Clinical Neurophysiology Practice最新文献_第10页

The N13 somatosensory evoked potential in complex regional pain syndrome – A potential marker for central sensitization? 复杂局部疼痛综合征的N13体感诱发电位-中枢致敏的潜在标志？

IF 2.3

Clinical Neurophysiology Practice Pub Date : 2026-01-01 Epub Date: 2026-07-01 DOI: 10.1016/j.cnp.2026.06.013

Florin Allmendinger, Martin Schubert, Florian Brunner, Caterina Leone, Michèle Hubli

{"title":"The N13 somatosensory evoked potential in complex regional pain syndrome – A potential marker for central sensitization?","authors":"Florin Allmendinger, Martin Schubert, Florian Brunner, Caterina Leone, Michèle Hubli","doi":"10.1016/j.cnp.2026.06.013","DOIUrl":"10.1016/j.cnp.2026.06.013","url":null,"abstract":"<div><h3>Objective</h3><div>The cervical N13 component of upper-limb somatosensory evoked potentials (SEP) is thought to arise from segmental, post-synaptic dorsal horn neurons. Recent studies have shown that N13 SEPs were increased after experimentally-induced central sensitization in healthy individuals, suggesting its potential as a readout of spinal hyperexcitability. This study aimed to assess the clinical utility of N13 SEPs in individuals with complex regional pain syndrome (CRPS), showing pronounced signs of central sensitization.</div></div><div><h3>Methods</h3><div>Ten individuals with CRPS and 10 healthy controls (HC) were enrolled in this pilot study. Sensory function was well characterized and multilevel SEPs (i.e., N9, N13 and N20/P25) were recorded bilaterally after electrical stimulation of the median nerve.</div></div><div><h3>Results</h3><div>Although the CRPS cohort showed signs of central sensitization (i.e., mechanical hyperalgesia and increased temporal pain summation) there was no difference in N13 amplitudes between the two cohorts (<em>p</em> = 0.53).</div></div><div><h3>Conclusion</h3><div>Our findings challenge the use of N13 SEPs as a reliable marker of increased dorsal horn excitability in CRPS. Additional influences, including peripheral sensitization and medication effects may mask potential differences and need to be considered in future applications.</div></div><div><h3>Significance</h3><div>This study highlights the obstacles of translating neurophysiological markers of central sensitization from experimental models into clinical pain cohorts.</div></div>","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"11 ","pages":"Pages 551-559"},"PeriodicalIF":2.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13355545/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148425342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A comment on “Electrodiagnostic criteria for neuromuscular transmission disorders suggested by a European consensus group” 对“欧洲共识小组提出的神经肌肉传导障碍电诊断标准”的评论

IF 2

Clinical Neurophysiology Practice Pub Date : 2026-01-01 DOI: 10.1016/j.cnp.2025.12.009

Leyla Das Pektezel , Mehmet Yasir Pektezel

引用次数: 0

Symptomatic palatal myoclonus as a rare manifestation of neuro-behcet́s disease: A case report 症状性腭肌阵挛是神经白塞病的一种罕见表现：1例报告。

IF 2

Clinical Neurophysiology Practice Pub Date : 2026-01-01 Epub Date: 2026-02-11 DOI: 10.1016/j.cnp.2026.02.004

Andrés Hormaza-Jaramillo , Valentina Quintana-Peña , Harry Pachajoa , Estephania Candelo , Sara Alejandra Benavides-Ibarra , Jorge Luis Orozco

引用次数: 0

Practical assessment of motor preparation–execution coupling during active ankle dorsiflexion in post-stroke gait: A pilot study 卒中后步态中主动踝关节背屈运动准备-执行耦合的实际评估：一项试点研究

IF 2

Clinical Neurophysiology Practice Pub Date : 2026-01-01 Epub Date: 2026-01-19 DOI: 10.1016/j.cnp.2026.01.004

Hiroki Ito , Hideaki Yamaguchi , Kazumasa Ukai , Ryosuke Yamauchi , Ken Kitai , Takayuki Kodama

{"title":"Practical assessment of motor preparation–execution coupling during active ankle dorsiflexion in post-stroke gait: A pilot study","authors":"Hiroki Ito , Hideaki Yamaguchi , Kazumasa Ukai , Ryosuke Yamauchi , Ken Kitai , Takayuki Kodama","doi":"10.1016/j.cnp.2026.01.004","DOIUrl":"10.1016/j.cnp.2026.01.004","url":null,"abstract":"<div><h3>Objective</h3><div>Active ankle dorsiflexion (AAD) has been proposed as a surrogate measure for gait-related motor control. However, whether the neural coupling between motor preparation and execution during AAD predicts gait ability remains unclear. This study examined whether μ–γ coupling was evaluated as a practical neurophysiological marker of gait performance.</div></div><div><h3>Methods</h3><div>In this study, 12 healthy adults and 4 patients with chronic stroke performed an AAD task and an overground walking task. Ankle kinematics, surface electromyography, and electroencephalography were simultaneously recorded. Corticomuscular coherence (CMC) and phase–amplitude coupling (PAC) were analyzed as indices of motor preparation–execution coupling. Gait performance was assessed based on gait speed and a Gait Assessment and Intervention Tool (G.A.I.T.).</div></div><div><h3>Results</h3><div>Patients with stroke showed significantly lower gait speed (0.60 vs. 1.24 m/s, p < 0.001) and G.A.I.T. scores compared to controls. In the AAD task, patients with stroke exhibited significantly reduced ankle angular velocity and lower CMC between Cz and the tibialis anterior compared to controls (p < 0.05). Source localization revealed diminished activity in the middle temporal gyrus, inferior parietal lobule, and insula in patients with stroke. Notably, the PAC-derived modulation index (MI) at Cz was markedly reduced in patients with stroke (0.03) compared to controls (1.50, p < 0.001), clearly discriminating between the groups.</div></div><div><h3>Conclusions & significance</h3><div>Motor preparation–execution coupling during AAD strongly reflects gait capacity after stroke. PAC-MI is a novel neurophysiological marker; requires validation biomarker for the early and objective evaluation of gait-related motor control with potential utility in stroke rehabilitation.</div></div>","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"11 ","pages":"Pages 54-64"},"PeriodicalIF":2.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146023155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuronavigation‑guided rTMS of the facial motor cortex for atypical facial pain: Two case reports 神经导航引导的面部运动皮质rTMS治疗非典型面部疼痛：2例报告

IF 2

Clinical Neurophysiology Practice Pub Date : 2026-01-01 Epub Date: 2026-01-10 DOI: 10.1016/j.cnp.2026.01.001

Dongsheng Xiao 肖东升 , Wei Tao 陶蔚 , Yongjie Li 李勇杰 , Matilde Balbi , Yuqing Zhang 张宇清

{"title":"Neuronavigation‑guided rTMS of the facial motor cortex for atypical facial pain: Two case reports","authors":"Dongsheng Xiao 肖东升 , Wei Tao 陶蔚 , Yongjie Li 李勇杰 , Matilde Balbi , Yuqing Zhang 张宇清","doi":"10.1016/j.cnp.2026.01.001","DOIUrl":"10.1016/j.cnp.2026.01.001","url":null,"abstract":"<div><h3>Objective</h3><div>Evaluate safety and analgesic effect of neuronavigation-guided 10 Hz rTMS precisely targeting facial M1 in atypical facial pain (AFP).</div></div><div><h3>Methods</h3><div>Two adults with refractory AFP received 10 daily sessions (2,500 pulses/day) of 10 Hz rTMS at 110 % resting motor threshold. Targeting used MRI/CT-integrated neuronavigation to the facial M1. Pain severity (Barrow Neurological Institute [BNI] scale I–V) and adverse events were recorded through treatment and short follow-up.</div></div><div><h3>Results</h3><div>Both completed treatment without serious adverse events. Case 1 improved from BNI V at baseline to II at end of treatment, persisting BNI III for 15 days. Case 2 improved from BNI IV to I, with BNI III for 2 days after therapy; both reported better sleep and mood.</div></div><div><h3>Conclusions</h3><div>Neuronavigation-guided 10 Hz rTMS of facial M1 was well tolerated and associated with rapid, clinically meaningful analgesia in two AFP cases.</div></div><div><h3>Significance</h3><div>Pilot data support sham-controlled studies to define dose–response and durability, identify responders, and formalize navigated rTMS as a physiological screen to select candidates and targets for implanted brain stimulations.</div></div>","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"11 ","pages":"Pages 38-44"},"PeriodicalIF":2.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146023156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Educational and training needs in clinical neurophysiology among professionals in African countries: results of a survey 非洲国家专业人员在临床神经生理学方面的教育和培训需求：一项调查的结果。

IF 2

Clinical Neurophysiology Practice Pub Date : 2026-01-01 Epub Date: 2026-03-14 DOI: 10.1016/j.cnp.2026.03.002

Stephen Acheampong , Antonio Martins da Silva , Antonin Gechev , Agnes Trebuchon , Andrea Antal , Anita Kamondi , Hatice Tankisi

引用次数: 0

Interventions to mitigate pain and reduce skin impedance during neuromuscular electrical stimulation 在神经肌肉电刺激过程中减轻疼痛和降低皮肤阻抗的干预措施

IF 2

Clinical Neurophysiology Practice Pub Date : 2026-01-01 Epub Date: 2026-02-13 DOI: 10.1016/j.cnp.2026.02.005

Philip Wackendal , Ines Shopi , Robin Juthberg , Paul W Ackermann

{"title":"Interventions to mitigate pain and reduce skin impedance during neuromuscular electrical stimulation","authors":"Philip Wackendal , Ines Shopi , Robin Juthberg , Paul W Ackermann","doi":"10.1016/j.cnp.2026.02.005","DOIUrl":"10.1016/j.cnp.2026.02.005","url":null,"abstract":"<div><h3>Objective</h3><div>High skin–electrode impedance limits neuromuscular electrical stimulation (NMES) by increasing discomfort and impairing efficacy. This study compared the effects of mechanical exfoliation and gel pad (hydrogel) application on skin impedance, NMES current intensity, and pain perception.</div></div><div><h3>Methods</h3><div>In a within-subject design, 49 healthy participants (28 males, 21 females) received NMES on both calves with randomized interventions (dry electrode, gel pad, exfoliation, combined). Impedance, NMES current intensity and pain (Numerical Pain Rating Scale, NPRS, 0–10 (no-maximum pain)) at plantar flexion (PF) were recorded.</div></div><div><h3>Results</h3><div>Gel pads produced the largest impedance reduction (∼10 kΩ) in participants reaching PF at lower intensities (PF range: 5–20 mA). All interventions significantly reduced impedance (∼1.5 kΩ) and current intensity (∼1 mA) at PF versus dry electrodes (p < 0.001). Gel pads, alone or combined with exfoliation, reduced pain by ∼ 1 NPRS point (p < 0.001), while exfoliation alone had no effect. Over 20% of participants reported persistent pain (NPRS ≥ 4) despite interventions. Higher impedance was significantly associated with lower physical activity level.</div></div><div><h3>Conclusion</h3><div>Gel pads effectively reduced both impedance and pain during NMES, while exfoliation reduced impedance without affecting pain.</div></div><div><h3>Significance</h3><div>Hydrogel pads improve NMES tolerability, yet persistent discomfort warrants improved skin–electrode interfaces.</div></div>","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"11 ","pages":"Pages 199-207"},"PeriodicalIF":2.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147538663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intraoperative motor evoked potentials (MEP) improvement predicts functional outcomes in intracranial surgery 术中运动诱发电位（MEP）改善预测颅内手术的功能结局

IF 2

Clinical Neurophysiology Practice Pub Date : 2026-01-01 Epub Date: 2026-04-13 DOI: 10.1016/j.cnp.2026.04.006

Prasuna Velur , Marvin Gong , Gabriel Zada , Robert Briggs , Vibha Velur

引用次数: 0

Exploration of sleep spindles from surgically induced unilaterally deaf adult humans with and without tinnitus 伴有或不伴有耳鸣的单侧耳聋成人的睡眠纺锤波探索

IF 2

Clinical Neurophysiology Practice Pub Date : 2026-01-01 Epub Date: 2026-05-05 DOI: 10.1016/j.cnp.2026.05.001

MinChul Park , Robin Guillard , Greg A. O’Beirne , Philip A. Bird , Michael R.D. Maslin

{"title":"Exploration of sleep spindles from surgically induced unilaterally deaf adult humans with and without tinnitus","authors":"MinChul Park , Robin Guillard , Greg A. O’Beirne , Philip A. Bird , Michael R.D. Maslin","doi":"10.1016/j.cnp.2026.05.001","DOIUrl":"10.1016/j.cnp.2026.05.001","url":null,"abstract":"<div><h3>Objective</h3><div>In the neural noise-cancellation mechanism, reduced auditory thalamic reticular nucleus (TRN) activity is thought to result in tinnitus. As a biomarker of TRN activity is sleep spindles, we performed an exploratory study to ask whether individuals with tinnitus would exhibit altered sleep spindles compared with controls.</div></div><div><h3>Methods</h3><div>Unilaterally deaf adults with tinnitus (UD+T; n = 13), without tinnitus (UD-T; n = 8), and controls without tinnitus or UD (CO; n = 13) were recruited. 2-hour polysomnography nap data were obtained from 64-channels. Spindles were characterised in both frequency and time domains.</div></div><div><h3>Results</h3><div>We observed no statistically significant differences between our groups in any parameter. However, a dual trend towards lower spindle density (1.8 ± 2.1 spindles/min) and higher spindle amplitude (24.6 ± 9.1 µV) amongst the UD+T group was noted.</div></div><div><h3>Conclusions</h3><div>A tentative interpretation of the dual trends is the possible altered auditory TRN function associated with tinnitus. Albeit not statistically significant, these exploratory data at least provide a valuable foundation for future studies to probe the effect further. This includes a higher sample size and longer overnight sleep data.</div></div><div><h3>Significance</h3><div>This is the first study which investigated sleep spindles in UD patients with and without tinnitus.</div></div>","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"11 ","pages":"Pages 352-358"},"PeriodicalIF":2.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147849720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Perioperative dynamic EEG patterns correlated with changes in cognitive subdomains 围手术期动态脑电图模式与认知子域变化相关。

IF 2.3

Clinical Neurophysiology Practice Pub Date : 2026-01-01 Epub Date: 2026-07-14 DOI: 10.1016/j.cnp.2026.07.009

Duygu Aydin, Mariana Thedim, Chiewlin Liew, Gerhard Schneider, Susana Vacas, Matthias Kreuzer

{"title":"Perioperative dynamic EEG patterns correlated with changes in cognitive subdomains","authors":"Duygu Aydin, Mariana Thedim, Chiewlin Liew, Gerhard Schneider, Susana Vacas, Matthias Kreuzer","doi":"10.1016/j.cnp.2026.07.009","DOIUrl":"10.1016/j.cnp.2026.07.009","url":null,"abstract":"<div><h3>Objective</h3><div>Surgery and anesthesia can be associated with postoperative neurological injury, especially in individuals with diminished cognitive reserve. Timely identification of at-risk patients enables deployment of preventive strategies. Despite consistent recommendations, perioperative cognitive risk assessment remains largely overlooked. We explored which dynamic electroencephalogram (EEG) patterns are correlated with cognitive subdomains significantly affected by surgery and anesthesia.</div></div><div><h3>Methods</h3><div>This was a secondary analysis of two prospective observational studies that included patients undergoing elective laparoscopic abdominal or pelvic surgery under general anesthesia. Cognition was assessed using the Mini-Mental State Exam, 2nd edition (MMSE-2) and the Montreal Cognitive Assessment (MoCA) within one week before and up to 48 h after surgery. Frontal EEG was recorded pre-induction to extubation. Cognitive subdomains and EEG changes were explored using linear regression and accuracy analyses.</div></div><div><h3>Results</h3><div>Data were obtained from 23 surgical patients (median [IQR] age, 63 [16] years; 52% female). Auditory-verbal delayed recall (MMSE-2, <em>p</em> = 0.001 AUC = 0.76 [0.62–0.89]; MoCA, <em>p</em> < 0.001 AUC = 0.75 [0.6–0.89]) and processing speed (MMSE-2, p < 0.001 AUC = 0.85 [0.72–0.95]) were significantly affected postoperatively. Delta power at the end of maintenance, changes in theta, alpha power, aperiodic slope, offset were correlated with processing speed changes.</div></div><div><h3>Conclusion</h3><div>Dynamic EEG patterns were correlated with processing speed changes. Integrating EEG into perioperative risk assessment may contribute to early identification of vulnerability.</div></div><div><h3>Significance</h3><div>This study demonstrates the correlation between changes in perioperative EEG and cognitive subdomains.</div></div>","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"11 ","pages":"Pages 601-609"},"PeriodicalIF":2.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13393008/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148580512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0