Zhiyong Lin , Jierong Mo , Peiyi Liu , Zhiquan Li , Ran Zhan , Jun Jiang , Tianen Zhou
{"title":"一氧化碳中毒后神经根病伴完整中枢神经系统影像学1例","authors":"Zhiyong Lin , Jierong Mo , Peiyi Liu , Zhiquan Li , Ran Zhan , Jun Jiang , Tianen Zhou","doi":"10.1016/j.cnp.2025.07.004","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><div>To report and analyze a unique case of selective brachial plexopathy following carbon monoxide poisoning without central nervous system involvement.</div></div><div><h3>Methods</h3><div>Clinical examination, laboratory tests, neuroimaging, serial electrophysiological studies, and functional assessments were performed on a 25-year-old female presenting with severe left upper extremity weakness after CO exposure. Treatment included hyperbaric oxygen therapy, steroid therapy, and rehabilitation.</div></div><div><h3>Results</h3><div>Following carbon monoxide poisoning, the patient developed complete left upper extremity paralysis with selective C5-C7 motor deficits and preserved sensory function. Brain MRI showed no abnormalities. Electrophysiological studies confirmed preganglionic radiculopathy with reduced motor nerve amplitudes and normal sensory conduction. Ultrasonography demonstrated C5-C7 nerve root swelling. Following hyperbaric oxygen therapy, corticosteroids, and rehabilitation, motor function gradually recovered with distal grip strength reaching 86% of the unaffected side at 120-day follow-up.</div></div><div><h3>Conclusions</h3><div>This case demonstrates an uncommon manifestation of carbon monoxide poisoning characterized by isolated brachial radiculopathy with preserved central nervous system function on neuroimaging. These findings expand the recognized spectrum of carbon monoxide neurotoxicity.</div></div><div><h3>Significance</h3><div>This case expands our understanding of CO neurotoxicity beyond the traditional basal ganglia paradigm, emphasizing the importance of peripheral nervous system assessment even when central neuroimaging is normal.</div></div>","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"10 ","pages":"Pages 324-330"},"PeriodicalIF":2.0000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Brachial radiculopathy with intact central nervous system imaging following carbon monoxide poisoning: A case report\",\"authors\":\"Zhiyong Lin , Jierong Mo , Peiyi Liu , Zhiquan Li , Ran Zhan , Jun Jiang , Tianen Zhou\",\"doi\":\"10.1016/j.cnp.2025.07.004\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objective</h3><div>To report and analyze a unique case of selective brachial plexopathy following carbon monoxide poisoning without central nervous system involvement.</div></div><div><h3>Methods</h3><div>Clinical examination, laboratory tests, neuroimaging, serial electrophysiological studies, and functional assessments were performed on a 25-year-old female presenting with severe left upper extremity weakness after CO exposure. Treatment included hyperbaric oxygen therapy, steroid therapy, and rehabilitation.</div></div><div><h3>Results</h3><div>Following carbon monoxide poisoning, the patient developed complete left upper extremity paralysis with selective C5-C7 motor deficits and preserved sensory function. Brain MRI showed no abnormalities. Electrophysiological studies confirmed preganglionic radiculopathy with reduced motor nerve amplitudes and normal sensory conduction. Ultrasonography demonstrated C5-C7 nerve root swelling. Following hyperbaric oxygen therapy, corticosteroids, and rehabilitation, motor function gradually recovered with distal grip strength reaching 86% of the unaffected side at 120-day follow-up.</div></div><div><h3>Conclusions</h3><div>This case demonstrates an uncommon manifestation of carbon monoxide poisoning characterized by isolated brachial radiculopathy with preserved central nervous system function on neuroimaging. These findings expand the recognized spectrum of carbon monoxide neurotoxicity.</div></div><div><h3>Significance</h3><div>This case expands our understanding of CO neurotoxicity beyond the traditional basal ganglia paradigm, emphasizing the importance of peripheral nervous system assessment even when central neuroimaging is normal.</div></div>\",\"PeriodicalId\":45697,\"journal\":{\"name\":\"Clinical Neurophysiology Practice\",\"volume\":\"10 \",\"pages\":\"Pages 324-330\"},\"PeriodicalIF\":2.0000,\"publicationDate\":\"2025-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical Neurophysiology Practice\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2467981X25000381\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"NEUROSCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Neurophysiology Practice","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2467981X25000381","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
Brachial radiculopathy with intact central nervous system imaging following carbon monoxide poisoning: A case report
Objective
To report and analyze a unique case of selective brachial plexopathy following carbon monoxide poisoning without central nervous system involvement.
Methods
Clinical examination, laboratory tests, neuroimaging, serial electrophysiological studies, and functional assessments were performed on a 25-year-old female presenting with severe left upper extremity weakness after CO exposure. Treatment included hyperbaric oxygen therapy, steroid therapy, and rehabilitation.
Results
Following carbon monoxide poisoning, the patient developed complete left upper extremity paralysis with selective C5-C7 motor deficits and preserved sensory function. Brain MRI showed no abnormalities. Electrophysiological studies confirmed preganglionic radiculopathy with reduced motor nerve amplitudes and normal sensory conduction. Ultrasonography demonstrated C5-C7 nerve root swelling. Following hyperbaric oxygen therapy, corticosteroids, and rehabilitation, motor function gradually recovered with distal grip strength reaching 86% of the unaffected side at 120-day follow-up.
Conclusions
This case demonstrates an uncommon manifestation of carbon monoxide poisoning characterized by isolated brachial radiculopathy with preserved central nervous system function on neuroimaging. These findings expand the recognized spectrum of carbon monoxide neurotoxicity.
Significance
This case expands our understanding of CO neurotoxicity beyond the traditional basal ganglia paradigm, emphasizing the importance of peripheral nervous system assessment even when central neuroimaging is normal.
期刊介绍:
Clinical Neurophysiology Practice (CNP) is a new Open Access journal that focuses on clinical practice issues in clinical neurophysiology including relevant new research, case reports or clinical series, normal values and didactic reviews. It is an official journal of the International Federation of Clinical Neurophysiology and complements Clinical Neurophysiology which focuses on innovative research in the specialty. It has a role in supporting established clinical practice, and an educational role for trainees, technicians and practitioners.