剪切波弹性图作为去神经支配肌肉组织各向异性的标志

IF 2 Q3 NEUROSCIENCES

Clinical Neurophysiology Practice Pub Date : 2025-01-01 DOI:10.1016/j.cnp.2025.02.007

Olli Kutvonen , Sari-Leena Himanen , Katri Mäkelä

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引用次数: 0

摘要

目的评价横波弹性成像（SWE）检测肌肉失神经的能力。方法36例患者均行下肢电诊断检查（EDX），并自愿行胫骨前肌（TA）和腓肠肌内侧肌（GCM）超声检查。通过计算纵向和横向横波速度（swed）之差，创建了一个反映各向异性水平的变量。结果在TA肌中，SWE-D与纤颤电位（FP）数量和干涉图（IP）减少程度分别呈负相关（p = 0.032, r = -0.185和p = 0.006, r = -0.236）。在GCM肌肉中，swed仅与正常体重患者的IP减少量相关（p = 0.030, r = -0.285）。正常体重患者与肥胖患者GCM肌肉的总体SWE-D值也有显著差异（p = 0.007）。结论肌肉组织失神经支配引起的各向异性丧失可通过计算纵、横横波速度之差来定量测量。然而，肥胖似乎阻碍了基于swed的肌肉去神经支配评估。意义：能够测量由去神经支配引起的各向异性是进一步发展SWE方法评估神经源性损伤的基础。

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Shear wave elastography as a marker of anisotropy in denervated muscle tissue

Objectives

To assess the capability of shear wave elastography (SWE) to detect muscle denervation.

Methods

36 patients underwent electrodiagnostic studies (EDX) of the lower limbs and volunteered to undergo ultrasound examination of the Tibialis anterior (TA) and the Gastrocnemius medialis (GCM) muscles. A variable reflecting the level of anisotropy was created by calculating the difference between the longitudinal and transverse shear wave velocity (SWE-D).

Results

In the TA muscles, SWE-D correlated negatively with the quantity of fibrillation potentials (FP) and the degree of interference pattern (IP) reduction (p = 0.032, r = -0.185 and p = 0.006, r = -0.236, respectively). In the GCM muscles, SWE-D only correlated with the amount of IP reduction among patients of normal weight (p = 0.030, r = -0.285). There was also a significant difference in the overall SWE-D values in the GCM muscles between patients of normal weight and obese patients (p = 0.007).

Conclusions

Loss of anisotropy caused by denervation of muscle tissue may be measured quantitatively by calculating the differences between longitudinal and transverse shear wave velocities. However, obesity seems to hinder the SWE-based assessment of muscle denervation.

Significance

Being able to measure anisotropy caused by denervation acts as a base for further development of SWE methods to evaluate neurogenic injury.

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来源期刊

Clinical Neurophysiology Practice NEUROSCIENCES-

CiteScore

3.90

自引率

0.00%

发文量

审稿时长

71 days

期刊介绍： Clinical Neurophysiology Practice (CNP) is a new Open Access journal that focuses on clinical practice issues in clinical neurophysiology including relevant new research, case reports or clinical series, normal values and didactic reviews. It is an official journal of the International Federation of Clinical Neurophysiology and complements Clinical Neurophysiology which focuses on innovative research in the specialty. It has a role in supporting established clinical practice, and an educational role for trainees, technicians and practitioners.