong Lin , Jierong Mo , Peiyi Liu , Zhiquan Li , Ran Zhan , Jun Jiang , Tianen Zhou","doi":"10.1016/j.cnp.2025.07.004","DOIUrl":"10.1016/j.cnp.2025.07.004","url":null,"abstract":"<div><h3>Objective</h3><div>To report and analyze a unique case of selective brachial plexopathy following carbon monoxide poisoning without central nervous system involvement.</div></div><div><h3>Methods</h3><div>Clinical examination, laboratory tests, neuroimaging, serial electrophysiological studies, and functional assessments were performed on a 25-year-old female presenting with severe left upper extremity weakness after CO exposure. Treatment included hyperbaric oxygen therapy, steroid therapy, and rehabilitation.</div></div><div><h3>Results</h3><div>Following carbon monoxide poisoning, the patient developed complete left upper extremity paralysis with selective C5-C7 motor deficits and preserved sensory function. Brain MRI showed no abnormalities. Electrophysiological studies confirmed preganglionic radiculopathy with reduced motor nerve amplitudes and normal sensory conduction. Ultrasonography demonstrated C5-C7 nerve root swelling. Following hyperbaric oxygen therapy, corticosteroids, and rehabilitation, motor function gradually recovered with distal grip strength reaching 86% of the unaffected side at 120-day follow-up.</div></div><div><h3>Conclusions</h3><div>This case demonstrates an uncommon manifestation of carbon monoxide poisoning characterized by isolated brachial radiculopathy with preserved central nervous system function on neuroimaging. These findings expand the recognized spectrum of carbon monoxide neurotoxicity.</div></div><div><h3>Significance</h3><div>This case expands our understanding of CO neurotoxicity beyond the traditional basal ganglia paradigm, emphasizing the importance of peripheral nervous system assessment even when central neuroimaging is normal.</div></div>","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"10 ","pages":"Pages 324-330"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144713191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comments on “Asymptomatic tarsal tunnel syndrome in rheumatoid arthritis: an electrophysiological perspective with insights into clinical and laboratory correlates” “类风湿性关节炎无症状跗骨隧道综合征：电生理学视角与临床和实验室相关性的见解”评论

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Clinical Neurophysiology Practice Pub Date : 2025-01-01 Epub Date: 2025-08-25 DOI: 10.1016/j.cnp.2025.08.004

Peyman Roomizadeh , Ayushi Chugh

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What is the best electrode setting to elicit motor evoked potentials in the muscles of lower extremities during supratentorial surgery? 幕上手术期间，在下肢肌肉中诱发运动诱发电位的最佳电极设置是什么？

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Clinical Neurophysiology Practice Pub Date : 2025-01-01 Epub Date: 2025-10-26 DOI: 10.1016/j.cnp.2025.10.005

Fares Komboz , Jan-Bernd Wemhoff , Andrea Szelényi , Beate Kranawetter , Tatiana Chacon , Angelina Nazarenus , Caspar Stephani , Veit Rohde , Tammam Abboud

{"title":"What is the best electrode setting to elicit motor evoked potentials in the muscles of lower extremities during supratentorial surgery?","authors":"Fares Komboz , Jan-Bernd Wemhoff , Andrea Szelényi , Beate Kranawetter , Tatiana Chacon , Angelina Nazarenus , Caspar Stephani , Veit Rohde , Tammam Abboud","doi":"10.1016/j.cnp.2025.10.005","DOIUrl":"10.1016/j.cnp.2025.10.005","url":null,"abstract":"<div><h3>Objective</h3><div>Eliciting lower extremity transcranial motor evoked potentials (LE-tcMEP) during supratentorial surgery can be challenging, as it often requires high current intensities, bearing the risk of bypass stimulation with false positive results. The aim of this study was to evaluate a new hemispheric electrode combination (C3/4 ↔ Cz + 6), and compare it with established ones, determining the best scalp electrode setting with the minimal motor thresholds (MT) to elicit LE-tcMEP.</div></div><div><h3>Methods</h3><div>Patients undergoing surgery for supratentorial lesion removal requiring intraoperative neuromonitoring were prospectively included. TcMEP were elicited using montages C1 ↔ C2, C3 ↔ C4, C3/4 ↔ Cz, C3/4 ↔ Cz + 6 and Cz ↔ Cz + 6. MT was established for each muscle and montage to determine the electrode combination with the lowest MT and highest selectivity.</div></div><div><h3>Results</h3><div>Based on 5880 measurements (70 patients), we found that the mean MT for eliciting LE-tcMEPs was lowest for C3 ↔ C4 (83.0 mA, p = 0.001), followed by C3/4 ↔ Cz + 6 (96.5 mA). Successfully eliciting contralateral LE-tcMEP was best achieved with C3 ↔ C4 (99.2 %, p < 0.0001), followed by C3/4-Cz + 6 (98.9 %). C3/4 ↔ Cz + 6 achieved the highest side selectivity (p < 0.001).</div></div><div><h3>Conclusion</h3><div>While electrical stimulation at C3 ↔ C4 requires the lowest MT to elicit LE-tcMEPs, stimulation at C3/4 ↔ Cz + 6 was the most selective.</div></div><div><h3>Significance</h3><div>C3/4 ↔ Cz + 6 may be a superior choice in supratentorial surgery, avoiding bypass-stimulation of deeper (e.g. brainstem) corticospinal fibers.</div></div>","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"10 ","pages":"Pages 493-498"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145415149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effects of stimulation waveform and carrier frequency on tolerance and motor thresholds elicited by transcutaneous spinal cord stimulation in stroke 刺激波形和载波频率对脑卒中经皮脊髓刺激引起的耐受性和运动阈值的影响

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Clinical Neurophysiology Practice Pub Date : 2025-01-01 Epub Date: 2025-04-22 DOI: 10.1016/j.cnp.2025.04.001

Chen Yang , Nicole C. Veit , Kelly A. McKenzie , Shreya Aalla , Ameen Kishta , Kyle Embry , Elliot J. Roth , Richard L. Lieber , Arun Jayaraman

{"title":"The effects of stimulation waveform and carrier frequency on tolerance and motor thresholds elicited by transcutaneous spinal cord stimulation in stroke","authors":"Chen Yang , Nicole C. Veit , Kelly A. McKenzie , Shreya Aalla , Ameen Kishta , Kyle Embry , Elliot J. Roth , Richard L. Lieber , Arun Jayaraman","doi":"10.1016/j.cnp.2025.04.001","DOIUrl":"10.1016/j.cnp.2025.04.001","url":null,"abstract":"<div><h3>Objective</h3><div>With growing interest in translating transcutaneous spinal cord stimulation (tSCS) into rehabilitation for different neurologic injuries, understanding the effects of various combinations of stimulation parameters becomes essential.</div></div><div><h3>Methods</h3><div>Twenty-one participants post-stroke completed an assessment to determine their resting motor threshold (RMT) (minimum current required to elicit a muscle response) and tolerance levels (uncomfortable current intensity) to 12 stimulation configurations: two square waveforms, biphasic and monophasic, paired with six carrier frequencies (unmodulated: 0, and modulated: 1, 3, 5, 7, and 10 kHz).</div></div><div><h3>Results</h3><div>The results demonstrated that increasing carrier frequency increased participants’ tolerance level and RMTs. Carrier frequency nor waveform type significantly altered discomfort when tolerance was normalized to the motor threshold, with 57 ± 23 % tolerated across all configurations. However, higher carrier frequencies, particularly biphasic waveforms at frequencies > 5 kHz, required more charge to reach a muscle activation and activated fewer muscles compared to unmodulated waveforms. No significant differences in discomfort relative to RMT were found between monophasic and biphasic waveforms.</div></div><div><h3>Conclusions</h3><div>Higher carrier frequency allows stimulation to be more comfortable at a given intensity, but it also requires more current to reach RMTs.</div></div><div><h3>Significance</h3><div>This study provides an essential feasibility assessment of tSCS configurations in a neurological population.</div></div>","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"10 ","pages":"Pages 150-158"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143876696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Contralateral R1 response in blink reflex in patients with amyotrophic lateral sclerosis 肌萎缩性侧索硬化症患者眨眼反射对侧R1反应

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Clinical Neurophysiology Practice Pub Date : 2025-01-01 Epub Date: 2025-02-22 DOI: 10.1016/j.cnp.2025.02.005

Julian Theuriet , Adrien Bohic , Maxime Bonjour , Emilien Bernard , Florent Cluse , Juliette Svahn , Laurent Jomir , Anne-Evelyne Vallet , Marion Demia , Lucie Roux , Ioana Cristina Bârsan , Léa Alves , Matthias Dion , Lionel Meens , Martin Moussy , Françoise Bouhour , Yann Péréon , Antoine Pegat

{"title":"Contralateral R1 response in blink reflex in patients with amyotrophic lateral sclerosis","authors":"Julian Theuriet , Adrien Bohic , Maxime Bonjour , Emilien Bernard , Florent Cluse , Juliette Svahn , Laurent Jomir , Anne-Evelyne Vallet , Marion Demia , Lucie Roux , Ioana Cristina Bârsan , Léa Alves , Matthias Dion , Lionel Meens , Martin Moussy , Françoise Bouhour , Yann Péréon , Antoine Pegat","doi":"10.1016/j.cnp.2025.02.005","DOIUrl":"10.1016/j.cnp.2025.02.005","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to compare the frequency of blink reflex’s contralateral R1 responses (R1′) between patients with amyotrophic lateral sclerosis (ALS), non-ALS motor deficit patients, and healthy volunteers.</div></div><div><h3>Methods</h3><div>A total of 120 participants were prospectively recruited: 40 with ALS, 40 with a non-ALS motor deficit, and 40 healthy volunteers. Blink reflexes were recorded from orbicularis oculi muscles following supraorbital nerve stimulation.</div></div><div><h3>Results</h3><div>R1′ was more frequent in the ALS group (42.5 %) compared to healthy volunteers (12.5 %, p = 0.00588), and compared to non-ALS patients (7.5 %, p = 0.000789). Bilateral R1′ was observed only in ALS patients (22.5 %). No clinically significant difference was found in the latencies or amplitudes of the R1, R2, or R1′ responses among groups. R1′ was more frequent in ALS patients with pseudobulbar affect (71.4 %) compared to those without (36.4 %).</div></div><div><h3>Conclusions</h3><div>The higher frequency of R1′ in ALS highlights its potential role in distinguishing ALS from other motor disorders. Its sensitivity was low, but bilateral R1′ was specific to ALS. The higher frequency of R1′ among ALS patients with pseudobulbar affect potentially reflects corticobulbar neuron degeneration.</div></div><div><h3>Significance</h3><div>The R1′, especially when bilateral, could serve as an additional diagnostic biomarker for ALS, although its clinical relevance should be considered within the broader diagnostic context.</div></div>","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"10 ","pages":"Pages 47-51"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143509107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0