Muscle excitability testing: Age and sex dependency of normative data

IF 2 Q3 NEUROSCIENCES

Clinical Neurophysiology Practice Pub Date : 2025-01-01 DOI:10.1016/j.cnp.2025.03.002

Matthias Thomas Exl , Belén Rodriguez , Karl Ng , Stella Veronica Tan , James Howells , Hugh Bostock , Hatice Tankisi , Werner J. Z’Graggen

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引用次数: 0

Abstract

Objective

To establish normative data for muscle excitability testing in the tibialis anterior muscle of a healthy population, and to determine their dependence on age and sex.

Methods

Parameters of muscle velocity recovery cycle recordings with 1, 2 and 5 conditioning stimuli of 197 healthy subjects and frequency ramp recordings of 151 healthy subjects were retrospectively analysed for age and sex differences.

Results

There were no differences by sex and only small age differences were found in healthy subjects older than 60 years for the muscle excitability parameters muscle relative refractory period, early supernormality and latency to the first response in a train at 15 Hz and 30 Hz.

Conclusions

In this study, based on a large sample of muscle velocity recovery cycle and frequency ramp recordings, we have provided normative data and shown that muscle excitability testing is not influenced by sex, and that age only has an influence from the age of 60 years onwards on parameters reflecting muscle membrane potential.

Significance

Our results suggest that future studies no longer need to control for sex when using a healthy control group.

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肌肉兴奋性测试：规范数据的年龄和性别依赖性

目的建立健康人群胫骨前肌兴奋性测试的规范性数据，并确定其对年龄和性别的依赖性。方法回顾性分析197名健康受试者在1、2、5条件刺激下的肌肉速度恢复周期记录参数和151名健康受试者的频率斜坡记录参数的年龄和性别差异。结果60岁以上健康受试者在15 Hz和30 Hz训练中肌肉兴奋性参数、肌肉相对不应期、早期异常和第一反应潜伏期均无性别差异，年龄差异较小。结论在本研究中，基于大量肌肉速度恢复周期和频率斜坡记录样本，我们提供了规范的数据，并表明肌肉兴奋性测试不受性别的影响，年龄仅在60岁以后对反映肌肉膜电位的参数有影响。意义：我们的研究结果表明，当使用健康对照组时，未来的研究不再需要对性行为进行控制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Neurophysiology Practice NEUROSCIENCES-

CiteScore

3.90

自引率

0.00%

发文量

审稿时长

71 days

期刊介绍： Clinical Neurophysiology Practice (CNP) is a new Open Access journal that focuses on clinical practice issues in clinical neurophysiology including relevant new research, case reports or clinical series, normal values and didactic reviews. It is an official journal of the International Federation of Clinical Neurophysiology and complements Clinical Neurophysiology which focuses on innovative research in the specialty. It has a role in supporting established clinical practice, and an educational role for trainees, technicians and practitioners.