Clinical Neurophysiology Practice最新文献

{"title":"Acute administration of methylphenidate modulates functional connectivity during irrelevant stimuli processing in Parkinson's disease","authors":"Ling Li,&nbsp;Tan Bo,&nbsp;Estela Martinez Lopez,&nbsp;Mirian Roson Gonzalez,&nbsp;Miguel Fernandez-del-Olmo,&nbsp;Tanya Gurevich,&nbsp;Lydia Vela Desojo,&nbsp;Noa Fogelson","doi":"10.1016/j.cnp.2026.09.001","DOIUrl":"10.1016/j.cnp.2026.09.001","url":null,"abstract":"<div><h3>Objective</h3><div>Methylphenidate (MPD) may have therapeutic benefits in Parkinson's disease (PD) patients. However, the effects of MPD on attentional functional connectivity (FC) networks, in PD, have not been investigated to date. Our objective was to examine the effects of a single dose of MPD, on event-related FC, in PD. The study was a randomized, double-blind, placebo-controlled, single-dose, cross-over clinical trial.</div></div><div><h3>Methods</h3><div>We recorded electroencephalogram (EEG) in PD patients during the performance of an extended version of a visual oddball task. We evaluated FC during the processing of task-relevant (targets, predictive sequence) and task-irrelevant (randomized standards) stimuli, using the weighted phase-locking index and graph theory. Two recording sessions (20 mg MPD or placebo) were performed in each patient.</div></div><div><h3>Results</h3><div>MPD, in comparison with placebo, modulated FC during the processing of standards, within the theta band, in PD patients. MPD induced decreases in the FC and global efficiency within fronto-parietal networks, during the processing of task-irrelevant stimuli.</div></div><div><h3>Conclusions</h3><div>In PD patients, the administration of a single dose of MPD, compared with placebo, attenuated FC within fronto-parietal networks, during the processing of non-informative standards.</div></div><div><h3>Significance</h3><div>MPD may have cognitive therapeutic effects in PD, by modulating attention during the processing of task-irrelevant stimuli.</div></div>","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"11 ","pages":"Pages 788-795"},"PeriodicalIF":2.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149004438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corollary discharge dysfunction in auditory verbal hallucinations: N100 suppression measured with semi-dry electrodes","authors":"Ella Sonnelid,&nbsp;Robert Boden,&nbsp;Caroline Wass,&nbsp;Jonas Persson","doi":"10.1016/j.cnp.2026.10.001","DOIUrl":"10.1016/j.cnp.2026.10.001","url":null,"abstract":"<div><h3>Objective</h3><div>Corollary discharge dysfunction in patients with auditory verbal hallucinations (AVH) is reflected in failure to attenuate the N100 event-related potential. Previous research has shown mixed findings regarding N100 suppression and hallucination severity, generally using broad symptom scales rather than AVH-specific measures. This study investigated corollary discharge and its relationship with comprehensively characterized auditory hallucinations.</div></div><div><h3>Methods</h3><div>Corollary discharge was investigated in 14 patients with persistent auditory hallucinations and 15 healthy controls using an EEG paradigm using semi-dry electrodes where participants self-generated sounds in a “talk” condition and listened to playback in a “listen” condition. N100 suppression was calculated as the peak-amplitude difference (μV) between talk and listen in the 60–150 ms window. Auditory hallucinations were assessed with the Psychotic Symptom Rating Scales Auditory Hallucination Subscale (PSYRATS-AHS).</div></div><div><h3>Results</h3><div>Between-group analysis of the fronto-central ROI (Fz-Cz) showed a statistically non-significant trend toward greater N100 suppression in healthy controls compared to AVH patients (<em>p</em> = 0.095, Cohen's d = 0.64). N100 suppression showed significant negative correlation with hallucination severity in the AVH group (<em>r</em> = −0.54, <em>p</em> = 0.047).</div></div><div><h3>Conclusions</h3><div>Hallucination severity is related to impaired corollary discharge mechanisms, supporting its role as a mechanistic basis for auditory hallucinations.</div></div><div><h3>Significance</h3><div>The preliminary correlation with PSYRATS-AHS suggests potential value in using symptom-specific assessment tools in research on auditory hallucinations, warranting replication in larger samples.</div></div>","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"11 ","pages":"Pages 851-857"},"PeriodicalIF":2.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149153375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to “Triphasic waves: To treat or not to treat?”: Do not overlook COVID-19 and Creutzfeldt-Jakob disease","authors":"Moisés León-Ruiz,&nbsp;Julián Benito-León,&nbsp;Carlos Castañeda-Cabrero","doi":"10.1016/j.cnp.2025.12.003","DOIUrl":"10.1016/j.cnp.2025.12.003","url":null,"abstract":"","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"11 ","pages":"Pages 1-2"},"PeriodicalIF":2.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145705724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to “Stimulation selectivity in transcranial motor evoked potentials for monitoring during surgery for supratentorial lesions”","authors":"Fares Komboz,&nbsp;Tammam Abboud","doi":"10.1016/j.cnp.2026.04.004","DOIUrl":"10.1016/j.cnp.2026.04.004","url":null,"abstract":"","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"11 ","pages":"Pages 271-272"},"PeriodicalIF":2.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147649503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hippocampal interictal discharges induce frontal spindles and enhance spindle–slow oscillation coupling in temporal lobe epilepsy","authors":"Taira Uehara ,&nbsp;Ela Austria Barcelon ,&nbsp;Hiroshi Shigeto ,&nbsp;Takahiko Mukaino ,&nbsp;Toshiki Okadome ,&nbsp;Nobutaka Mukae ,&nbsp;Ayumi Sakata ,&nbsp;Hiroyuki Murai ,&nbsp;Shozo Tobimatsu ,&nbsp;Noriko Isobe ,&nbsp;Jun-ichi Kira","doi":"10.1016/j.cnp.2026.04.005","DOIUrl":"10.1016/j.cnp.2026.04.005","url":null,"abstract":"<div><h3>Objective</h3><div> <!-->To investigate how hippocampal interictal epileptiform discharges (IEDs) influence cortical spindles, slow oscillations (SOs), and spindle–SO coupling, which are key components of sleep-dependent memory consolidation.</div></div><div><h3>Methods</h3><div> <!-->Simultaneous intracranial and scalp EEG was recorded during NREM sleep in 10 patients with temporal lobe epilepsy (TLE). Hippocampal IEDs were identified using depth electrodes, while spindles and SOs were detected from ipsilateral scalp EEG in frontal, central, parietal, and temporal regions. Peri-IED time histograms and spectral analyses were performed to evaluate the temporal associations between IEDs and the oscillatory events. Spindle–SO coupling was assessed using phase consistency and amplitude modulation metrics.</div></div><div><h3>Results</h3><div> <!-->Spindle occurrence increased in the frontal region 0.4–0.8 s after IEDs. This increase occurred regardless of their coincidence with SOs. The incidence of SOs increased within ± 0.4 s of IEDs across regions. Spectral analysis confirmed elevated frontal spindle-band power following IEDs. Phase consistency and amplitude modulation of spindle–SO coupling were higher for IED-coupled than for uncoupled spindles in the frontal region.</div></div><div><h3>Conclusions</h3><div> <!-->Hippocampal IEDs selectively induced frontal spindles and enhanced their coupling with SOs.</div></div><div><h3>Significance</h3><div> <!-->These findings suggest that IEDs may alter physiological hippocampal–cortical communication relevant to memory consolidation in TLE.</div></div>","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"11 ","pages":"Pages 321-331"},"PeriodicalIF":2.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147702548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disentangling Event-Related Potential and Oscillatory Sources using Time- and Frequency-Domain Source Imaging","authors":"Emma Depuydt ,&nbsp;Miet De Letter ,&nbsp;Pieter van Mierlo","doi":"10.1016/j.cnp.2026.01.007","DOIUrl":"10.1016/j.cnp.2026.01.007","url":null,"abstract":"<div><h3>Objective</h3><div>To determine whether event-related potentials (ERPs) and neural oscillations arise from common or distinct neural sources by combining two EEG source localization methods.</div></div><div><h3>Methods</h3><div>We applied eLORETA and DICS, which localize activity in the time and frequency domains respectively, to both simulated and real EEG data. Simulations assessed the spatial accuracy and specificity of each method. Real data analyses were used to examine the correspondence between ERP-related activity and oscillatory dynamics in relevant frequency bands.</div></div><div><h3>Results</h3><div>For the P300, eLORETA and DICS yielded overlapping source localizations, indicating a shared neural origin. Although alpha desynchronization temporally aligned with the P300, its sources were spatially distinct. In the case of the auditory N1, both methods revealed bilateral activation, with higher spatial precision observed using eLORETA. For the N400, DICS revealed sources that overlapped with eLORETA’s localization, suggesting a distributed semantic network engaged through amplitude asymmetry mechanisms.</div></div><div><h3>Conclusions</h3><div>ERP components may result from both shared and distinct oscillatory sources, varying by frequency band and cognitive function. The complementary use of eLORETA and DICS enhances interpretability of source dynamics.</div></div><div><h3>Significance</h3><div>This study underscores the value of integrating time- and frequency-domain source imaging to deepen our mechanistic understanding of stimulus-locked brain responses.</div></div>","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"11 ","pages":"Pages 103-114"},"PeriodicalIF":2.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146173194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic value of auditory evoked potentials in disorders of consciousness: a systematic literature review","authors":"Panithi Khusakul ,&nbsp;Ioan Valnarov-Boulter ,&nbsp;Aden Noronha ,&nbsp;Wanapas Wachiradejkul ,&nbsp;Tim M. Young ,&nbsp;Blake Hale","doi":"10.1016/j.cnp.2026.01.005","DOIUrl":"10.1016/j.cnp.2026.01.005","url":null,"abstract":"<div><h3>Objective</h3><div>Decisions regarding withdrawal of life support in disorders of consciousness (DoC) are challenged by prognostic uncertainty.<!--> <!-->Auditory evoked potentials (AEPs) are widely used, yet no recent systematic review has focused exclusively on their prognostic value. Given evidence that some withdrawal decisions are based on inaccurate prognoses, this study aimed to evaluate the prognostic utility of AEPs in DoC using recent evidence.</div></div><div><h3>Methods</h3><div>Comprehensive literature searches of PubMed, Scopus, and Web of Science Core Collection identified studies published between 2013 and 2023 assessing AEPs for prognostication in DoC. Three authors independently screened studies using predefined criteria. Eligible studies were original English-language research evaluating prognostic outcomes in adults (≥18 years) with DoC. Reviews and secondary literature were excluded. Risk of bias was assessed using the QUADAS-2 tool.</div></div><div><h3>Results</h3><div>Of 2249 records screened, 24 studies met inclusion criteria, encompassing 1562 patients. Mismatch negativity (MMN), the most frequently studied AEP, reliably predicted both favourable and unfavourable outcomes. P300 demonstrated potential for predicting recovery, though findings were inconsistent. Although less studied, the absence of N100 predicted poor functional outcomes, including reduced autonomy. Absence of brainstem or middle-latency AEPs predicted negative outcomes with high specificity but low sensitivity.</div></div><div><h3>Conclusion</h3><div>MMN, P300, and N100 demonstrate meaningful prognostic value in DoC. Despite methodological heterogeneity, current evidence supports AEPs as useful clinical prognostic tools. Standardised, blinded protocols are needed to improve reliability.</div></div><div><h3>Significance</h3><div>Integrating AEPs into multimodal prognostic frameworks may enhance outcome prediction. Advances in electrode coverage, machine learning, and automated detection paradigms offer promising future directions.</div></div>","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"11 ","pages":"Pages 72-85"},"PeriodicalIF":2.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146173146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility and diagnostic added value of a point of care mobile EEG system","authors":"Sidsel Armand Larsen,&nbsp;Louise Klok,&nbsp;Louise Maria Andersen,&nbsp;Marlene Linnebjerg Kudsk,&nbsp;Pirgit Meritam Larsen,&nbsp;Anne Sabers,&nbsp;Sándor Beniczky","doi":"10.1016/j.cnp.2026.07.014","DOIUrl":"10.1016/j.cnp.2026.07.014","url":null,"abstract":"<div><h3>Objective</h3><div>EEG is an essential diagnostic tool in epilepsy. Many patients with intellectual disability and epilepsy reside in residential care facilities and do not have access to EEG, as the modality is not available on-site. Additionally, due to poor cooperation, transporting these patients to specialized hospital-based EEG centers is often difficult or impossible resulting in lack or delayed diagnostic evaluation. Mobile, point-of-care EEG systems, with electrodes that can be easily applied outside the hospital by caregivers without formal training in EEG recording, have the potential to bridge this diagnostic gap.</div></div><div><h3>Methods</h3><div>In this prospective multicenter study, we assessed the feasibility and clinical utility of a point-of-care EEG system in residential care facilities. EEG electrodes were applied by local personnel without prior training in EEG recording. Data was uploaded to a secure cloud platform and remotely interpreted by experts.</div></div><div><h3>Results</h3><div>We recruited 25 participants. EEG recording could be completed in 22 participants. The recordings were clinically interpretable in 17 participants and provided complete answers to the referrals in 11 participants. No technical failures of the EEG device or data transmission were observed.</div></div><div><h3>Conclusions</h3><div>Our results demonstrate the feasibility and clinical utility of point-of-care mobile EEG for the diagnosis of epilepsy in residential care facilities.</div></div><div><h3>Significance</h3><div>Point-of-care mobile EEG has the potential to improve equity in access to neurophysiological diagnostics.</div></div>","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"11 ","pages":"Pages 642-647"},"PeriodicalIF":2.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148634199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Arcuate fasciculus cortico-cortical and axono-cortical evoked potentials with post-resection excitability changes in perisylvian glioma","authors":"Ryan P. Hamer,&nbsp;Andrew Morokoff,&nbsp;Chris Donaldson,&nbsp;Kristian Bulluss,&nbsp;Andrew Gogos,&nbsp;Mohammed Awad,&nbsp;Santosh Poonnoose,&nbsp;Ahmad Badran,&nbsp;Adrian Praeger","doi":"10.1016/j.cnp.2026.07.013","DOIUrl":"10.1016/j.cnp.2026.07.013","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the feasibility and clinical utility of arcuate fasciculus cortico-cortical evoked potentials (AF-CCEP) and axono-cortical evoked potentials (AF-ACEP) during perisylvian supratentorial tumor surgery, and examine whether morphology changes serve as electrophysiological biomarkers of postoperative language function.</div></div><div><h3>Methods</h3><div>We analysed 19 patients with tumors involving or adjacent to the arcuate fasciculus across multiple tertiary centers. AF-CCEPs were elicited by monophasic stimulation toward the inferior frontal gyrus and recorded over the middle or posterior superior temporal gyrus; AF-ACEPs were obtained via subcortical bipolar stimulation. Primary outcomes explored N1 morphology pre- and post-resection, with subgroup analyses by tumor grade, location, montage, and anesthesia.</div></div><div><h3>Results</h3><div>822 AF-CCEPs and 134 AF-ACEPs were acquired intraoperatively; 133 and 37 matched recordings were included for analysis, respectively. Post-resection N1 peak amplitude increased cohort-wide, while onset latency remained stable. One patient demonstrated signal loss associated with postoperative aphasia. AF-ACEP amplitudes were higher under general anesthesia, in higher-grade tumors, and with proximity to the AF on tractography.</div></div><div><h3>Conclusions</h3><div>AF-CCEP and AF-ACEP are feasible intraoperative adjuncts, with signal degradation associated with language morbidity. Post-resection amplitude increases may reflect intact AF conduction with increased cortical excitability following tumor removal.</div></div><div><h3>Significance</h3><div>When awake craniotomy is contraindicated, AF-CCEP and AF-ACEP may represent a viable alternative for monitoring AF integrity and reducing postoperative language morbidity.</div></div>","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"11 ","pages":"Pages 629-641"},"PeriodicalIF":2.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148634324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Somatosensory evoked fields at 36 weeks' gestation in preterm infants: A pilot study of thalamocortical maturation","authors":"Stephanie C. Schüssler,&nbsp;Fabian B. Fahlbusch,&nbsp;Undine Niederreiter,&nbsp;Martin Kaltenhäuser,&nbsp;Heiko Reutter,&nbsp;Regina Trollmann,&nbsp;Stefan Rampp","doi":"10.1016/j.cnp.2026.08.003","DOIUrl":"10.1016/j.cnp.2026.08.003","url":null,"abstract":"<div><h3>Objective</h3><div>Somatosensory evoked fields (SEF) recorded using magnetoencephalography enable non-invasive measurement of the cortical activity within the afferent somatosensory pathway. Because MRI studies suggest that delayed myelination and damage to the white matter contribute to adverse effects on neurological development in preterm infants, early functional markers of brain maturation are of particular interest.</div></div><div><h3>Methods</h3><div>In this single-center pilot study, SEFs were recorded using tactile stimulation in 13 preterm infants examined at 36 weeks' gestational age (GA) and 8 term infants examined at 40 weeks' GA. Latencies to the first cortical deflection in the somatosensory cortex were analyzed and compared across gestational ages at recording and between very preterm (26–31 weeks of GA at birth) and moderate/late preterm infants (32–36 weeks GA).</div></div><div><h3>Results</h3><div>SEF waveforms were obtained in all infants. Latencies were longer in preterm infants at 36 weeks' GA compared to term infants at 40 weeks' GA and decreased significantly with advancing GA. No significant latency differences were found between very preterm and moderate/late preterm infants at 36 weeks' GA.</div></div><div><h3>Conclusions</h3><div>MEG-based SEF recording is feasible in preterm infants at 36 weeks' GA. SEF latency did not provide evidence of a significant delay in somatosensory maturation in very preterm compared with moderate/late preterm infants and does not support the hypothesis of a delayed myelination in very preterm infants.</div></div><div><h3>Significance</h3><div>Although limited by sample size, single time-point measurements, and lack of magnetic resonance imaging (MRI), our study lays a foundation for future MEG investigations of premature infants in early life.</div></div>","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"11 ","pages":"Pages 707-713"},"PeriodicalIF":2.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148770103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}