Nerve enlargement differs among chronic inflammatory demyelinating polyradiculoneuropathy subtypes and multifocal motor neuropathy

IF 2 Q3 NEUROSCIENCES

Clinical Neurophysiology Practice Pub Date : 2023-01-01 DOI:10.1016/j.cnp.2023.10.002

Masaaki Yoshikawa , Kenji Sekiguchi , Hirotomo Suehiro , Shunsuke Watanabe , Yoshikatsu Noda , Hideo Hara , Riki Matsumoto

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引用次数: 1

Abstract

Objective

We aimed to evaluate differences in ultrasonographic nerve enlargement sites among typical chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), distal CIDP, multifocal CIDP and multifocal motor neuropathy (MMN) in a Japanese population.

Methods

We retrospectively reviewed medical records and selected 39 patients (14 with typical CIDP, 7 with multifocal CIDP, 4 with distal CIDP, and 14 with MMN) who underwent ultrasonography. Median and ulnar nerve cross-sectional areas (CSAs) were measured at the wrist, forearm, elbow, and upper arm. CSA ratios for each nerve were calculated as: wrist-to-forearm index (WFI) = wrist CSA/forearm CSA; elbow-to-upper arm index (EUI) = elbow CSA/upper arm CSA; and intranerve CSA variability (INCV) = maximal CSA/minimal CSA.

Results

Significant differences were observed among typical CIDP, multifocal CIDP, distal CIDP, and MMN in CSA at the forearm and upper arm in the median nerves (p < 0.05). Patients with multifocal CIDP had lower WFI and EUI and higher INCV than the other groups (p < 0.05).

Conclusions

Regardless of the untreated period, compared with other CIDP subtypes and MMN, multifocal CIDP showed a focal and marked nerve enlargement in the Japanese population.

Significance

Differences in nerve enlargement site may be an underlying feature of multifocal CIDP.

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慢性炎症性脱髓鞘多发性运动神经病亚型和多灶性运动神经病的神经扩大程度不同

方法我们回顾性地查阅了病历，选择了 39 名接受超声波检查的患者（14 名典型 CIDP 患者、7 名多灶 CIDP 患者、4 名远端 CIDP 患者和 14 名 MMN 患者）（14 名典型 CIDP 患者、7 名多灶 CIDP 患者、4 名远端 CIDP 患者和 14 名 MMN 患者）。在腕部、前臂、肘部和上臂测量了正中神经和尺神经的横截面积（CSA）。每条神经的 CSA 比值计算公式为：腕部至前臂指数 (WFI) = 腕部 CSA/前臂 CSA；肘部至上臂指数 (EUI) = 肘部 CSA/上臂 CSA；神经内 CSA 变异性 (INCV) = 最大 CSA/最小 CSA。结果观察到典型 CIDP、多灶性 CIDP、远端 CIDP 和 MMN 的正中神经前臂和上臂 CSA 存在显著差异（p <0.05）。结论无论未治疗时间长短，与其他 CIDP 亚型和 MMN 相比，多灶性 CIDP 在日本人群中表现出局灶性和明显的神经肿大。意义神经肿大部位的差异可能是多灶性 CIDP 的一个潜在特征。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Neurophysiology Practice NEUROSCIENCES-

CiteScore

3.90

自引率

0.00%

发文量

审稿时长

71 days

期刊介绍： Clinical Neurophysiology Practice (CNP) is a new Open Access journal that focuses on clinical practice issues in clinical neurophysiology including relevant new research, case reports or clinical series, normal values and didactic reviews. It is an official journal of the International Federation of Clinical Neurophysiology and complements Clinical Neurophysiology which focuses on innovative research in the specialty. It has a role in supporting established clinical practice, and an educational role for trainees, technicians and practitioners.