定量脑电图在路易体痴呆诊断中的应用

IF 2 Q3 NEUROSCIENCES

Clinical Neurophysiology Practice Pub Date : 2025-01-01 DOI:10.1016/j.cnp.2025.06.008

Abhimanyu Mahajan , Alberto Jaramillo-Jimenez , Anita D’Anselmo , Giulia Prete , Lucrezia Bristot , Sara Varanese , Alberto Di Domenico , Nicola Mammarella , Luca Tommasi , Michele Tinazzi , Dag Aarsland , Claudio Babiloni , Alberto J. Espay , Laura Bonanni

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引用次数: 0

摘要

静息状态闭眼脑电图（rsEEG）活动的频谱分析通常显示异常的δ (<；4赫兹),θ（4 - 7赫兹）和α（8-12赫兹）功率的老年患者由于进行性神经退行性疾病的认知障碍。有趣的是，异常突出的后侧rsEEG功率<；在国际指南中，在α前/ θ范围内周期性波动的8hz已被认为是诊断路易体（DLB）引起的前驱或明显痴呆患者的支持性生物标志物。在这里，一个专家小组简要回顾了丘脑皮质节律异常作为一种可能的神经生理振荡机制在DLB患者中产生这些rsEEG异常的概念。它还建议如何记录和定量分析前驱和表现为DLB的患者的rsEEG活性，以便在临床实践中应用这种成本效益高且广泛可用的诊断程序。

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Quantitative electroencephalography in the diagnosis of dementia with Lewy bodies

The spectral analysis of the resting-state eyes-closed electroencephalographic (rsEEG) activity typically shows abnormal delta (< 4 Hz), theta (4–7 Hz), and alpha (8–12 Hz) power in older patients with cognitive deficits due to progressive neurodegenerative diseases. Interestingly, abnormally prominent posterior rsEEG power < 8 Hz with periodic fluctuations in the pre-alpha/theta range has been considered a supportive biomarker for diagnosing patients with prodromal or manifest dementia due to Lewy bodies (DLB) in international guidelines. Here, a panel of experts shortly reviews the concepts of thalamocortical dysrhythmia as a possible neurophysiological oscillatory mechanism generating those rsEEG abnormalities in DLB patients. It also recommends how to record and quantitatively analyze rsEEG activity in prodromal and manifesting DLB patients for the application of that cost-effective and largely available diagnostic procedure in clinical practice.

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来源期刊

Clinical Neurophysiology Practice NEUROSCIENCES-

CiteScore

3.90

自引率

0.00%

发文量

审稿时长

71 days

期刊介绍： Clinical Neurophysiology Practice (CNP) is a new Open Access journal that focuses on clinical practice issues in clinical neurophysiology including relevant new research, case reports or clinical series, normal values and didactic reviews. It is an official journal of the International Federation of Clinical Neurophysiology and complements Clinical Neurophysiology which focuses on innovative research in the specialty. It has a role in supporting established clinical practice, and an educational role for trainees, technicians and practitioners.