The effect of acute respiratory events and respiratory stimulants on EEG-recorded brain activity in neonates: A systematic review

IF 2 Q3 NEUROSCIENCES

Clinical Neurophysiology Practice Pub Date : 2023-01-01 DOI:10.1016/j.cnp.2023.11.002

Fatima Usman , Simon Marchant , Luke Baxter , Hamisu M. Salihu , Muktar H. Aliyu , Eleri Adams , Caroline Hartley

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引用次数: 0

Abstract

Objective

We conducted a systematic review to investigate electroencephalography (EEG) changes during periods of acute respiratory events such as apnoea and the effect of respiratory stimulants on EEG features in infants.

Methods

Studies examining respiration and EEG-recorded brain activity in human neonates between 28 and 42 weeks postmenstrual age were included. Two reviewers independently screened all records and included studies were assessed using the Joanna Briggs Institute Critical Appraisal Tool. The protocol was registered in PROSPERO (CRD42022339873).

Results

We identified 14 studies with a total of 534 infants. Nine articles assessed EEG changes in relation to apnoea, one assessed hiccups, and four investigated the effect of respiratory stimulants. The relationship between neonatal apnoea and EEG changes was inconsistent; EEG suppression and decreased amplitude and frequency were observed during some, but not all, apnoeas. Respiratory stimulants increased EEG continuity compared with before use.

Conclusions

Current studies in this area are constrained by small sample sizes. Diverse exposure definitions and outcome measures impact inference.

Significance

This review highlights the need for further work; understanding the relationship between respiration and the developing brain is key to mitigating the long-term effects of apnoea.

查看原文本刊更多论文

急性呼吸事件和呼吸刺激剂对新生儿脑电图记录的脑活动的影响:一项系统综述

目的对婴儿急性呼吸事件(如呼吸暂停)期间的脑电图变化及呼吸刺激剂对脑电图特征的影响进行系统回顾。方法对经后28 ~ 42 周的新生儿进行呼吸和脑电图记录的脑活动研究。两位审稿人独立筛选了所有记录，并使用乔安娜布里格斯研究所关键评估工具对纳入的研究进行了评估。该协议已在PROSPERO (CRD42022339873)中注册。结果:我们纳入了14项研究，共纳入534名婴儿。九篇文章评估了与呼吸暂停有关的脑电图变化，一篇评估了打嗝，四篇研究了呼吸兴奋剂的作用。新生儿呼吸暂停与脑电图变化的关系不一致;在部分(但不是全部)呼吸暂停期间观察到脑电图抑制和幅度和频率下降。与使用前相比，呼吸兴奋剂增加了脑电图的连续性。结论目前在该领域的研究受样本量小的限制。不同的暴露定义和结果测量影响推断。本综述强调了进一步工作的必要性;了解呼吸和大脑发育之间的关系是减轻呼吸暂停长期影响的关键。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Neurophysiology Practice NEUROSCIENCES-

CiteScore

3.90

自引率

0.00%

发文量

审稿时长

71 days

期刊介绍： Clinical Neurophysiology Practice (CNP) is a new Open Access journal that focuses on clinical practice issues in clinical neurophysiology including relevant new research, case reports or clinical series, normal values and didactic reviews. It is an official journal of the International Federation of Clinical Neurophysiology and complements Clinical Neurophysiology which focuses on innovative research in the specialty. It has a role in supporting established clinical practice, and an educational role for trainees, technicians and practitioners.