当遗传学占上风时：脑刺激无法克服脑源性神经营养因子Val66Met的学习缺陷

IF 2 Q3 NEUROSCIENCES

Clinical Neurophysiology Practice Pub Date : 2025-01-01 DOI:10.1016/j.cnp.2025.08.009

Perianen Ramasawmy , Krisztián Iszak , Steffen Brüshaber , Viktória Kállay , Géza Gergely Ambrus , Walter Paulus , Andrea Antal

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引用次数: 0

摘要

背外侧前额叶皮层（DLPFC）是记忆分类的关键贡献者。脑源性神经营养因子（BDNF） Val66Met多态性影响神经元可塑性诱导的效果。我们研究了dlpfc -经颅直流电刺激（tDCS）是否影响分类性能，以及BNDF基因型是否调节这种影响。方法在原型扭曲任务的训练阶段，将62名健康个体随机分为两组，分别接受10 min的1 mA正极右DLPFC-tDCS和假tDCS。在刺激期间、刺激后不久和刺激后的早晨分别评估了分类性能。通过BNDF基因分型确定Val66Met多态性状态。结果val66met携带者的分类能力较Val/Val纯合子差（p < 0.0001）。tDCS总体上没有提高分类性能，也没有减少与这些特定刺激参数相关的基因型差异。然而，tDCS消除了我们样本中观察到的分类任务的原型效应。结论BDNF多态性在类别学习中的重要作用。在测试条件下，1 mA阳极右DLPFC优于右DLPFC并不能改善性能或抵消基因型差异。bdnf Val66Met多态性影响类别学习，而低强度tDCS并不能抵消这种影响，这强调了完善基因型特异性认知增强刺激方案的必要性。

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When genetics prevail: brain stimulation fails to overcome learning deficits from brain-derived neurotrophic factor Val66Met

Background

The dorsolateral prefrontal cortex (DLPFC) is a key contributor to memory categorization. Brain-Derived Neurotrophic Factor (BDNF) Val66Met polymorphism affects the efficacy of neuronal plasticity induction. We investigated whether DLPFC-transcranial direct current stimulation (tDCS) influences categorization performance, and whether BNDF genotype modulates this effect.

Methods

Sixty-two healthy individuals were randomized to receive 10 min of either anodal right DLPFC-tDCS at 1 mA, or sham tDCS during the training phase of a prototype distortion task. Categorization performance was assessed during, shortly after, and the morning following the stimulation. Val66Met polymorphism status was determined through BNDF genotyping.

Results

Val66Met carriers showed poorer categorization ability than Val/Val homozygotes (p < 0.0001). tDCS did not enhance categorization performance overall, or reduce genotype-associated differences with these specific stimulation parameters. However, tDCS extinguished the prototype effect of the categorization task observed in our sample.

Conclusions

Our findings underscore the importance of BDNF polymorphism in category learning. 1 mA anodal right DLPFC over the right DLPFC does not improve performance or offset genotype differences under tested conditions.

Significance

BDNF Val66Met polymorphism influences category learning, and low-intensity tDCS does not counteract this effect, emphasizing the need to refine stimulation protocols for genotype-specific cognitive enhancement.

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来源期刊

Clinical Neurophysiology Practice NEUROSCIENCES-

CiteScore

3.90

自引率

0.00%

发文量

审稿时长

71 days

期刊介绍： Clinical Neurophysiology Practice (CNP) is a new Open Access journal that focuses on clinical practice issues in clinical neurophysiology including relevant new research, case reports or clinical series, normal values and didactic reviews. It is an official journal of the International Federation of Clinical Neurophysiology and complements Clinical Neurophysiology which focuses on innovative research in the specialty. It has a role in supporting established clinical practice, and an educational role for trainees, technicians and practitioners.