Clinical Neurophysiology Practice最新文献

{"title":"Re-evaluating transcranial static magnetic stimulation (tSMS): No inhibitory effects on motor cortex across hemispheres","authors":"Sabrina Lorenz ,&nbsp;Linda Bartusch ,&nbsp;Cornelia Heusler ,&nbsp;Stefan Götz ,&nbsp;Thomas Kammer","doi":"10.1016/j.cnp.2026.02.008","DOIUrl":"10.1016/j.cnp.2026.02.008","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate whether transcranial static magnetic stimulation (tSMS) exerts inhibitory effects on the human motor cortex and whether these effects differ between dominant and non-dominant hemispheres.</div></div><div><h3>Methods</h3><div>Participants underwent tSMS (20 min) and sham stimulation, targeting either the left (dominant, n = 19) or right (non-dominant, n = 19) motor cortex in a between-subject design. Corticospinal excitability was assessed with transcranial magnetic stimulation (TMS), using single-pulse motor evoked potentials (MEPs) and paired-pulse paradigms (short-interval intracortical inhibition SICI, intracortical facilitation ICF). Neuronavigation ensured stable hotspot localization.</div></div><div><h3>Results</h3><div>No significant differences in MEP amplitudes were observed between tSMS and sham stimulation. Paired-pulse measures confirmed robust inhibition and facilitation, with higher reliability for SICI. However, neither SICI nor ICF showed modulation by tSMS.</div></div><div><h3>Conclusions</h3><div>tSMS modulated excitability in neither the dominant nor the non– dominant hemisphere. The results suggest that previously reported effects may reflect methodological limitations, particularly absence of neuronavigation or low trial numbers.</div></div><div><h3>Significance</h3><div>This study provides the first direct hemispheric comparison of tSMS using neuronavigation and robust stimulation protocols, questioning the robustness of earlier findings and highlighting methodological standards for future research.</div></div>","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"11 ","pages":"Pages 163-171"},"PeriodicalIF":2.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147385309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to CNP-D-25–204 “Triphasic waves: To treat or not to treat?”: Do not overlook COVID-19 and Creutzfeldt-Jakob disease","authors":"Brin E. Freund ,&nbsp;Khalil S. Husari ,&nbsp;José L. Fernández-Torre ,&nbsp;Philippe Gélisse ,&nbsp;Peter W. Kaplan","doi":"10.1016/j.cnp.2025.12.007","DOIUrl":"10.1016/j.cnp.2025.12.007","url":null,"abstract":"","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"11 ","pages":"Pages 34-35"},"PeriodicalIF":2.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145926445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Educational needs and training conditions of young clinical neurophysiologists: survey of IFCN-young neurophysiologists network","authors":"Orsolya Györfi ,&nbsp;Thananan Thammongkolchai ,&nbsp;Ricardo Kienitz ,&nbsp;Nortina Shahrizaila ,&nbsp;Hatice Tankisi ,&nbsp;Anita Kamondi","doi":"10.1016/j.cnp.2026.01.009","DOIUrl":"10.1016/j.cnp.2026.01.009","url":null,"abstract":"<div><h3>Objectives</h3><div>In 2022, the International Federation of Clinical Neurophysiology (IFCN) launched the Young Neurophysiologists Network to support the representation of its younger members. This survey assessed the training of early-career clinical neurophysiologists and identify unmet needs.</div></div><div><h3>Methods</h3><div>A 31-item online questionnaire was distributed to IFCN members under 40 years of age, evaluating educational goals, mentorship, expertise levels, and preferences for e-learning.</div></div><div><h3>Results</h3><div>From 57 countries 331 participants responded. Marked regional differences emerged in training quality, confidence, and needs. In high-income countries, satisfaction with core modules—EEG, ENG–EMG, and video-EEG—was highest, while lower ratings were reported in low-income countries, especially for EEG. Training priorities also varied: neuromuscular ultrasound was the most requested topic in both high- and middle-income countries, while low-income countries prioritized video-EEG and evoked potentials. Mentorship significantly improved continued training. Online education was used by 58%, with 64% preferring IFCN Masterclasses.</div></div><div><h3>Conclusion</h3><div>Young neurophysiologists show strong interest in advanced training, particularly in neuromuscular ultrasound. Expanding mentorship and access to IFCN resources could help address global disparities.</div></div><div><h3>Significance</h3><div>This survey highlights significant regional differences in young neurophysiologists’ training and underscores the need to expand mentorship and equitable access to advanced educational resources.</div></div>","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"11 ","pages":"Pages 93-102"},"PeriodicalIF":2.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146173148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Selective loss of ulnar somatosensory evoked potentials revealing a focal cervical cord plaque in multiple sclerosis","authors":"Julian Cheron ,&nbsp;Bernard Dachy","doi":"10.1016/j.cnp.2025.12.002","DOIUrl":"10.1016/j.cnp.2025.12.002","url":null,"abstract":"","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"11 ","pages":"Pages 3-4"},"PeriodicalIF":2.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145738791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Home-based transcranial static magnetic field stimulation − concept, development, and clinical applications: IFCN handbook chapter","authors":"Claudia Ammann ,&nbsp;Vanesa Soto-León","doi":"10.1016/j.cnp.2026.04.001","DOIUrl":"10.1016/j.cnp.2026.04.001","url":null,"abstract":"<div><div>Non-invasive brain stimulation (NIBS) techniques, such as transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS), have significantly advanced neuroscience research and clinical practice. However, these approaches can involve costly equipment (particularly TMS) and varying degrees of technical complexity, especially for protocols requiring precise targeting. Transcranial static magnetic field stimulation (tSMS) has recently emerged as a novel, accessible alternative. This technique uses a simple, constant magnetic field—typically generated by a neodymium magnet—to modulate cortical excitability without electrical input, or perceptible sensation. While static magnets have long been associated with pseudoscientific practices, rigorous studies since 2011 have established the physiological effects of tSMS, demonstrating its capacity to transiently reduce cortical excitability in humans. The simplicity, portability, and excellent safety profile of tSMS make it especially well-suited for home-based applications and long-duration protocols. Although its modulatory effects tend to be modest and transient, recent research indicates that longer stimulation durations can extend the effects, and its predominantly inhibitory action may be advantageous for specific clinical targets. While the static nature of the magnetic field limits depth penetration, ongoing innovations may help address this constraint. Overall, tSMS represents a low-cost, well-tolerated, and practical addition to the NIBS toolkit, with growing potential to support individualized neuromodulation strategies in both research and therapeutic settings.</div></div>","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"11 ","pages":"Pages 282-293"},"PeriodicalIF":2.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147649500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasonographic cross-sectional area in classifying ulnar neuropathy at the elbow","authors":"Nathan J. Savage,&nbsp;John S. McKell","doi":"10.1016/j.cnp.2026.05.009","DOIUrl":"10.1016/j.cnp.2026.05.009","url":null,"abstract":"<div><h3>Objective</h3><div>Ulnar neuropathy at the elbow (UNE) is a common entrapment neuropathy for which electrodiagnostic (EDX) testing is frequently used. Although multi-tiered electrophysiologic severity classifications exist, the extent to which ultrasound imaging (USI)-derived ulnar nerve cross-sectional area (CSA) provides incremental discrimination across severity categories and informs probabilistic clinical decision-making remains unclear.</div></div><div><h3>Methods</h3><div>This retrospective analysis of prospectively collected cross-sectional data included 299 elbows from 262 patients referred for EDX testing with clinical suspicion of UNE. Elbows were classified using two multi-tiered electrophysiologic systems (Padua and Zeidman) and consolidated binary categorizations (Negative vs UNE). USI-derived ulnar nerve CSA was evaluated using receiver operating characteristic analyses and likelihood ratios to estimate post-test probability shifts across severity categories and binary classifications, accounting for clustering of bilateral elbows.</div></div><div><h3>Results</h3><div>CSA demonstrated limited incremental discrimination between adjacent categories within multi-tiered electrophysiologic classifications, resulting in modest post-test probability shifts. In contrast, binary categorizations showed stronger discriminative performance. CSA values &lt;6 mm² identified a low probability, whereas values &gt;15–16 mm² identified a high probability of electrophysiologic abnormality suggesting UNE. Thresholds derived from Youden's index (≤8 mm² and ≥ 9 mm²) produced smaller, non-conclusive probability shifts. Age and sex influenced electrophysiologic findings but did not materially alter CSA-based probabilistic interpretation.</div></div><div><h3>Conclusions</h3><div>USI-derived ulnar nerve CSA does not reliably discriminate between adjacent electrophysiologic severity categories of UNE. A simplified binary interpretive framework using CSA thresholds may offer greater clinical utility.</div></div><div><h3>Significance</h3><div>These findings support probabilistic, rather than severity-grading, use of USI when evaluating suspected UNE in patients referred for EDX testing.</div></div>","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"11 ","pages":"Pages 434-441"},"PeriodicalIF":2.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13293735/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148346491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resting-state EEG reveals slowing and altered functional connectivity in children and young adults with severe chronic kidney disease","authors":"S. Lijdsman,&nbsp;M. Königs,&nbsp;M.S. van Sandwijk,&nbsp;A.H. Bouts,&nbsp;K. van Hoeck,&nbsp;H. de Jong,&nbsp;H. Bruining,&nbsp;F.J. Bemelman,&nbsp;A.F. van Rootselaar,&nbsp;K.J. Oostrom,&nbsp;J.W. Groothoff,&nbsp;C.A. Bosman","doi":"10.1016/j.cnp.2026.06.002","DOIUrl":"10.1016/j.cnp.2026.06.002","url":null,"abstract":"<div><h3>Objective</h3><div>Explore associations between quantitative markers of resting-state electroencephalography (EEG), severe chronic kidney disease (CKD), and neurocognition in children and young adults.</div></div><div><h3>Methods</h3><div>We included 25 patients with CKD with an estimated glomerular filtration rate &lt; 30 ml/min/1.73m² aged 8–30 years, on different treatment modalities (pre-dialysis [<em>n</em> = 6], dialysis [<em>n</em> = 8], transplanted [<em>n</em> = 11]). EEG parameters of power spectrum analysis and functional connectivity were obtained using the Fourier transformation and amplitude envelope correlation (AEC) analysis, respectively. Neurocognition was measured using a comprehensive neurocognitive test battery. Mixed model analyses assessed relations between CKD parameters, EEG parameters and neurocognitive functions.</div></div><div><h3>Results</h3><div>A longer time on dialysis in the past was significantly related to a higher delta and lower alpha power, which related to poorer Processing Speed and Working Memory. Patients on kidney replacement therapy had significantly higher delta AEC than pre-dialysis patients. A higher eGFR after transplantation was related to a higher delta AEC. Delta AEC was not related to neurocognitive performance.</div></div><div><h3>Conclusion</h3><div>Abnormal high delta power may be indicative of clinically apparent encephalopathy in young patients with kidney failure. The role of increased functional connectivity as potential compensatory mechanism should be further explored.</div></div><div><h3>Significance</h3><div>Minimizing dialysis-time by early transplantation may be advantageous in the prevention of encephalopathy in young CKD patients.</div></div>","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"11 ","pages":"Pages 528-537"},"PeriodicalIF":2.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13330574/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148392068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring electrode montages to optimize the non-invasive clinical recording of auditory evoked AP/wave I","authors":"Ludivine Beaud-Henry,&nbsp;Aurélien Mulliez,&nbsp;Alann Renault,&nbsp;Katia Bouton,&nbsp;Paul Avan,&nbsp;Fabrice Giraudet","doi":"10.1016/j.cnp.2026.07.001","DOIUrl":"10.1016/j.cnp.2026.07.001","url":null,"abstract":"<div><h3>Objectives</h3><div>Recent advances in electrocochleography (ECochG), particularly the development of minimally invasive ear-canal electrodes, have renewed interest in the objective assessment of auditory disorders such as endolymphatic hydrops, auditory neuropathy spectrum disorders, and cochlear synaptopathy. This study aimed to identify the optimal recording configuration for maximizing compound action potential (AP)/auditory brainstem response (ABR) wave I amplitude in normal-hearing adults.</div></div><div><h3>Methods</h3><div>Forty-seven normal-hearing young adults (24 women) underwent ABR and ECochG recordings using a conventional clinical evoked-potential system. Six electrode montages combining earlobe, ear-canal, Cz, and Fz electrodes were evaluated. Rarefaction and condensation click stimuli were presented separately. AP/wave I latency and baseline-to-peak amplitude were compared according to recording protocol, electrode montage, click polarity, and sex.</div></div><div><h3>Results</h3><div>AP/wave I latency remained stable across recording protocols, electrode configurations, click polarities, and sex. In contrast, AP/wave I amplitude was strongly influenced by recording conditions. Rarefaction clicks consistently produced larger amplitudes than condensation clicks. Ear-canal electrodes significantly enhanced AP/wave I amplitude compared with conventional earlobe electrodes, with amplitude enhancement ratios ranging from 1.40 ± 0.55 to 2.14 ± 1.90. The vertical ear-canal/Fz montage provided the most robust responses in both ABR and ECochG recordings.</div></div><div><h3>Conclusions</h3><div>ECochG recordings obtained with an ear-canal electrode and rarefaction click stimulation optimize AP/wave I amplitude while maintaining a non-invasive and clinically applicable procedure.</div></div><div><h3>Significance</h3><div>Optimized ECochG acquisition with a non-invasive ear-canal electrode enhances the identification and quantification of AP/wave I and may improve the electrophysiological assessment of auditory neuropathy, cochlear synaptopathy, and endolymphatic hydrops in routine clinical practice.</div></div>","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"11 ","pages":"Pages 543-550"},"PeriodicalIF":2.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13355502/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148425331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re-assessing the clinical significance of long-term neuromuscular alterations following Onabotulinumtoxin-A (BoNTA) in chronic migraine: Letter to the editor on behalf of the GRASP study group","authors":"Andreas A. Argyriou,&nbsp;Emmanouil V. Dermitzakis,&nbsp;Dimitrios Rikos,&nbsp;Panagiotis Soldatos,&nbsp;Michail Vikelis,&nbsp;Greek Research Alliance for the Study of Headache and Pain (GRASP) Study Group","doi":"10.1016/j.cnp.2026.08.004","DOIUrl":"10.1016/j.cnp.2026.08.004","url":null,"abstract":"","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"11 ","pages":"Pages 677-678"},"PeriodicalIF":2.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148737279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantifying motor unit loss prior to functional impairment in muscles affected by amyotrophic lateral sclerosis","authors":"Boudewijn T.H.M. Sleutjes,&nbsp;Anna Bystrup Jacobsen,&nbsp;Hatice Tankisi,&nbsp;N. Gorkem Sirin,&nbsp;A. Emre Oge,&nbsp;Robert D. Henderson,&nbsp;Pieter A. van Doorn,&nbsp;Leonard H. van den Berg,&nbsp;Ruben P.A. van Eijk","doi":"10.1016/j.cnp.2026.06.012","DOIUrl":"10.1016/j.cnp.2026.06.012","url":null,"abstract":"<div><h3>Objectives</h3><div>The compound muscle action potential (CMAP) scan is a non-invasive method for deriving motor unit number estimates (MUNE) to track disease progression in muscles affected by amyotrophic lateral sclerosis (ALS). It remains to be established whether and how long motor unit loss precedes functional impairment.</div></div><div><h3>Methods</h3><div>In 56 patients with ALS, we compared the longitudinal trajectories of MUNE derived from thenar CMAP scans, and fine motor function (FMF) using a functional rating scale. Linear and sigmoidal disease trajectories were modelled from which time differences were estimated between these measures to reach their half-maximum scores.</div></div><div><h3>Results</h3><div>The normalized linear decline per month was 0.02 (95% CI 0.01 to 0.03) for FMF and 0.03 (95% CI 0.03 to 0.04) for MUNE. Half-maximum of FMF was reached after 26.3 months (95% CI 18.9 to 35.1) for the linear model, while MUNE had a shorter time required to reach 50% of its maximum with 13.0 months (95% CI 10.3 to 16.4). The head-to-head comparison between FMF and MUNE showed that MUNE values reached 50% of its maximum 13.1 months (95% CI 7.0–20.8) earlier. Results were similar for sigmoidal disease trajectories.</div></div><div><h3>Conclusions</h3><div>Simulated disease trajectories of MUNE values derived from CMAP scans in muscles affected by ALS indicated that MUNE may reach 50% of its maximum in approximately 60% of the time compared to functional impairment.</div></div><div><h3>Significance</h3><div>These explorative findings underscore how neurophysiological measures may be of use for early disease monitoring, with relevance for both care and research settings.</div></div>","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"11 ","pages":"Pages 538-542"},"PeriodicalIF":2.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13351403/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148425320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}