Repetitive transcranial magnetic stimulation for early-onset Alzheimer’s disease – A case report

IF 2 Q3 NEUROSCIENCES

Clinical Neurophysiology Practice Pub Date : 2023-01-01 DOI:10.1016/j.cnp.2023.07.003

Ali Elahi, Tiffany Frechette

引用次数: 0

Abstract

Background

Early-onset Alzheimer’s Disease (AD) is a rare form of AD defined as exhibiting signs and symptoms before age 65. Several studies have shown high frequency repetitive transcranial magnetic stimulation (rTMS) to be an effective treatment for individuals with mild cognitive impairment (MCI) and AD when applied to the left and/or right dorsolateral prefrontal cortex (DLPFC) with clear improvements found on standardized assessments of cognitive function.

Case report

Here, we present a case report of a 44-year-old patient with clinical and laboratory characteristics of definite early-onset AD.

Findings

rTMS led to marked cognitive improvements. We hope to inspire more clinical interest in exploring rTMS for treatment of dementia.

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重复经颅磁刺激治疗早发性阿尔茨海默病1例报告

背景早发性阿尔茨海默病（AD）是一种罕见的AD，被定义为在65岁之前表现出体征和症状。几项研究表明，当应用于左和/或右背外侧前额叶皮层（DLPFC）时，高频重复性经颅磁刺激（rTMS）对轻度认知障碍（MCI）和AD患者是一种有效的治疗方法，在认知功能的标准化评估中发现了明显的改善。病例报告在这里，我们提出了一个44岁的患者的病例报告，该患者具有明确的早发性AD的临床和实验室特征。我们希望在探索rTMS治疗痴呆症方面激发更多的临床兴趣。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Neurophysiology Practice NEUROSCIENCES-

CiteScore

3.90

自引率

0.00%

发文量

审稿时长

71 days

期刊介绍： Clinical Neurophysiology Practice (CNP) is a new Open Access journal that focuses on clinical practice issues in clinical neurophysiology including relevant new research, case reports or clinical series, normal values and didactic reviews. It is an official journal of the International Federation of Clinical Neurophysiology and complements Clinical Neurophysiology which focuses on innovative research in the specialty. It has a role in supporting established clinical practice, and an educational role for trainees, technicians and practitioners.